Exploring the correlation between nocturnal awakenings and occupational burnout in internal medicine physicians via online survey.

This study aims to screen for occupational burnout among internal medicine physicians through an online survey, and to explore the relationship between burnout and anxiety, depression, stress, and sleep. The findings are expected to help improve the mental and physical health of physicians, thereby enhancing the medical quality in hospitals. Maslach burnout inventory-general survey (MBI-GS) was used to assess physicians' burnout status, Minnesota satisfaction questionnaire (MSQ) was used to evaluate the job satisfaction, Generalized anxiety disorder 7 (GAD-7), Patient health questionnaire-9 (PHQ-9), and Perceived stress scale (PSS) were used to assess the psychological status, and Pittsburgh sleep quality index (PSQI) was used to evaluate sleep conditions.

Interaction effects of sleep duration and activities of daily living on depressive symptoms among Chinese middle-aged and older adult individuals: evidence from the CHARLS.

Objectives: Evidence on the combined effect of sleep duration and activities of daily living (ADL) on depressive symptoms is scarce. This study aimed to explore the interaction effects between sleep duration and ADL limitations on depressive symptoms among Chinese individuals aged ≥45 years.

Methods: Data were extracted from the China Health and Retirement Longitudinal Study (CHARLS) wave 2020.

An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding.

Antigenic peptide-based mRNA vaccines have been explored for immunotherapeutic use in various types of cancer because of their advantages in activating durable and specific immune responses. However, their role in modulating tumor metastasis is still unclear. Here, we identify a conserved linear epitope-based peptide, Ma3P, located in the proteolytic region of major histocompatibility complex (MHC) class I-related chain A (MICA) α3 and further design mCM10-L, an mRNA vaccine that encodes the carrier protein CRM197 and 10 tandem repeats of Ma3P.

Interaction effect between sleep duration and dynapenic abdominal obesity for predicting functional disability: A longitudinal study.

Objective: To assess the interaction of dynapenic abdominal obesity (DAO) and sleep duration on the risk of functional disability among middle-aged and older Chinese individuals.

Methods: Data were extracted from the China Health and Retirement Longitudinal Study conducted in 2011, 2013, 2015, 2018, and 2020. A total of 6,343 participants were enrolled in this retrospective cohort study.

Global research trends on gastrointestinal cancer and mental health (2004-2024): a bibliographic study.

Background: Gastrointestinal (GI) cancers impose a significant burden on global public health. Patients often experience mental health challenges due to physical changes and treatment-related symptoms, which can worsen their condition or delay recovery. Although research is mounting in this field, visual bibliometric analysis has not yet been conducted.

Examining the impact of globalization and natural resources on environmental sustainability in G20 countries.

The G20 countries are responsible for around 75% of the world's greenhouse gas (GHG) emissions, including the use of natural resources. In this regard, the role of globalization in achieving environmental sustainability is a relatively new topic of concern. As a result, the present study considers how globalization and natural resources affect GHG emissions, as well as the roles that renewable energy consumption and urbanization play in the G20 countries between 1990 and 2020.

Research into the Influence of Filtration Media Microstructure on Oil-Water Separation Performance.

Oil-water separation materials with specialized wettability have garnered significant attention in the field of oil-water separation due to the advantages of simple use and no secondary pollution. However, the adsorptive contamination of the filter surface by impurity phases and surfactants can cause a shift in the wettability of the filter surface. For efficient oil-water separation and improved resistance to adherent contamination on the oil-water separation membrane surface, herein, superwetted Cu nanofilms and smooth hydrophobic surfaces were prepared on SSM substrates by one-step electrodeposition and immersion methods, respectively.

Influence of Surface Wettability of Nonhomogeneous Proppant on Hydraulic Fracture Inflow Performance.

