Fluorinated albumin nanoplatform for F MRI-guided synergistic chemo-chemodynamic therapy and immune activation in breast cancer.

Developing nanomedicines from natural sources with synergistic effects to activate effective antitumor immune response remains a significant challenge. Here, we present a fluorinated bovine serum albumin (BSA)-based self-assembling nanoplatform that integrates chemotherapy (Chemo) and chemodynamic therapy (CDT) to induce immunogenic cell death (ICD) of breast cancer. This nanoplatform efficiently encapsulates doxorubicin (DOX) and fluorine-19 magnetic resonance imaging (F MRI)-sensitive F-oil in its core, with gallic acid (GA)-stabilized Fe on its surface.

Enabling F MRI and Boosting Phototherapy Through Facile Counterion Pairing of Photosensitizers.

Self-oxygenated phototherapy systems integrating near-infrared fluorescence imaging (NIR FLI) and fluorine-19 magnetic resonance imaging (F MRI) hold great promise for imaging-guided therapy of deep-seated hypoxic tumors. However, such systems are rare and often suffer from complex synthesis, suboptimal imaging and therapeutic performance. Here, a convenient and effective counterion pairing strategy is introduced to construct FNP, a dual-modal phototherapy nanoemulsion that integrates NIR FLI, F MRI, self-oxygenated photodynamic therapy, and photothermal therapy.

Efficient biotransformation of norfloxacin by Castellaniella defragrans HL-1: Kinetics, pathways, toxicity assessment, and genomic insights.

A novel strain, Castellaniella defragrans HL-1, was isolated from activated sludge acclimated to high norfloxacin (NOR) concentrations (5-45 mg/L) for 123 days. This strain exhibited efficient NOR biotransformation with sodium acetate (NaAc) as the primary carbon source. The optimal conditions (pH 7.

Simultaneous determination of pyroxasulfone and its metabolites in wheat: Implications for safe application.

Understanding pyroxasulfone residue dynamics in wheat under China's climatic and soil conditions is critical for establishing rational usage guidelines, setting maximum residue limits, and safeguarding human health. Field trials were conducted across 10 major wheat-producing regions to evaluate the residues of 40 % pyroxasulfone suspensions in winter wheat. A UPLC-MS/MS method was developed to simultaneously quantify pyroxasulfone and four metabolites in grains and straw.

Ocular biometric parameters among Han and Uyghur young adults with myopia in Xinjiang, China.

Aim: To describe ocular biometric parameters among Han and Uyghur myopic adults in Xinjiang, China.

Methods: A cross-sectional study was conducted. The different ocular biometric parameters collected using Pentacam were analyzed, including corneal curvature, corneal astigmatism (CA), horizontal corneal diameter (white-to-white, WTW), corneal volume (CV), pupil diameter (PD), anterior chamber angle (ACA), anterior chamber depth (ACD), anterior chamber volume (ACV) and axial length (AL).

Transcript-Wide Identification and Characterization of the BBX Gene Family in and Its Potential Roles in Development and Abiotic Stress.

has an impact on flowering physiology, photomorphogenesis, shade effects, and responses to both biotic and abiotic stresses. Although recent research described the BBX gene family in numerous plants, knowledge of the BBX gene in was sparse. In this study, we identified a total of 25 genes, and phylogenetic analysis showed that these genes were divided into five subfamilies.

Fluorination of Aza-BODIPY for Cancer Cell Plasma Membrane-Targeted Imaging and Therapy.

Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional PSs specifically designed for cancer PDT by fluorinating aza-BODIPY with perfluoro--butoxymethyl (PFBM) groups.

New cheaper human papilloma virus mass screening strategy reduces cervical cancer incidence in Changsha city: A clinical trial.

Background: Cervical cancer is the second leading cause of death in women worldwide, second only to breast cancer. Around 80% of women have been infected with human papillomavirus (HPV) in their lifetime. Early screening and treatment are effective means of preventing cervical cancer, but due to economic reasons, many parts of the world do not have free screening programs to protect women's health.

Acyclovir contamination in environment: Occurrence, transformation, toxicity, risk, and evaluation as a pharmaceutical indicator.

