Oxidative Stress Triggers Porcine Ovarian Granulosa Cell Apoptosis Through MAPK Signaling.

Follicle health determines the number and quality of sows' ovulation, thereby influencing the litter size and the piglets' viability. Granulosa cells (GCs) play a crucial role in follicular formation and development, and oxidative stress-induced GC death is a major cause of follicular dysplasia. Previous studies have confirmed that oxidative stress triggers apoptosis in granulosa cells.

Verification of the Impact of Sports Event Service Quality and Host Destination Image on Sports Tourists' Behavioral Intentions Through Meta-Analytic Structural Equation Modeling.

Given that participating in or spectating sports events plays a vital role in enhancing individuals' mental health, understanding the key factors that promote continued participation and attendance in sports events is of significant theoretical and practical importance within the context of sports tourism. From this perspective, the service quality of sports events and the image of the host destination have been identified as major determinants of sustained engagement among sports tourists. However, a review of the literature reveals that findings on the influence of sports event service quality and host destination image on the behavioral intentions of sports tourists have been inconsistent.

Bone marrow metastasis of gastric signet ring cell carcinoma complicated by thrombotic microangiopathy: A case report.

Background: Thrombotic microangiopathy (TMA) is an acute syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and multi-organ dysfunction due to the microcirculation of platelet thrombi. Cancer-associated TMA is a rare and fatal complication, which often occurs during cancer remission. It is frequently misdiagnosed because of limited clinical awareness.

Harnessing eDNA technology to identify fish diversity and distribution in the Kashi River, a tributary of the Ili River, Xinjiang, China.

Monitoring species diversity and distribution patterns in remote ecosystems presents significant challenges due to vast geographic coverage, harsh environmental conditions, and the limited availability of traditional survey resources. Environmental DNA (eDNA) technology has been proven to be an effective method for biodiversity assessment, offering a non-invasive, cost-effective, and efficient solution. The study used eDNA metabarcoding technology to investigate fish communities in the Kashi River, a vital waterway in Xinjiang.

MOCVD-grown InAs/InP quantum dot lasers with low threshold current.

We report low-threshold-current, high-yield InAs/InP quantum dot lasers in the C- and L-bands grown by metal-organic chemical vapor deposition (MOCVD). By optimizing the epitaxial growth conditions, including the introduction of a GaAs interfacial layer, we achieved more in-plane symmetric quantum dots with improved optical quality. Deep-etched ridge waveguide lasers with a 4 μm ridge width and top-top metal contacts were fabricated and characterized under pulsed injection.

Fungal Melanin in Plant Pathogens: Complex Biosynthesis Pathways and Diverse Biological Functions.

Fungal melanin plays a vital role in the survival, reproduction, infection, and environmental adaptation of plant pathogenic fungi. To develop innovative strategies for managing plant fungal diseases, comprehensive investigations into melanin are imperative. Such research is fundamental to elucidating the mechanistic basis of fungal pathogenesis and holds promise for the design of targeted interventions against melanin-mediated virulence determinants.

Depression links to unstable resting-state brain dynamics: insights from hidden markov models and functional network variability.

Background: Depression is closely associated with abnormalities in brain function. Traditional static functional connectivity analyses offer limited insight into the temporal variability of brain activity. Recent advances in dynamic analyses enable a deeper understanding of how depression relates to temporal fluctuations in brain activity.

Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential.

Breast cancer (BC) is the most prevalent malignant tumor among females. The primary therapeutic options currently available include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the emergence of drug resistance has resulted in a gradual decline in the efficacy of these treatments.

Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies.

Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging. Protein post-translational modifications (PTMs) are critical for governing protein expression, localization, functions, and interactions with other cellular molecules, which notably build up the diversity and complexity of the proteome. A growing body of evidence supports that PTMs influence immunotherapy efficacy and outcomes by post-translationally modulating the expression and functions of immune checkpoints.

Low threshold InAs/InP quantum dot lasers.

