Mechanical Behavior of Topology-Optimized Lattice Structures Fabricated by Additive Manufacturing.

Lattice-based metamaterials have attracted much attention due to their excellent mechanical properties. Nevertheless, designing lattice materials with desired properties is still challenging, as their mesoscopic topology is extremely complex. Herein, the bidirectional evolutionary structural optimization (BESO) method is adopted to design lattice structures with maximum bulk modulus and elastic isotropy.

Development of a bispecific antibody-drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors.

Epithelial cell adhesion molecule (EpCAM), a tumor antigen for antibody-drug conjugates (ADCs), is highly expressed in many epithelial cancers. However, the clinical progress of EpCAM ADCs has been challenging, primarily due to their toxicity in normal high-expression tissues such as the gastrointestinal tract. CLDN3 is highly co-expressed with EpCAM in various human malignancies, coupled with its minimal presence in normal tissues, rendering it an ideal target for developing potent therapeutic ADCs.