Chronically Stable, High-Resolution Micro-Electrocorticographic Brain-Computer Interfaces for Real-Time Motor Decoding.

Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG electrode array, capable of chronically stable and real-time motor decoding. Leveraging micro-nano manufacturing technology, the µECoG BCI achieves a 64-fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability.

Role of thrombus-derived exosomal lncRNA LOC101928697 in regulating endothelial function via FUS protein interaction in myocardial infarction.

ObjectiveType 1 myocardial infarction (T1MI) is primarily caused by the formation of coronary thrombi, which leads to acute myocardial ischemia and hypoxia and is associated with high morbidity and mortality rates. However, the effects of thrombus-derived exosomes (TEs) on endothelial cell function remain unclear. The aim of this study was to investigate the interaction between lncRNA LOC101928697, which is enriched in TEs, and FUS proteins, as well as their impact on endothelial cell function.

Prophylactic VA-ECMO During Complex High-Risk PCI: A Randomized Controlled Trial.

Background: Evidence on prophylactic venoarterial extracorporeal membrane oxygenation (VA-ECMO) during elective percutaneous coronary intervention (PCI) in patients with complex high-risk coronary artery lesions is limited.

Objectives: The authors aimed to assess the safety and effectiveness of prophylactic VA-ECMO during PCI.

Methods: This single-center, randomized trial enrolled 70 patients with complex high-risk coronary lesions (Synergy Between PCI with Taxus and Cardiac Surgery [SYNTAX] score ≥33) who declined coronary artery bypass grafting.

Da Vinci Xi robot -assisted subxiphoid resection of thymoma and reconstruction of the left brachiocephalic vein: A case report.

Background: Thymomas are the most common anterior mediastinal malignancies, typically requiring surgical resection. While median sternotomy has been the traditional approach, robotic-assisted thymectomy using the Da Vinci Xi system is reshaping minimally invasive surgery. Its 12× magnification, 3D visualization, and articulating instruments with tremor suppression allow precise dissection in anatomically constrained areas, particularly in tumors with vascular invasion, compared with the more aggressive classical approach.

A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity.

Certain messenger RNA antigens in mRNA vaccines elicit an insufficient immune response due to challenges in cell surface translocation (CST) of the antigens. Here we develop a modular vaccine platform (MVP) to enhance the immunogenicity of challenging mRNA antigens by optimizing antigen expression and presentation. MVPs enable the modular assembly of chimeric antigens.

Decomposing decision mechanisms in female substance use disorder: drift diffusion modeling of context-dependent biases in gain and loss processing.

Background: Decision-making impairments are central to substance use disorder (SUD), particularly in evaluating immediate versus delayed outcomes. However, conventional behavioral analyses provide limited insight into underlying cognitive mechanisms. This study applies the Drift Diffusion Model (DDM) to investigate intertemporal decision-making in female SUD across both gain and loss contexts, addressing a significant gap in understanding context-dependent decision processes.

Small Molecule-Degrader Conjugates: Evaluating the Structure-Activity Relationship of Linkers to Overcome In Vivo Barriers in PROTAC Delivery.

Precise control of proteolysis on target cells is important for proteolysis-targeting chimeras (PROTAC) to minimize off-tissue toxicities. Small-molecule ligand-guided PROTACs, namely, small molecule-degrader conjugates (SMDCs), offer many advantages, but some flaws in the previous designs, especially linker chemistry, cause a considerable defect in pharmacokinetics, which impedes in vivo applications. Here, we investigated the relationship of linker structures with in vivo factors, including serum stability, blood retention, controlled PROTAC release, targetability, and potency.

Differential pathways from personality to risk-taking: how extraversion and negative emotionality shape decision-making through overconfidence.

Introduction: Understanding mechanisms through which personality traits influence risk decision-making remains crucial in behavioral research. This study examined overconfidence as a mediator in personality-risk relationships, focusing on Extraversion and Negative Emotionality.

Methods: We recruited 110 university students to complete the Game of Dice Task, Big Five Inventory-2, and General Knowledge Questionnaire.