InAs/InP quantum dot (QD) lasers are promising light sources for optical communication due to their discrete energy states, offering advantages such as low threshold current density and enhanced thermal stability. However, challenges remain in achieving uniform QDs on the InAs/InAlGaAs/InP material system to ensure low threshold current density and high-temperature operation. This work demonstrates low threshold, high-temperature L-band InAs/InAlGaAs/InP QD lasers grown on InP (001) substrates with the indium-flush technique to optimize QD uniformity.

Enhanced nitrogen removal by Comamonas 110 colonization and bioaugmentation in sequencing batch activated sludge bioreactor.

While pure functional strains demonstrate high pollutant removal efficiency, their environmental persistence remains challenging. This study optimized Comamonas 110 inoculation strategies in activated sludge systems, enhancing nitrogen removal efficiency (44 % of nitrogen removal at day 180) and achieving stable colonization (15.22 % abundance at day 180) through 30 % initial dosage combined with operational parameter regulation.

Preparation of Palladium Nanoflowers Supported on Carbon Catalyst and Its Effect on the Electrochemical Hydrogenation of Soybean Oil.

The efficiency of oil hydrogenation processes is significantly influenced by the morphology of the catalyst. This study aims to enhance the catalytic efficiency and longevity of palladium nanoflower (PdNFs) catalysts by developing catalysts with a high specific surface area and abundant active sites. Using an electrochemical hydrogenation system, the effects of this catalyst on trans fatty acid (TFA) content and hydrogenation selectivity in the hydrogenated oil were investigated.

Study on the Mechanism of Dihydromyricetin in Alleviating Depressive-Like Behavior in Rats Based on Network Pharmacology.

Depression is a chronic and recurrent neuropsychiatric disorder with complex pathophysiology. Dihydromyricetin (DMY), a bioactive flavonoid compound isolated from Ampelopsis grossedentata (commonly known as rattan tea), has demonstrated multiple pharmacological properties including anti-inflammatory, antioxidant, antitumor, and antimicrobial activities. In the present study, a well-established rodent model of depression was generated through chronic unpredictable mild stress (CUMS) paradigm combined with social isolation.

Insights into roles of biochar on migration and accumulation of cadmium in Spartina alterniflora Loisel. -sediment systems and their microbial effects.

It is widely recognized that remediating cadmium (Cd)-contaminated sediments using biochar (BC) can significantly influence plant growth and development. However, the efficiency of such remediation often diminishes in field trials compared to greenhouse experiments, likely due to limited comprehension of the BC addition on the plant-sediment-microbe interaction. In this study, a 56-day pot experiment demonstrated that BC application offered (i) enhanced plant root length and biomass, (ii) increased proline content, (iii) improved photosynthetic capacity (e.

Exploring 3,4-dihydroxybenzaldehydefunctionalized MIL-88A(In:Fe) towards the efficient adsorption of tetracycline-hydrochloride.

The incorporation of metal-organic frameworks (MOFs) towards the removal of organic pollutants has triggered increasing research over the past decade. This study investigated the impact of binary metal sites (Fe:M, where M = Co, Cd, Cu, Mn, Mg, Ni, and In) and secondary organic ligands (malonic acid, cinnamaldehyde, pyrrole-2-carboxylic acid, 3,4-dihydroxybenzaldehyde, and diethylenetriaminepentaacetic acid) on the MIL-88A material. For the first time, a flexible 3,4-dihydroxybenzaldehyde-In/Fe-MOF was used for the adsorption of tetracycline hydrochloride.

STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.

STING, a pentameric transmembrane protein, plays a vital role in regulating the innate immune response to viral and bacterial infections. Recent research has underscored its significance in acute liver injury, yet its involvement in hepatic ischemia-reperfusion injury (HIRI) has not been thoroughly explored. To bridge this knowledge gap, we embarked on a comprehensive study using wild-type mice to investigate STING activation following surgical intervention for HIRI.

Anti-neuroinflammatory naphthol dimers from the marine-derived fungus Penicillium sp. HQ1-23.

