Combined endurance and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults.

Chronic exercise training substantially improves skeletal muscle function and performance. The repeated demands and stressors of each exercise bout drive coordinated molecular adaptations within multiple cell types, leading to enhanced neuromuscular recruitment and contractile function, stem cell activation, myofiber hypertrophy, mitochondrial biogenesis, and angiogenesis, among others. To comprehensively profile molecular changes induced by combined resistance and endurance exercise training, we employed spatial transcriptomics coupled with immunofluorescence and computational approaches to resolve effects on myofiber and mononuclear cell populations in human muscle.

CSFformer: Redefining multi-channel time series analysis with cross-scale fusion Transformer.

Current Transformer models with channel independence (CI) have made tremendous achievements in time series data analysis. However, the CI methods suffer from short-term fluctuations with intra-channel noise and long-term trend extraction. The fixed receptive field of CI models struggles with capturing multi-scale temporal features within each channel.

Identification of hub gene associated with colorectal cancer: Integrating Mendelian randomization, transcriptome analysis and experimental verification.

Background: Colorectal cancer (CRC) is a prevalent malignancy with significant mortality rates globally. Understanding the genetic and molecular mechanisms underlying CRC development is crucial for improving therapeutic strategies.

Method: In this study, we utilized cis-eQTL summary data to identify genes potentially causally associated with CRC.

The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies.

Background: Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota's role in sleep regulation through the gut-brain axis. This systematic review aims to summarise current evidence on the role of gut microbiota alterations in insomnia.

High flavonoid-producing tomato reduces whitefly phloem-feeding efficiency by inducing reactive oxygen species accumulation and callose deposition.

The whitefly (Hemiptera: Aleyrodidae) is economically one of the most threatening pests in tomato cultivation, which not only causes direct damage but also transmits many viruses. Breeding whitefly-resistant tomato varieties is a promising and environmentally friendly method to control whitefly populations in the field. Accumulating evidence from tomato and other model systems demonstrates that flavonoids contribute to plant resistance to herbivorous insects.

Kernel-FastICA-Based Nonlinear Blind Source Separation for Anti-Jamming Satellite Communications.

Satellite communication systems, as a core component of global information infrastructure, have undergone unprecedented development. However, the open nature of satellite channels renders them vulnerable to electromagnetic interference, making anti-jamming techniques a persistent research focus in this domain. Satellite transponders contain various power-sensitive components that exhibit nonlinear characteristics under interference conditions, yet conventional anti-jamming approaches typically neglect the nonlinear distortion in transponders when suppressing interference.

Gastrointestinal health and nutritional strategies in autism spectrum disorder.

Beyond the hallmark social and sensory difficulties in autism spectrum disorder (ASD), the comorbid gastrointestinal (GI) conditions and their potential link to the severity of core symptoms require clinical attention. Although evidence indicates that autistic children face a greater risk of GI disorders and require more intensive nutritional management compared to neurotypical peers, standard guidelines for managing GI symptoms in this population remain lacking. This review seeks to pinpoint critical considerations for the implementation of nutrition-based strategies aimed at addressing GI dysfunction in individuals with ASD.

Unilateral incentive alignment in two-agent stochastic games.

Multiagent learning is challenging when agents face mixed-motivation interactions, where conflicts of interest arise as agents independently try to optimize their respective outcomes. Recent advancements in evolutionary game theory have identified a class of "zero-determinant" strategies, which confer an agent with significant unilateral control over outcomes in repeated games. Building on these insights, we present a comprehensive generalization of zero-determinant strategies to stochastic games, encompassing dynamic environments.

Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects.

Fecal microbiota transplant (FMT) is an increasingly used intervention, but its suitability to restore regional gut microbiota, particularly in the small bowel (SB), must be questioned because of its predominant anaerobic composition. In human subjects receiving FMT by upper endoscopy, duodenal engraftment of anaerobes was observed after 4 weeks. We hypothesized that peroral FMTs create host-microbe mismatches that impact SB homeostasis.

