Correction: Identification and validation of a m7G-related lncRNA signature for predicting the prognosis and therapy response in hepatocellular carcinoma.

[This corrects the article DOI: 10.1371/journal.pone.

Deep learning model for predicting lymph node metastasis around rectal cancer based on rectal tumor core area and mesangial imaging features.

Unlabelled: Assessing lymph node metastasis (LNM) involvement in patients with rectal cancer (RC) is fundamental in disease management. In this study, we used artificial intelligence (AI) technology to develop a segmentation model that automatically segments the tumor core area and mesangial tissue from magnetic resonance T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) images collected from 122 RC patients to improve the accuracy of LNM prediction, after which omics machine modeling was performed on the segmented ROI. An automatic segmentation model was developed using nn-UNet.

Targeting the mPGES-PGE-EP4 pathway with MF63, MK886, and Grapiprant as a potential therapeutic strategy for Escherichia coli-induced endometritis in dairy cows.

Escherichia coli (E. coli) is the primary causative agent of endometritis in dairy cows. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are the main treatments; however, prolonged antibiotic use promotes bacterial resistance, while NSAIDs can delay ovulation and impair reproduction.

Exogenous prostaglandin D as a modulator in bovine endometritis: implications for reducing antibiotic use in dairy cattle.

Introduction: Bovine endometritis is a common postpartum uterine infection that significantly impacts the health and production performance of dairy cows, leading to economic losses for farms. Bovine endometritis is closely associated with pathogenic microorganisms, disturbances in uterine microecology, and localized inflammatory damage. () is the primary pathogenic bacterium responsible for bovine endometritis.

Predicting the Efficacy of Neoadjuvant Chemotherapy Combined with Immunotherapy for Esophageal Squamous Cell Carcinoma via Enhanced CT Radiomics Combined with Clinical Features.

IntroductionTo evaluate the predictive efficacy of enhanced Computed Tomograph(CT) radiomics combined with clinical features for assessing treatment response to neoadjuvant chemotherapy plus immunotherapy in esophageal squamous cell carcinoma (ESCC) patients.MethodsWe retrospectively analyzed 189 pathologically confirmed esophageal squamous cell carcinoma patients (treated between January 2020 and October 2024) who underwent neoadjuvant chemoimmunotherapy. Patients were stratified into remission and non-remission groups based on pathological response and randomly divided into training (n = 114) and testing (n = 75) sets (6:4 ratio).

Diagnostic value of serum TSI levels in Graves' disease and direct comparison of diagnostic performance with TRAb: A systematic review and meta-analysis.

This study aimed to systematically assess the diagnostic value of thyroid-stimulating immunoglobulin on the Siemens Immulite platform (the TSI assay) and to conduct a direct comparison with thyrotropin receptor antibodies on the Roche cobas platform (the TRAb assay) for the diagnosis of Graves' disease (GD). We performed systematic literature searches across multiple databases. Following strict screening, we identified 20 eligible clinical studies that evaluated the diagnostic value of the TSI assay, either alone or in comparison with the TRAb assay.

Bergamotane-family sesquiterpenes from histone deacetylase inhibitor modified cultures of the fungicolous fungus Montagnula donacina (Niessl) Wanas., E.B.G. Jones & K.D. Hyde.

Epigenetic modification is an effective strategy for uncovering novel metabolites in fungi. In this study, chemical epigenetic manipulation was applied to culture of the fungicolous fungus Montagnula donacina, resulting in significant changes of its specialised metabolite profile. Seventeen undescribed (nor)-bergamotane-type sesquiterpenoids (1-17) were isolated from the culture broth of M.

Robust Density Peaks Clustering for Manifold Data with Multiple Peaks.

Density peaks clustering (DPC) is an excellent clustering algorithm that does not need any prior knowledge. However, DPC still has the following shortcomings: (1) The Euclidean distance used by it is not applicable to manifold data with multiple peaks. (2) The local density calculation for DPC is too simple, and the final results may fluctuate due to the cutoff-distance d.

Role of the PomiR171n-PoUGT89B2 module in regulating the petal senescence of tree peony.

Tree peony is a traditional and popular ornamental flower. However, its short and concentrated flowering period restricts the development of the tree peony industry. In this study, the function of the PomiR171n-PoUGT89B2 combination related to senescence regulation was analyzed, using Paeonia ostii 'Fengdan' (P.

