Associations between season of conception and maternal and perinatal health: a prospective birth cohort study.

Background: Global maternal health progress stagnated during the Sustainable Development Goal era, while the impact of meteorological conditions on maternal-infant outcomes remains contentious. We aimed to investigate the relationship between the season of conception and adverse perinatal outcomes.

Methods: We conducted a prospective cohort study, collecting basic demographic characteristics of pregnant women and estimating the season of conception based on the date of the last menstrual period.

Comparison of the accuracy of predictive models in early detection of clinically relevant posthepatectomy liver failure.

Background: Post-hepatectomy liver failure (PHLF) is a leading cause of perioperative mortality following liver resection. Early detection and prediction of clinically relevant post-hepatectomy liver failure (CR-PHLF) remain critical but challenging. Lactate has shown promise as a biomarker, but its predictive power when combined with other factors remains unclear.

First trimester metabolic syndrome insulin resistance index and offspring congenital heart disease risk: The mediating role of gestational diabetes mellitus.

Background: The purpose of this research was to investigate the association between the first trimester metabolic score for insulin resistance (METS-IR) index and offspring congenital heart disease (CHD), and to pay special attention to the mediating role of gestational diabetes mellitus (GDM).

Methods: A total of 21,401 women without pre-existing diabetes were enrolled in a prospective birth cohort study conducted in China. The participants were categorized into four groups based on their METS-IR index scores.

Enhanced PCB defect detection via HSA-RTDETR on RT-DETR.

Common PCB (Printed Circuit Board) defects include missing holes, shorts, spurs, etc., which may lead to product performance degradation, malfunction or safety hazards. Within the framework of Smart Manufacturing and Industry 4.

Perioperative and long-term outcomes of laparoscopic liver resection for combined hepatocellular carcinoma and cholangiocarcinoma versus intrahepatic cholangiocarcinoma: A propensity score matching analysis.

Background: Laparoscopic liver resection (LLR) has been increasingly used to treat intrahepatic cholangiocarcinoma (ICC), yet the role of LLR on combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) remains unclear. The purpose of this study was to compare the perioperative efficacy and long-term prognosis of LLR for cHCC-CC and ICC through the use of propensity score matching (PSM) analysis.

Methods: Clinicopathologic, perioperative, and survival data of patients with cHCC-CC and ICC who underwent LLR from November 2018 to May 2023 at our institution were retrospectively collected.

Mechanical Behavior of Topology-Optimized Lattice Structures Fabricated by Additive Manufacturing.

Lattice-based metamaterials have attracted much attention due to their excellent mechanical properties. Nevertheless, designing lattice materials with desired properties is still challenging, as their mesoscopic topology is extremely complex. Herein, the bidirectional evolutionary structural optimization (BESO) method is adopted to design lattice structures with maximum bulk modulus and elastic isotropy.

A real-time end-to-end detector for detecting surface defects on oversized rings.

Oversized rings in wind turbines are regarded as crucial components because they often serve as the main load-bearing and connector structures. Surface defects on these rings can disrupt the normal operation of the entire unit. Detecting surface defects on oversized rings in wind turbine generators (WTGs) is highly challenging due to the huge ring size and small target defects, which will cause the detection process to be very time-consuming and difficult to achieve the expected accuracy.

CRCFound: A Colorectal Cancer CT Image Foundation Model Based on Self-Supervised Learning.

Accurate risk stratification is crucial for determining the optimal treatment plan for patients with colorectal cancer (CRC). However, existing deep learning models perform poorly in the preoperative diagnosis of CRC and exhibit limited generalizability, primarily due to insufficient annotated data. To address these issues, CRCFound, a self-supervised learning-based CT image foundation model for CRC is proposed.

Tumor-Targeted PLGA Nanospheres Enhance Therapeutic Effect of Lenvatinib in Hepatocellular Carcinoma via Photothermal and Photodynamic Therapy.

Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive forms of liver cancer, with limited therapeutic options and a high recurrence rate. Traditional treatments include surgery and systemic therapy, but systemic therapy has side effects, such as poor specificity, systemic toxicity, and drug resistance. Herein, we designed a multimodal diagnostic and therapeutic-integrated nanosphere for packaging and delivering lenvatinib (LVN).

PpMATE49, a multidrug and toxic compound extrusion transporter, confers manganese toxicity tolerance in peach (Prunus persica).

Multidrug and toxic compound extrusion (MATE) transporters play critical roles in plant stress responses, including heavy metal detoxification. Although manganese (Mn) toxicity severely limits crop productivity worldwide, the involvement of MATE transporters in Mn tolerance remains poorly understood, especially in perennial fruit crops. In this study, we identified 65 MATE genes in Prunus persica genome, phylogenetically classified into four distinct clades.

Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.

Background And Aims: The impact of sex disparity on the patterns of recurrence after curative resection of hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to comprehensively investigate the influence of sex differences in HCC recurrence following curative hepatectomy.

Methods: Patients who underwent curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively.

Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.

Pulmonary fibrosis (PF) is a serious interstitial lung disease characterized by declining pulmonary function but with few effective drugs and limited therapies. New anti-fibrosis drugs and targets are required to combat PF. Celastrol, a triterpenoids component isolated from Tripterygium wilfordii, has many kinds of pharmacological and physiological activities, such as anti-fibrosis, however its potential mechanisms and direct targets remain unclear.

Radiomics analysis based on dynamic contrast-enhanced MRI for predicting early recurrence after hepatectomy in hepatocellular carcinoma patients.

This study aimed to develop a machine learning model based on Magnetic Resonance Imaging (MRI) radiomics for predicting early recurrence after curative surgery in patients with hepatocellular carcinoma (HCC).A retrospective analysis was conducted on 200 patients with HCC who underwent curative hepatectomy. Patients were randomly allocated to training (n = 140) and validation (n = 60) cohorts.