Enhancing human gut health: Global innovations in dysbiosis management.

The microbiota, comprising all the microorganisms within the body, plays a critical role in maintaining good health. Dysbiosis represents a condition resulting from an imbalance or alteration of the microbiota. This study comprehensively investigates the patent literature on dysbiosis over the past 20 years.

Corneal Biomechanics as a Causal Factor in Myopia and Astigmatism: Evidence from Mendelian Randomization.

Purpose: The causal relationship between refractive errors and corneal biomechanical properties remains uncertain. This study aimed to clarify this relationship using Mendelian randomization (MR), offering new insights into the prevention and treatment of refractive errors.

Design: A bidirectional, 2-sample MR analysis.

Skin Regeneration and Wound Healing by Plant Protein-Based Electrospun Fiber Scaffolds and Patches for Tissue Engineering Applications.

Plant protein-based electrospun fibers are emerging as promising biomaterials for skin regeneration and wound healing due to their unique properties, including biocompatibility, antimicrobial effects, and anti-inflammatory activity. This review examines four widely used plant-derived proteins: zein, soy, wheat gluten, and pea protein, focusing on their role in tissue engineering. For designing advanced biomaterials with tailored properties to accelerate tissue repair, the stages of wound healing are introduced.

Real "zero energy consumption" for efficient antibiotics degradation by floating photocatalysis: modeling, degradation pathway and toxicity assessment.

Floating photocatalysis is a real "zero energy consumption" and practicable green water treatment technology because of no need for reactor and pump, and direct contact with sunlight to produce more free radicals compared to traditional immersion photocatalysts. To realize "green" and "safe" practical application, efficiency for different water quality bodies and toxicity assessment of degradation products are key factors. In this work, an economic and efficient floating photocatalyst Bi doped P25-TiO (Bi@P25)/expanded perlite (EP), named BTEP was successfully constructed, exhibiting stronger visible light absorption and faster photogenerated carriers separation ability due to Bi doping and formation of Bi-O-Si bond.

Joint Task Offloading and Power Allocation for Satellite Edge Computing Networks.

Low Earth orbit (LEO) satellite networks have shown extensive application in the fields of navigation, communication services in remote areas, and disaster early warning. Inspired by multi-access edge computing (MEC) technology, satellite edge computing (SEC) technology emerges, which deploys mobile edge computing on satellites to achieve lower service latency by leveraging the advantage of satellites being closer to users. However, due to the limitations in the size and power of LEO satellites, processing computationally intensive tasks with a single satellite may overload it, reducing its lifespan and resulting in high service latency.

Evolutionary dynamics of behavioral motivations for cooperation.

Human decision-making is shaped by underlying motivations, which reflect both subjective well-being and fundamental biological needs. Different needs are often prioritized and traded off against one another. Here we develop a theoretical framework to study the evolution of behavioral motivations, encompassing both philanthropic (cooperating after personal needs are met) and aspirational (cooperating to fulfill personal needs) motivations.

Conformal Retinal Image Sensor Based on Electrochemically Exfoliated MoS Nanosheets.

Retina-like photoimaging devices with features such as a wide-field-of-view and high spatial resolution have wide application prospects in retinal prosthetics and remote sensing. However, the fabrication of flexible and conformal surfaces is hindered by the incompatible microfabrication processes of traditional rigid, silicon-based substrates. A kirigami strategy for hemispherical surface assembly is proposed to construct a MoS-based retina-like photodetector array.

An Off-the-Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment.

Cell therapy is a promising approach in regenerative medicine. However, maintaining the survival and function of injected or implanted therapeutic cells remains a substantial challenge to success. In vivo modulatory strategy for cell therapeutics has been recently developed, but suffers from limited regenerative efficacy in injured tissue microenvironment with chronic inflammation.

Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile.

