Ring type furnace integrated into DAC chamber for stable and uniform sample heating up to 2000 K.

The diamond anvil cell is a powerful tool for investigating material behavior under extreme pressure and temperature, but achieving efficient and uniform heating remains challenging. This study introduces a ring-type furnace integrated into a gasket with a metal-insulator-metal sandwich structure, using tantalum (Ta) for heating, tungsten (W) for electrodes, and mica-ceramic powder for insulation, enabling stable and uniform heating up to 2000 K. A calibration method combining thermocouple data and finite element simulations ensures accurate temperature measurement.

Serum STARD4-AS1 As a Novel Marker for Gastric Cancer Diagnosis and Promotes Gastric Cancer Progression.

Background: Gastric cancer (GC) is a lethal malignant tumor necessitating high-sensitivity detection to improve diagnostic accuracy and the prognosis of patients. Alterations in long noncoding RNAs can influence cancer progression through various mechanisms. Our study tried to explore the potential of STARD4-AS1 as a GC biomarker and its mechanism of action in GC development.

Construction and validation of medication deviation in cancer pain patients with oral opioid formulations during hospital-to-home transition.

Objective: The transition from hospital to home is a high-risk period for medication errors, particularly in patients receiving opioids. We constructed and validated a Medication Deviation Risk Prediction Model (MDRP) in cancer pain patients during hospital-to-home transition.

Methods: The medication deviation assessment table was constructed to determine whether there was a medication deviation in the MDRP modeling group.

Advanced Magnetic Imprinted Polymers Integrated with In Situ Ionization Mass Spectrometry for High-Throughput Pesticide Screening and Detection in Food Matrices.

This research introduces magnetic molecularly imprinted polymers (MMIPs) as a novel tool for the efficient extraction and detection of pesticide residues in food products. The MMIPs exhibit a notable adsorption capacity ranging from 15.70 to 23.

circRNA-miRNA interactions regulate the immune response by activating the NF-κB pathway through targeting IκBα in Sebastes schlegelii.

Non-coding RNAs (ncRNAs) play crucial regulatory roles in the NF-κB signaling pathway in fish. IκB (inhibitor of kappa B) acts as a key inhibitor of NF-κB. In our study on black rockfish (Sebastes schlegelii), we identified two paralogous copies of the IκBα gene, designated IκBα1 and IκBα2.

Change in social isolation and risk of frailty among older adults: results from two prospective cohorts.

Objective: This study investigates the longitudinal association between changes in social isolation and incident frailty in older adults.

Methods: Older adults from the China Health and Retirement Longitudinal Study (CHARLS) and the Survey of Health, Ageing, and Retirement in Europe (SHARE). About 3931 participants from CHARLS and 15,817 participants from SHARE aged 60 years and older who were non-frail at baseline were included.

Achieving Chromosome-Level Genome Assembly of Onychostoma macrolepis with PacBio Sequencing and Hi-C Technologies.

Onychostoma macrolepis is an emerging commercial fish with high edible value. Due to overfishing and environmental pollution, the wild population of Onychostoma macrolepis is declining sharply. In this study, we successfully assembled a chromosome-level genome for Onychostoma macrolepis using a comprehensive approach that integrated Illumina sequencing, PacBio sequencing, and Hi-C technology.

An Animal Model of Liuzijue Based on Kinematic Features Exploration: A Pilot Study Conducting in COPD.

Background: Liuzijue is an essential nonpharmacological intervention within the comprehensive management strategies for chronic obstructive pulmonary disease (COPD) patients. However, the absence of an animal model for Liuzijue presents methodological limitations in its basic research. This study aimed to apply interventions with kinematic characteristics of Liuzijue to COPD mice, with the objective to explore an animal model of Liuzijue suitable for experimental studies.

The predictive value of SOFA and APSIII scores for 28-day mortality risk in SIMI: a cohort study based on the MIMIC-IV database.

Objective: The objective of this study was to systematically identify and evaluate scoring systems that predict the prognosis of patients with sepsis-induced myocardial injury (SIMI).

Methods: Data were retrieved from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Logistic and Cox regression analyses were conducted to identify risk factors associated with 28-day mortality in patients with sepsis-induced myocardial injury (SIMI).

Softening and instability evolution of strip coal pillar under water immersion in goaf.

The softening and instability of the coal pillar caused by water immersion is the primary factor contributing to water inrush in the goaf of the same layer. Similarly, the softening and instability of underground reservoir dam bodies due to water immersion is a critical factor leading to reservoir water failure and dam breakage. Investigating the dynamic process of coal pillar softening and instability under water immersion conditions is of paramount importance for the prevention and control of mine water hazards in mining areas and the safety assessment of underground reservoirs.

Endoscopic ultrasound features in predicting noncurative resection of endoscopic submucosal dissection in patients with rectal neuroendocrine neoplasms.

Purpose: To explore the factors influencing noncurative resection (NCR) in patients with rectal neuroendocrine neoplasms (R-NENs) on the basis of endoscopic ultrasonography (EUS) findings and to construct and validate a nomogram prediction model based on these factors.

Methods: This retrospective cohort study included 244 patients with pathologically confirmed R-NEN who underwent endoscopic submucosal dissection (ESD) at the Affiliated Hospital of Qingdao University between March 2016 and June 2023. The patients' EUS and clinical features were collected to identify independent factors influencing NCR following ESD.

Structure-activity relationships study on inhibition of CRISPR-Cas9 by glycosaminoglycans.

