CIRBP Stabilizes mRNA to Sustain the SLC7A11/GPX4 Antioxidant Axis and Limit Ferroptosis in Doxorubicin-Induced Cardiotoxicity.

Doxorubicin-induced cardiotoxicity (DIC) significantly constrains the clinical efficacy of anthracycline chemotherapy, primarily through the induction of ferroptosis, an iron-dependent, regulated cell death driven by oxidative stress and lipid peroxidation. However, the upstream regulators of ferroptosis in DIC remain incompletely defined. Cold-inducible RNA-binding protein (CIRBP) exhibits cardioprotective effects in various pathological contexts, but its precise role in ferroptosis-related cardiotoxicity is unknown.

A Predictive Model Study on Differentiating Intrahepatic Cholangiocarcinoma From Hepatocellular Carcinoma Using Contrast-Enhanced Ultrasound, Shear Wave Elastography, and Clinical Feature-Based Nomogram.

Objectives: This study sought to design and verify a nomogram that utilizes ultrasonographic and clinical indicators to differentiate between intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC).

Methods: From November 2022 to September 2024, 136 patients with confirmed ICC or HCC were enrolled and randomly assigned to training and validation groups in a 7:3 ratio. Preoperative B-mode ultrasound, contrast-enhanced ultrasound, two-dimensional shear wave elastography features, and clinical indicators were retrieved and compared.

Assessment of understanding, attitudes, and clinical practices regarding osteoporosis among postgraduate students in China.

Background: While medical postgraduates should possess strong osteoporosis knowledge to improve public health, data on their knowledge and practices are lacking in China. This study compares osteoporosis-related knowledge, attitudes, and practices between professional-degree (clinical) and academic-degree (research) medical postgraduates.

Methods: A structured 14-item questionnaire regarding knowledge of osteoporosis, awareness and education level, and clinical practices related osteoporosis was electronically distributed to 97 postgraduates.

Non-Invasive Kupffer-CEUS Enhances the Accuracy of Focal Liver Lesions Diagnosis in Patients with Liver Cirrhosis or Fibrosis: A Prospective Multicenter Study from China.

Introduction: It is challenging to diagnose liver masses in the context of a rough liver background using computed tomography and magnetic resonance imaging. Perfluorobutane CEUS microbubble, an ultrasound (US) contrast agent, has a unique phase called the Kupffer phase. This study aimed to explore whether the diagnostic ability of Kupffer-CEUS is affected by the rough liver background.

Association between basal metabolic rate and cognitive function in Chinese older adults: the mediating effect of sarcopenia.

Background: Cognitive aging poses a major worldwide health concern. The association between basal metabolic rate (BMR) and cognition isn't well understood. This research examines sarcopenia's potential role as a mediator: linking BMR to cognitive function.

Demographic and clinical characteristics of MASLD and Met-ALD patients: Insights from NHANES 2017-2020.

Introduction And Objectives: Recent reclassifications of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic-associated alcoholic liver disease (Met-ALD) have prompted the need for better characterization of these conditions. This study aimed to explore the demographic and clinical features of these liver diseases.

Materials And Methods: Data from the 2017-2020 National Health and Nutrition Examination Survey identified 3755 participants with steatotic liver disease (SLD) using ultrasound transient elastography.

Finite element analysis of the impact of different traction anchorage locations on maxillary molar distalization with clear aligners and implant screws.

Objective: This study aims to evaluate the impact of different implant screw insertion sites and traction point combinations of clear aligners on anchorage control during maxillary molar distalization using a three-dimensional finite element analysis.

Methods: A finite element model was developed with the second maxillary molar distalized by 2 mm, followed by the distalization of the first maxillary molar by 0.25 mm.

Deep learning radiomics of elastography for diagnosing compensated advanced chronic liver disease: an international multicenter study.