Social participation and insomnia in Chinese older adults with multimorbidity: mediating roles of frailty, anxiety, and depression.

Background: The harm of insomnia to the body and mind of the older adults with multimorbidity cannot be ignored. Increased social participation may improve insomnia, and that frailty, anxiety and depression may also have an impact on insomnia in older adults with multimorbidity. However, the mechanisms between social participation and insomnia in older adults remain understudied.

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins.

Background: This study aimed to employ Mendelian randomization (MR) analysis to investigate the causal relationship between sodium-glucose cotransporter 2 (SGLT2) inhibition and atrial fibrillation (AF), as well as assess the potential mediating role of inflammatory proteins in this association.

Methods: A two-sample MR analysis was conducted using summary-level data from the genome-wide association study (GWAS) were used to evaluate the genetic prediction of SGLT2 inhibition and AF. Additionally, a two-step MR approach was applied to explore the causal mediation effects of inflammatory proteins in the SGLT2-AF pathway.

Correction: Berberine ameliorates subarachnoid hemorrhage injury via induction of Sirtuin 1 and inhibiting HMGB1/Nf-κB pathway.

[This corrects the article DOI: 10.3389/fphar.2020.

Ptbp1 Knockdown in Glial Cells Promotes Motor and Sensory Function Recovery After Peripheral Nerve Injury.

Background: Peripheral nerve injury (PNI) frequently causes persistent sensory and motor deficits with limited therapeutic options. While Ptbp1-mediated astrocyte reprogramming shows promise in central nervous system repair, its role in PNI-particularly regarding spinal cord astrocytes and dorsal root ganglia (DRG) satellite glial cells (SGCs)-remains unexplored.

Aims: This study aimed to determine whether Ptbp1 knockdown in glial cells enhances functional recovery after sciatic nerve injury (SNI) by dual mechanisms: (1) converting spinal cord astrocytes to motor neurons and polarizing them toward neuroprotective A2 phenotype, and (2) activating regenerative signaling pathways in DRG SGCs.

A Molecular Recruitment Colocalization Platform for Visualizing Multi-Protein Interactions and Engineering Biomolecular Condensates in Living Cells.

Visualizing dynamic protein-protein interactions (PPIs) and phase-separated biomolecular condensates in live cells is crucial for understanding cellular processes. Here, a method is introduced for analyzing both PPIs and condensates, termed molecular recruitment colocalization (MRC), which localizes interacting partners and generates fluorescent signals at designated genomic loci. MRC enables the simultaneous visualization of multi-protein interactions and the preliminary estimation of binding affinities during PPIs.

TRAF6 regulates ubiquitination-independent TDP-43 condensation and related neurodegeneration.

Cytoplasmic aggregates of TDP-43 are hallmarks of multiple neurodegenerative diseases. However, the underlying mechanisms driving TDP-43 pathological aggregation remain elusive. In this study, we revealed that TNF receptor-associated factor 6 (TRAF6) promotes TDP-43 condensation, and disrupting TRAF6-TDP-43 interactions effectively suppresses its aggregation.

Discovery of pinonic acid derivatives containing triazole Schiff base fragment as fungicidal candidates against Gaeumannomyces graminis var. tritici.

Background: Wheat Take-all disease seriously threatens global wheat production, while current fungicides are limited by high cost, toxicity, and emerging resistance. To reduce its threat to agricultural production and overcome the limitations of existing prevention and control methods, this study chose turpentine, a natural product with a unique structure and biological activity, to provide a promising alternative fungicide.

Results: A series of pinonic acid triazole Schiff base compounds with good antifungal activity from natural product turpentine were successfully synthesized and evaluated.

Microfluidic Fabrication of Hyaluronic Acid-Cysteine-Modified Chitosan Microspheres for CD44-Targeted Probiotic Delivery in Colitis Treatment.

Probiotics play a crucial role in regulating intestinal immune homeostasis and supporting gut health; however, oral administration faces challenges such as nonspecific distribution and low efficacy. To achieve precise and efficient delivery, in this study, a targeted delivery system embedded probiotics to the colonic inflammatory site CD44 was constructed by covalently linking yaluronic acid (HA) to ysteine-modified hitosan (CCH) using microfluidic technology. Two probiotic strains, FL-276.