Idiopathic pulmonary fibrosis (IPF) is a severe lung disease occurring throughout the world; however, few clinical therapies are available for treating this disorder. Overactivated fibroblasts drive abnormal fibrosis accumulation to maintain dynamic balance between inflammation and extracellular matrix (ECM) stiffness. Given pulmonary cell can regenerate, the lung may possess self-repairing abilities if fibrosis is removed via clearance of overactivated fibroblasts.

Identification of RCC2 as a Risk Gene Associated With Basal Cell Carcinoma and Experimental Validation.

Basal cell carcinoma (BCC) is a common type of skin cancer that is increasing in prevalence worldwide. Previous genome-wide association studies (GWAS) have identified certain genetic loci associated with BCC. However, many potential disease-causing genes of BCC remain to be discovered.

Lysosomal PIP revealed by genetically encoded lipid biosensors.

3-Phosphoinositides (3-PIs), phosphatidylinositol (3,4) bisphosphate [PI(3,4)P] and phosphatidylinositol (3,4,5) trisphosphate (PIP), are important lipid second messengers in the Phosphoinositide 3-Kinase (PI3K)/Akt signaling pathway, which is crucial to cell growth and frequently dysregulated in cancer. Emerging evidence suggests these lipid second messengers may be present in membranes beyond the plasma membrane, yet their spatial regulation within other membrane compartments is not well understood. To dissect the spatial regulation of specific 3-PI species, we developed genetically encodable biosensors with selectivity for PIP or PI(3,4)P.

Flavonoids enhance tomato plant resistance to whitefly by interfering with the expression of a salivary effector.

Plants can deploy chemical defenses that poison herbivorous insects or deter their feeding; however, insects can counter by secreting effector proteins that modulate these defense responses. In principle, plants might therefore interfere with the expression of insect effector proteins, but knowledge about such a process remains limited. Here, we explored the mechanisms underlying how resistant tomato (Solanum lycopersicum) influences the effector proteins of whiteflies (Bemisia tabaci), thereby affecting the interaction of B.

Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk.

Unlabelled: Glucagon stimulates hepatic glucose production, in part by promoting the uptake and catabolism of amino acids. Inhibition of the liver glucagon receptor (GCGR) results in elevated plasma amino acids, which triggers the proliferation of pancreatic α-cells, forming a liver-α-cell loop. This study aims to delineate hepatic signaling molecules downstream of GCGR that mediate the liver-α-cell loop.

Power-free knee rehabilitation robot for home-based isokinetic training.

Robot-assisted isokinetic training has been widely adopted for knee rehabilitation. However, existing rehabilitation facilities are often heavy, bulky, and extremely energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. In this study, we introduce a highly integrated and lightweight (52 kg) knee rehabilitation robot that can provide home-based isokinetic training without external power.

A plant virus manipulates both its host plant and the insect that facilitates its transmission.

Tomato yellow leaf curl virus (TYLCV), a devastating pathogen of tomato crops, is vectored by the whitefly , yet the mechanisms underlying TYLVC epidemics are poorly understood. We found that TYLCV triggers the up-regulation of two β-myrcene biosynthesis genes in tomato, leading to the attraction of nonviruliferous . We also identified BtMEDOR6 as a key whitefly olfactory receptor of β-myrcene involved in the distinct preference of MED for TYLCV-infected plants.

Printed Two-Dimensional Materials for Flexible Photodetectors: Materials, Processes, and Applications.

With the rapid development of micro-nano technology and wearable devices, flexible photodetectors (PDs) have drawn widespread interest in areas such as healthcare, consumer electronics, and intelligence interfaces. Two-dimensional (2D) materials with layered structures have excellent optoelectronic properties and mechanical flexibility, which attract a great deal of attention in flexible applications. Although photodetectors based on mechanically exfoliated 2D materials have demonstrated superior performance compared to traditional Si-based PDs, large-scale manufacturing and flexible integration remain significant challenges for achieving industrial production.