The CRISPR-Cas9 system is a revolutionary genome editing system known for its precision, simplicity and efficiency, playing a crucial role in gene-editing. It has enabled applications ranging from biomedicine to agriculture. However, the uncontrollable activity of Cas9 has raised significant safety concerns in clinical settings, limiting its broader application.

Characteristic activation of respiratory muscles in Liuzijue practice: a preliminary study based on surface electromyography in healthy individuals.

Purpose: Liuzijue, a traditional Chinese Qigong, is effective for respiratory rehabilitation, yet its underlying mechanisms remain largely theoretical due to complex movement patterns. This study aimed to record respiratory muscle surface electromyography (EMG) during Liuzijue practice, analyze muscle activation characteristics, and provide a scientific basis for its clinical application.

Methods: Thirty-two proficient Liuzijue practitioners underwent calm breathing, deep breathing, and Liuzijue training with surface EMG recordings.

Construction and efficiency analysis of an embedded system-based verification platform for edge computing.

With the profound convergence and advancement of the Internet of Things, big data analytics, and artificial intelligence technologies, edge computing-a novel computing paradigm-has garnered significant attention. While edge computing simulation platforms offer convenience for simulations and tests, the disparity between them and real-world environments remains a notable concern. These platforms often struggle to precisely mimic the interactive behaviors and physical attributes of actual devices.

Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification.

Objective: This study aimed to elucidate the mechanisms underlying the protective effects of Zhenxin Formula (ZXF) against doxorubicin (Dox)-induced HF through the integration of network pharmacology, phospho-antibody array analysis, and experimental validation.

Methods: The active components and potential targets of ZXF were identified via the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform, while HF-associated target genes were retrieved from the OMIM, Genecards, and TTD databases. Protein-protein interaction (PPI) networks and compound-disease target networks were constructed using Cytoscape 3.

Risk factors for refractory in Chinese children: a meta-analysis.

Background: With the increase of the incidence rate of in children and the widespread use of azithromycin, the number of cases of refractory increased accordingly. infection was generally considered a self-limiting disease. However, under certain special circumstances, it was highly likely to develop into a refractory disease.

Association of remnant cholesterol with new-onset hypertension among middle-aged and older adults in China.

Although remnant cholesterol has been associated with cardiovascular disease, the risk of remnant cholesterol and blood pressure remains unclear. This study aimed to investigate the association between remnant cholesterol and new-onset hypertension. We used middle-aged and older adults aged ≥ 45 years from the first three waves of the China Health and Retirement Longitudinal Study (CHARLS).

Zebrafish models in glioma research: advances in methodologies, mechanistic insights, and therapeutic frontiers.

Glioma is the most common primary malignant brain tumor, which faces great challenges in clinical treatment due to its high invasiveness and resistance to existing treatments. In recent years, the zebrafish model has gradually become an important tool for glioma research due to its advantages such as easy genetic manipulation, strong optical transparency, and suitability for high-throughput imaging and drug screening. This article systematically reviews the three main strategies for zebrafish glioma modeling - chemical mutagenesis, genetic engineering and xenotransplantation, and describes their research applications in tumorigenesis, invasion process and treatment response.

The association between obesity-related indicators and female infertility: the United States National Health and Nutrition Examination Survey, 2013-2018.

Background: Infertility is a public health issue closely related to obesity. However, the relationship between obesity-related indicators and infertility is currently uncertain. The present study aimed to explore the association between obesity-related indicators and female infertility.

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer's disease following early social isolation.

Background: Both social and physical environmental factors influence the progression of Alzheimer's disease (AD), but the underlying mechanisms are not yet fully understood. This study aims to investigate how an enriched environment (EE) alleviates the detrimental effects of early social isolation (SI) on AD-like pathophysiology.

Methods: Four-week-old 5×FAD transgenic mice were randomly divided into group-housed and isolated groups.

Sandwich-like WS@MoS 2/1D Core-Shell Heterostructures for Efficient Nitrogen Electroreduction to Ammonia.

The electrocatalytic nitrogen reduction reaction (eNRR) into ammonia is considered a sustainable alternative to the traditional Haber-Bosch process. However, the problematic N activation and the competing hydrogen evolution reaction (HER) significantly hinder achieving satisfactory performance in aqueous electrolytes. Herein, we synthesized an eNRR electrocatalyst featuring MoS nanowire (NW) arrays that grow uniformly and vertically through intercalation between the interlayers of WS nanosheets (NSs), forming sandwich-like WS@MoS 2/1D core-shell heterostructures.

Identifying potential beneficiaries of neoadjuvant therapy in borrmann type III and IV gastric cancer: A treatment heterogeneity analysis using causal survival forests.

Background: Neoadjuvant chemotherapy (NAC) is a standard treatment for locally advanced gastric cancer, but its efficacy for Scirrhous-type Gastric Cancer (SGC) remains uncertain. This study evaluated the effectiveness of NAC and identified characteristics of potential beneficiaries within this patient population.

Methods: A retrospective single-center analysis included patients with large SGC who underwent either NAC followed by surgery (NAC group) or upfront surgery (SUR group).

Machine learning-driven prediction of cycloplegic refractive error in Chinese children.

Objective: To develop and validate machine learning (ML) models for predicting cycloplegic spherical equivalent refraction (SER) using non-cycloplegic parameters, addressing challenges in pediatric ophthalmic assessments.

Methods: A prospective cohort of 2,274 Chinese children (4,548 eyes) aged 3∼16 years was stratified into development ( = 1819) and validation ( = 455) datasets. Six ML models (linear regression, random forest, extreme gradient boosting, multilayer perceptron, support vector machine, and light gradient boosting machine) were trained on demographics, non-cycloplegic refractive error, and ocular biometrics.