Effect of Thermal Cycles on the Compressive Properties of 3D-Printed Polymeric Lattice-Reinforced Cement-Based Materials.

Existing studies have shown that placing 3D-printed lattices in cement matrices can effectively improve the ductility of cement-based composites. However, the influence of thermal fatigue effect on the mechanical properties of 3D-printed lattice-reinforced cement-based composites during service remains to be studied. In this paper, cement-based materials without lattices were used as the control group, and the uniaxial compressive mechanical properties of 3D-printed lattice-reinforced cement-based composites after thermal fatigue treatment under a temperature difference of 60 °C were tested.

Li Qi Huo Xue Di Wan alleviates hypoxia-induced injury in human cardiac microvascular endothelial cells by inhibiting apoptosis and necroptosis pathways.

Objectives: Injury to human cardiac microvascular endothelial cells (HCMECs) compromises myocardial microcirculation and may contribute to major cardiovascular events such as coronary heart disease, posing a serious health threat. Understanding the mechanisms of hypoxia-induced HCMEC damage is thus of great clinical relevance. This study aims to investigate the protective effects and underlying mechanisms of Li Qi Huo Xue Di Wan against hypoxia-induced HCMEC injury.

A Multidirectional Piezoelectric-Electromagnetic Vibration Energy Harvester for Sustainable Power Generation in Dynamic Environments.

With the growing demand for self-powered sensing in wireless sensor networks and IoT applications, vibration energy harvesting has become a key solution for sustainable power generation. This study proposes a multidirectional piezoelectric-electromagnetic vibration energy harvester capable of capturing energy from multiple directions (MD-PEVEH). The MD-PEVEH adopts a pendulum structure to improve the multidirectional adaptability of the harvester and also integrates an electromagnetic module and a piezoelectric module.

Long-Term Outcomes of Endovascular Treatment versus Best Medical Treatment in Patients with Large-Vessel Occlusion Stroke: A Meta-Analysis.

Introduction: For patients with acute ischaemic stroke caused by large vessel occlusion (LVO), there is limited evidence regarding the long-term outcomes of endovascular treatment (EVT) compared with best medical treatment (BMT). The objective of this study was to evaluate the long-term efficacy and safety of EVT in LVO stroke patients.

Methods: This study systematically searched electronic databases from January 2015 to August 2024 and included seven eligible trials.

Telaprevir attenuates caspase-11-dependent pyroptosis in mouse heart following ischemia/reperfusion via inhibition of MALT1/TRAF6 pathway.

Pyroptosis is one of the major forms of cardiomyocyte death following ischemia/reperfusion (I/R). Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)/Tumor necrosis factor receptor associated factor 6 (TRAF6) pathway is involved in cardiomyocyte pyroptosis in mouse heart following I/R, and telaprevir, a hepatitis C virus protease inhibitor, has been predicted as a potential inhibitor of MALT1. This study aims to explore the effect of telaprevir on I/R-induced cardiomyocyte pyroptosis.

Surgical evacuation without versus with middle meningeal artery embolization in chronic subdural hematoma: A meta-analysis of randomized controlled trials.

Objective: This meta-analysis evaluates the efficacy and safety of middle meningeal artery embolization (MMAE) combined with surgery versus surgery alone in chronic subdural hematoma (CSDH).

Methods: We systematically searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) comparing MMAE combined with surgery to surgery alone. And outcomes were pooled using a random-effects model.

Neuroendoscopy-Assisted Modified Anterior Approach for Contralateral Cervical 7 Nerve Transfer: A Cadaveric Study.

Background: This study aims to investigate a safer and more minimally invasive method for transferring the contralateral C7 nerve in the treatment of central spastic paralysis of the upper limb, while also providing anatomic data to support this approach.

Methods: Eight anatomic specimens from the head and neck were utilized: 4 dry specimens were used to measure anatomic data, whereas the other 4 fresh specimens were used to simulate the transposition of the contralateral C7 nerve for observing bilateral nerve anastomosis. Relevant anatomic landmarks and their surrounding relationships were examined using a neuroendoscope, and anatomic data were subsequently measured and analyzed.