Quartz sand proppant is widely used in hydraulic fracturing and the extraction of low-permeability reservoirs to prevent fracture closure and enhance reservoir recovery effectively. The influence of proppant size and type on well productivity has been widely studied, but the mechanism of proppant surface wettability on the hydraulic fracture inflow performance has not been thoroughly investigated. To further understand the influence of proppant wettability on fracture inflow performance, in this work, a hydrophobic quartz sand proppant was prepared by a simple dip-coating method using silane solution with a static water contact angle of 136.

Work stress and professional quality of life among Chinese nurses during the COVID-19 pandemic: the chain mediating role of self-compassion and benefit finding.

Background: Since the outbreak of the Coronavirus Disease 2019 (COVID-19), front-line nurses have faced not only daily work stress but also a high risk of infection and excessive workload, leading to unsatisfactory professional quality of life (ProQOL). This study aimed to explore whether self-compassion (SC) and benefit finding (BF) play a chain mediating role between work stress and ProQOL among Chinese nurses during the COVID-19 pandemic.

Methods: From March to April 2022, a sample of 13,936 Chinese nurses was recruited through snowball sampling.

Bibliometric and visualized analysis of global research on microRNAs in gastric cancer: from 2013 to 2023.

Gastric cancer (GC) imposes a heavy burden on global public health, and microRNAs (miRNAs) play a crucial role in the diagnosis and treatment of GC. Therefore, it is necessary to clarify the hotspots and frontiers in the field of miRNAs in GC to guide future research. A total of 2,051 publications related to miRNAs in GC from January 2013 to December 2023 were searched from the Web of Science Core Collection database.

Nurse-to-patient ratios and readiness for hospital discharge: A moderated mediation model.

Aim: To explore whether and to what extent, nurse-patient assessment differences mediate the association between nurse-to-patient ratios and readiness for hospital discharge, and examine whether nurse-patient characteristics moderate the indirect and/or direct effect of mediation model.

Design: A cross-sectional study was carried out from March 2021 to December 2022.

Methods: A total of 523 pairs of gastrointestinal cancer patients with PICC and their nurses were recruited.

Global status of research on gastrointestinal cancer patients' quality of life: A bibliometric and visual analysis from 2003 to 2023.

Objective: To analyze the current research status, hotspots, and frontiers in the field of Gastrointestinal (GI) cancer and quality of life (QoL) through the bibliometrics method, and to provide references and guidance for future research.

Methods: Literature related to GI cancer and QoL from April 1, 2003 to March 31, 2023 was retrieved from the Web of Science Core Collection database. CiteSpace 6.

Clinical evaluation of a multitarget fecal immunochemical test-sDNA test for colorectal cancer screening in a high-risk population: a prospective, multicenter clinical study.

Colorectal cancer (CRC) is a major malignancy threatening the health of people in China and screening could be effective for preventing the occurrence and reducing the mortality of CRC. We conducted a multicenter, prospective clinical study which recruited 4,245 high-risk CRC individuals defined as having positive risk-adapted scores or fecal immunochemical test (FIT) results, to evaluate the clinical performance of the multitarget fecal immunochemical and stool DNA (FIT-sDNA) test for CRC screening. Each participant was asked to provide a stool sample prior to bowel preparation, and FIT-sDNA test and FIT were performed independently of colonoscopy.

Morphology, Histopathology, and Anatomical Distribution of Sporadic Colorectal Polyps in Chinese Patients.

Background And Aims: There are limited data regarding the morphology, histopathology, and anatomical distribution of sporadic colorectal polyps in Chinese patients. We evaluated these characteristics of sporadic polyps to guide the endoscopic detection and excision of colorectal polyps.

Methods: This was a retrospective single-center observational study involving 7381 patients with sporadic colorectal polyps.

Differential responses from the left postcentral gyrus, right middle frontal gyrus, and precuneus to meal ingestion in patients with functional dyspepsia.

