Ultrabroadband Photosensitivity and Frequency-Mixing in Anisotropic Weyl Semimetal NbNiTe.

Broadband anisotropic photodetectors show great promise for polarization-sensitive imaging and multispectral optoelectronic systems yet face critical challenges in material anisotropy modulation and broadband sensitivity. Weyl semimetals exhibit giant optical anisotropy and tunable heterojunction band alignment, enabling high-performance anisotropic photodetection. Herein, ultrabroadband PDs based on the NbNiTe (niobium nickel telluride), enabled by antenna integration and heterostructure engineering, achieve high sensitivity from visible to Terahertz (THz).

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report a prodrome consistent with infection. We present a multi-omics analysis based on plasma metabolomic and proteomic profiling, and immune responses to microbial stimulation, before and after exercise.

The design and preparation of novel imidazolinone-backbone chiral N,P ligands and their highly effective performances in enantioselective allylations.

Based on a patented new concept of general chiral catalysis, a series of new chiral ligands integrating both a MacMillan imidazolinone organocatalyst and a chiral N,P-ligand scaffold has been designed and concisely prepared from commercially available chiral α-amino acids and 2-diphenylphosphino-benzaldehyde. These chiral ligands have shown good to excellent enantioselectivities (up to 97% ee) with satisfactory yields (up to 95%) in enantioselective Pd-catalyzed allylations with 1,3-dicarbonyls and amines.

The effects of L-carnitine in children with kidney failure undergoing dialysis: a systematic review.

Background: Patients on dialysis often suffer from carnitine deficiency due to reduced intake, reduced synthesis in the kidneys, and clearing through dialysis. Carnitine deficiency may lead to anemia, cardiomyopathy, hypotension, and so on. Several studies have shown that supplementing with L-carnitine can diminish the above symptoms in adult dialysis patients, but whether children can benefit from L-carnitine remains unclear.

Transport Measurements of Majorization Order for Wave Coherence.

We investigate the majorization order for comparing wave coherence and reveal its fundamental consequences in transport measurements, including power distribution, absorption, transmission, and reflection. We prove that all these measurements preserve the majorization order under unitary control, enabling direct experimental characterization of the majorization order. Specifically, waves with lower coherence in the majorization order exhibit more restricted ranges of achievable measurement values.

Applications of nanomaterials in head and neck squamous cell carcinoma: current progress and perspectives.

Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor that affects the head and neck area. HNSCC typically has complex clinical symptoms and is detected at a late stage. Therefore, it is quite difficult to give patients the best possible care and treatment.

Novel pathogenic MAN2B2 variants cause systemic lupus erythematosus and dysregulated glycosylation.

Genetic factors have been demonstrated to play essential roles in the pathogenesis of systemic lupus erythematosus (SLE). Identifying novel disease-causing genes of SLE helps to reveal its molecular mechanisms and new therapeutic targets. In this study, we identified biallelic loss-of-function variants of MAN2B2 gene in five unrelated SLE patients by whole exome sequencing.

Asparaginase enhances CAR-T cell antitumor immunity by asparagine metabolic reprogramming and central memory induction in ALL.

High levels of asparagine synthetase (ASNS) in acute lymphoblastic leukemia (ALL) lead to immunotherapy resistance. Our study showed that ASNS overexpression (OE) in NALM6-GL cancer cells attenuated chimeric antigen receptor (CAR)-T cell-mediated cancer cell lysis. Asparaginase (ASPG) is an approved drug that breaks down circulating asparagine in leukemia cells, thereby depriving cancer cells of asparagine and inhibiting cancer growth.

Co-Parenting Behaviors and Parenting Stress Amid China's Cultural Shifts in Parental Roles: Dual Perspectives From Mothers and Fathers.

With sociocultural changes in China, the traditional mother-dominated parenting model has shifted toward a more collaborative approach. However, the role of fathers in Chinese family parenting and the dyadic relationship between co-parenting behaviors and parenting stress remain insufficiently explored. This study explores the relationship between Chinese parents' co-parenting behaviors and their own and their partner's parenting stress, and further reveals the diversity of co-parenting behavior patterns in Chinese adolescent families and examines the variations in parenting stress across different co-parenting types.

