Upgrading Coal Gangue Waste into Molecular Sieves for Sustainable Wastewater Purification.

The disposal and management of coal gangue (CG) waste from coal mining pose significant environmental pollution challenges. Here, we propose utilizing CG as raw material to synthesize CG-based NaA-type molecular sieves (CG@NaA MS) through a high-temperature alkali fusion combined with a hydrothermal process. This approach enables the sustainable treatment of copper ions and methylene blue (MB) in wastewater.

Local stress-assisted fabrication of supramolecular structural color materials for anti-counterfeiting applications.

Supramolecular colloidal photonic crystals possess the advantages of both photonic crystals and supramolecular materials to prepare dynamically reversible structural color materials with high flexibility, functionality and recyclability. However, the driving force for the ordered arrangement of colloidal nanoparticles is limited since the significant increase of the viscosity in the system, consequently the shear-induced technique with complicated equipment needs to be applied to achieve the assembly of colloidal nanoparticles. Herein, we report a local stress-assisted assembly strategy for fabricating high-performance supramolecular colloidal photonic crystal films without the need of complex shearing equipment.

High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis.

Notum, a negative feedback regulator of the Wnt signaling, has emerged as a promising target for treating glucocorticoid-induced osteoporosis (GIOP). This study showcases an efficient strategy for discovering the anti-Notum constituents from herbal medicines (HMs) as novel anti-GIOP agents. Firstly, a rapid-responding near-infrared fluorogenic substrate for Notum was rationally engineered for high-throughput identifying the anti-Notum HMs.

Visible light-induced controlled release and biological evaluation of bismuth sulfide quantum dots and silver nanoparticles co-sensitized titanium dioxide nanotubes.

Controlled drug delivery has attracted significant attention because of its ability to release therapeutic agents at specific times and locations. Titanium dioxide nanotubes (TNTs), which are known for their unique tubular morphology, large surface area and excellent biocompatibility, have been widely investigated as drug carriers. However, their application in light-induced drug release is limited by their reliance on ultraviolet (UV) light.

Peptide codes for organ-selective mRNA delivery.

Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in the hepatic delivery of mRNA using lipid nanoparticles (LNPs), current strategies for extrahepatic-organ-selective mRNA delivery still have limitations. Here we report a peptide-encoded organ-selective targeting (POST) method for the delivery of mRNA to extrahepatic organs after systemic administration, which is based on the modular tuning of LNPs through surface engineering with specific amino acid sequences (POST codes).

Association between the Dietary Index for Gut Microbiota and periodontitis: mediation by systemic inflammation.

Objective: This study aimed to explore the association between the Dietary Index for Gut Microbiota (DI-GM) and periodontitis, and to investigate the mediating role of systemic inflammation in this relationship.

Methods: We performed a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2014, including 9,022 participants. DI-GM scores were derived from 14 dietary components known to influence gut microbiota.

Crown rot in wheat: pathogen biology, host responses, and management strategies.

Crown rot (CR), caused by Fusarium pseudograminearum and related species, is a soil-borne disease threatening global wheat (Triticum aestivum) production, with yield losses exceeding 50% under severe infections. The rapid spread of CR in China, driven by straw retention policies and warming climates, highlights the need for interdisciplinary solutions. This review systematically integrates advances in CR research and addresses pathogen biology, host resistance, and sustainable management.

The global, regional, and national burden of Non-Hodgkin lymphoma in 204 countries and territories and 811 subnational locations, 1990-2021: an update from the Global Burden of Disease Study 2021.

Non-Hodgkin lymphoma (NHL) constitutes a significant portion of the global cancer burden and associated mortality. However, a comprehensive understanding of NHL's scale and trends remains limited, underscoring the need for evidence-based epidemiological research to inform healthcare decisions and planning effectively. Incidence, mortality, and disability-adjusted life-years (DALYs) estimates, along with 95% uncertainty intervals (UIs), were derived from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Effectiveness of family-based behavioral intervention for smoking cessation in low-income households: a systematic review and meta-analysis.

Background: Smoking-attributable harms are substantial in low-income households. The effectiveness of family-based behavioral interventions for smoking cessation in this population remains uncertain. This review aims to assess the effectiveness of family-based behavioral interventions on smoking cessation in low-income households.

Early gestational weight gain and birth weight outcome: a Chinese population-based cohort.

