Mediating role of social support between stigma and social alienation in patients with inflammatory bowel disease: a cross-sectional study.

Background: Stigma is a prevalent issue with well-documented negative consequences, including its association with social alienation. However, this relationship-and the mechanisms underlying it-remain underexplored in individuals with inflammatory bowel disease (IBD). This study aimed to examine the relationships among stigma, social support, and social alienation in IBD patients in China and to determine whether social support mediates the association between stigma and social alienation.

Analysis of the Genetic Mechanism of Yield-Related Traits of Maize in Cold Regions.

Background: Maize is an important food crop in cold regions, especially in Northeast China. However, its short growth period and low-temperature stress pose challenges to the breeding of high-yield hybrids. With climate warming, the maize planting area continues to expand to high latitudes.

Cathepsin S regulates ferroptosis sensitivity in hepatocellular carcinoma through the KEAP1-NRF2 signaling pathway.

Ferroptosis is a newly discovered iron-dependent programmed cell death characterized by excess lipid peroxidation. It is emerging as a promising target for tumor therapies. In the present study, we first identify Cathepsin S (CTSS) as a novel ferroptosis regulator.

Unveiling the diagnostic and causal role of hyperlipidemia- and lipophagy-associated genes PLAUR, IVNS1ABP, and QKI in acute myocardial infarction.

Background: Hyperlipidemia (HLP) exacerbates myocardial cell injury by impairing lipophagy, a crucial lipid metabolic process, thereby increasing the risk of acute myocardial infarction (AMI). This study aims to identify biomarkers associated with HLP and lipophagy that are relevant to AMI risk through a combined transcriptomic and Mendelian randomization (MR) approach.

Methods: mRNA expression data for AMI, along with genes related to HLP (HRGs) and lipophagy (LRGs), were obtained from public databases.

Slow synaptic plasticity from the hippocampus underlies gradual mapping and fragmentation of novel spaces by grid cells.

Animals construct internal "cognitive maps" of the world during navigation in spatial and non-spatial domains, with grid cells in the medial entorhinal cortex (MEC) playing a key role. This requires associating internal position estimates with external cues to reduce spatial uncertainty over time. However, how grid cell representations evolve in novel spaces to support map formation is unclear.

Efficacy of paliperidone palmitate once-monthly (PP1M) in improving social functioning and reducing caregiver burden in patients with schizophrenia: a six-month follow-up study.

Background: Schizophrenia is a complex chronic mental disorder that severely impairs patients' social functioning and quality of life, while imposing substantial burdens on families and society. Long-acting injectable antipsychotics (LAIs) have demonstrated potential advantages in improving both symptoms and social functioning. This study investigated the effects of transitioning from oral antipsychotics (OAPS) to Paliperidone Palmitate Once-Monthly (PP1M) on symptom control, social functioning, and caregiver burden in schizophrenia patients.

[Mechanism of Gegen Qinlian Decoction in treatment of ulcerative colitis through affecting bile acid synthesis].

Gegen Qinlian Decoction(GQD) is a classic prescription for the clinical treatment of ulcerative colitis(UC). This study, based on the differences in efficacy observed in UC mice under different level of bile acids treated with GQD, aims to clarify the impact of bile acids on UC and its therapeutic effects. It further investigates the expression of bile acid receptors in the liver of UC mice, and preliminarily reveals the mechanism through which GQD affects bile acid synthesis in the treatment of UC.

Research progress of polysaccharide drug delivery systems in the treatment of intestinal diseases: A review.

Intestinal diseases (IDs), as a type of complex immune-related diseases, have long faced challenges such as low drug delivery efficiency, insufficient targeting, and significant systemic toxic and side effects in their treatment strategies. Although oral administration is widely adopted due to its noninvasiveness and high patient compliance, the heterogeneity of the gastrointestinal environment severely limits the precise release and effective accumulation of drugs in the colon. Therefore, developing a new type of drug carrier system that can overcome physiological barriers and achieve colonic targeted delivery has become one of the core research directions in the field of ID therapy.