Precision replication and quality analysis of the molded glass cylindrical lens array.

Precision glass molding (PGM) is a well-established and cost-effective manufacturing process used to fabricate high-quality and high-precision optical elements with complex geometries, such as aspherical lens, microlens array, and microprisms. This study focuses on the replication quality of molded glass cylindrical lens arrays, which is critical for achieving exceptional precision and consistency in optical applications. The effect of process parameters on replication quality of the molded cylindrical lens array was studied.

Portable lensfree imaging platform based on prior-guided phase retrieval.

We presented a portable lensfree imaging platform that can achieve complex wavefield reconstruction with multi-distance intensity measurements. In our platform, 400 LEGO bricks and a bare CMOS sensor chip are integrated into a lensfree in-line holographic imaging system, where a motor and a set of gear modules from LEGO are designed to control the axial movement of a sample to generate multi-plane intensity patterns. In data processing, the intensity images are calculated in a computer to show the retrieved amplitude and phase of the sample.

High-fidelity dual-wavelength phase retrieval for lensless wavelength-multiplexed microscopy.

Lensless wavelength-multiplexed microscopy provides an effective imaging solution for single-frame wavefield recovery, in which three lasers with different wavelengths simultaneously illuminate a sample to capture a color hologram. In data processing, the recorded color hologram is divided into three intensity images and then input into multi-wavelength phase retrieval (MWPR) for image recovery. However, the performance of MWPR on data-reduced measurements, such as dual-wavelength imaging, is undermined by the stagnant convergence.

Agrimonolide from Agrimonia pilosa Ledeb attenuates cholestatic liver injury and macrophage infiltration via the inhibition of bile acid excretion transporters.

Background: Cholestasis is a complex hepatobiliary syndrome without effective treatment. Agrimonia pilosa Ledeb has been used in traditional Chinese medicine for centuries to treat various diseases, including inflammatory diseases, liver and gallbladder disorders. The active ingredient of agrimonolide (AM) is a derivative of the isocoumarin from Agrimonia pilosa Ledeb.

Heightened innate immunity may trigger chronic inflammation, fatigue and post-exertional malaise in ME/CFS.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained fatigue, post-exertional malaise (PEM), and cognitive dysfunction. ME/CFS patients often report a prodrome consistent with infection. We present a multi-omics analysis based on plasma metabolomic and proteomic profiling, and immune responses to microbial stimulation, before and after exercise.

Hes1 in malignant tumors: from molecular mechanism to therapeutic potential.

The occurrence and development of malignant tumors involve abnormalities in complex molecular regulatory networks, among which the abnormal activation of the transcriptional regulator hairy and enhancer of split 1 (Hes1) has attracted significant attention in recent years and is closely associated with prognosis in various malignancies. Hes1 exhibits high expression in various solid tumors and hematological malignancies, where it participates in alterations involving diverse immune cells, inflammatory factors, and the immune microenvironment, thereby promoting tumor cell proliferation, invasion, metastasis, and resistance to treatment. Recent studies have widely investigated the potential of targeting Hes1 and inhibiting its expression as a cancer therapeutic strategy, although its precise mechanisms of action are not yet fully elucidated.

Elucidating the mechanism of dibutyl phthalate on Alzheimer's disease through network toxicology, molecular docking and validation in mouse neuroblastoma cells.

Dibutyl phthalate (DBP), a widely used plasticizer, has been suggested to be neurotoxic. We aim to explore possible molecular mechanisms of DBP on Alzheimer's disease (AD) using a combined approach of network toxicology, molecular docking and experimental validations. We retrieved targets of DBP from ChEMBL and STITCH databases, while obtaining AD-related targets from GeneCards and OMIM databases.

Growing Minds, Diverging Paths: Psychological Suzhi Trajectories and Adolescent Adjustment in China.

