SCL15 Regulates the Release of Seed Dormancy in Arabidopsis thaliana by Integrating the Circadian Clock, Hormonal Signals and Cell Wall Remodelling.

Dormancy release and germination of the seed are two separate, but continuous phases controlled by both external (e.g., light and temperature) and internal (e.

Mapping Disease Burden of Major Depressive Disorder and Its Risk Factors in Low- and Middle-Income Countries.

Background: This study aims to examine the disease burden, risk factors, and temporal trends of Major Depressive Disorder (MDD) in low- and middle-income countries (LMIC) from 1990 to 2021.

Methods: Disability-Adjusted Life Years (DALYs) data for 135 LMIC were obtained from the 2021 Global Burden of Disease (GBD) database. To assess trends in the burden of MDD, segmented regression analysis was applied to calculate the Estimated Annual Percentage Change (EAPC).

Efficacy and Safety of 0.01% Atropine Eye Drops and Novel Lenslet-ARray-Integrated Spectacle Lenses for the Prevention of Myopia Progression Among Children with Premyopia: A Randomized Clinical Trial.

Introduction: Previous studies have suggested that premyopia shows high prevalence and high risk of progression to myopia among children. Therefore, the purpose of this study was to investigate the efficacy and safety of 0.01% atropine eye drops and novel positive Lenslet-ARray-Integrated spectacle lenses (LARI) in slowing myopia onset and myopic shift among children with premyopia in China.

Miconazole activates MAPK-driven oligodendrogenesis to promote myelin regeneration and neurological recovery after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) induces multifaceted brain injuries, with white matter injury (WMI) exhibiting dual pathological features resembling traumatic brain injury and cerebral ischemia. Inflammatory responses triggered by SAH lead to extensive axonal and myelin disintegration in white matter, resulting in severe neurological dysfunction. Myelin regeneration post-injury primarily relies on promoting the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLs).

TransPRK in the treatment of low to moderate and high myopia: a comparative study of the clinical outcomes.

The aim of this study is to compare the refractive parameters and visual quality of patients with low to moderate myopia and high myopia before and after transepithelial photorefractive keratectomy(transPRK)to evaluate the efficacy and safety of transPRK in correcting different degrees of myopia, and to explore the impact of the surgery on the visual quality of patients with different spherical equivalent(SER). This study retrospectively included myopic patients who underwent transPRK using the Schwind Amaris excimer laser. The patients were divided into the low to moderate and high myopia groups according to the preoperative spherical equivalent.

Disease Burden, Risk Factors, and Temporal Trends in Breast Cancer in Low- and Middle-Income Countries: A Global Study.

Introduction: Breast cancer poses significant health risks to women and strains healthcare systems extensively. In low- and middle-income countries (LMICs), limited resources and inadequate healthcare infrastructures further exacerbate the challenges of breast cancer prevention, treatment, and awareness.

Methods: We examined the prevalence, risk factors, and trends of breast cancer in LMICs.

Machine learning and multi-omics analysis reveal key regulators of proneural-mesenchymal transition in glioblastoma.

Glioblastoma (GBM) is classified into subtypes according to the molecular expression profile; the proneural subtype has a relatively good prognosis, and the mesenchymal type is the most aggressive form with the worst prognosis. GBM undergoes proneural-mesenchymal transition (PMT) during its evolution or in response to changes in the microenvironment or therapeutic interventions. PMT is accompanied by infiltration of non-tumor cells, decreased tumor purity, and immune evasion.

Development and evaluation of machine learning models for individualized prediction of myopia control efficacy treated with overnight orthokeratology.

Purpose: The primary objective of this study is to develop a predictive model utilizing fundamental clinical and ocular measurements to predict the effect of overnight orthokeratology on myopia control. Accordingly, this study aims to assist ophthalmologists in selecting adolescent myopia control methods.

Methods: This retrospective study used one-year follow-up data of 225 myopia children treated with orthokeratology.

The ubiquitin ligase SINA3 and the transcription factor WOX14 regulate tomato growth and development.

In this study, we demonstrated that a regulatory module consisting of the SEVEN IN ABSENTIA (SINA) ubiquitin ligase SINA3 and the WUSCHEL homeobox-containing (WOX) transcription factor WOX14 fine-tunes tomato (Solanum lycopersicum) growth and development. Overexpression of SINA3 in tomato (SINA3-OX) resulted in dwarfism due to shortened internodes with smaller cells. SINA3 regulates WOX14 levels through ubiquitin-independent proteasome-mediated degradation, wherein SINA3 acts as a linker between WOX14 and the proteasome subunits REGULATORY PARTICLE NON-ATPASEs 9 and 13 (RPN9 and RPN13).

Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.

Motor function recovery after complete spinal cord injury remained as a challenge in medical field, while one of the key approaches is promoting the local microenvironments. In this research, we performed a conjugated therapy by transplantation of neural stem cell (NSC) scaffolds and umbilical cord mesenchymal stem cell derived exosomes (ucMSC-exos) for the treatment of complete transactional spinal cord injury (SCI). We first demonstrated the anti-inflammatory effects of ucMSC-exos and found that ucMSC-exos could regulate microglia polarization from M1 to M2, an anti-inflammatory phenotype.

Distribution, Risk Factors and Epidemiological Trends of Pancreatic Cancer Across Countries' Income Levels: A Comprehensive Analysis.

