Tailoring the Electronic Landscape and Metal-Support Interface of High-Entropy Alloys for Efficient Bifunctional Electrocatalysis.

High-entropy alloy (HEA) electrocatalysts exhibit a rich diversity of synergistic active sites but still face persistent challenges, such as unstable metal-support interfaces and intricate electronic structure modulation. Here, inspired by cell membrane-embedded synthetase catalytic units in the photosystem, we report a MnFeCoNiCuRu HEA electrocatalyst anchored on carbon nanofibers (CNFs) via the concurrent growth of HEA nanocrystals and CNF film support, which exhibits stable and strong metal-carbon interface coupling. In this architecture, trace Ru (∼4 wt %) acts as an electronic modulator, shifting the d-band center closer to the Fermi level and modulating the linear correlation between adsorption energies and the d-band center, thereby greatly enhancing intrinsic catalytic activity.

Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction.

Objectives: Intrauterine growth restriction (IUGR) significantly affects neonatal development, but its pathogenesis is not fully understood. Klotho protein is involved in aging-related diseases, and its role in fetal growth is unclear. This study aims to explore Klotho's role in IUGR.

Large-Scale Roll-to-Roll Manufacturing of Flexible, Hydrophobic, and Fire-Resistant Mica/SiO Nanofiber Aerogel Paper.

Oxide ceramic aerogels offer exceptional thermal insulation and chemical stability but face limitations due to brittleness, moisture sensitivity, and costly, complex manufacturing. Here, we present a roll-to-roll method for producing flexible, hydrophobic, and fire-resistant silica/mica hybrid aerogel paper. The process bypasses the need for expensive polymer sacrificial templates and high temperature sintering, instead forming aerogels directly through electrospinning stabilized tetraethyl orthosilicate and a synthetic fluorophlogopite sol.

Role of the PomiR171n-PoUGT89B2 module in regulating the petal senescence of tree peony.

Tree peony is a traditional and popular ornamental flower. However, its short and concentrated flowering period restricts the development of the tree peony industry. In this study, the function of the PomiR171n-PoUGT89B2 combination related to senescence regulation was analyzed, using Paeonia ostii 'Fengdan' (P.

Comparison of five-year physical outcomes in patients undergoing laparoscopic sleeve gastrectomy plus jejunojejunal bypass versus Roux-en-Y gastric bypass.

Background: Sleeve gastrectomy plus jejunojejunal bypass (SG + JJB) is increasingly accepted as a surgical treatment for severe obesity. However, data on the long-term results of this procedure are limited, and studies comparing it with other bariatric procedures are scarce.

Objectives: The objective of this study was to compare 5-year outcomes following SG + JJB and Roux-en-Y gastric bypass (RYGB).

Ultrahigh Strength and Exceptional Work Hardening in a Hierarchical-Structured Alloy via Hetero-Interface-Mediated Twinning.

Yield strength and work hardening are two critical mechanical properties of metallic structural materials. However, increasing yield strength through conventional strengthening mechanisms often restricts further dislocation multiplications and interactions, which significantly reduces work hardening and poses a challenge to achieving an optimal balance between these properties in material design. Here, an innovative approach to simultaneously enhance both yield strength and work hardening in a heterostructured, nanoprecipitation-strengthened alloy is reported.

Spatiotemporal Circadian Oscillator Manipulation for Enhanced Ovarian Cancer Therapy Using a Versatile Nanoplatform.

Circadian rhythm (CR) disruption has been confirmed as a contributing factor to tumor progression. However, regulating circadian genes shows an inhibitory effect on ovarian tumor initiation and progression, which highlights the urgent necessity to regulate tumors' CR to understand their role in ovarian cancer (OC) therapy precisely. Herein, a novel near-infrared (NIR) light-controlled spatiotemporal strategy is presented, aiming to manipulate ovarian tumors' CR while enhancing the efficacy of chemotherapy agents.

An Ultrafast Charge-Driven Topological Intercalation Prelithiation Strategy for Carbon-Silicon Composite Anodes.

Prelithiation emerges as an effective technique to enhance the initial Coulombic efficiency (ICE) and cycling stability of silicon oxide based carbon composite (C/SiO) anodes, yet traditional approaches remain plagued by sluggish kinetics, cumbersome procedures, safety hazards, and inadequate precision. Here, a facile topological intercalation prelithiation method capable of forming a robust and homogeneous solid electrolyte interface (SEI) network on porous C/SiO nanofiber anodes in merely 30 s is reported. Through constructing three charge-driven topology models derived from flexible SiO/porous carbon nanofiber (SiO/PCNF) films, the mechanism of this fast Li-intercalation process is unraveled.

Dynamics of the vibro-impact capsule robot with a truss.

Functionalised nonlinear structures employing structural instabilities for rapid response shape-shifting are emerging technologies with a wide range of potential applications. The truss is a widely employed model for such functionalised nonlinear structures; however, few studies have delved into its functionality when integrated with a complex dynamical system. This paper investigates its efficacy on enhancing the progression speed of a vibration-driven robot, known as the vibro-impact capsule robot, which is a piecewise-smooth dynamical system having abundant coexisting attractors.

