Homoeologous recombination-based transfer and cytological mapping of the novel powdery mildew resistance gene Pm7C from Aegilops caudata.

A novel powdery mildew resistance gene Pm7C from Aegilops caudata was introgressed into common wheat through ph1b-induced homoeologous recombination and mapped to the 7CL bin FL 0.90-0.96 on chromosome 7C.

A novel comprehensive model of indicators reflecting the relative spatial position of the anterior cervical structures for predicting difficult laryngoscopy in patients with cervical spondylosis.

Background: Accurate assessment of difficult airway (DA) is critical, as failure to identify DA may lead to life-threatening complications. This study aimed to develop a multiparameter predictive model for DA using a novel ultrasound reference line (XU-line).

Methods: In this prospective, observational, single-blinded study, patients scheduled for elective cervical spondylosis surgery at Peking University Third Hospital underwent preoperative airway evaluation via physical indices and ultrasonography.

Deep-ultraviolet plasmon resonances on hybrid Si nanostructures for photoluminescence enhancement.

Deep ultraviolet (DUV) nanophotonic technologies are of vital importance for applications in biomedical sensing, advanced lithography, light sources, and optoelectronic devices. Plasmonic nanostructures with DUV resonance properties can generate highly confined optical fields. They therefore have great potential in amplifying spectral signals from molecules with intense vibronic transitions in the DUV region and improving the sensitivity of solar-blind detection.

Reconstruction of Electric Double Layer via Cationic Electrostatic Shielding and Anionic Preferential Adsorption Toward the Sustainable Zinc Metal Batteries.

Zinc metal is considered one of the most promising anodes for zinc-based batteries in energy storage systems. Nonetheless, zinc anodes are associated with some irreversible issues, Zn, which significantly restrict the endurance of aqueous zinc-ion batteries (AZIBs). This study adds a multifunctional electrolyte additive Ce(NO) to a 3 m ZnSO₄ electrolyte to addressed these challenges.

Prenatal Exposure to PM2.5 Components and Preterm Birth: A Case-Crossover Study in Shijiazhuang, China.

Objective: The aim of the study was to study maternal exposure to PM2.5 components and preterm birth.

Methods: Counts of hospitalizations due to preterm birth at the Fourth Hospital of Shijiazhuang City were collected from 2014 to 2019.

Microwave-driven lipid remodeling coordinates flavor genesis in : a multi-omics interrogation.

Flavoromics and metabolomics were used to analyze flavor and metabolic changes of during microwave vacuum drying. 21 alcohols, 28 aldehydes and other volatile compounds were identified. Volatile compound diversity and concentration, mainly of alcohols and aldehydes, declined as drying advanced.

Sirtuin 3, a pivotal actor in liver diseases: research progress and implications.

The liver is very important in preserving physiological homeostasis via its immune response, detoxification, and metabolism functions. A multitude of factors, such as alcohol, can detrimentally impact liver function, resulting in acute or chronic liver injury, which may subsequently progress to liver cancer. Liver diseases comprise a broad range of disorders primarily characterized by damage to hepatocytes, inflammatory cell infiltration, and hepatic stellate cells activation.

Prediction system for gallbladder cancer distant metastasis a retrospective cohort study based on machine learning.

Background: The prognosis for gallbladder cancer (GBC) patients is generally poor due to the early occurrence of distant metastasis (DM). However, research on predicting the risk of DM in GBC patients is still limited. Therefore, this study aimed to apply the Surveillance, Epidemiology, and End Results (SEER) database with machine learning (ML) methods to construct a novel model for predicting the risk of DM in GBC patients.

The construction and analysis of a prognostic model based on CD8 T cell immune-related genes in hepatocellular carcinoma.

The effector functions of CD8 T cell significantly influence the immunosuppressive microenvironment in hepatocellular carcinoma (HCC), which is intricately associated with HCC prognosis. Nevertheless, a comprehensive investigation into the relationship between CD8 T cell immune-related genes and HCC prognosis remains lacking. This study aimed to construct a prognostic model for HCC using CD8 T cell immune-related genes to provide insights for clinical management and prognosis.

Single-Port Robotic Resection of Recurrent Hepatocellular Carcinoma in the Right Anterior Lobe: A Case Report.

Background: We report the first case of single-port robotic liver tumour resection in a patient with recurrent hepatocellular carcinoma in the right anterior lobe of the liver.

Methods: A 65-year-old male with recurrent hepatocellular carcinoma in the right anterior lobe underwent robotic liver tumour resection using the EDGE SP1000, a single-port laparoscopic surgical robot. The procedure involved resection of a 2.

β-arrestin2 depletion attenuates autoimmune hepatitis in mice via preventing intestinal barrier disruption and inhibiting ERS mediated intestinal epithelial cells apoptosis.

Autoimmune hepatitis (AIH) is a progressive immune-mediated inflammatory liver disease. Recent studies have highlighted the association between intestinal barrier dysfunction and chronic liver diseases, but the specific role of intestinal barrier dysfunction in AIH remains unclear and needs to be elucidated. β-arrestin2, a multifunctional scaffolding protein, has been reported to be involved in various hepatic disorders, such as acute liver injury and liver fibrosis.

Harness the wild: progress and perspectives in wheat genetic improvement.

Common wheat (Triticum aestivum L.) is a staple hexaploid crop with numerous wild relatives. However, domestication and modern breeding have significantly narrowed its genetic diversity, diminishing its capacity to adapt to climate change.

Simplex-structured matrix factorisation: application of soft clustering to metabolomic data.