Background: Functional dyspepsia (FD) is most often a meal-induced syndrome. Studies using resting-state functional magnetic resonance imaging (rs-fMRI) reported abnormal connectivity in areas related to pain processing in FD. However, only a few studies have attempted to determine how meal ingestion affects the brain's working patterns.

Global research on cancer and sleep: A bibliometric and visual analysis of the last two decades.

Objective: The study aimed to analyze the research status, hotspots, and frontiers of global research on cancer and sleep through bibliometrics and provide references and guidance for future research.

Methods: The literature regarding cancer and sleep from 2002 to 2022 was searched from the Web of Science Core Collection (WoSCC) database. CiteSpace 5.

Consumption frequencies of beverages and the hypertension risk in adults: a cohort study in China.

Objective: To explore the associations between the consumption frequencies of alcohol, tea and sugar-sweetened beverages (SSBs) and the hypertension risk among Chinese adults.

Design: A longitudinal study of the effect of beverage consumption on hypertension risk.

Setting: Nine provinces in China, including Jiangsu, Hubei, Hunan, Guangxi, Guizhou, Liaoning, Heilongjiang, Shandong and Henan.

ETNPPL modulates hyperinsulinemia-induced insulin resistance through the SIK1/ROS-mediated inactivation of the PI3K/AKT signaling pathway in hepatocytes.

Hyperinsulinemia is a critical risk factor for the pathogenesis of insulin resistance (IR) in metabolic tissues, including the liver. Ethanolamine phosphate phospholyase (ETNPPL), a newly discovered metabolic enzyme that converts phosphoethanolamine (PEA) to ammonia, inorganic phosphate, and acetaldehyde, is abundantly expressed in liver tissue. Whether it plays a role in the regulation of hyperinsulinemia-induced IR in hepatocytes remains elusive.

Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma.

Ferroptosis, a newly defined and iron-dependent cell death, morphologically and biochemically differs from other cell deaths. Melanoma is a serious type of skin cancer, and the poor efficacy of current therapies causes a major increase in mortality. Sorafenib, a multiple kinase inhibitor, has been evaluated in clinical phase trials of melanoma patients, which shows modest efficacy.

Replenishment of the Gas in a Hydrophobically-Structured Surface by Mass Transfer at the Liquid-Gas Interface for Improving the Stability of Entrapped Gas.

The underwater nonwetted state on a superhydrophobic surface is hardly maintained in flowing water because the entrapped gas dissolves into the water or is carried off by flow. Therefore, a source gas is necessary to maintain a superhydrophobic state for its applications under realistic conditions. As detailed in this paper, based on the gas entrapped on a hydrophobic structured surface, the gas regeneration was experimentally achieved to replenish the losses of gas carried off by the flowing and reduced through dissolution.

Interaction effect between overweight/obesity and alcohol consumption on hypertension risk in China: a longitudinal study.

Objective: To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.

Design: A longitudinal study of the independent and combined effects of hypertension risk factors.

Setting: Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai, Jiangsu, Shandong, Henan, Hubei, Hunan, Guangxi, Guizhou and Chongqing.

A high-generalizability machine learning framework for predicting the progression of Alzheimer's disease using limited data.

Alzheimer's disease is a neurodegenerative disease that imposes a substantial financial burden on society. A number of machine learning studies have been conducted to predict the speed of its progression, which varies widely among different individuals, for recruiting fast progressors in future clinical trials. However, because the data in this field are very limited, two problems have yet to be solved: the first is that models built on limited data tend to induce overfitting and have low generalizability, and the second is that no cross-cohort evaluations have been done.

Effects of physical exercise on cognitive function of breast cancer survivors receiving chemotherapy: A systematic review of randomized controlled trials.

Background: Cognitive impairment has a great negative impact on quality of life for breast cancer survivors. Emerging evidence suggested that physical exercise can improve cognitive function in order adults with Alzheimer's disease. However, less is known about the effects of physical exercise on cognitive function for breast cancer survivors.