Structural and Energetic Insights into SARS-CoV-2 Evolution: Analysis of hACE2-RBD Binding in Wild-Type, Delta, and Omicron Subvariants.

The evolution of SARS-CoV-2, particularly the emergence of Omicron variants, has raised questions regarding changes in its binding affinity to the human angiotensin-converting enzyme 2 receptor (hACE2). Understanding the impact of mutations on the interaction between the receptor-binding domain (RBD) of the spike protein and hACE2 is critical for evaluating viral transmissibility, immune evasion, and the efficacy of therapeutic strategies. Here, we used molecular dynamics (MD) simulations and binding energy calculations to investigate the structural and energetic differences between the hACE2- RBD complexes of wild-type (WT), Delta, and Omicron subvariants.

Protein Ubiquitination Modification in Pulmonary Fibrosis.

Pulmonary fibrosis (PF) is a chronic, progressive fibrotic interstitial lung disease characterized by a high incidence and mortality rate, which encompasses features, such as diffuse alveolar inflammation, invasive fibroblast activation, and uncontrolled extracellular matrix (ECM) deposition. Beyond the local pathological processes, PF can be better understood in light of interorgan communication networks that are involved in its progression. Notably, pulmonary inflammation can affect cardiovascular, renal, hepatic, and neural functions, highlighting the importance of understanding these systemic interactions.

High-Temperature Compressive Properties of 3D Printed Polymeric Lattice-Reinforced Cement-Based Materials.

Currently, research has confirmed the significant potential of 3D printed polymer lattices in enhancing the mechanical properties of cement-based composites. Polymer materials are influenced by high-temperature environments. This study aims to further explore the impact of 3D printed lattice structures on the compressive mechanical properties of cement-based materials under high-temperature conditions.

Altered functional connectivity of brainstem ARAS nuclei unveils the mechanisms of disorders of consciousness in sTBI: an exploratory study.

Objective: To investigate the functional connectivity (FC) characteristics of Ascending Reticular Activating System (ARAS) in patients with disorders of consciousness (DOC) following severe traumatic brain injury (sTBI), while introducing the Linear support vector machine (LSVM) to predict the recovery of consciousness.

Methods: Resting-state MRI was used to measure FC changes between the brainstem ARAS nuclei and whole-brain voxels. We compared the differences in FC between sTBI patients and healthy controls, as well as between the wake and DOC groups.

Deletion of p75NTR rescues behavioral and cognitive dysfunction in SPS-induced PTSD mice through hippocampal PI3K/Akt/mTOR pathway.

Post-traumatic stress disorder (PTSD) is a persistent mental illness caused by severe traumatic events, and its pathogenesis is still unclear. Recent studies indicate that p75 neurotrophic factor receptor (p75NTR) plays a crucial role in neurological diseases, but the role of p75NTR in PTSD is currently unknown. To investigate the effects and mechanisms of p75NTR in PTSD, in this study, a functional p75NTR-deficient mouse was used to establish a PTSD model by single prolonged stress (SPS) paradigm, then the behavioral effects and underlying mechanisms were further investigated.

A High-Throughput Screening Strategy for Producing Menaquinone-7 Based on Fluorescence-Activated Cell Sorting.

Menaquinone-7 (MK-7) is recognized for its important biological activity, and is the preferred strain for its fermentative production. However, the limited phenotypic diversity among high-yielding strains complicates the development of rapid screening methods. To address this, we utilized the effect of MK-7 on transmembrane potential to develop a high-throughput screening (HTS) strategy for efficiently identifying strains with improved MK-7 production.

Efficacy and safety of low-molecular-weight-heparin plus citrate in nephrotic syndrome during continuous kidney replacement therapy: retrospective study.

Background: Nephrotic syndrome (NS) is a condition often necessitating continuous kidney replacement therapy (CKRT) due to severe edema and other complications. Anticoagulation is critical in CKRT to prevent filter clotting, with regional citrate anticoagulation (RCA) being the first-line method. However, the hypercoagulable state of NS may require alternative strategies.

Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.