Acyclovir (ACV), a widely used antiviral medication effective against herpes simplex viruses (HSV), is raising concern due to its pervasive presence in global water and the associated potential risks. ACV can undergo transformation under varying conditions, leading to the generation of diverse transformation products that may exhibit heightened toxicity. This review aims to present a comprehensive overview of the environmental impact of ACV.

Delineating Molecular Regulatory of Flavonoids Indicated by Transcriptomic and Metabolomics Analysis during Flower Development in .

Flavonoids are pharmacologically active compounds in flowers of '' (); however, the molecular regulatory network governing flower development remains largely elusive. Flower samples were collected at four stages, namely budding (BD), bud breaking (BB), early blooming (EB), and full blooming (FB), for omics analysis. We revealed distinct transcriptional regulation patterns at these four stages of the flower from the perspective of differentially expressed unigenes (DEGs).

Aptamer-controlled stimuli-responsive drug release.

Aptamers have been widely researched and applied in nanomedicine due to their programmable, activatable, and switchable properties. However, there are few reviews on aptamer-controlled stimuli-responsive drug delivery. This article highlights the mechanisms and advantages of aptamers in the construction of stimuli-responsive drug delivery systems.

Biosynthesis and Anticancer Activity of Genistein Glycoside Derivatives.

As a beneficial natural flavonoid, genistein has demonstrated a wide range of biological functions via regulating a number of targets and signaling pathways, such as anti-cancer, antioxidant, antibacterial, antiinflammatory, antifungal, antiviral, iron chelation, anti-obesity, anti-diabetes, and anti-hypertension. Pub- Med/Medline and Web of Science were searched using appropriate keywords until the end of December 2023. Despite its many potential benefits, genistein's clinical application is limited by low hydrophilicity, poor solubility, and suboptimal bioavailability due to its structure.

Bio-degraded of sulfamethoxazole by microbial consortia without addition nutrients: Mineralization, nitrogen removal, and proteomic characterization.

Sulfamethoxazole (SMX) is widely employed as an antibiotic, while its residue in environment has become a common public concern. Using 100 mg/L SMX as the sole nutrient source, the acclimated sludge obtained by this study displayed an excellent SMX degradation performance. The addition of SMX resulted in significant microbiological differentiation within the acclimated sludge.

Can the home experience in luxury hotels promote pro-environmental behavior among guests?

While the home is an important place for individuals to act pro-environmentally, researchers have rarely explored the pro-environmental behavior of hotel customers in terms of their home away from home experiences during their travels. This study uses a combination of qualitative (interviews) and quantitative (questionnaires) methods to explore customer experiences of home spaces in the hotel context and the relationship between people's experience in hotels and their pro-environmental behavior. The study shows that (1) customers' experience of home spaces in hotels occurs through three dimensions: the function of home, the emotion of home, and the imagination of home.

CRISPR/Cas9 systems: Delivery technologies and biomedical applications.

The emergence of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a significant revolution in the realm of managing human diseases, establishing animal models, and so on. To fully harness the potential of this potent gene-editing tool, ensuring efficient and secure delivery to the target site is paramount. Consequently, developing effective delivery methods for the CRISPR/Cas9 system has become a critical area of research.

Cellular organelles as drug carriers for disease treatment.

Organelles not only constitute the basic structure of the cell but also are important in maintaining the normal physiological activities of the cell. With the development of biomimetic nanoscience, researchers have developed technologies to use organelles as drug carriers for disease treatment. Compared with traditional drug carriers, organelle drug carriers have the advantages of good biocompatibility, high drug loading efficiency, and modifiability, and the surface biomarkers of organelles can also participate in intracellular signal transduction to enhance intracellular and intercellular communication, and assist in enhancing the therapeutic effect of drugs.

Transcript-wide identification and expression pattern analysis to comprehend the roles of AP2/ERF genes under development and abiotic stress in Trichosanthes kirilowii.

Background: The APETALA 2/ ethylene-responsive element binding factors (AP2/ERF), are thought to be associated with plant abiotic stress response, and involved in some plant hormone signaling pathways. Trichosanthes kirilowii is an important edible and medicinal crop, so far no research has been conducted on the TkAP2/ERF genes.

