Examining the after-school study burden of Chinese secondary school students following burden reduction policies: a sociological analysis.

Background: To address the significant issue of students' heavy after-school study burden, many countries have enacted relevant policies. However, the effects of policy implementation are not always desirable. This study is informed by an analysis of how dominant social imaginaries and discourses in China-emphasizing accountability, performativity, competitiveness, and capital accrual-contribute to students' burdens.

Methylation-induced suppression of BEX1 activates AKT/ERK/STAT3 signaling pathways regulating cell cycle and apoptosis in glioma.

Gliomas are highly aggressive brain tumors with complex molecular characteristics. The role of BEX1 methylation in gliomas is not well understood, despite its potential implications for tumor biology and therapy. Investigating this relationship could uncover critical mechanisms underlying glioma pathogenesis and highlight therapeutic targets.

Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.

The novel protein acylation modifications have played a vital role in protein post-translational modifications. However, the functions and effects of the protein acylation modifications in lung adenocarcinoma are still uncertain. Currently, there is still a lack of global identification of acylation modifications in lung adenocarcinoma cells.

Inhibition of P2X7R by hypericin improves diabetic cardiac autonomic neuropathy through the proteasome- Nrf2 - GPX4 signaling axis.

Hypericin (HYP), a primary active compound derived from Hypericum perforatum has been studied in the context of diabetes. The purpose of this study is to observe whether HYP can improve diabetic cardiac autonomic neuropathy (DCAN) and its possible mechanism. The current findings suggest that multiple drivers of ferroptosis in DCAN converge on the antioxidant protein nuclear factor erythroid 2-related factor 2(Nrf2).

Prophylactic cranial irradiation in resected early stage small cell lung cancer: an updated systematic review and meta-analysis.

Background: The use of prophylactic cranial irradiation (PCI) in early stage small cell lung cancer (SCLC) patients post-surgery remains controversial. This meta-analysis aimed to evaluate the efficacy of PCI in resected early stage SCLC patients.

Methods: Relevant literature was reviewed through PubMed, Cochrane, and Embase databases.

Targeted sequencing identifies 33 novel mutations in 130 ClinGen curated hearing loss genes among 253 pediatric patients: A retrospective case study.

Hearing loss (HL) can occur at any age, with hereditary HL being one of the most prevalent congenital disabilities. In the present study, a cohort of pediatric patients with HL was established, comprising 259 individuals at the Children's Hospital of Zhejiang University from 2017-2022. All patients underwent comprehensive diagnostic evaluations, including complete clinical examinations and audiological assessments.

Efficacy analysis of non-invasive correction for congenital cryptotia with auricular cartilage deformities.

Objectives: To investigate the efficacy of non-invasive correction for congenital cryptotia with auricular cartilage deformities in infants.

Methods: A total of 42 cases of congenital cryptotia with auricular cartilage deformities treated with non-invasive auricular correctors in our hospital from January 2019 to December 2023 were collected. The enrolled children were divided into four groups (A: less than 28-days, B: 28-90 days, C: 90-180 days, D: more than 180-days) based on age.

Dimethyl Pent-2-Enedioate inhibits LPS-induced inflammatory response in macrophages.

Background: Endogenous metabolite itaconate and its derivative Dimethyl itaconate (DMI) exhibit significant anti-inflammatory effects. Dimethyl Pent-2-Enedioate (DMP), an isomer of DMI, may possess similar properties. This study investigates the anti-inflammatory effects of DMP in LPS-induced macrophages and explores its potential regulatory mechanisms.

[Efficacy and safety assessment of transnasal nebulisation of budesonide in children with adenoid hypertrophy].

To investigate the efficacy and assess the safety of transnasal nebulisation of budesonide in children with adenoid hypertrophy. Children with adenoid hypertrophy who attended the Children's Hospital of Zhejiang University School of Medicine between December 2021 and December 2022 were randomly assigned to budesonide high-dose group（Group A: budesonide 1 mg/dose + saline nasal rinse）, budesonide low-dose group（Group B: budesonide 0.5 mg/dose + saline nasal rinse）, and control group（Group C: saline nasal rinse）, and each group 20 children were collected separately, The efficacy and safety of transnasal nebulisation of budesonide in children with adenoid hypertrophy were assessed by comparing the symptomatic VAS scores, adenoidal nasopharyngeal lateral radiographs A/N values, nocturnal sleep oximetry（SaO2）, and the incidence of adverse events during the treatment period of 8-week in the three groups.

[Piriform sinus hamartoma in children: a case report and literature review].

