Multi-view Contrastive Learning for Drug-Drug Interaction Event Prediction.

Drug-drug interactions (DDIs) represent a critical challenge in pharmacology, often leading to adverse effects and compromised therapeutic efficacy. Accurate prediction of DDI events, which involve not only identifying interacting drug pairs but also characterizing the specific nature and context of their interactions, is essential for drug safety and personalized medicine. In this study, we propose a novel Multi-view Contrastive Learning framework, namely MCL-DDI, for DDI Event Prediction by leveraging multi-view representations of drugs to enhance predictive performance.

Amine-functionalized covalent organic frameworks for high-performance carbon dioxide capture.

Covalent organic frameworks (COFs) have garnered significant interest as advanced platforms for carbon capture, utilization, and storage, owing to their high surface area, tunable porosity, and excellent chemical stability. However, their practical deployment for carbon dioxide (CO) capture, particularly under the low-concentration conditions characteristic of industrial flue gas, remains a major challenge. Herein, an amine-functionalized COF, designated TaTp-COF, is synthesized via spontaneous enol-to-ketoamine tautomerization, introducing a high density of uniformly distributed secondary amine groups that enhance CO binding affinity.

Integrating S-scheme photocatalysis with tandem carbonylation: A green and scalable strategy for CO valorization.

The rapid increase in atmospheric CO levels due to industrialization underscores the urgent need for innovative carbon valorization strategies. Photocatalytic CO reduction presents a sustainable solution; however, conventional systems suffer from inefficient charge separation and limited product applicability. Herein, a green and scalable tandem strategy is developed by integrating S-scheme photocatalysis with palladium-catalyzed carbonylation.

Enabling Multicolor Circularly Polarized Organic Long Persistent Luminescence through Chiral Exciplex.

Circularly polarized organic long persistent luminescence (CP-OLPL) has garnered significant attention due to its distinctive properties. However, achieving CP-OLPL materials with ultralong durations remains a formidable challenge. Herein, an effective strategy is proposed to obtain long-lived CP-OLPL by constructing a self-designed chiral donor for developing a host-guest chiral exciplex system.

Chebulagic acid inhibits lipopolysaccharide-induced endometritis by regulating mitogen-activated protein kinase/nuclear factor-κB signaling.

This study investigates the potential protective effects of chebulagic acid (CA) against endometritis and its underlying molecular mechanisms. Network pharmacology analysis identified 19 potential targets of CA related to endometritis, mainly associated with the mitogen-activated protein kinase (MAPK) signaling pathways. Molecular docking analysis further indicated that MAPK14 and MAPK3 are critical targets of CA, suggesting its potential role in modulating inflammatory responses.

Joint Association of Combined Healthy Lifestyle Factors and Hearing Loss With Cognitive Impairment in China.

Background: Hearing loss and lifestyle factors have been associated with cognitive impairment. We aimed to explore the joint association of combined healthy lifestyle factors and hearing loss with cognitive impairment, which has been scarcely studied.

Methods: This baseline study used data from the CHOICE-Cohort study (Chinese Hearing Solution for Improvement of Cognition in Elders).

Analysis of risk factors for weaning failure from mechanical ventilation in critically ill older patients with coronavirus disease 2019.

Objective: This study aimed to investigate the factors influencing weaning failure from invasive mechanical ventilation (IMV) in critically ill older patients with coronavirus disease 2019 (COVID-19).

Methods: We enrolled critically ill older patients with COVID-19 who were admitted to the medical intensive care unit (ICU) and received IMV between December 2022 and June 2023.

Results: We included 68 critically ill older patients with COVID-19 (52 male [76.

A high-performance organic fluorescent probe with aggregation-induced emission properties for long-term tumor monitoring.

Near-infrared organic fluorescent probes have great need in biological sciences and medicine but most of them are still largely unable to meet demand. In this work, a delicate multipurpose organic fluorescent probe (DPPM-TPA) with aggregation-induced emission performances is designed and prepared by facile method to reflect fluorescence labeling, two-photon imaging, and long-term fluorescent tracking. Specifically, DPPM-TPA NPs was constructed from 4-(diphenylamino)phenylboronic acid and DPPM-Br by classical Suzuki coupling reaction and then coated with F127.

IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signaling.

Tryptophan metabolism plays a crucial role in facilitating various cellular processes essential for maintaining normal cellular function. Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan (Trp) into kynurenine (Kyn), thereby initiating the degradation of Trp. The resulting Kyn metabolites have been implicated in the modulation of immune responses.

PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation.

Unlabelled: Viruses exploit the host cell's energy metabolism system to support their replication. Mitochondria, known as the powerhouse of the cell, play a critical role in regulating cell survival and virus replication. Our prior research indicated that the classical swine fever virus (CSFV) alters mitochondrial dynamics and triggers glycolytic metabolic reprogramming.

Triethanolamine-modified layered double oxide for efficient CO capture with low regeneration energy.

Various adsorbents for CO capture have been developed to mitigate the greenhouse effect. In this work, a novel CO adsorbent was fabricated by depositing triethanolamine (TEOA) onto the surface of nickel-cobalt-aluminum layered double oxide (NiCoAl-LDO) via the impregnation method. The CO capacity of the TEOA-LDO composite reached 1.