AKT signaling upregulates BDNF expression in induced neural stem cells that interact with microglia.

Background: Brain-derived neurotrophic factor (BDNF) has the capacity to promote neuronal survival that is crucial to neurological recovery after closed head injury (CHI). We previously reported that intracerebral-transplanted induced neural stem cells (iNSCs) can up-regulate BDNF levels to exert neurotrophic effects in CHI-damaged brains. Here we aim to elucidate the mechanism of BDNF up-regulation in iNSCs.

Investigating the role of the mPGES-PGE₂-EP4 pathway in -induced mastitis in dairy cows: insights for non-antibiotic therapeutic strategies.

() is the primary causative agent of bovine mastitis. Currently, antibiotic therapy remains the cornerstone of mastitis treatment; necessitating the identification of alternative therapeutic options. This study employed cultured bovine bone marrow-derived macrophages (BMDMs) to systematically assess the potential of microsomal prostaglandin e synthase-1 (mPGES-1) inhibitors (MF63, MK886) and EP4 receptor inhibitor (Grapiprant) in modulating inflammatory responses and reducing tissue damage.

Impact of drug concentration and ADA assay drug tolerance on the assessment and correlation of titer and signal to noise.

Background/aim: The three-tiered testing strategy for an anti-drug antibody (ADA) assay is a common practice for assessing the immunogenicity to therapeutic products. Efforts to streamline the ADA testing process led to proposals of using signal to noise () as a substitute for titer when determining ADA magnitude. This study aims to identify the critical factors that may influence the correlation of and titer.

Arbuscular mycorrhizal fungi enhance the tolerance of Casuarina equisetifolia to drought and salt stress under coral sand matrix conditions.

To evaluate the effects of arbuscular mycorrhizal fungi (AMF) on the stress tolerance of Casuarina equisetifolia in coral sand matrix, we inoculated seedlings with Funneliformis mosseae and Rhizophagus intraradices and subjected them to salt stress (SS) and drought stress (DS). The results indicated that AMF colonization significantly (p < 0.05) enhanced height (42-123 %), proline and soluble sugar concentrations, and the peroxidase and superoxide dismutase activities (0.

Self-reconstruction of FeCoNiMoW high entropy alloy to boost OER activity with robust stability for anion exchange membrane water electrolyzer.

Anion exchange membrane water electrolysis (AEMWE) is a promising advanced strategy for large-scale green hydrogen production. Developing highly active, stable, and low-cost oxygen evolution reaction materials is still challenging. Herein, a core-shell FeCoNiMoW@FeCoNiOOH electrocatalyst was fabricated by self-reconstruction of FeCoNiMoW high entropy alloy prepared the fast carbothermal shock method.

Evolution analysis of GH3 gene family in five Rosaceae species and FaGH3.17, FaGH3.18 improve drought tolerance in transgenic Arabidopsis.

Background: Gretchen Hagen 3 (GH3), one of the important auxin-responsive gene families, plays essential roles in plant growth, development process, and stress response by regulating hormone homeostasis. However, the evolutionary analysis of the GH3 gene family in Rosaceae species has not been well-studied and the specifc functions of Fragaria ananassa are not well-documented.

Results: In the current study, 64 members of the GH3 family genes were identifed from five Rosaceae species and divided into 8 groups.

High-temperature stored soybean meal alters intestinal chyme composition and disrupts intestinal redox balance by increasing jejunal MAPK14 protein expression in broilers.

This study aimed to investigate the effects of feeding broilers basal diets with high-temperature (35°C) stored soybean meal (SBM). A total of 192 one-day-old Arbor Acres Plus broilers (male) were divided into three groups with eight replicates for a 42-d experimental period. The three groups were fed a basal diet with fresh SBM, SBM stored at 35°C for 2 and 4 wks, respectively.

Tailoring coordinated steps with Ni-substituted CoO asymmetric active unit for durable and efficient acidic water oxidation.