Background: Globally, pancreatic cancer poses a significant concern for public health.

Aims: The objective of this study was to assess the burden of pancreatic cancer on varying income levels.

Methods And Results: Data from the Global Burden of Disease Study (GBD) 2021 and Gross Domestic Product Per Capita data were utilised in this study.

Enhanced Proton Conduction in Metal-Organic Frameworks through Single-Crystal to Single-Crystal Transformation.

In this work, an anionic framework Co-MOF () was elaborately constructed, which underwent single-crystal-to-single-crystal (SC-SC) transformation to produce and after immersion in a CrCl or FeCl solution. Despite the similar crystal structure, the significantly enhanced proton conductivities of and far exceed that of at all humidity and temperature conditions. Even at 30 °C and 98% RH, the proton conductivity of and can reach up to high values of 1.

Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma.

Background: Histone lactylation is a novel epigenetic modification that is involved in a variety of critical biological regulations. However, the role of lactylation-related genes in lung adenocarcinoma has yet to be investigated.

Methods: RNA-seq data and clinical information of LUAD were downloaded from TCGA and GEO datasets.

Construction of a MoO/MoS Heterojunction via the Surface Sulfurization of the Oxide and Its Photocurrent-Switching Characteristics in the Range of the Broadband Light Spectrum.

In order to utilize the longer wavelength light, the surface sulfurization of MoO was carried out. The photocurrent responses to typical 650, 808, 980, and 1064 nm light sources with Au gap electrodes were investigated. The results showed that the surface S-O exchange of MoO improved the interfacial charge transfer in the range of the broadband light spectrum.

A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study.

Background: Observational studies and experimental evidence have shown that chemokines play important roles in lung cancer development, progression, and treatment. However, few studies have examined the causal association between them.

Methods: Summary data of chemokines and lung cancer were obtained from genome-wide association studies.

A canonical protein complex controls immune homeostasis and multipathogen resistance.

The calcium (Ca) sensor ROD1 (RESISTANCE OF RICE TO DISEASES1) is a master regulator of immunity in rice. By screening suppressors of mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in (), (), (), and () all abolish enhanced disease resistance of plants.

Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.

The recurrence of glioma after treatment has remained an intractable problem for many years. Recently, numerous studies have explored the pivotal role of the mouse double minute 2 (MDM2)/p53 pathway in cancer treatment. Lysine phosphate phosphohistidine inorganic pyrophosphate phosphatase (LHPP), a newly discovered tumor suppressor, has been confirmed in numerous studies on tumors, but its role in glioma remains poorly understood.

Green Preparation of S, N Co-Doped Low-Dimensional C Nanoribbon/C Dot Composites and Their Optoelectronic Response Properties in the Visible and NIR Regions.

The green production of nanocomposites holds great potential for the development of new materials. Graphene is an important class of carbon-based materials. Despite its high carrier mobility, it has low light absorption and is a zero-bandgap material.

The SINA1-BSD1 Module Regulates Vegetative Growth Involving Gibberellin Biosynthesis in Tomato.

In plants, vegetative growth is controlled by synergistic and/or antagonistic effects of many regulatory factors. Here, the authors demonstrate that the ubiquitin ligase seven in absentia1 (SINA1) mammalian BTF2-like transcription factors, Drosophila synapse-associated proteins, and yeast DOS2-like proteins (BSD1) function as a regulatory module to control vegetative growth in tomato via regulation of the production of plant growth hormone gibberellin (GA). SINA1 negatively regulates the protein level of BSD1 through ubiquitin-proteasome-mediated degradation, and the transgenic tomato over-expressing SINA1 (SINA1-OX) resembles the dwarfism phenotype of the BSD1-knockout (BSD1-KO) tomato plant.

Charged functional groups modified porous spherical hollow carbon material as CDI electrode for salty water desalination.

As a new electrochemical technology, capacitive deionization (CDI) has been increasingly applied in environmental water treatment and seawater desalination. In this study, functional groups modified porous hollow carbon (HC) were synthesized as CDI electrode material for removing Na and Cl in salty water. Results showed that the average diameter of HC was approximately 180 nm, and the infrared spectrum showed that its surface was successfully modified with sulfonic and amino groups, respectively.

6-Phosphogluconate dehydrogenase promotes glycolysis and fatty acid synthesis by inhibiting the AMPK pathway in lung adenocarcinoma cells.

Abnormal metabolism has emerged as a prominent hallmark of cancer and plays a pivotal role in carcinogenesis and progression of lung adenocarcinoma (LUAD). In this study, single-cell sequencing revealed that the metabolic enzyme 6-phosphogluconate dehydrogenase (PGD), which is a critical regulator of the pentose phosphate pathway (PPP), is significantly upregulated in the malignant epithelial cell subpopulation during malignant progression. However, the precise functional significance of PGD in LUAD and its underlying mechanisms remain elusive.

Causal role of immune cells in asthma: a Mendelian randomization study.

Background: Immune cells may have a significant role in the pathophysiology of asthma, according to increasing evidence, although it is yet unclear how immune cells cause asthma. Therefore, we aimed to use Mendelian randomization (MR) methods to investigate this causal relationship.

Methods: This study explored the causal effects between immune cells and asthma using a two-sample MR technique.