Development of a Triplex Real-Time PCR Method for the Simultaneous Detection of Porcine Circovirus 2, 3, and 4 in China Between 2023 and 2024.

Background: Porcine circovirus disease (PCVD), caused by porcine circovirus (PCV), is a significant swine disease characterized by porcine dermatitis, nephrotic syndrome, and reproductive disorders in sows. Given the overlapping clinical presentations of PCV2, PCV3, and PCV4, a rapid and accurate method for their differential detection is essential.

Methods: In this study, specific primers and probes were designed based on the conserved regions of the genes of PCV2 and PCV4, as well as the gene of PCV3.

Study on the Degradation of Aflatoxin B1 by 3J2MO.

To address the issue of aflatoxin contamination, which poses a significant threat to food safety and human health, we have conducted extensive research. We have isolated a strain of (3J2MO) from the soil that exhibited remarkable efficiency in degrading various aflatoxin types, including AFB1, AFB2, AFG1, AFG2, and AFM1. SDS-PAGE analysis confirmed the purity of the enzymes to be over 95%.

PERK-mediated eIF2α phosphorylation suppresses porcine epidemic diarrhea virus replication by attenuating global protein synthesis and inducing IFN-Ⅰ production.

Porcine epidemic diarrhea virus (PEDV) is one of the most important porcine pathogens for which no preventive and antiviral treatment measures are available. A pervious study revealed that the unfolded protein response (UPR) induced by endoplasmic reticulum (ER) stress can be utilized to inhibit PEDV replication. Here, we demonstrated that the UPR suppresses the replication of multiple genotypes of PEDV in both Vero and swine testis (ST) cells, primarily through activation of the PERK-eIF2α branch among the three UPR pathways.

The research of dapagliflozin on cognitive function in middle-aged and older patients with type 2 diabetes mellitus and mild cognitive impairment: a 36-week prospective parallel control study.

Sodium-glucose co-transporter 2 inhibitors have demonstrated potential for improving cognitive function in preclinical studies; however, robust clinical evidence supporting this effect in humans remains limited. We conducted a prospective trial to assess the effect of dapagliflozin on cognitive function in middle-aged and older patients with type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI). Ninety participants were randomly assigned to either the dapagliflozin or control group for 36 weeks.

Thermal decomposition mechanism of HMX/DNAN at high temperatures by reactive molecular dynamics simulations.

This work investigated the thermal decomposition process of the HMX/DNAN melt-cast explosive system at high temperatures using reactive molecular dynamics. The initial reaction paths of the system and the effects of DNAN on the thermal decomposition of HMX were revealed. The findings indicated that the H atoms and nitro groups produced by the decomposition of DNAN were reacted with HMX and its intermediates, which in turn promoted the pyrolysis of HMX, while the OH radicals produced by the decomposition of HNO continued to induce the decomposition of HMX.

Mid-infrared spectroscopic identification of the right-fermented Baiyaojian for pulmonary inflammation therapy.

Baiyaojian is a product co-fermented from Chinese gallnut, tea leaves, and distillers' grains. Baiyaojian shows a significant therapeutic effect in the treatment of pulmonary inflammation. In the process of fermentation, the content of components in Baiyaojian changes all the time, resulting in different anti-inflammatory effects.

Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of the gut microbiota and metabolites.

The increasing incidence and associated metabolic complications pose major challenges in the treatment of hyperlipidaemia. Cinnamon is a food and medicinal resource associated with lipid metabolism, but the mechanism by which its active components, cinnamic acid (CA) and cinnamaldehyde (CM), alleviate hyperlipidaemia remains unclear. Biochemical, pathological, gut microbiota, and metabolomic analyses were performed to investigate the effects of CA and CM on HFD-fed mice and the underlying mechanisms involved.

Metagenomic Microbial Signatures for Noninvasive Detection of Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with poor early detection rates owing to the limited sensitivity and specificity of the current biomarker CA19-9. Gut microbiota dysbiosis plays a key role in PDAC pathogenesis. This study aimed to evaluate the noninvasive approach we developed, combining metagenome-derived microbial signatures with CA19-9, to improve PDAC detection.

