Transcriptomic Analysis Reveals C-C Motif Chemokine Receptor 1 as a Critical Pathogenic Hub Linking Sjögren's Syndrome and Periodontitis.

Compelling evidence has demonstrated a bidirectional relationship between Sjögren's syndrome (SS) and periodontitis (PD). Nevertheless, the underlying mechanisms driving their co-occurrence remain unclear, highlighting the need for finding the hub gene. This study sought to examine the common genes and any connections between SS and PD.

Potential common mechanisms between primary Sjögren's syndrome and Hashimoto's thyroiditis: a public databases-based study.

Objective: Primary Sjögren's syndrome (pSS) and Hashimoto thyroiditis (HT) can occur in the same patient population, but the mechanism of co-occurrence remains unknown. This study aims to explore the underlying mechanism.

Methods: We screened differentially expressed genes (DEGs) in the pSS and HT-related transcriptomic microarrays.

CRYAA activates the SIRT1-pi3K/AKT signaling pathway by suppressing mir-155-5p to protect the RPE.

Background: Retinal degenerative diseases are important causes of blindness, and their pathogenesis is related to degenerative changes in the retinal pigment epithelium (RPE). αA-Crystallin (CRYAA) plays a role in maintaining cellular protein homeostasis and has been shown to protect the retina from stress; however, the detailed mechanisms involved in this protection are not known.

Methods: In vitro, ARPE-19 cells stably overexpressing CRYAA were generated from CRYAA-RPE cells.

A Gaze Estimation Method Based on Spatial and Channel Reconstructed ResNet Combined with Multi-Clue Fusion.

The complexity of various factors influencing online learning makes it difficult to characterize learning concentration, while Accurately estimating students' gaze points during learning video sessions represents a critical scientific challenge in assessing and enhancing the attentiveness of online learners. However, current appearance-based gaze estimation models lack a focus on extracting essential features and fail to effectively model the spatio-temporal relationships among the head, face, and eye regions, which limits their ability to achieve lower angular errors. This paper proposes an appearance-based gaze estimation model (RSP-MCGaze).

Ephemeral Emotional Resonance: User-Perceived Functional Value Leading to Short-Form Video Use.

With the rapid development of short-form videos, more and more people have gained a deep understanding of the functional value of short-form videos. Based on structuration theory, this paper explores the reasons why users use short-form videos. The authors conducted a questionnaire survey on 2613 Chinese short video users, and found that bridging social capital played a mediating role between users' perceived functional value of short-form videos and their use of short-form videos.

Preparation, characterization and antimicrobial properties of double lysine-modified chitosan and its preservation ability in chicken meat refrigeration.

In this study, to increase the antimicrobial activity of chitosan, lysine was grafted onto chitosan, resulting in a novel derivative named double lysine-modified chitosan (DL-chitosan). The use of H NMR, FT-IR, SEM, TG and DTG analyses provided compelling evidence of the structure of the newly developed derivatives. The MICs of DL-chitosan ranged from 0.

Accuracy and operation procedure of robotic computer-aided implant surgery.

This study assessed the accuracy of robotic computer-aided implant surgery (rCAIS) in partially edentulous patients using a standard operation procedure. Patients who underwent implant placement surgeries using the robotic system under a standard operation procedure were recruited. Deviations of dental implants were calculated after superimposition of the preoperative and postoperative cone-beam computed tomography (CBCT) images.

Progressive decrease in partial pressure of end-tidal CO during posterior spinal fusion surgery in a child with idiopathic scoliosis and pectus excavatum: a case report.

Background: Scoliosis surgery performed in a prone position may result in thoracic anatomical compression and alter local hemodynamics, increasing surgical risk, especially in patients with pectus excavatum. Most commonly, refractory hypotension is the first symptom of these circulatory changes. Here, we report a case with scoliosis and pectus excavatum under posterior spinal fusion that presented as a progressive decrease in the partial pressure of end-tidal CO (PCO) as the first symptom in the prone position.

Anesthesia management of CRS and HIPEC in advanced ovarian cancer with ultra-high intra-abdominal pressure: a case report.

Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a leading treatment for advanced ovarian cancer, significantly improving overall survival and disease-free survival. This case involves a patient with peritoneal metastasis and ultra-high intra-abdominal pressure (36 mmHg). CRS + HIPEC induces extensive pathological and physiological changes affecting respiratory, circulatory, renal, coagulation, and metabolic systems.

Hierarchical Nano/Micro-Array Structured CuMgAl-LDH/rGO Hybrids for Remarkably Improved Flame Retardancy and Smoke Suppression Performance of Flexible Polyvinyl Chloride.

In this study, we explored the rational integration of layered double hydroxides (LDHs) with reduced graphene oxide (rGO) to create a hierarchical nano/microarray structured CuMgAl-LDH/rGO hybrid aimed at enhancing the flame retardancy and smoke suppression properties of polymer nanocomposites. The results indicated that the limiting oxygen index (LOI) value of the G-CuMgAl/polyvinyl chloride (PVC) composite reached 35.8%, reflecting a 6.