Metabolomics is the measurement of metabolites in biological samples to reveal information on metabolic pathways and phenotypes. Cluster analysis is a popular multivariate technique employed in metabolomics to characterise observations with similar features. Previous work in the field has applied hard clustering approaches to group observations into distinct clusters.

Integrating network pharmacology and experimental validation to investigate the mechanism of Gualou Xiebai Banxia decoction against myocardial ischemia.

Background: Gualou Xiebai Banxia Decoction (GXBD), a traditional Chinese medicine, is used to treat myocardial ischemia (MI). However, the molecular mechanisms underlying its effects remain unclear. This study integrated network pharmacology and experimental validation to investigate the efficacy and potential mechanisms of GXBD in MI treatment.

Cholesterol metabolism-related genes predict immune infiltration and prognosis in gastric cancer patients.

Gastric cancer (GC) is one of the most prevalent malignant diseases worldwide. Abnormal metabolic reprogramming, particularly cholesterol metabolism, influences tumor development and treatment outcomes. This study investigates the predictive and functional significance of cholesterol metabolism-related genes in gastric cancer patients.

A promising endeavor against human cytomegalovirus: Predominant epitopes-based recombinant subunit vaccine RH.

Human cytomegalovirus (HCMV) is widespread in the population, typically remaining latent. However, it can cause severe morbidity and mortality in transplant patients and immunodeficient individuals. Currently, there is no approved vaccine against HCMV.

Scale-Wise Semantic Alignment Enhanced Multigrained Adaptive Fusion for Virtual Try-On.

Image-based virtual try-on aims to fit garments onto a target person accurately and naturally while preserving the textural details of the garment. Inspired by the dynamic perception process of the human visual system, which transitions from global perception to local details, we propose a novel multigrained adaptive fusion network for virtual try-on framework named MA-VITON. MA-VITON precisely aligns clothing semantic features with human body parts across different scales, reduces unrealistic textures caused by garment distortion, and employs coarse-to-fine clothing features to progressively guide the generation of try-on results.

Electrochemically Promoted Activation of Light Alkanes at Ambient Conditions.

The electrochemical activation of light alkanes into value-added products represents a promising pathway for sustainable chemical synthesis and the storage of renewable energy. In this study, we introduce an electrochemically promoted system that employs copper plates as electrode and oxygen as oxidant, capable of converting ethane into ethylene and acetic acid with production rates of 6.9 and 6.

Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases.

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are emerging with therapeutic agents for the treatment of two of the most prevalent metabolic disorders: diabetes and obesity. However, the causal relationship between GLP-1R agonists and autoimmune diseases is still unclear.

Methods: The available cis-eQTLs for drug target genes (GLP-1Rs) were used as proxies for exposure to GLP-1R agonists.

Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway.

Methods: This study used a combination of and experiments to investigate the role of amylin in the progression of GC. The expression of amylin in GC and its clinical correlation were evaluated using 38 pairs of GC and healthy human clinical samples. studies, human GC cell lines were treated with amylin to evaluate the effects of amylin on the proliferation, apoptosis and migration of GC cells.

Laparoscopic Left Approach Resection of the Caudate Lobe.

Laparoscopic caudate lobectomy (LCL) is one of the most challenging types of laparoscopic liver resections. The main difficulty lies in the deep anatomical position of the caudate lobe, which is closely adjacent to the first and second hepatic ports and the inferior vena cava, increasing the risk of major bleeding during surgery. In addition to a thorough understanding of the anatomy of the caudate lobe tumor, comprehensive imaging assessment, and three-dimensional reconstruction, the flexible choice of surgical approach is also key to reducing surgical difficulty and improving safety.

FovealNet: Advancing AI-Driven Gaze Tracking Solutions for Efficient Foveated Rendering in Virtual Reality.

Leveraging real-time eye tracking, foveated rendering optimizes hardware efficiency and enhances visual quality virtual reality (VR). This approach leverages eye-tracking techniques to determine where the user is looking, allowing the system to render high-resolution graphics only in the foveal region-the small area of the retina where visual acuity is highest, while the peripheral view is rendered at lower resolution. However, modern deep learning-based gaze-tracking solutions often exhibit a long-tail distribution of tracking errors, which can degrade user experience and reduce the benefits of foveated rendering by causing misalignment and decreased visual quality.

Effects of Different Drying Methods on Volatile Flavor Compounds in Idesia Polycarpa Maxim Fruit and Oil.

This study combined gas chromatography-ion mobility spectrometry (GC-IMS) and multivariate statistical analysis to explore the differences in the characteristic aroma of Maxim () fruit and oil under different drying methods: natural drying (ND), hot air drying (HAD), microwave drying (MD), and microwave vacuum drying (MVD). The results revealed that 91 volatile compounds were identified in the fruit, and 82 were found in the oil of . HAD and MD resulted in the most significant loss of volatile aroma in both the fruit and oil.

Construction of a physical map for Aegilops geniculata chromosome 7M and localization of its novel purple coleoptile gene.

A physical map of Aegilops geniculata chromosome 7M was constructed, and a novel purple coleoptile gene was localized at 7MS bin FL 0.60-0.65 by development of wheat-Ae.

Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer.

ATP citrate lyase (ACLY) and acyl-CoA short-chain synthetases 2 (ACSS2) are key enzymes in lipid metabolism. We explored the role of ACLY in gastric cancer (GC) and the effect of ACLY and ACSS2 compensation on GC growth. We used immunohistochemistry to verify the expression level of ACLY in GC, shRNA to stably knock down the expression level of ACLY in GC cells.