Publications by authors named "Zhi-Can Yang"
Aims/hypothesis: Glucose homeostasis, essential for metabolic health, requires coordinated insulin and glucagon activity to maintain blood glucose balance. Dysregulation of glucose homeostasis causes hyperglycaemia and glucose intolerance, hallmark features of type 2 diabetes. While SEC16 homologue B (SEC16B), an endoplasmic reticulum export factor, has been linked to obesity, type 2 diabetes and lipid metabolism, its role in glucose regulation remains poorly defined.
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- Anti-obesity medications, like Metformin (Met) and mirabegron (Mir), can lower body weight by reducing energy intake or increasing energy expenditure, but their combined effects were not previously studied.* -
- This study showed that using Met and Mir together led to greater weight loss in both prevention and treatment models, with significant reductions in body weight gain and enhanced fat loss in obese mice.* -
- The combination therapy improved metabolic health markers like glucose tolerance and insulin sensitivity, while also avoiding any negative effects on cardiovascular health, suggesting it could be a valuable obesity treatment strategy.*