Result: In this study, a total of 135 TkERFs were identified, these genes were divided into 4 subfamilies and clustered into 13 groups.

stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment.

The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials play important roles. constructed nanomaterials are formed spontaneously without human intervention and have promising applications in bioscience. However, due to the complex physiological environment of the human body, designing stimulus-responsive self-assembled nanomaterials is a challenging problem for researchers.

Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection.

The systemic benefits of anti-inflammatory pharmacotherapy vary across cardiovascular diseases in clinical practice. We aimed to evaluate the application of artificial intelligence to acute type A aortic dissection (ATAAD) patients to determine the optimal target population who would benefit from urinary trypsin inhibitor use (ulinastatin). Patient characteristics at admission in the Chinese multicenter 5A study database (2016-2022) were used to develop an inflammatory risk model to predict multiple organ dysfunction syndrome (MODS).

Efficient degradation of hexabromocyclododecane using montmorillonite supported nano-zero-valent iron and Citrobacter sp. Y3.

The coupling of modified nanoscale zero-valent iron (nZVI) with organohalide-degrading bacteria provides a promising solution for the remediation of hexabromocyclododecane (HBCD)-contaminated environments. However, the interactions between modified nZVI and dehalogenase bacteria are intricate, and the mechanisms of synergistic action and electron transfer are not clear, and requires further specific investigation. In this study, HBCD was used as a model pollutant, and stable isotope analysis revealed that organic montmorillonite (OMt)-supported nZVI coupled with the degrading bacterial strain Citrobacter sp.

Adsorbed copper on urea modified activated biochar catalyzed HO for oxidative degradation of sulfadiazine：Degradation mechanism and toxicity assessment.

The combined pollution of heavy metals and organic compounds usually occurs simultaneously and induces high toxicity. The technology of simultaneous removal of combined pollution is lacking and the removal mechanism is not clear. Sulfadiazine (SD), a widely used antibiotic, was used as a model contaminant.

Dimorphism of Candida tropicalis and its effect on nitrogen and phosphorus removal and sludge settleability.

Candida tropicalis PNY, a novel dimorphic strain with the capacity of simultaneous carbon, nitrogen and phosphorus removal in anaerobic and aerobic conditions, was isolated from activated sludge. Dimorphism of C. tropicalis PNY had effect on removing nitrogen and phosphorous and slightly affected COD removal under aerobic condition.

Circulating biomarker-based risk stratifications individualize arch repair strategy of acute Type A aortic dissection via the XGBoosting algorithm.

Aims: The incremental usefulness of circulating biomarkers from different pathological pathways for predicting mortality has not been evaluated in acute Type A aortic dissection (ATAAD) patients. We aim to develop a risk prediction model and investigate the impact of arch repair strategy on mortality based on distinct risk stratifications.

Methods And Results: A total of 3771 ATAAD patients who underwent aortic surgery retrospectively included were randomly divided into training and testing cohorts at a ratio of 7:3 for the development and validation of the risk model based on multiple circulating biomarkers and conventional clinical factors.

Perchlorate reduction kinetics and genome-resolved metagenomics identify metabolic interactions in acclimated saline lake perchlorate-reducing consortia.

Perchlorate is a widely detected environmental contaminant in surface and underground water, that seriously impacts human health by inhibiting the uptake of thyroidal radioiodine. Perchlorate reduction due to saline lake microorganisms is not as well understood as that in marine environments. In this study, we enriched a perchlorate-reducing microbial consortium collected from saline lake sediments and found that the perchlorate reduction kinetics of the enriched consortium fit the Michaelis-Menten kinetics well, with a maximum specific substrate reduction rate (q) of 0.

A Novel Inflammation-Based Risk Score Predicts Mortality in Acute Type A Aortic Dissection Surgery: The Additive Anti-inflammatory Action for Aortopathy and Arteriopathy Score.

Objective: To develop an inflammation-based risk stratification tool for operative mortality in patients with acute type A aortic dissection.

Methods: Between January 1, 2016 and December 31, 2021, 3124 patients from Beijing Anzhen Hospital were included for derivation, 571 patients from the same hospital were included for internal validation, and 1319 patients from other 12 hospitals were included for external validation. The primary outcome was operative mortality according to the Society of Thoracic Surgeons criteria.