Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats.

Aim: To analyze visual dysfunction in rats under simulated weightlessness (SW) by examining trans-laminar cribrosa pressure difference (TLCPD) and neuroimmune responses.

Methods: The 72 male Sprague-Dawley rats were randomly assigned into two groups (ground control and hindlimb unloading-simulated microgravity) using stratified randomization, with each group further subdivided into three exposure durations: SW 2-week (SW-2W), 4-week (SW-4W), and 8-week (SW-8W), =12 per subgroup. At the designated time points for each group, intraocular pressure (IOP) and intracranial pressure (ICP) were measured, and the trans-laminar cribrosa pressure difference (TLCPD) was calculated.

Network meta-analysis of intraocular lens power calculation formulas based on artificial intelligence in short eyes.

Purpose: To systematically assess and compare the accuracy of artificial intelligence (AI) -based intraocular lens (IOL) power calculation formulas with traditional IOL formulas in patients with short eye length.

Design: A systematic review and network meta-analysis.

Methods: We performed an exhaustive search of the PubMed, Embase, Web of Science, and Cochrane Library databases to identify relevant studies published until February 2024.

Intraocular lens power calculation in cataract patients with keratoconus: Bayesian network meta-analysis.

Purpose: To compare the accuracy of intraocular lens (IOL) power calculation formulas in cataract patients with keratoconus (KC).

Methods: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis statementand and was registered on PROSPERO (CRD42024568997). Pubmed, Web of Science, Cochrane Library, and EMBASE were searched for retrospective and prospective clinical studies published until October 2024.

The Association of Myopia Progression with Changes in Retinal Thickness among Primary School Students with Myopia.

Purpose: To observe the relationship between myopia progression and changes in retinal thickness during one year of follow-up among primary school children.

Methods: The study included 1161 eyes of 708 myopic children, with 616 (53.06%) right eyes and 545 (46.

Knockout of TGF-β receptor II by CRISPR/Cas9 delays mesenchymal transition of Lens epithelium and posterior capsule opacification.

Posterior capsule opacification (PCO) is the most common postoperative complication of cataract surgery. Transforming growth factor-β (TGF-β) is related to epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) that is proven to induce PCO formation in clinical and experimental studies. In this study, CRISPR sequences targeting exon of TGF-βRII were knocked out with lentiviral transfection in LECs.

Congenital coralliform cataract is the predominant consequence of a recurrent mutation in the CRYGD gene.

Background: Congenital cataract is a leading cause of treatable childhood blindness and both clinically and genetically heterogeneous. Among the already characterized phenotypes, coralliform cataract is a rare special form of congenital cataracts. Although previous studies had shown that mutations in the γD-crystallin (CRYGD) can result in congenital coralliform cataracts, no conclusive genotype-phenotype correlation might be drawn.

Comparison of different pupil dilatation methods for phacoemulsification in eyes with a small pupil.

Purpose: To compare 6 methods for intraoperative pupil dilatation in eyes with insufficient pupil size during phacoemulsification.

Methods: This was a prospective case-control study. 99 microcoria cataract patients (120 eyes) were collected and were divided into 6 groups(20 eyes each group), and their pupils were dilated by bimanual stretching pupil (group I), pupil radial cut open(group II), mechanical pupil dilatation with iris-retractor hooks (group III), OASIS iris expander (group IV), and Malyguin-ring (Microsurgical company, America) (group V), B-HEX Pupil Expander (Med Invent Devics, India)(group VI),respectively.

NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification.

Posterior capsule opacification (PCO) is the most common complication after cataract surgery and is likely to cause the second loss of vision. Pharmacological PCO prophylaxis has been proved to be effective, yet no clinical option is available due to the lack of a suitable mode of administration. In this work, we propose a unique concept of NIR dual-triggered drug release from black phosphorus (BP)-based implantable intraocular lens (IOL) for controlled drug release and chemo-photothermal combination therapy of PCO.

The association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy in primary school students.

Purpose: To study the association of myopia progression with the morphological changes of optic disc and β-peripapillary atrophy (β-PPA) in 8-11 years old primary school students.

Methods: This study was a prospective, school-based investigation. This study included 610 children (1008 eyes) who were continuously observed and had data available from 2016 to 2017 in the Sanhe Cohort Study of the Risk Factors for Myopia (SCSRFM).