Local stress-assisted fabrication of supramolecular structural color materials for anti-counterfeiting applications.

Supramolecular colloidal photonic crystals possess the advantages of both photonic crystals and supramolecular materials to prepare dynamically reversible structural color materials with high flexibility, functionality and recyclability. However, the driving force for the ordered arrangement of colloidal nanoparticles is limited since the significant increase of the viscosity in the system, consequently the shear-induced technique with complicated equipment needs to be applied to achieve the assembly of colloidal nanoparticles. Herein, we report a local stress-assisted assembly strategy for fabricating high-performance supramolecular colloidal photonic crystal films without the need of complex shearing equipment.

Single-cell profiling identifies biomarkers for immunochemotherapy in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) remains a highly aggressive malignancy with limited therapeutic options. While immune checkpoint blockade (ICB) combined with chemotherapy has improved outcomes, resistance mechanisms and predictive biomarkers are poorly understood. This study aims to characterize the dynamic changes in the tumor microenvironment (TME) during ICB treatment and identify cell populations and molecular programs associated with therapeutic response.

Transparent and flexible photonic crystal films with enhanced optical performance for multi-level anti-counterfeiting applications.

Self-assembly of colloidal particles in photocurable monomer provides a facile way to fabricate functional photonic crystal (PC) films. However, the inadequate optical performance of PC films limits their practical applications. In this work, we develop a new method to fabricate versatile PC films with enhanced optical performance assisted by solvent.

Real-world single-center data analysis of dual immunotherapy in advanced NSCLC: Efficacy, survival, and adverse events.

We collected 96 patients who received dual immunotherapy between January 2019 and June 2024, in a 1:1:1 ratio based on PD-L1 expression levels of negative (<1%), medium (1% ≤ PD-L1 ≤ 49%), and high (PD-L1 ≥ 50%). This study evaluates the efficacy and safety of dual immunotherapy in patients with advanced NSCLC, stratified by PD-L1 expression levels. Among the 96 patients, the objective response rate (ORR) was 37.

Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma.

Background: Abnormalities in trace elements and the incidence of oesophageal squamous cell carcinoma (ESCC) have been reported in China. Zinc ions (Zn) are known to regulate DNA methylation by stabilizing methylase activity. However, the relationship between DNA methylation and Zn dysregulation in ESCC cells remains unclear.

Outcomes of neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma.

Background: Esophageal squamous carcinoma is a prevalent cancer worldwide, particularly in China. Few studies have compared the treatment effects of neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy on the long-term prognosis of patients with esophageal squamous carcinoma. This study analyzed the 3-year overall survival rate of patients with locally advanced esophageal squamous carcinoma treated with esophagectomy after neoadjuvant immunochemotherapy or neoadjuvant chemoradiotherapy.

Ultrasensitive Room-Temperature NO Gas Sensor Based on MXene-CuO Composites.

The development of real-time trace-level NO quantification platforms that can be operated at room temperature constitutes a critical advancement for occupational safety and public health monitoring systems. This study demonstrates a room-temperature NO sensor using MXene-CuO composites prepared via a hydrothermal method. Systematic evaluation of MXene-introduced effects identified the 0.

Age at menarche and risk of non-alcoholic fatty liver disease: Insights from the NHANES 2017-2020 and Mendelian randomization analyses.

Background: This study aimed to explore the causal relationship between age at menarche (AAM) and non-alcoholic fatty liver disease (NAFLD), leveraging data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES) alongside Mendelian randomization (MR) analyses. Notably, this research represents the first attempt to link AAM to NAFLD using genetic methodologies, thereby providing novel insights into the interplay between these two conditions.

Methods: Cross-sectional data from 2730 participants were analyzed using logistic regression to evaluate the association between AAM and NAFLD risk.

Predictive models of epidermal growth factor receptor mutation in lung adenocarcinoma using PET/CT-based radiomics features.

Background: Lung adenocarcinoma (LAC) comprises a substantial subset of non-small cell lung cancer (NSCLC) diagnoses, where epidermal growth factor receptor (EGFR) mutations play a pivotal role as indicators for therapeutic intervention with targeted agents. The emerging field of radiomics, which involves the extraction of numerous quantitative attributes from medical imaging, when coupled with positron emission tomography/ computed tomography (PET/CT) technology, has demonstrated promise in the prognostication of EGFR mutation status. The objective of this investigation is to construct and validate predictive models for EGFR mutations in LAC by leveraging PET/CT-derived radiomics features, thereby refining diagnostic precision and facilitating tailored treatment strategies.

Neoadjuvant Chemoradiotherapy vs Chemoimmunotherapy for Esophageal Squamous Cell Carcinoma.

Importance: The association of neoadjuvant chemoimmunotherapy (NCIT) vs chemoradiotherapy (NCRT) with tumor downstaging and survival in locally advanced esophageal squamous cell carcinoma (ESCC) remains unclear because of limited evidence.

Objective: To compare the associations of NCIT and NCRT with tumor regression and long-term survival in patients with locally advanced ESCC.

Design, Setting, And Participants: In this comparative effectiveness research study, from January 2016 to March 2023, patients with locally advanced ESCC who underwent esophagectomy following NCRT or NCIT were identified from a prospective database of 8 high-volume esophageal surgery centers in China.

Optically active chiral photonic crystals exhibiting enhanced fluorescence and circularly polarized luminescence.

