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Article Abstract
Background: Insomnia is one of the most prevalent health concerns and has a major impact on human health and quality of life. Increasing evidence indicates the gut microbiota's role in sleep regulation through the gut-brain axis. This systematic review aims to summarise current evidence on the role of gut microbiota alterations in insomnia.
Methods: We searched PubMed, Embase, and Cochrane Library through November 2024 for case-control studies comparing gut microbiota in insomnia subjects and controls. The primary outcome was changes in microbiota diversity and bacteria taxonomy.
Results: We included 15 case-control studies from 14 articles, consisting of 1321 subjects (603 insomnia; 718 controls). Eight studies showed reduced alpha diversity and eleven showed altered beta diversity in insomnia subjects. Depletions of specific taxa such as Lactobacillales (class Bacilli), , and and the enrichment of Actinobacteria, Bacteroidales (class Bacteroidia), and several genera, including , , , , , and , were observed in insomnia subjects. There was a negative association between insomnia severity and abundance of and , and positive associations with .
Conclusions: This systematic review identifies specific alterations in gut microbiota among insomnia subjects characterised by taxonomic changes that may serve as promising therapeutic targets for sleep disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299568 | PMC |
| http://dx.doi.org/10.3390/life15071086 | DOI Listing |
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