Post-traumatic stress disorder (PTSD) is a long-term delayed mental disorder caused by sudden, threatening or catastrophic life events. Chlorogenic acid (CGA) is a polyphenolic acid rich in Eucommia ulmoides and other plants with potential neuroprotective effects, effectively enhances learning and memory, and exerts a beneficial impact on improving mood and attention. However, the effects and mechanisms of CGA on PTSD-like behaviors remain uncertain.

Impact Damage Localization in Composite Structures Using Data-Driven Machine Learning Methods.

Due to the uncertainty of material properties of plate-like structures, many traditional methods are unable to locate the impact source on their surface in real time. It is important to study the impact source-localization problem for plate structures. In this paper, a data-driven machine learning method is proposed to detect impact sources in plate-like structures and its effectiveness is tested on three plate-like structures with different material properties.

Synaptic-mitochondrial transport: mechanisms in neural adaptation and degeneration.

Synaptic plasticity is the basis for the proper functioning of the central nervous system. Synapses are the contact points between neurons and are crucial for information transmission, the structure and function of synapses change adaptively based on the different activities of neurons, thus affecting processes such as learning, memory, and neural development and repair. Synaptic activity requires a large amount of energy provided by mitochondria.

Electrocatalytic Mapping of Metal Fatigue with Persistent Slip Bands.

Metal fatigue, characterized by the accumulation of dislocation defects, is a prevalent failure mode in structural materials. Nondestructive early-stage detection of metal fatigue is extremely important to prevent disastrous events and protect human life. However, the lack of a precise quantitative method to visualize fatigue with spatiotemporal resolution poses a significant obstacle to timely detection.

The Chinese Herbal Medicine Li Qi Huo Xue Di Wan Ameliorates Ischemia or Hypoxia-Induced Cardiac Injury and Remodeling in the Heart Through a Mechanism Involving Reduction of Necroptosis.

Li Qi Huo Xue Di Wan (LQHXDW), a Chinese herbal medicine, is commonly used to treat symptoms such as palpitations, chest tightness, chest pain, and shortness of breath. However, its potential to reduce ischemia or hypoxia-induced cardiac injury and remodeling, along with the precise mechanisms involved, remains unclear. This study aims to investigate the effects of LQHXDW on cardiac injury and remodeling induced by ischemia or hypoxia, both in vivo and in vitro, and to elucidate the underlying mechanisms.

Comparative study of fenpropathrin and its main metabolite in soil-earthworm microcosms: Toxicity, degradation, transcriptome, and oxidative stress.

This study comprehensively investigated the comparative acute toxicities, degradation, transcriptome, and oxidative stress induction of fenpropathrin (FEN) and its main metabolite 3-phenoxybenzoic acid (3-PBA)in soil-earthworm microcosms. FEN degradation half-life ranged from 19.09 to 28.

p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway.

Aims: Major depressive disorder (MDD) is an enduring and severe mood disorder. Previous studies have indicated that p75NTR is involved in neuronal survival and death. However, the specific mechanism of p75NTR in depression remains unknown.

Investigating the NH Preintercalation and Surface Coordination Effects on MnO for Ammonium-Ion Supercapacitors.

Ion preintercalation is an effective method for fine-tuning the electrochemical characteristics of electrode materials, thereby enhancing the performance of aqueous ammonium-ion hybrid supercapacitors (A-HSCs). However, much of the current research on ion preintercalation lacks controllability, and the underlying mechanisms remain unclear. In this study, we employ a two-step electrochemical activation approach, involving galvanostatic charge-discharge and cyclic voltammetry, to modulate the preintercalation of NH in MnO.

Contrast-enhanced ultrasound findings of primary hepatic non-Hodgkin's lymphoma: a case report.

Primary hepatic lymphoma (PHL) is rare, and its early diagnosis is difficult. This article presents a primary hepatic non-Hodgkin's lymphoma (NHL) case report. A 52-year-old woman was admitted to the hospital due to a fever.

Swertiamarin relieves radiation-induced intestinal injury by limiting DNA damage.

Radiotherapy is the conventional treatment for pelvic abdominal tumors. However, it can cause some damage to the small intestine and colorectal, which are very sensitive to radiation. Radiation-induced intestinal injury (RIII) affects the prognosis of radiotherapy, causing sequelae of loss of function and long-term damage to patients' quality of life.