Accurate, noninvasive diagnosis of compensated advanced chronic liver disease (cACLD) is essential for effective clinical management but remains challenging. This study aimed to develop a deep learning-based radiomics model using international multicenter data and to evaluate its performance by comparing it to the two-dimensional shear wave elastography (2D-SWE) cut-off method covering multiple countries or regions, etiologies, and ultrasound device manufacturers. This retrospective study included 1937 adult patients with chronic liver disease due to hepatitis B, hepatitis C, or metabolic dysfunction-associated steatotic liver disease.

Error Analysis and Suppression of Rectangular-Pulse Binary Phase Modulation Technology in an Interferometric Fiber-Optic Sensor.

In the field of interferometric fiber-optic sensing, the phase-shifting technique is well known as a highly efficient method for retrieving the phase signal from the interference light intensity. The rectangular-pulse binary phase modulation (RPBPM) method is a typical phase-shifting method with the advantages of high efficiency, low complexity, and easy array multiplexing. Exploring the impact of the parameters on the performance is of great significance for guiding its application in practical systems.

Associations of handgrip strength, walking times, and dementia among Chinese adults: A cross-sectional analysis from CHARLS.

Introduction: The progression of dementia poses a major public health issue. While handgrip strength (HGS) and walking times are linked to dementia, their relationship needs clarification. This study explored how walking times mediates the connection between HGS and dementia.

Mediation of the frailty index, the relationship between sleep duration and chronic pain in different body regions: insights from the CHARLS cross-sectional study.

Background: Sleep duration and frailty index are knowm to influence chronic pain. However, the manner in which these factors interact to influence chronic pain remains unclear. The present study investigates the link between sleep duration and chronic pain using a cross-sectional design while also examining the potential mediating role of the frailty index.

The mediating effect of handgrip strength on the association between sleep duration and basal metabolic rate in middle-aged and older adults: evidence from the China health and retirement longitudinal study.

Background: Anomalies in basal metabolic rate (BMR) among middle-aged and older populations can lead to various metabolism-related diseases, presenting a significant global public health challenge. The association and mechanism between sleep duration and BMR remain unclear. This study aimed to investigate the mediating role of handgrip strength in the relationship between sleep duration and BMR.

Associations between sleep duration trajectories and physical dysfunction among middle-aged and older Chinese adults.

Background: The relationship between a single time-point measurement of sleep duration and physical dysfunction has been extensively investigated. However, few researches has concentrated on the effects of sleep duration trajectories. This study sought to evaluate the association between sleep duration trajectories and physical dysfunction in a longitudinal cohort of middle-aged and older Chinese individuals.

Predictive value of the ratio of fusion segments to main curve segments for postoperative curve progression in congenital scoliosis with solitary hemivertebra.

Purpose: To investigate the influence of the preoperative compensatory curve on the postoperative curve progression in congenital scoliosis (CS) patients following hemivertebra (HV) resection and short fusion and to analyze the risk factors for postoperative curve progress.

Methods: This study retrospectively reviewed a consecutive cohort of CS patients who underwent HV resection and short fusion with a minimum follow-up of 2 years. General demographic information, as well as preoperative, postoperative, and latest follow-up radiographic data, were collected.

Amlodipine overdose rescued with extracorporeal membrane oxygenation: A case report.

Rationale: Amlodipine, a calcium channel blocker, is widely prescribed for managing hypertension through vascular smooth muscle relaxation. However, severe amlodipine toxicity can lead to profound hypotension and refractory shock, often unresponsive to conventional treatments.

Patient Concerns: In this report, we reported a 32-year-old female case of amlodipine overdose who was admitted to our hospital on March 1, 2024, due to intentionally ingesting approximately 84 tablets of amlodipine (5 mg each).

Breaking barriers in ICD classification with a robust graph neural network for hierarchical coding.

The accurate classification of International Classification of Diseases (ICD) codes is a complex and critical multi-label task in clinical documentation, involving the assignment of diagnostic codes to medical discharge summaries. Existing automated methods face challenges due to the sparsity and nuanced nature of medical text, while traditional backpropagation-based models often lack flexibility and robustness. To address these issues, we propose Labeled Graph Generation with Node Representation Grasp (LGG-NRGrasp), an advanced adversarial learning framework that models ICD coding as a labeled graph generation problem.

