Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis.

Background: Fibrotic remodeling of the nucleus pulposus (NP) has been increasingly recognized as a key driver of intervertebral disc degeneration (IVDD), highlighting the role of fibroblast-like NP cells and myofibroblasts in excessive collagen deposition and tissue stiffening. Meanwhile, small-molecule compounds capable of modulating multiple pathological pathways have drawn growing attention in recent research, making them attractive candidates for IVDD treatment.

Methods: We first analyzed the GSE27494 dataset to identify IL11 dysregulation in degenerated human NP tissues and performed KEGG pathway analysis.

Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer's Disease.

While both Primary Age-Related Tauopathy (PART) and Alzheimer's Disease (AD) involve the accumulation of hyperphosphorylated tau (pTau)-positive neurofibrillary tangles (NFTs) in the hippocampus, PART is distinguished by the absence of β-amyloid (Aβ) deposition and is generally associated with milder cognitive impairment than AD. To delineate cellular and molecular mechanisms that are common or uniquely linked to disease progression in PART and AD, we constructed a transcriptome-wide, high-resolution atlas of the human hippocampus using samples from six individuals spanning the aged control (AC), PART, and AD groups. Our results supported that PART represent a precursor stage of AD, as evidenced by the altered transcriptional profiles of excitatory neurons (Exc) in the PART group, which exhibited a markedly increased capacity to promote Aβ production compared to both AC and AD groups.

Tailored professional identity personas of male undergraduate nursing students: a secondary analysis of qualitative data.

Background: With the gradual diversification of the gender structure in Chinese nursing undergraduate education, the number of male nursing students has steadily increased. However, research on the professional identity formation of male nursing students is still limited, particularly in terms of systematically identifying and understanding their intrinsic differences. Therefore, this study aims to identify the professional identity personas of male nursing undergraduates through secondary analysis of existing interview data and explore the characteristics of professional identity construction under different personas.

SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study.

Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are guideline-recommended agents for treating heart failure (HF), but the role of metabolomic biomarkers in underlying mechanisms, particularly acylcarnitines, remains unclear. This study examined the associations of acylcarnitines with SGLT2 inhibition and incident HF.

Methods: This subcohort study included 2178 participants from the prospective China Kadoorie Biobank without cardiovascular disease, diabetes or cancer at baseline.

Mediating role of social support between stigma and social alienation in patients with inflammatory bowel disease: a cross-sectional study.

Background: Stigma is a prevalent issue with well-documented negative consequences, including its association with social alienation. However, this relationship-and the mechanisms underlying it-remain underexplored in individuals with inflammatory bowel disease (IBD). This study aimed to examine the relationships among stigma, social support, and social alienation in IBD patients in China and to determine whether social support mediates the association between stigma and social alienation.

Magnetic relaxation switching biosensor based on CRISPR-mediated cascade reaction for the amplification-free detection of Salmonella.

Sensitive and accurate detection of foodborne pathogens is crucial for preventing foodborne outbreaks and ensuring public health safety, but challenged by extremely low infectious doses of many foodborne pathogens and matrix interference effects. In this study, we developed a magnetic relaxation switching biosensor boosted by CRISPR/Cas12a-mediated enzymatic cascade reaction (CMCR-MRS) for amplification-free detection of Salmonella typhimurium (S. typhimurium).

Research on the synthesis of lithium iron phosphate using vivianite prepared from municipal sludge.

Sewage treatment facilities are widespread in cities throughout China, and municipal sludge, a byproduct of wastewater treatment, often leads to resource waste and secondary pollution. Concurrently, the global community faces a critical shortage of phosphorus resources. In this study, we propose an innovative resource recycling strategy to address the challenges presented by global resource scarcity and municipal sludge disposal.

Immobilization of enzyme with MOF enhances colorimetric performance for fast, sensitive, and economical detection of chloramphenicol.

To ensure the safety of animal-derived foods, rapid and sensitive detection of chloramphenicol (CAP) residues is essential for monitoring antibiotic presence. To address this need, a modulated Metal-organic frameworks (MOFs) named NU-902 was synthesized, immobilizing horseradish peroxidase (HRP) onto its surface. Leveraging its colorimetric properties, the NU-902@HRP (NH) immuno-functionalized carrier was developed as a colorimetric probe.

Patterns and correlates of visual impairment and ocular hypertension among older adults in the general Chinese population: results from the CKB Biobank.

