Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: This umbrella review aimed to synthesize evidence from systematic reviews of clinical trials on the efficacy of tranexamic acid in gynecology and obstetrics procedures.
Methods: We searched Medline, Embase, SciELO and Cochrane Database of Systematic Reviews on March 11, 2024, using the term "tranexamic acid". Four reviewers independently select studies and extract data. We assessed the quality of systematic review and the quality of evidence, using AMSTAR 2 and GRADE tools, respectively.
Results: Of 651 systematic reviews identified, 16 reviews with 96663 patients were included. The surgical procedures were cesarean section, myomectomy, hysterectomy, and cervical intraepithelial neoplasia surgery. All reviews showed a statistically significant and clinically relevant reduction in intraoperative and post-procedure blood loss, associated with intravenous or topical use of tranexamic acid. Tranexamic acid resulted in a significant reduction in the need for blood transfusions and a less pronounced drop in postoperative hematocrit and hemoglobin levels in cesarean section. Several reviews addressed the same question, but the number of included trials varied substantially, which might indicate flaws in search and selection of studies of these reviews. The quality of systematic reviews was low or critically low, and the quality of evidence was moderate.
Conclusions: This umbrella review shows that tranexamic acid can reduce blood loss and hemorrhage in gynecology and obstetrics procedures. High quality systematic reviews are still needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097445 | PMC |
| http://dx.doi.org/10.61622/rbgo/2025rbgo18 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
eHealth and Hypertensive Disorders of Pregnancy: Systematic Review.
J Med Internet Res
September 2025
Faculty of Medicine, The University of Sydney, Sydney, Australia.
Background: Hypertensive disorders of pregnancy (HDP) affect up to 10% of pregnancies and can have adverse short and long-term implications for women and their babies. eHealth interventions include any health service or treatment delivered using the internet and related technology that aims to facilitate, capture, or exchange knowledge. eHealth interventions are increasingly used across many health care settings with improved outcomes.
View Article and Find Full Text PDFEffects of Injury Registry Data on Policymaking, Hospitalizations, and Mortality: Systematic Review.
JMIR Public Health Surveill
September 2025
Hospital Israelita Albert Einstein, 755 Comendador Elias Jafet Street, L1 Floor, Room 134, São Paulo, 05653-000, Brazil.
Background: The Brazilian project, launched in 2021, aims to establish a nationwide injury registry that systematically collects detailed information on incidents and individuals across the country, regardless of injury severity. The registry integrates information from prehospital and hospital care, various health systems lacking interoperability, and data from sectors such as firefighters and police. Its primary aim is to enhance health surveillance by providing timely, high-quality information that guides prevention strategies and informs policymaking.
View Article and Find Full Text PDFHuman papillomavirus: problems and prospects for women's reproductive health (systematic review).
Pol Merkur Lekarski
September 2025
LLC "ECOFARM", KYIV, UKRAINE.
Objective: Aim: To consider the specific activity of drops and suppositories of PROTEFLAZID® at the stage of preclinical study, to assess the effectiveness and safety of use in clinical practice in papillomavirus-associated diseases of the female reproductive system..
Patients And Methods: Materials and Methods: Analysis of scientific publications on the treatment of palilomavirus infection with PROTEFLAZID® in women over the past decade.
Temperature elevation intensifies the toxicity of metals to terrestrial invertebrates: results of a meta-analysis.
Braz J Biol
September 2025
Universidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Departamento de Engenharia Ambiental, São José dos Campos, SP, Brasil.
The present study carried out the first systematic review with meta-analysis on the effects of metals and temperature rise individually and their associations with terrestrial invertebrates. Initially, a systematic review of peer-reviewed articles was performed. Meta-analysis demonstrated that metals negatively affected the fitness of annelids, arthropods, and nematodes and positively affected physiological regulation in annelids.
View Article and Find Full Text PDFEFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS.
Arq Gastroenterol
September 2025
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Objective: To verify the effect of physical exercise on the quality of life of patients with liver cirrhosis (LC).
Methods: the sample included controlled and randomized experimental studies of individuals with LC, at any stage of the disease, over 18 years of age, of both sexes, who performed any type of physical exercise compared to any other intervention or no intervention, with quality of life as the outcome assessed by the Chronic Liver Disease Questionnaire (CLDQ). The search for articles was conducted in 11 databases.