CSFV restricts necroptosis to sustain infection by inducing autophagy/mitophagy-targeted degradation of RIPK3.

CSFV infection in pigs causes persistent high fever, hemorrhagic necrotizing multi-organ inflammation, and high mortality, which seriously threatens the global swine industry. Cell death is an essential immune response of the host against pathogen invasion, and lymphopenia is the most typical clinical feature in the acute phase of CSFV infection, which affects the initial host antiviral immunity. As an "old" virus, CSFV has evolved mechanisms to evade host immune response after a long genetic evolution.

Transcriptome Shock in Developing Embryos of a and Hybrid.

Interspecific crosses that fuse the genomes of two different species may result in overall gene expression changes in the hybrid progeny, called 'transcriptome shock'. To better understand the expression pattern after genome merging during the early stages of allopolyploid formation, we performed RNA sequencing analysis on developing embryos of , , and their synthesized allotriploid hybrids. Here, we show that the transcriptome shock occurs in the developing seeds of the hybrids.

A method for extracting tumor events from clinical CT examination reports.

Accurate and efficient extraction of key information related to diseases from medical examination reports, such as X-ray and ultrasound images, CT scans, and others, is crucial for accurate diagnosis and treatment. These reports provide a detailed record of a patient's health condition and are an important part of the clinical examination process. By organizing this information in a structured way, doctors can more easily review and analyze the data, leading to better patient care.

High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study.

Background: Limited data are available about the clinical outcomes of AECOPD patients with respiratory acidosis treated with HFNC versus NIV.

Methods: We conducted a retrospective study to compare the efficacy of HFNC with NIV as initial ventilation support strategy in AECOPD patients with respiratory acidosis. Propensity score matching (PSM) was implemented to increase between-group comparability.

The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection.

CSFV (classical swine fever virus) is currently endemic in developing countries in Asia and has recently re-emerged in Japan. Under the pressure of natural selection pressure, CSFV keeps evolving to maintain its ecological niche in nature. CSFV has evolved mechanisms that induce immune depression, but its pathogenic mechanism is still unclear.

HSP90AA1 interacts with CSFV NS5A protein and regulates CSFV replication the JAK/STAT and NF-κB signaling pathway.

Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), is a highly contagious and fatal viral disease, posing a significant threat to the swine industry. Heat shock protein 90 kDa alpha class A member 1 (HSP90AA1) is a very conservative chaperone protein that plays an important role in signal transduction and viral proliferation. However, the role of HSP90AA1 in CSFV infection is unknown.

Genomic Characteristics and E Protein Bioinformatics Analysis of JEV Isolates from South China from 2011 to 2018.

Japanese encephalitis is a mosquito-borne zoonotic epidemic caused by the Japanese encephalitis virus (JEV). JEV is not only the leading cause of Asian viral encephalitis, but also one of the leading causes of viral encephalitis worldwide. To understand the genetic evolution and E protein characteristics of JEV, 263 suspected porcine JE samples collected from South China from 2011 to 2018 were inspected.

Viruses Hijack ERAD to Regulate Their Replication and Propagation.

Endoplasmic reticulum-associated degradation (ERAD) is highly conserved in yeast. Recent studies have shown that ERAD is also ubiquitous and highly conserved in eukaryotic cells, where it plays an essential role in maintaining endoplasmic reticulum (ER) homeostasis. Misfolded or unfolded proteins undergo ERAD.

Harvesting the infrared part of solar light to promote charge transfer in BiS/WO photoanode for enhanced photoelectrochemical water splitting.

Infrared light absorbed by semiconductors hardly contributes to the solar energy conversion due to its low photon energy. Herein, photothermal effect activated by infrared part of solar light is introduced to promote the photoelectrochemical (PEC) water splitting of photoanodes. Narrow band-gap semiconductor BiS is deposited on the surface of WO nanosheets, exhibiting a broad-spectral response.

Swine Enteric Coronavirus: Diverse Pathogen-Host Interactions.

Swine enteric coronavirus (SeCoV) causes acute gastroenteritis and high mortality in newborn piglets. Since the last century, porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) have swept farms all over the world and caused substantial economic losses. In recent years, porcine delta coronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV) have been emerging SeCoVs.

Spinel-Oxide-Integrated BiVO Photoanodes with Photothermal Effect for Efficient Solar Water Oxidation.

Spinel oxide materials have been widely used as oxygen evolution catalysts to enhance the photoelectrochemical (PEC) performance of photoelectrodes. Herein, we demonstrate that the water splitting efficiency of a photoanode can be further enhanced by introducing its photothermal effect. Under near-infrared radiation, the temperature of the NiCoO/BiVO photoanode increases moderately, leading to improved water oxidation kinetics and charge transport simultaneously.

Molecular Events Occurring in Lipophagy and Its Regulation in Infection.

Diseases caused by have a wide global and economic impact due to high morbidity and mortality. infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) caused by dengue virus (DENV). Given the highly complex pathogenesis of infections, they are still not fully understood at present.