Effects of Brown Algae () Extract on Growth Performance, Immune Function and Intestinal Health of Largemouth Bass ().

This study used largemouth bass (initial average weight: 33.33 ± 1.8 g) to explore the effects of adding different brown algae extracts to feed on the fish's growth, immunity and intestinal health.

The profiles of immunosuppressive microenvironment in the Lauren intestinal-type gastric adenocarcinoma.

Background: Gastric adenocarcinoma (GAC), particularly the Lauren intestinal-type GAC (IGAC), leads to significant mortality in China due to the limited effectiveness of current treatments. This study aims to investigate the mechanisms of immune suppression in IGAC to identify potential targets for enhancing immunotherapy outcomes.

Methods: Performing an extensive collection and re-analysis of single-cell RNA sequencing (scRNA-seq) of tumor tissues and the corresponding noncancerous mucosae from 15 Chinese patients diagnosed with IGAC, we identified cell subpopulations involved in immune suppression within the tumor microenvironment (TME).

scRNA-Seq Analysis Revealed CAFs Regulating HCC Cells via PTN Signaling.

Background: Cancer-associated fibroblasts (CAFs) play a pivotal role in shaping the microenvironment of hepatocellular carcinoma (HCC). However, the mechanisms through which CAFs influence the progression of HCC remain incompletely understood.

Methods: Single-cell RNA sequencing datasets (GSE158723 and GSE112271) were retrieved from the Gene Expression Omnibus (GEO) database at the National Center for Biotechnology Information (NCBI) and analyzed using R software.

A rapid-response soft end effector inspired by the hummingbird beak.

Biology is a wellspring of inspiration in engineering design. This paper delves into the application of elastic instabilities-commonly used in biological systems to facilitate swift movement-as a power-amplification mechanism for soft robots. Specifically, inspired by the nonlinear mechanics of the hummingbird beak-and shedding further light on it-we design, build and test a novel, rapid-response, soft end effector.

The up-regulation of PD-L1 during boningmycin-induced senescence in human cancer cells depends on the activation of the JAK/STAT signaling pathway mediated by SASP.

Therapy-induced senescence can regulate both the innate and adaptive immune systems, thereby affecting therapeutic efficacy. Bleomycin is a major component of combined chemotherapy regimens, utilized for the treatment of multiple tumors, whereas pulmonary toxicity severely restricts its clinical benefits. As a member of the bleomycin family, boningmycin (BON) exhibits potent anticancer activity with minimal pulmonary toxicity, making it a potential alternative to bleomycin.

Physiological and molecular mechanism of Populus pseudo-cathayana × Populus deltoides response to Hyphantria cunea.

Populus pseudo-cathayana × Populus deltoides is a crucial artificial forest tree species in Northeast China. The presence of the fall webworm (Hyphantria cunea) poses a significant threat to these poplar trees, causing substantial economic and ecological damage. This study conducted an insect-feeding experiment with fall webworm on P.

Exploring the role of CD8 T cells in clear renal cell carcinoma metastasis.

Clear cell renal cell carcinoma (ccRCC) accounts for approximately 75-80% of all patients with renal cell carcinoma. Despite its prevalence, little is known regarding the key components involved in ccRCC metastasis. In this study, scRNA-seq analysis was employed to classify CD8 T cells into four sub-clusters based on their genetic profiles and immunofluorescence experiments were used to validate two key clusters.

Comparison of Sleeve Gastrectomy with Loop Duodenojejunal Bypass Versus One Anastomosis Gastric Bypass for Type 2 Diabetes: The Role of Pylorus Preservation.

Background: One anastomosis gastric bypass (OAGB) is recognized as a standard procedure in metabolic surgery. However, concerns about postoperative bile reflux and nutritional risks are prevalent. Comparatively, sleeve gastrectomy with loop duodenojejunal bypass (SG + LoopDJB) bypasses an equivalent length of the foregut as OAGB while maintaining pyloric function.

Identification and functional analysis of the gene family in : implications for development and stress response.

Background: Populus simonii, a notable native tree species in northern China, demonstrates impressive resistance to stress, broad adaptability, and exceptional hybridization potential. DOF family is a class of specific transcription factors that only exist in plants, widely participating in plant growth and development, and also playing an important role in abiotic stress response. To date, there have been no reported studies on the DOF gene family in P.

FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2.

FBXO43 is a member of the FBXO subfamily of F-box proteins, known to be a regulatory hub during meiosis. A body of data showed that FBXO43 is overexpressed in a number of human cancers. However, whether and how FBXO43 affects cell cycle progression and growth of cancer cells remain elusive.

The current status and challenges of perioperative management of patients with a BMI of greater than or equal to 50 kg/m 2 undergoing bariatric surgery in China: a multicenter cross-sectional study.

Background: Performing bariatric surgery on patients with a BMI of over 50 kg/m 2 is challenging. This study aimed to explore the status and challenges related to the perioperative management of such patients in China.

Materials And Methods: A prospective survey was designed to investigate the perioperative management of patients with a BMI of greater than or equal to 50 kg/m 2 undergoing bariatric surgery in China.