Background: While numerous ophthalmology-specific cohort studies have been conducted in China, there is a significant lack of comprehensive, population-based study on the potential determinants of visual impairment and ocular hypertension (OHT) in the general Chinese population.

Methods: In the 2020-2021 resurvey of the China Kadoorie Biobank study, ~25 000 randomly selected participants from 10 diverse localities (5 urban and 5 rural) were surveyed. Presenting visual acuity (PVA) was measured using the Random E eye chart and intraocular pressure (IOP) was measured using a handheld Icare (ic100) tonometer.

Strategies of tea polyphenol-mediated delivery systems based on Mannich reaction for precision nutrition.

Food bioactive compounds are mostly unstable during production, storage, and severe gastrointestinal conditions, limiting their bioavailability and practical application. Therefore, it is necessary to find effective methods to protect the food bioactive compounds from degradation and exert their potential benefits. Functionalized tea polyphenol-mediated delivery systems based on Mannich condensation reactions have been extensively developed and applied as nanocarriers to improve the bioavailability of food bioactive compounds, and exhibit great potential in precision nutrition research and applications.

Spinal Tuina ameliorates cerebral palsy-associated neural impairment in hypoxia-ischemia model rats via BMSC-derived exosomal microRNAs.

Background: Spinal Tuina is effective for cerebral palsy (CP), but its molecular mechanism remains unclear. Prior studies indicate that acupoint stimulation regulates miRNAs in bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exo) to promote brain repair. This study explores whether Spinal Tuina treats CP via a similar mechanism.

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning.

Accurate risk stratification is crucial for determining the optimal treatment plan for patients with colorectal cancer (CRC). However, existing deep learning models perform poorly in the preoperative diagnosis of CRC and exhibit limited generalizability, primarily due to insufficient annotated data. To address these issues, CRCFound, a self-supervised learning-based CT image foundation model for CRC is proposed.

Pseudomonas fluorescens P34 colonization impacts expression changes in wheat roots, reshapes rhizosphere microbial communities and promotes wheat plant growth.

Plant growth-promoting rhizobacteria (PGPR) can stimulate crop growth and performance through multiple mechanisms, making them promising bioinoculants for sustainable agriculture. Among known PGPR species, Pseudomonas fluorescens has attracted considerable attention because of its superior growth-promoting mechanisms and broad adaptability. Although P.

Effect of Bariatric Surgery on Non-alcoholic Fatty Liver Disease: An Exploratory Metabolomics and Validation Study.

Background: Bariatric surgery presents a significant alleviation for non-alcoholic fatty liver disease (NAFLD), which relies in part on achieving substantial weight loss in post-surgical period. We aimed to understand the effect of bariatric surgery on NAFLD remission via metabolomics and to validate the results in a general population-based cohort.

Methods: In a pilot study, ten patients with NAFLD who underwent bariatric surgery were enrolled.

Artificial Intelligence-Assisted Visualized Microspheres for Biochemical Analysis: From Encoding to Decoding.

ConspectusAs an essential branch of chemical science, biochemical analysis is widely applied in disease diagnosis, food safety testing, environmental monitoring, and other fields. Artificial intelligence (AI) technology has substantially advanced biochemical analysis, enabling the prediction and extraction of key information from large volumes of image data; these tasks were previously unattainable, particularly in visualized single-microsphere counting for biosensing assays. By modification of different biorecognition molecules, encoded microspheres of various colors and sizes can serve as ideal optical multiprobes.

Relational job characteristics and turnover intention among nurses: the mediating role of subjective well-being.

Objective: The relationship between relational job characteristics, subjective well-being, and turnover intention among clinical nurses remains insufficiently understood. This study examines these associations to inform nursing management strategies and and reduce turnover rates.

Methods: A cross-sectional survey of 1013 clinical nurses was conducted using questionnaires to assess relational job characteristics, subjective well-being, and turnover intention.

Exploring the correlation between nocturnal awakenings and occupational burnout in internal medicine physicians via online survey.

This study aims to screen for occupational burnout among internal medicine physicians through an online survey, and to explore the relationship between burnout and anxiety, depression, stress, and sleep. The findings are expected to help improve the mental and physical health of physicians, thereby enhancing the medical quality in hospitals. Maslach burnout inventory-general survey (MBI-GS) was used to assess physicians' burnout status, Minnesota satisfaction questionnaire (MSQ) was used to evaluate the job satisfaction, Generalized anxiety disorder 7 (GAD-7), Patient health questionnaire-9 (PHQ-9), and Perceived stress scale (PSS) were used to assess the psychological status, and Pittsburgh sleep quality index (PSQI) was used to evaluate sleep conditions.