Developing highly active and robust non-noble metal-based electrocatalysts for acidic oxygen evolution reaction (OER) is still tremendously challenging. Herein, we prepared a Ni substituting octahedral Co sites in CoO catalyst with simultaneously enhanced activity and durability, evidenced by an overpotential of 334 mV at 10 mA cm and exceptional stability exceeding 130 h. The resulting asymmetric active Co-O-Ni coordinated with strong electron coupling effects accelerates the electron transfer from Ni to Co sites for enhanced activity and stability.

Simulating rabies post-exposure prophylaxis among patients with human immunodeficiency virus infection using a six-dose Essen regimen administrated with human diploid cell vaccine: A single-arm pilot study in Chinese population.

To explore the immunogencity and safety of HDCV using a six-dose Essen regimen in human immunodeficiency virus (HIV) infected patients. We conducted a single-arm pilot study by simulating post-exposure prophylaxis (PEP) in HIV-infected patients. All patients were administrated with HDCV using a 6-dose Essen regimen (consisting of 2 doses on day 0, and 4 doses each on day 3, 7, 14, and 28).

Smart Bioelectronics for Real-Time Diagnosis and Therapy of Body Organ Functions.

Noncommunicable diseases (NCDs) associated with cardiovascular, neurological, and gastrointestinal disorders remain a leading cause of global mortality, sounding the alarm for the urgent need for better diagnostic and therapeutic solutions. Wearable and implantable biointegrated electronics offer a groundbreaking solution, combining real-time, high-resolution monitoring with innovative treatment capabilities tailored to specific organ functions. In this comprehensive review, we focus on the diseases affecting the brain, heart, gastrointestinal organs, bladder, and adrenal gland, along with their associated physiological parameters.

ATG9B-4 accelerates the proliferation and migration of liver cancer cells in an ARNTL-CDK5 pathway-dependent manner: A case-control study.

Lnc ATG9B-4 aggravated the progression of liver cancer by up-regulating cyclin-dependent-kinase 5 (CDK5). It could be inferred that ATG9B-4 indirectly regulates the expression of CDK5 via lncRNA-mediated negative regulation of target genes. Therefore, the specific molecular mechanism by which ATG9B-4 regulates the malignant characteristics of liver cancer cells still needs further study.

Elevated CD4 CD8 double-negative T cells in the peripheral blood of SFTS patients are associated with disease severity.

Background: Severe fever with thrombocytopenia syndrome (SFTS), caused by the Dabie bandavirus, is a fatal infectious disease with no specific vaccines or antiviral treatments. Early diagnosis and severity assessment are critical for clinical management.

Methods: This study analyzed peripheral blood samples from 81 SFTS patients and healthy controls, focusing on the distribution of CD4, CD8, CD4CD8 double-positive T (DPT) cells, and CD4CD8 double-negative T (DNT) cells.

Towards efficient in situ gas thermal desorption remediation assisted with cross-borehole resistivity tomography.

Tracking the spatial and temporal characteristics of contaminant distribution and energy consumption is crucial for optimizing in situ gas thermal desorption (GTD) remediation efficiency at NAPL-contaminated sites. This study utilized time-lapse cross-borehole resistivity to monitor the in situ GTD remediation process at a field-scale NAPL-contaminated site. By integrating stratigraphic and sampling data, areas with resistivity values exceeding 50 Ω·m before remediation were identified as two contaminated layers.

Prognostic factors in locally advanced oesophageal squamous cell carcinoma: a clinical and radiomic analysis of neoadjuvant immunochemotherapy before surgery.

Background: The treatment of locally advanced oesophageal squamous cell carcinoma (LAESCC) without distant metastasis remains a subject of debate. Neoadjuvant immunochemotherapy (NIC) combined with surgery is the preferred initial approach for managing LAESCC. However, information on the clinical efficacy and survival of patients with LAESCC treated with NIC followed by surgery is limited.

Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.

Motor function recovery after complete spinal cord injury remained as a challenge in medical field, while one of the key approaches is promoting the local microenvironments. In this research, we performed a conjugated therapy by transplantation of neural stem cell (NSC) scaffolds and umbilical cord mesenchymal stem cell derived exosomes (ucMSC-exos) for the treatment of complete transactional spinal cord injury (SCI). We first demonstrated the anti-inflammatory effects of ucMSC-exos and found that ucMSC-exos could regulate microglia polarization from M1 to M2, an anti-inflammatory phenotype.