Five undescribed naphthol dimers, penibinaphthols A-E (1-5), and two known analogues (6 and 7), were isolated from the marine-derived fungus Penicillium sp. HQ1-23. Their structures were elucidated based on spectroscopic data analysis, and the absolute configurations were determined by X-ray crystallographic data and ECD spectroscopic analysis.

Trans-Kingdom RNA Dialogues: miRNA and milRNA Networks as Biotechnological Tools for Sustainable Crop Defense and Pathogen Control.

MicroRNAs (miRNAs) are a class of non-coding RNAs approximately 20-24 nucleotides in length, which play a crucial role during gene regulation in plant-pathogen interaction. They negatively regulate the expression of target genes, primarily at the transcriptional or post-transcriptional level, through complementary base pairing with target gene sequences. Recent studies reveal that during pathogen infection, miRNAs produced by plants and miRNA-like RNAs (milRNAs) produced by fungi can regulate the expression of endogenous genes in their respective organisms and undergo trans-kingdom transfer.

Preparation, characterization, and binding mechanism of pH-driven gliadin/soy protein isolate nanoparticles.

Protein nanoparticles have attracted significant attention due to their low cost and high bioavailability; however, their poor stability limits their functional applications. To address this challenge, hydrophobic gliadin (G) and hydrophilic soy protein isolate (SPI) were co-assembled using the pH-driven method to evaluate the impact of different G/SPI ratios on their structural and functional properties. The results revealed that at G/SPI ratios between 1:1 and 1:8, the nanoparticles exhibited smaller particle sizes and higher zeta potentials.

Removal of copper, lead and cadmium from water through enzyme-induced carbonate precipitation by soybean urease.

Enzyme-induced carbonate precipitation (EICP) is widely recognized as a green and sustainable technology for heavy metal remediation. In this study, a novel spherical porous vaterite (0.05-5 μm) was synthesized via EICP, demonstrating exhibited excellent performance in heavy metals removal from contaminated water.

Association of high-normal blood pressure defined by the 2023 European Society of Hypertension guideline with mortality in the Chinese population: a nationwide, population-based, prospective study of 3.6 million adults.

Background: The relationship between high-normal blood pressure (BP) and mortality lacks high-quality evidence based on large population cohorts. This study aims to comprehensively investigate the association of high-normal BP and its trajectory with all-cause and cause-specific mortality.

Methods: In this community-based population cohort from the China Health Evaluation And risk Reduction Through nationwide teamwork (ChinaHEART) project, 3,598,940 participants aged 35-75 years with data for baseline BP were included.

Polygonum multiflorum Stilbene Glycoside Oligomers induce the ferroptosis of triple negative breast cancer cells.

The quality control testing component and main active ingredient of Polygonum multiflorum Thunb. (P. multiflorum), known as trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG), exhibits diverse biological activities.

Effects of Huoxue Chubi decoction on protein kinase B-mammalian target of rapamycin autophagy pathway in scleroderma Balb/c model mice.

Objective: To explore the mechanisms by which Huoxue Chubi decoction (, HXCB) affects the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) autophagy pathway in scleroderma Balb/c model mice.

Methods: A scleroderma model was established in male Balb/c mice, followed by daily administration of HXCB (4.6, 2.

To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.

Background: Liver cancer has a high incidence and mortality worldwide, especially in China. Herein, we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma (HCC), with a focus on the of phosphoinositide 3-kinases (PI3K)/AKT signaling pathway.

Aim: To investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and Huh7.

Modelling and optimization of Ge/GaAs uni-travelling carrier photodiodes.

Uni-Travelling-Carrier Photodiodes (UTC-PDs) are pivotal for the advancement of high-speed optical communication systems. Current UTC-PDs have a trade-off between high performance and low production costs. The performance of conventional Ge/Si UTC-PDs is limited by the materials, primarily due to the relatively low electron mobility of Si compared with that of GaAs and InP.