To investigate the clinical manifestations and treatment of laryngopharynx hamartoma in children. The clinical data of a child with piriform sinus hamartoma treated in our hospital were analyzed retrospectively. The age, gender, clinical manifestations, auxiliary examination, location of the tumor and surgical methods were analyzed.

Co-transport of polystyrene microplastics and kaolinite colloids in goethite-coated quartz sand: Joint effects of heteropolymerization and surface charge modification.

This study investigated the transport behavior of polystyrene microplastics (MPs) in saturated quartz sand and goethite-coated sand in the presence of coexisting kaolinite colloids. Column experiments were conducted under a wide range of solution chemistry conditions, including pH levels of 6.0, 7.

Research Advances on Stem Cell-Derived Extracellular Vesicles Promoting the Reconstruction of Alveolar Bone through RANKL/RANK/OPG Pathway.

Periodontal bone tissue defects and bone shortages are the most familiar and troublesome clinical problems in the oral cavity. Stem cell-derived extracellular vesicles (SC-EVs) have biological properties similar to their sources, and they could be a promising acellular therapy to assist with periodontal osteogenesis. In the course of alveolar bone remodeling, the RANKL/RANK/OPG signaling pathway is an important pathway involved in bone metabolism.

Technology development and cost analysis of multiple pollutant abatement for ultra-low emission coal-fired power plants in China.

The implementation of ultra-low emission (ULE) limits (SO: 35 mg/m, NOx: 50 mg/m, PM: 10 mg/m) promoted the development of flue gas treatment technologies in China. Pollutant control technology development for Chinese coal-fired power plants was summarized and an analysis of the applicability and cost of pollutant control technologies was conducted. Detailed data were collected from 30 ultra-low emission coal-fired units across China.

Advances in air pollution control for vessels in China.

Vessel emissions have contributed a great deal to air quality deterioration in China. Hence, the Chinese government has promulgated a series of stringent emission regulations. It is in this context that vessel emission control technology research is in full swing.

Is simultaneous cranioplasty with cerebrospinal fluid shunts implantation as safe as staged procedures?

Objective: The combination of cranioplasty and ventriculoperitoneal shunt is a therapeutic strategy for patients with hydrocephalus after decompressive craniectomy (DC). However, the efficacies of simultaneous vs. staged surgery in reducing postoperative complications have not been conclusively determined.

Comparison of the Value of Conventional Ultrasound and Contrast-Enhanced Ultrasound-Guided Puncture Biopsy in Different Sizes of Peripheral Pulmonary Lesions.

Objective: To compare the clinical value of contrast-enhanced ultrasound and conventional ultrasound-guided puncture biopsy in peripulmonary lesions of different sizes.

Materials And Methods: 110 patients with peripulmonary lesions were randomly divided into two groups: the conventional ultrasound-guided group and the contrast-enhanced ultrasound-guided group. The lesions in the two groups were further divided into two groups according to the size of the lesions, and the tissues taken after puncture biopsy were sent for pathological examination.

Neck and mediastinal hematoma caused by a foreign body in the esophagus with diagnostic difficulties: A case report.

Background: Esophageal foreign body (FB) is a common clinical emergency. Clinically, computed tomography (CT) scans are important in the diagnosis of FBs in the esophagus. Here, we report a case of esophageal perforation and cervical hematoma, caused by a FB, whose uniqueness made rapid diagnosis difficult.

Osteogenic peptides in periodontal ligament stem cell-containing three-dimensional bioscaffolds promote bone healing.

Bone tissue engineering shows great potential in bone regeneration; however, the lack of bone growth factors with high biocompatibility and efficiency is a major concern. Oligopeptides have drawn great attention due to their high biological efficacy, low toxicity, and low molecular weight. The oligopeptide SDSSD promotes the osteogenesis of human periodontal ligament stem cells (hPDLSCs) The SDSSD-modified three-dimensional (3D) bioscaffolds promote osteogenesis and bone formation in the subcutaneous pockets of BALB/c nude mice and facilitate bone healing .

Correlation between anxiety-depression symptoms and immune characteristics in inpatients with 2019 novel coronavirus in Wuhan, China.

Background: Coronavirus disease 2019 (COVID-19) is widely acknowledged as a severe traumatic event, and depression, anxiety, and psychological distress are common in diagnosed patients. However, the correlations of biological indicators with emotion are rarely reported. The primary objective of this study was to explore the dysfunction of immune-inflammatory characteristics in patients with depression-anxiety symptoms.