Prolactin impairs erectile function via eNOS suppression independently of testosterone.

Erectile dysfunction (ED) frequently occurs in men with prolactin-secreting pituitary tumors (prolactinomas), even when serum testosterone levels remain normal. The precise mechanisms responsible for this phenomenon are poorly understood. We aimed to explore whether elevated prolactin directly impairs erectile function independently of testosterone, and to identify the underlying molecular pathways involved.

Endoscopic management of refractory gastrointestinal-tracheobronchial fistulas with two novel occluders: a comparative cohort study.

Refractory gastrointestinal (GI)-tracheobronchial fistulas are challenging to manage. This study compared the outcomes of two novel occluders specifically designed for endoscopic occlusion of GI-tracheobronchial fistulas.In this retrospective cohort study, 86 patients with refractory GI-tracheobronchial fistulas who underwent endoscopic occlusion using either a double umbrella-shaped (DU; n = 36) or mushroom umbrella-shaped (MU; n = 50) occluder were included.

New insights into metabolic dysfunction-associated steatotic liver disease and oxidative balance score.

Background: The relationship between oxidative stress and metabolic dysfunction-associated steatotic liver disease (MASLD) has not been studied, which remains inadequately recognized. This is a cross-sectional study in a US adult population to explore the relationship between MASLD and oxidative balance scores (OBS), which containing integrating dietary nutrition and lifestyle factors.

Methods: We analyzed data from National Health and Nutrition Examination Survey during 2017-2018.

Clinicopathological characteristics of synchronous multiple primary early esophageal cancer and risk factors for multiple lesions.

Background: With the development of endoscopic technology, the detection rate of synchronous multiple primary early esophageal cancer (SMPEEC) is increasing; however, the risk factors remain unclear. We aimed to assess the clinicopathological characteristics of patients with SMPEEC and investigate the risk factors contributing to the development of multiple lesions.

Methods: A retrospective cohort study was conducted on 911 consecutive patients who underwent Endoscopic submucosal dissection (ESD) for primary esophageal neoplasms from January 2013 to June 2021.

Ten-Day Vonoprazan-Amoxicillin Dual Therapy as a First-Line Treatment of Helicobacter pylori Infection Compared With Bismuth-Containing Quadruple Therapy.

Introduction: No study has investigated the efficacy and safety of vonoprazan-amoxicillin dual therapy compared with bismuth quadruple therapy (B-quadruple). This study aimed to evaluate the efficacy and safety of 10-day vonoprazan-amoxicillin dual therapy as a first-line treatment of Helicobacter pylori infection compared with B-quadruple and to explore the optimal dosage of amoxicillin in the dual therapy.

Methods: A total of 375 treatment-naive, H.

Endoscopic closure of refractory upper GI-tracheobronchial fistulas with a novel occluder: a prospective, single-arm, single-center study (with video).

Background And Aims: Upper GI-tracheobronchial fistula is a morbid condition with high mortality. It is a challenge for endoscopists because currently available treatments have severe limitations. In this study we assessed the efficacy and safety of an occluder we invented for endoscopic closure of refractory upper GI-tracheobronchial fistulas.

Anesthesia management for tracheoesophageal fistula closed with a new gastrointestinal occluder device: a case report.

Background: Tracheoesophageal fistula (TEF) is a rare but life-threatening complication after esophagectomy. A new gastrointestinal occluder device provides treatment for TEF patients. However, TEF-related pneumonia and respiratory failure increase the difficulty of anesthesia management, especially in airway management.

The efficacy and long-term outcomes of endoscopic full-thickness suturing for chronic gastrointestinal fistulas with an Overstitch device: is it a durable closure?

Background And Aim: Endoscopic closure of chronic gastrointestinal fistulas (CGFs) is challenging due to their epithelialized surfaces. The aim of this study was to assess the efficacy and long-term closure rate of endosuturing for CGFs with an Apollo Overstitch device.

Patients And Methods: Consecutive CGF patients undergoing endosuturing for fistula closure from April 2018 to January 2020 at the First Affiliated Hospital of Nanjing Medical University were enrolled for retrospective review.

Differential diagnosis for esophageal protruded lesions using a deep convolution neural network in endoscopic images.

Background And Aims: Recent advances in deep convolutional neural networks (CNNs) have led to remarkable results in digestive endoscopy. In this study, we aimed to develop CNN-based models for the differential diagnosis of benign esophageal protruded lesions using endoscopic images acquired during real clinical settings.

Methods: We retrospectively reviewed the images from 1217 patients who underwent white-light endoscopy (WLE) and EUS between January 2015 and April 2020.

Expression and clinical significance of girdin in gastric cancer.

Gastric cancer is one of the most common malignant tumors and the second leading cause of cancer-related mortality. Elucidating the molecular mechanism underlying the development of gastric cancer is crucial in identifying gastric cancer-susceptible populations, screening for tumor markers and in the application of gene therapy. This study was conducted to investigate girdin expression in gastric cancer and para-cancer tissues and to elucidate the role of girdin in the development of gastric cancer.

Anticancer effects of sodium butyrate on hepatocellular carcinoma cells in vitro.

In the present study, we investigated the anticancer effects of sodium butyrate (NaBu) on hepatocellular carcinoma (HCC) cells in vitro. As a histone deacetylase (HDAC) inhibitor, NaBu upregulated Ac-H3 and inhibited HDAC4 protein expression in a time- and dose-dependent manner. MTT assays showed that treatment with NaBu at high concentrations significantly inhibited the growth of various HCC cells.