Background: Early gestational weight gain (E-GWG) plays a crucial role in fetal development. Its timing and sex-specific impacts have not been thoroughly investigated, especially in Asian populations.

Methods: In this retrospective cohort study, 66,291 mother-infant pairs from the Tianjin Women and Children's Health Care System were analyzed.

HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition.

Atherosclerosis (AS), driven by vascular endothelial dysfunction and poses a global health threat. This study compared the therapeutic effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on vascular endothelial function in early-stage AS mice, specifically investigating PCSK9 modulation and the TRX/TXNIP/NLRP3/GSDMD-N pathway. ApoE mice (n = 6/group) fed a high-fat diet for 12 weeks were randomized into sedentary (AS-S), HIIT (AS-HIIT), and MICT (AS-MICT) groups, with wild-type mice as control.

Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats.

Aim: To analyze visual dysfunction in rats under simulated weightlessness (SW) by examining trans-laminar cribrosa pressure difference (TLCPD) and neuroimmune responses.

Methods: The 72 male Sprague-Dawley rats were randomly assigned into two groups (ground control and hindlimb unloading-simulated microgravity) using stratified randomization, with each group further subdivided into three exposure durations: SW 2-week (SW-2W), 4-week (SW-4W), and 8-week (SW-8W), =12 per subgroup. At the designated time points for each group, intraocular pressure (IOP) and intracranial pressure (ICP) were measured, and the trans-laminar cribrosa pressure difference (TLCPD) was calculated.

Association of gestational weight gain with pregnancy complications and delivery outcomes in twins: a study in Northern China.

Background: This study aimed to develop a gestational age-specific gestational weight gain (GWG) reference for twins in northern China and analyze its impact on pregnancy complications and delivery outcomes considering GWG during different trimesters of pregnancy.

Methods: This study analyzed 9375 twin pregnant women in Tianjin (2010-2018) after outlier and missing data exclusion. Using the lambda - mu - sigma - tau (LMS) method with GAMLSS package in R, BMI- and trimester-specific GWG percentiles were established.

Inhibition of inducible nitric oxide synthase (iNOS) alleviates thoracic aortic aneurysm by regulating mitochondrial dynamics.

Thoracic aortic aneurysm (TAA) is life-threatening once developing to dissection (TAAD) or rupture and currently there is no effective pharmacological treatment. The abnormal activity of inducible nitric oxide synthase (iNOS) has been related with syndromic TAA, but its potential role in non-syndromic TAA is unknown. Here we identified elevations of inducible nitric oxide synthase (iNOS) and its downstream protein kinase G1 (PRKG1) in both human non-syndromic TAA and β-aminopropionitrile (BAPN)-induced mouse model of TAA.

Transparent and flexible photonic crystal films with enhanced optical performance for multi-level anti-counterfeiting applications.

Self-assembly of colloidal particles in photocurable monomer provides a facile way to fabricate functional photonic crystal (PC) films. However, the inadequate optical performance of PC films limits their practical applications. In this work, we develop a new method to fabricate versatile PC films with enhanced optical performance assisted by solvent.

Gestational phthalate levels and biomarkers of aging in infants and children from New York City.

Background: Phthalates, a group of endocrine disrupting chemicals used in plastics, are ubiquitous in the environment and may influence cellular processes related to child health and development. Mitochondrial DNA copy number (mtDNAcn), telomere length (TL), and DNA methylation-based epigenetic gestational age acceleration (EGAA) are accessible biomarkers associated with biological aging and development. Little is known about how gestational phthalate exposure, individually and in mixtures, may impact biomarkers of biological aging through childhood.

The Profiles of Diet- or Exercise-Related Self-Efficacy and Social Support Associated with Insufficient Fruit/Vegetable Intake and Exercise in Women with Abdominal Obesity.

Background/objectives: Prioritizing diet- or exercise-related self-efficacy and social support with their interactions may improve the effectiveness of interventions aimed at increasing daily fruit/vegetable intake and exercise, thereby reducing the risk of metabolic disorders in abdominally obese women. This study aimed to identify the profiles of diet- or exercise-related self-efficacy and social support among women with abdominal obesity, examine profiles related to insufficient fruit/vegetable intake and exercise, and explore associating factors of these profiles.