Sarcopenia as a mediator: Bridging basal metabolic rate and depression in middle-aged and older populations.

Background: Depression greatly affects global health. Although the link between basal metabolic rate (BMR) and depression risk is established, the role of sarcopenia is uncertain. This study explored if sarcopenia mediates the BMR-depression risk relationship.

An Inchworm-Inspired Fast-Moving Micro Flexible Robot for Autonomous Terrain-Adaptive Exploration.

Soft robots with motion sensing can achieve motion feedback and monitor environmental changes. Motion sensing significantly expands the potential applications of soft robots in exploration and other fields. This study investigates an inchworm-like miniature soft robot capable of rapid locomotion and autonomous terrain-adaptive exploration.

Which factors affect anxiety in rural older adults in China?

Objective: To explore the influencing factors of individual anxiety in rural older adults in China and analyze the relative importance of each factor, so as to provide scientific basis for the development of intervention measures to improve the mental health of rural older adults. The study also aims to improve the well-being and quality of life of older adults.

Methods: A multi-stage cluster random sampling was conducted in rural Anhui Province, China from July 2023 to February 2024, involving a total of 1,546 older adults.

Colorectal Liver Metastasis Pathomics Model: Integrating Single-Cell and Spatial Transcriptome Analysis With Pathomics for Predicting Liver Metastasis in Colorectal Cancer.

The liver is the primary target organ for hematologic metastasis of colorectal cancer (CRC), and CRC liver metastasis (CRLM) often precludes radical resection, making it the leading cause of death in patients with CRC. To improve the identification and prediction of liver metastasis risk, we identified a cell type of liver metastasis--triggering malignant cells (LMTMCs) through integrating single-cell RNA sequencing and spatial transcriptome analysis. Multiomics cell communication analysis indicated that the interaction between fibroblasts and LMTMCs through the COL1A1-CD44/SDC4 and LAMA4-CD44 signaling axes could promote CRLM.

Machine learning-based fusion model for predicting HER2 expression in breast cancer by Sonazoid-enhanced ultrasound: a multicenter study.

Purpose: To predict human epidermal growth factor receptor 2 (HER2) expression in breast cancer (BC) using Sonazoid-enhanced ultrasound in a machine learning-based model.

Materials And Methods: Between August 2020 and February 2021, patients with breast cancer who underwent surgical treatment without neoadjuvant chemotherapy were prospectively enrolled from 17 hospitals in China. HER2 expression status was assessed by immunohistochemistry or fluorescence hybridization (FISH).

The relationship between intrinsic capacity and sarcopenia in middle-aged and older Chinese populations: the mediating influence of a novel nutritional index.

Background: Sarcopenia poses a major global health issue, with intrinsic capacity (IC) linked to its risk. This study examined the link between IC and sarcopenia in middle-aged and older Chinese individuals, focusing on the mediating role of triglycerides-total cholesterol-body weight index (TCBI), a new easy-to-calculate nutritional indicator.

Methods: The investigation utilized 2015 data from the China Health and Retirement Longitudinal Study (CHARLS), focusing on individuals aged 45 years or older.

Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation.

Transcranial focused ultrasound is a promising non-invasive method for neuromodulation, particularly for neurodegenerative and psychiatric conditions. However, its use in wearable systems has been limited due to bulky devices and reliance on ultrasound gel, which dehydrates and lacks stable adhesion for long-term use. Here, we present a miniaturized wearable ultrasound device, comparable in size to standard electrophysiological electrodes, integrated with a bioadhesive hydrogel for stable, long-term somatosensory cortical stimulation.

Extended Strange Metal Phase in Electron-Doped LaCeCuO.

Landau's Fermi liquid theory offers a profound understanding of conduction electrons in metals. However, many strongly correlated materials, including heavy-fermions, cuprates, iron-based superconductors, and nickelates, exhibit non-Fermi liquid (NFL) behavior. A hallmark is the strange metal state, characterized by linear-in-temperature resistivity and a linear-in-energy single-particle decay rate.