Increased bone mass but delayed mineralization: in vivo and in vitro study for zoledronate in bone regeneration.

Background: Bisphosphonates (BPs) are widely used to inhibit excessive osteoclast activity. However, the potential to compromise bone defect healing has limited their broader application. To better understand the influence of BPs on bone regeneration, we established a bone grafting model with Zoledronate administration, aiming to deepen the understanding of bone remodeling and mineralization processes.

Shexiang Tongxin dropping pill ameliorates microvascular obstruction via downregulating ALOX12 after myocardial ischemia-reperfusion.

Background: Microvascular dysfunction (MVD) is common in patients with myocardial infarction receiving reperfusion therapy and is associated with adverse cardiac prognosis. Accumulating evidence suggests a protective role of Shexiang Tongxin dropping pill (STDP) in MVD. However, the specific effects and the underlying mechanisms of STDP in the context of MVD after myocardial ischemia-reperfusion (IR) remains unclear.

Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy.

Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients.

Methods: A total of 58 female patients (aged 20-60 years, ASAⅠ-Ⅱ) scheduled for elective hysteroscopy were enrolled and randomly divided into 2 groups, one of which was administered 0.2 mg/kg of esketamine (K1 group, n = 28) and the other 0.

Case report: Anesthetic management for removal of tumor thrombus in the inferior vena cava and pulmonary artery in renal cell carcinoma.

Anesthetic management of patients with renal cell carcinoma with tumor thrombus in the inferior vena cava (IVC) is challenging. This paper reports the experience of anesthesia management in a patient with advanced renal cell carcinoma with thrombus accumulation in the IVC, right atrium, and pulmonary artery who underwent radical nephrectomy and tumor thrombus removal assisted by cardiopulmonary bypass. The emboli, measuring approximately 3 × 6 cm in the left inferior pulmonary artery and 4 × 13 cm in the right main pulmonary artery, were removed completely.

Identification of a Novel NLRP12 Frameshift Mutation (Val730Glyfs41) by Whole-Exome Sequencing in Patients with Crohn's Disease.

encodes the nucleotide-binding leucine-rich repeat-containing receptor 12 protein and has been linked to familial cold autoinflammatory syndrome 2 (FCAS2). Previous studies have reported that NLRP12 protein can dampen inflammatory responses in DSS-induced mice colitis. To date, only four alterations in the gene have been associated with Crohn's disease (CD).

Global trends in research of pseudomyxoma peritonei: a bibliometric and visualization analysis.

Objective: Pseudomyxoma peritonei (PMP) was a complex disease that had attracted increasing attention. However, there had been no bibliometric analysis of this disease so far. This study aimed to explore the current situation and frontier trend of PMP through bibliometric and visualization analysis, and to indicate new directions for future research.

Correlation between peri-implant bone mineral density and primary implant stability based on artificial intelligence classification.

Currently, the classification of bone mineral density (BMD) in many research studies remains rather broad, often neglecting localized changes in BMD. This study aims to explore the correlation between peri-implant BMD and primary implant stability using a new artificial intelligence (AI)-based BMD grading system. 49 patients who received dental implant treatment at the Affiliated Hospital of Stomatology of Fujian Medical University were included.

Study on the Thermal Stabilizing Process of Layered Double Hydroxides in PVC Resin.

Poly(vinyl chloride) (PVC) is widely used in various fields and requires the use of thermal stabilizers to enhance its thermal stability during processing because of its poor thermal stability. Layered double hydroxides (LDHs) are widely considered to be one kind of highly efficient and environmentally friendly PVC thermal stabilizer. To investigate the thermal stabilizing process of layered double hydroxides (LDHs) in PVC resin, PVC and MgAl-LDHs powders with different interlayer anions (CO, Cl, and NO) were physically mixed and aged at 180 °C.

A patient with acute myocardial infarction with acute lower extremity arterial embolization underwent amputation under general anesthesia.

Introduction: Acute peripheral and coronary artery embolism are common complications of diabetes mellitus and greatly affect the clinical outcome of patients with diabetes; however, there are few reports about the symptoms and prognosis of patients with acute myocardial infarction (AMI) and concurrent acute lower extremity arterial embolism (ALEAE).

Case Presentation: A 44-year-old man with a history of 4 years of type 1 diabetes was admitted to hospital after suddenly experiencing severe pain in his right lower limb and feeling tightness in the left anterior chest area. Ultrasonography revealed distal occlusion of the right superficial femoral artery, and an electrocardiogram showed acute anterior interstitial myocardial infarction.

Characterization of the Complete Chloroplast Genome of D.Don 1825 (Ericaceae).

D.Don 1825 (Ericaceae) is a traditional Chinese medicinal plant used to treat rheumatoid arthritis. The complete chloroplast genome of .