Methods: A cross-sectional investigation in central south mainland China collected sociodemographic, anthropometric, and health-related variables, diet-related self-efficacy (Diet-SE) and social support (Diet-SS), exercise-related self-efficacy (Exercise-SE) and social support (Exercise-SS), and daily fruit/vegetable intake and exercise.

Does Short-Distance Migration Facilitate the Recovery of Black-Necked Crane Populations?

Understanding the migratory strategies of plateau-endemic species is essential for informing effective conservation, especially under climate change. The Black-necked Crane (), a high-altitude specialist, has shown notable population growth in recent years. We analysed satellite tracking data from 16 individuals of a western subpopulation in the lake basin region of northern Tibet (2021-2024), focusing on migration patterns, stopover use, and habitat selection.

Diagnostic value of serum TSI levels in Graves' disease and direct comparison of diagnostic performance with TRAb: A systematic review and meta-analysis.

This study aimed to systematically assess the diagnostic value of thyroid-stimulating immunoglobulin on the Siemens Immulite platform (the TSI assay) and to conduct a direct comparison with thyrotropin receptor antibodies on the Roche cobas platform (the TRAb assay) for the diagnosis of Graves' disease (GD). We performed systematic literature searches across multiple databases. Following strict screening, we identified 20 eligible clinical studies that evaluated the diagnostic value of the TSI assay, either alone or in comparison with the TRAb assay.

Chronic exposure to environmentally-relevant sulfamethoxazole alters ammonia-oxidizing microbial communities in managed aquifer recharge systems.

Managed aquifer recharge (MAR) is a critical technology for water resource management and purification, yet its capacity to remove antibiotics remains limited. Understanding the response of ammonia-oxidizing microorganisms (AOMs) to antibiotics exposure is essential for optimizing MAR-based antibiotic mitigation strategies. This study investigated the long-term effects of sulfamethoxazole (SMX, ∼500 ng/L) on AOM communities through a 20-month controlled MAR column experiment.

Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease.

Diabetic kidney disease (DKD), a common microvascular complication of diabetes, has emerged as the leading cause of end-stage renal disease (ESRD), with its prevalence increasing annually, thereby constituting a global epidemiological crisis. Despite this, the search for effective therapeutic strategies remains challenging, underscoring the urgent need for innovative treatments. In recent years, numerous studies have highlighted the role of inflammation in DKD progression, with fibrosis serving as a critical mechanism driving DKD towards ESRD.

Optimization of deep learning-based denoising for arterial spin labeling: Effects of averaging and training strategies.

Purpose: Systematic study of the effects of averaging and other relevant training strategies in deep learning (DL)-based denoising is required to optimize such processing pipelines for improving the quality of arterial spin labeling (ASL) images.

Methods: Different averaging strategies, including windowed and interleaved averaging methods, and different levels of averaging before and after convolutional neural network-based and transformer-based denoising were studied. The experiments were performed on 152 single-delay ASL scans from 152 subjects, including pulsed and pseudo-continuous ASL acquisitions.

Applications of Biodegradable Polymeric Nanomaterials as Drug Delivery Systems.

There are a variety of biodegradable polymers, including natural polysaccharides, proteins, nucleic acids, etc., in animals and plants, as well as some polymers that are synthesized by microorganisms, such as poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). At present, the most common polymers are those that are artificially synthesized, such as polyethylene glycol, polylactic acid, and polycaprolactone.

Plasmodium yoelii infection regulates M1 macrophage polarization and function through TLR7/STAT3 signaling pathway.

Macrophages play a crucial role in innate immunity and are essential for resisting Plasmodium infection. However, the regulatory mechanisms of Plasmodium infection on macrophage function and subsequent effects on adaptive immune responses remain incompletely understood. In this study, we investigated the functional regulatory mechanism of macrophages during Plasmodium yoelii (P.

Chitosan/polyethylene glycol diglycidyl ether/aminated lignin composite coating to enhance wet strength of paper as a low-carbon alternative to single-use plastics.

The potential of paper as a plastic alternative is hindered by limited water resistance and mechanical strength. To address these challenges, this study developed a water-soluble chitosan/polyethylene glycol diglycidyl ether (PEGDE)/aminated lignin (AL) composite coating (CPA), which significantly enhanced the mechanical strength and water resistance of paper through molecular crosslinking and interface enhancement strategies. The CPA formed a dense crosslinked network on the surface and within the pores between fibers, enhancing the wet tensile strength of the paper by up to 75×.