Transcript-Wide Identification and Characterization of the BBX Gene Family in and Its Potential Roles in Development and Abiotic Stress.

has an impact on flowering physiology, photomorphogenesis, shade effects, and responses to both biotic and abiotic stresses. Although recent research described the BBX gene family in numerous plants, knowledge of the BBX gene in was sparse. In this study, we identified a total of 25 genes, and phylogenetic analysis showed that these genes were divided into five subfamilies.

Effects of Light Quality and Photoperiod on Growth, Dry Matter Production and Yield of Ginger.

We investigated the effects of light quality and photoperiod on the phenotypic characteristics, dry matter production, and yield of ginger under three light quality ratios (A1: blue light: white light = 1:4; A2: blue light: white light = 1:1; A3: pure white light) and two photoperiod conditions (B1: 12/12 h·d; B2: 16/8 h·d). The results demonstrated that blue light treatment significantly reduced plant height and the dry matter distribution ratio of stems and sheaths. In contrast, stem diameter, tiller number, leaf area, theoretical biomass (TBY), maximum accumulation rate (), average accumulation rate (), time point of maximum accumulation (), rapid growth period (DRGP), dry matter distribution ratio of leaves, roots, and rhizomes, number of rhizomes per plant, average rhizome weight, and yield all significantly increased with an increasing blue light ratio.

Chemical Isotope Labeling Liquid Chromatograph-Mass Spectrometer: A Powerful Tool for Analyzing Non-Volatile Organic Acids in Baijiu.

Non-volatile organic acids (NVOAs) are essential to the flavor profile of Baijiu. However, the low levels and diversity of NVOAs in Baijiu make their isolation, annotation, and quantification challenging. In this study, a well-established pipeline combining chemical derivatization, isotope labeling, and high-resolution mass spectrometry with a three-tier annotation process was used to quantify NVOAs in three typical flavor types of Baijiu with high coverage and confidence.

An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.

Metabolic-associated fatty liver disease (MAFLD) is a common chronic metabolic disease worldwide that seriously threatens human health. The Xiaoji-chenpi formula (XCF), derived from QingGanSan (QGS), has previously been proven to be clinically effective in MAFLD. However, its pharmacological activity and mechanism have not been studied in depth.

A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders.

According to traditional Chinese medicine (TCM) constitutional theory, individuals with phlegm-dampness constitution (PDC) are at increased risk for metabolic disorders. Previous studies have indicated that PDC individuals exhibit gene expression changes associated with metabolic disorders, even individuals with normal metabolic indices. However, the biological mechanisms underlying these changes remain unclear.

Dual-channel compression mapping network with fused attention mechanism for medical image segmentation.

Accurate image segmentation is the key to quantitative analysis and recognition of pathological tissues in medical imaging technology, which can provide important technical support for medical diagnosis and treatment. However, the task of lesion segmentation is particularly challenging due to the difficulty in identifying edges, the complexity of different tissues, and the variability in their shapes. To address these challenges, we propose a dual-channel compression mapping network (DCM-Net) with fused attention mechanism for medical image segmentation.

hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model.

Mounting evidence suggests that immunotherapies are promising strategies for fighting against cancers. However, the immunosuppressive tumor microenvironment (TME), insufficient lymphocytic infiltration, and poor immunogenicity hamper the broader implementation of immunotherapies. LIGHT, a member of the TNF superfamily, has been shown to recruit T cells into the TME, turning "cold" tumors into "hot" ones.

Polymerization of beneficial plant height QTLs to develop superior lines which can achieving hybrid performance levels.

Unlabelled: Heterosis, a key technology in modern commercial maize breeding, is limited by the narrow genetic base which hinders breeders from developing superior hybrid varieties. By integrating big data and functional genomics technologies, it becomes possible to create new super maize inbred lines that resemble hybrid varieties through the aggregation of multiple QTL parental advantage loci. In this study, we utilized a combination of resequencing and field selfing selection methods to develop three pyramiding QTL lines (PQLs) (PQL4, 6, and 7), each containing 15, 12, and 12 QTL loci respectively.