Psychological suzhi is a culturally rooted construct that emerged from China's quality-oriented educational reform, aiming to promote positive adolescent development. It integrates cognitive, individuality, and adaptability qualities, forming a dynamic internal system that supports resilience and mental health in Chinese contexts. Despite its theoretical prominence in Chinese educational discourse, research on its developmental trajectory and long-term implications for adolescent adjustment remains limited.

Association between dietary oxidative balance score and cognitive function among older adults: A sex- and sex hormone-stratified analysis from the National Health and Nutrition Examination Surveys 2013-2014.

Background: Cognitive decline is associated with oxidative stress, which varies between males and females. Nevertheless, the sex- and sex hormone-stratified relevance of dietary oxidative balance score (DOBS) with cognitive function in older adults is unclear.

Methods: We analyzed 1094 participants aged 60 and older from the National Health and Nutrition Examination Surveys 2013-2014, assessed cognitive performance by animal fluency test (AFT), digit symbol substitution test (DSST), immediate recall tests (IRT) and delayed recall test (DRT), and created a total Z-score for impairment.

Enhancing Fuel Cell Performance by Constructing a Gas Diffusion Layer with Gradient Microstructure.

This study focuses on addressing the issues of water flooding and mass transfer limitations in proton exchange membrane fuel cells (PEMFCs) under high current density conditions. A multi-scale gradient pore gas diffusion layer (GDL) is designed to enhance fuel cell performance. The pore structure is precisely controlled using a self-assembled mold, resulting in the fabrication of a GDL with a gradient distribution of pore diameters ranging from 80 to 170 μm.

Parental educational levels association with autism risk in offsprings and their autistic phenotypes.

This study aims to explore the association between parental education levels and the risk of autism in offspring, as well as to further investigate the relationship between parental education and the phenotypic characteristics of autistic symptoms. The study is based on an autism cohort of 835 autistic children, with a control group of 504 typically developing children randomly selected for comparison. Socioeconomic data from the parents of the study participants were collected, and the clinical phenotypes of the autistic children were assessed.

Cost-effectiveness analysis of first-line treatment for advanced soft tissue sarcomas in China.

Objectives: To evaluate the cost-effectiveness of four first-line treatment strategies-anlotinib, pazopanib, regorafenib, and conventional chemotherapy-for patients with advanced soft tissue sarcomas (STSs) in China.

Methods: A partitioned survival model was developed to simulate costs and quality-adjusted life years (QALYs) over a lifetime horizon from the Chinese healthcare system perspective. Relative treatment efficacies were derived from a network meta-analysis (NMA).

Serum α-Klotho mediates the association between blood toluene and BUN: A cross-sectional study from NHANES 2013-2016.

Background: Toluene is a common volatile organic compound (VOC) that usually enters the body through breathing or skin absorption. Blood urea nitrogen (BUN) is a by-product of protein metabolism and is commonly used as an indicator to assess renal function. α-Klotho protein is detected mainly in the kidney and has antioxidant, anti-aging, and nephroprotective properties.

SU-8 micro-machined WR-4 H-plane diplexer with dual-mode resonator.

This article presents a WR-4 band (170-260 GHz) H-plane diplexer based on the SU-8 micromachining process with a dual-mode resonator structure. The proposed diplexer features two fourth-order bandpass filters, achieving passbands of 215-218 and 221-224 GHz. This proposed design employs dual-mode rectangular waveguide resonators, and a non-resonant junction is formed by three non-resonant node resonators connecting the two passbands.

MCT1-mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells.

As a major fuel source for the tricarboxylic acid cycle, lactate controls energy metabolism through cell-to-cell or tissue-to-tissue lactate shuttles via monocarboxylate transporters (MCTs). Although lactate is shown to influence macrophage functions via histone lactylation, the specific functions of MCTs in macrophages remain incompletely understood. This study discovers that MCT1 and MCT4 have contrasting effects on regulating macrophage polarization.