Dielectric Properties and Defect Chemistry of Tb/Ho-Co-Doped BaTiO Ceramics.

Co-doping at Ba and Ti sites with double rare-earth elements has proven an effective strategy for enhancing the dielectric properties of BaTiO ceramics. Among intermediate-sized rare-earth ions, Tb and Ho exhibit amphoteric behavior, occupying both Ba and Ti sites. Investigating the site occupation, defect chemistry, and dielectric effects of Tb and Ho in BaTiO is therefore valuable.

A Multifunctional Photothermal Catalyst Enabling Full-Day Sustainable Power and Indoor Air Quality Control.

Solar photothermal catalytic (PTC) purification holds great potential for indoor air pollution control, but efficiently collecting energy at the catalytic interface to maximize solar energy utilization and meet building requirements remains a global challenge. This study develops a novel infrared-light-driven photothermal catalyst, MnCoCeO, which efficiently utilizes solar and ambient energy, offering three functions: catalysis, heating, and cooling. Furthermore, this study proposes an innovative hybrid system that integrates PTC film, thermoelectric generator (TEG), and metal-organic frameworks (MOFs).

Prognostic Value of Des-Gamma-Carboxy Prothrombin in AFP-Negative Hepatocellular Carcinoma Patients Following Liver Resection: .

Hepatocellular carcinoma (HCC) is a major global health concern with high postoperative recurrence rates. Des-gamma-carboxy prothrombin (DCP) is a promising biomarker for HCC prognosis, but its optimal cutoff value remains unclear, especially in AFP-negative patients. This study aimed to determine the ideal cutoff value of DCP in AFP-negative HCC patients following liver resection and to investigate its impact on long-term outcomes.

Exosome miRNA Profiles: The Reduced Expression of miRNA-27a-5p and Predictive miRNAs for Gestational Diabetes Mellitus.

Gestational diabetes mellitus (GDM) poses both short-term and long-term health risks to mothers and infants. This study aims to examine the mechanisms involving insulin resistance mediated by exosomal miRNAs. We enrolled 2284 pregnant women from First People's Hospital of Kunshan, Jiangsu Province in this continuous follow-up study.

A Dual-Mode Textile for Year-Round Passive Thermal Regulation Combining Radiative Cooling and Solar Heating.

Maintaining a stable body temperature proves to be critical for human survival and functional capacity. However, conventional textiles exhibit significant limitations in preserving thermoregulatory microenvironments during dynamic climatic variations. Herein, we present a dual-mode textile (DMT) that combines radiative cooling and solar thermal harvesting technology to achieve year-round passive thermal regulation.

Primary intracranial immature teratoma in an adult woman: case report and literature review.

Background: Primary immature teratoma of the parietal lobe is an exceptionally rare intracranial germ cell tumor, accounting for < 1% of all primary intracranial malignancies. Due to its rarity and overlapping radiological features with other tumors, such as glioma, immature teratomas are often misdiagnosed. Here, we report the case of a 48-year-old woman with a parietal lobe immature teratoma, initially misdiagnosed as a "glioma," highlighting the diagnostic challenges and management strategies.

Disruption of cTnT-Mediated Sarcomere-Mitochondrial Communication Results in Dilated Cardiomyopathy.

Background: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation between sarcomeres and mitochondria. Mitochondrial stress dysregulation is linked to DCM progression, yet mechanisms remain unclear.

Alterations of white matter functional networks in pediatric drug-resistant temporal lobe epilepsy: A graph theory analysis study.

Neurological disorder can cause functional network changes in white matter (WM). However, changes in the WM functional network in children with drug-resistant temporal lobe epilepsy (DRTLE) require further clarification. Therefore, we combine graph theory with resting-state functional magnetic resonance imaging (rs-fMRI) and T-weighted imaging (TWI) to investigate the topological features of the WM network in children with DRTLE, discover potential biomarkers, and understand the underlying neurological mechanisms.

Enantioselective Metabolism of Chiral Fungicide Prothioconazole by sp. Y-3 and Its Bioaugmentation.

Prothioconazole (PTC) is a kind of chiral triazole fungicide widely used in agricultural production, which can easily cause residual contamination and chiral selective toxicity. Microorganisms are the main participants involved in pollutant degradation in the environment. However, studies on the microbial enantioselective degradation of PTC and bioaugmentation of PTC-contaminated soil are still scarce.

Signature of Topological Surface Bands in Altermagnetic Weyl Semimetal CrSb.

As a special type of collinear antiferromagnetism (AFM), altermagnetism has garnered significant research interest recently. Altermagnets exhibit broken parity-time symmetry and zero net magnetization, leading to substantial band splitting in the momentum space. Meanwhile, parity-time symmetry breaking is a prerequisite for nontrivial band topology in Weyl physics.

High-Temperature Compressive Properties of 3D Printed Polymeric Lattice-Reinforced Cement-Based Materials.

Currently, research has confirmed the significant potential of 3D printed polymer lattices in enhancing the mechanical properties of cement-based composites. Polymer materials are influenced by high-temperature environments. This study aims to further explore the impact of 3D printed lattice structures on the compressive mechanical properties of cement-based materials under high-temperature conditions.

Probing Electronic Band Structure of Monolayer MoS in Gate-Controlled Resonant Tunneling Diodes.

Experimental determination of band structures of monolayer transition metal dichalcogenides (TMDCs) is crucially important in the design and tailoring of the properties of TMDCs. Resonant tunneling spectroscopy (RTS) is an effective technique to probe the band structures of low-dimensional systems by measuring the density of states (DOS) and energy dispersions. Here, we report the investigation of the band structure of monolayer MoS (ML-MoS) in a gate-controlled resonant tunneling diode.