Photonic crystals with advanced, unique and well-defined functional nanostructures demonstrate exquisite controllable modulation in light harvesting and emission for unrivalled optical performance. Herein, through ingeniously integrating aggregation-induced emission (AIE) luminogens and chiral helical media into ordered periodic structures, the resulting optically active photonic crystal films exhibit an enhanced photoluminescence (PL) characteristic (increased to 2.2 times the original value) and distinctive emerging circular dichroism (CD) responses near the photonic bandgap (PBG) of the photonic crystal.

Peacock-Inspired Janus Structural Color Materials for Multi-Level Encryption and Anti-Counterfeiting.

The existence of different miraculous structural colors in nature inspires us to continuously create new techniques, however, limitations in existing fabrication techniques, including low efficiency, small area, and imprecise structure control, have impeded their real applications. Mimicking the multi-level structure of peacock feathers, a one-step strategy is developed to efficiently manufacture the Janus structural color materials (JSCMs). Using the surface tension-regulated self-assembly of SiO nanoparticles in polyethylene glycol (PEG) solution under 80 °C, the manufacturing process can be completed in a matter of minutes, which greatly improves the efficiency of photonic crystal preparation.

Controlling crystallization in covalent organic frameworks to facilitate photocatalytic hydrogen production.

The catalytic performance, depending on the surface nature, is ubiquitous in photocatalysis. However, surface engineering for organic photocatalysts through structural modulation has long been neglected. Here, we propose a zone crystallization strategy for covalent organic frameworks (COFs) that enhances surface ordering through regulator-induced amorphous-to-crystalline transformation.

A clinical analysis and literature review of eleven cases with primary pulmonary angiosarcoma.

Objective: The aim of this study is to explore the clinicopathological features, radiographic manifestations, treatment options, and prognosis of primary pulmonary angiosarcoma (PPAS).

Method: We summarized and analyzed the clinical data of 11 patients with primary pulmonary angiosarcoma treated at the First Affiliated Hospital of Guangzhou Medical University between January 2018 and January 2024. A retrospective analysis was conducted in conjunction with a review of the relevant literature.

Delineation of intersegmental plane: application of blood flow blocking method in pulmonary segmentectomy.

Background: The Modified Inflation-Deflation Method (MIDM) is widely used in China in pulmonary segmentectomies. We optimized the procedure, which was named as Blood Flow Blocking Method (BFBM), also known as "No-Waiting Segmentectomy". This method has produced commendable clinical outcomes in segmentectomies.

Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior.

Psychological stress and its sequelae pose a major challenge to public health. Immune activation is conventionally thought to aggravate stress-related mental diseases such as anxiety disorders and depression. Here, we sought to identify potentially beneficial consequences of immune activation in response to stress.

A chemiluminescence immunosensor for biomarker detection based on boronic acid-modified magnetic composite microspheres.

High-sensitivity detection of biomarkers in biological samples is crucial for the early diagnosis and treatment of diseases. In this paper, a versatile and flexible immobilization technique based on the specific affinity interaction between boronic acid and -diol groups of antibodies was developed for biomarker detection. As a model, the boronic acid-modified immunomagnetic beads were used for facile and quick immobilization of the alpha-fetoprotein (AFP) antibody due to the specific affinity interactions.

Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids.

A variety of abnormal epithelial cells and immature and mature immune cells in thymic epithelial tumors (TETs) affect histopathological features, the degree of malignancy, and the response to treatment. Here, gene expression, trajectory inference, and T cell antigen receptor (TCR)-based lineage tracking are profiled in TETs at single-cell resolution. An original subpopulation of KRT14 progenitor cells with a spindle cell phenotype is shown.

Design of Unconventional Polymers with Thermal Contraction Units for High-Performance Dental Adhesives.

The coefficient of thermal expansion (CTE) of adhesives is considered to be a vital parameter for dental restoration due to the oral temperature fluctuation induced by hot and cold drinks in daily life. Even more challenging, the adhesives need to bond various materials with different CTE values, and mismatched thermal expansion at the interface of two materials will produce thermal stress and cause cracking, leading to bond failure. In this study, we designed and synthesized a divinyl monomer containing a dibenzocyclooctadiene (DBCOD) unit, which was incorporated into a commercial adhesive, Single Bond Universal (SBU) to prepare low CTE adhesives.

Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice.

Dysbiosis of the gut microbiota has been implicated in the pathogenesis of metabolic syndrome (MetS) and may impair host metabolism through harmful metabolites. Here, we show that Desulfovibrio, an intestinal symbiont enriched in patients with MetS, suppresses the production of the gut hormone glucagon-like peptide 1 (GLP-1) through the production of hydrogen sulfide (HS) in male mice. Desulfovibrio-derived HS is found to inhibit mitochondrial respiration and induce the unfolded protein response in intestinal L cells, thereby hindering GLP-1 secretion and gene expression.

Radiotherapy for patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant immunotherapy combined with chemotherapy.

With the success of immunotherapy in advanced esophageal cancer, neoadjuvant chemo-immunotherapy (CIT) is being increasingly used for local staged esophageal cancer, especially in the context of clinical trials, which brings similar pCR with neoadjuvant chemoradiotherapy and shows promising results. However, there is still a part of potentially operable patients can't undergo surgery after neoadjuvant chemo-immunotherapy. The follow-up treatment and prognosis of this population remain unclear.

Application of color doppler ultrasound and US shear wave elastography with connective tissue growth factor in the risk assessment of papillary thyroid carcinoma.

Background: This study aims to investigate the role of shear wave elastography (SWE) and connective tissue growth factor (CTGF) in the assessment of papillary thyroid carcinoma (PTC) prognosis.

Methods: CTGF expression was detected with immunohistochemistry. Clinical and pathological data were collected.