Phenome-wide association of physical activity with morbidity and mortality risk in China: A prospective cohort study.

Research in high-income countries has established the health benefits of physical activity (PA), but evidence from low- and middle-income countries, including China, where PA patterns vary from those in high-income countries, remains limited. Moreover, previous research, mainly focused on specific diseases, failing to fully capture the health impacts of PA. We investigated the associations of PA with 425 distinct diseases and 53 causes of death using data from 511,088 participants aged 30-79 years in the China Kadoorie Biobank.

From the frontlines to the future: Anti-epidemic volunteer experience and career rewards for doctors.

Amid a series of sudden public health crises that have erupted since the beginning of the 21st century, healthcare professionals in China have consistently been recognized as frontline heroes. This study, based on unique data from a major hospital in China, focuses on doctors who volunteered during the COVID-19 outbreak in Wuhan, China. We examine the changes in remuneration and career trajectories of these volunteers upon their return to regular duties.

Reasons for Frail Older Adults in Nursing Homes Declining Participation in Exercise Interventions: A Life Course Perspective Qualitative Study.

Aim: To explore how life course factors shape the exercise participation decisions of frail older adults living in nursing homes.

Design: This qualitative study is from the approach of social constructivism.

Methods: Seventeen frail older adults were purposefully recruited from a nursing home in Beijing, China.

Prospective associations of diabetes with 15 cancers in 2.2 million UK and Chinese adults.

Background: Diabetes has been associated with the risk of numerous cancers but the causal relevance of many of these associations remains unclear.

Methods: We investigated associations between diabetes and risks of 15 cancers using Cox-regression and individual-level data from 2.2 million adults (334,978 incident cancer cases) in three prospective cohorts, UK Biobank (UKB), Million Women Study (MWS), and China Kadoorie Biobank (CKB).

Polydopamine-Mediated Flexible Spatial Barrier Facilitates Multilayer Assembly of Nanozymes to Co-Strength Point-of-Care Immunoassays.

The development of effective diagnostic strategies is crucial for ensuring the public health security. Here, we present a composite probe with exceptional peroxidase-like activity suitable for ultrasensitive and rapid immune-quantitative analysis. The probe is prepared via the polydopamine (PDA)-mediated flexible spatial barrier strategy, which overcomes performance limitations associated with inadequate or excessive loading that causes aggregation.

Proton Conduction Study in 2D Layered Polyoxovanadoborate Frameworks Based on Two Types of Open-Type {VB} Clusters.

Two organic-inorganic hybrid polyoxovanadoborates frameworks were constructed using transition metal complexes (Cd(en), Cu(en); en = ethylenediamine) as templating agents and open-type {VB} clusters as building blocks, forming 2D layered architectures. The O-H···O hydrogen bonds between the clusters link the layers to form a 3D supramolecular structure. Single-crystal analysis and two-dimensional correlation infrared spectroscopy (2D-COS-IR) revealed that the two isostructural compounds exhibit distinct hydrogen-bonding patterns, channel dimensions, and porosity due to differences in the coordinated transition metal ions, ultimately leading to variations in solvent molecule content.

Development of a predictive tool for long-term prognosis in clear cell adenocarcinoma of the cervix: a large population-based real-world study.

Background: Clear cell adenocarcinoma of the cervix (CCAC) is a rare malignancy without a well-established prognostic model. Our study aimed to develop and validate a nomogram to estimate overall survival in CCAC patients.

Methods: We collected data on 630 CCAC patients from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2021).

Global, Regional and National Burden of Low Back Pain in Adolescents Aged 10-19 years, 1990-2021: A Systematic Analysis of the Global Burden of Disease Study 2021.

Objective: To comprehensively analyze the levels and trends of low back pain (LBP) prevalence, incidence, and years lived with disability (YLDs) among adolescents aged 10-19 globally from 1990 to 2021, stratified by sex and the Socio - Demographic Index (SDI), and analyze the risk factors.

Summary Of Background Data: LBP affects adolescents, but its global burden and trends among this age group need exploration.

Methods: Estimations were carried out using the Bayesian meta-regression tool, DisMod-MR(Disease Modeling Meta-Regression) 2.