Comprehensive New Insights into Sweet Taste Transmission Mechanisms and Detection Methods.

Sweet taste plays a pivotal role in human dietary behavior and metabolic regulation. With the increasing incidence of metabolic disorders linked to excessive sugar intake, the development and accurate evaluation of new sweeteners have become critical topics in food science and public health. However, the structural diversity of sweeteners and their complex interactions with sweet taste receptors present major challenges for standardized sweetness detection.

Association between the seroprevalence of infectious pathogens and depression in U.S. adults.

Background: There is a paucity of knowledge concerning the relationship between exposure to various pathogens and depression in adults residing in the United States. The objective of the study was to examine the prevalence and severity of depression in populations at risk of viral infections and to investigate the potential association between these two factors.

Methods: This study was derived from the National Health and Nutrition Examination Survey (NHANES), which included 39,749 participants aged 20 years or older between 2005 and 2018.

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis.

Alzheimer's disease (AD) is defined by β-amyloid plaques and tau-containing neurofibrillary tangles, but the ensuing cellular derangements that culminate in neurodegeneration remain elusive. Here, a mechanistic link between two AD pathophysiological hallmarks: energy insufficiency and oxidative stress is revealed. It is demonstrated that mitochondrial function and glutathione (GSH) flux are coupled, impacting neuronal ferroptosis susceptibility.

[Rapid screening of 125 pesticide residues in tea substitutes by multi-plug filtration cleanup method combined with gas chromatography-tandem mass spectrometry].

A rapid screening method for 125 pesticide residues of different polarities in tea substitutes matrix was developed using rapid screening combined with gas chromatography-tandem mass spectrometry （GC-MS/MS）. The targets were separated on DB-1701MS quartz capillary column （30 m×0.25 mm×0.

Calcified necrotizing funisitis and its association with adverse neonatal outcomes: a case-control study.

Background: Necrotizing funisitis (NF) is a rare but severe type of umbilical inflammation. Whether NF can affect the outcomes of newborns is still controversal. The aim of this article is to determine the association of calcified necrotizing funisitis with adverse neonatal outcomes.

NHEJ1 Splice Variants Associated With Bone Marrow Failure and Hematologic Malignancy.

Nonhomologous end-joining (NHEJ)1 deficiency causes a genome maintenance disorder (GMD), classically associated with severe combined immunodeficiency. Here, we describe two cases of NHEJ1 deficiency presenting with cytopenias. One patient was an adolescent with recurrent cytopenias and frank immunodeficiency that evolved into bone marrow failure with myelodysplasia, then chronic myelomonocytic leukemia and ultimately treatment-refractory acute myeloid leukemia.

[Toric-ICL shows better predictability and efficacy than FS-LASIK for myopia correction in patients with moderate to high myopia and astigmatism].

Objectives: To compare the efficacy of toric implantable collamer lens (Toric-ICL) and femtosecond laser-assisted keratomileusis (FS-LASIK) for myopia correction in patients with moderate to high myopia complicated with astigmatism.

Methods: We retrospectively collected data from 64 patients (aged 18-42 years) with moderate to high myopia complicated with astigmatism (128 eyes) undergoing either Toric-ICL (28 patients/56 eyes) or FS-LASIK (36 patients/72 eyes) at our department between January, 2019 and December, 2020. The changes of uncorrected distance visual acuity (UCVA), spherical equivalent (SE), mean astigmatism correction index (CI), corneal endothelial cell density (ECD) and intraocular pressure (IOP) following the procedures were compared between the two groups.

A Comprehensive Bibliometric Analysis of Biomedical Research Waste: Current Situation, Development, and Trends.

Since the 20th century, the rapid increase in academic publications has turned research waste into a significant challenge in scientific research. However, there is currently no comprehensive bibliometric analysis available to evaluate the progress in this field. In this study, we retrieved all relevant articles published between January 1, 2004, and December 31, 2024, from the Web of Science (WoS) database, yielding a total of 876 articles.

Integrating Strategy of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Verification to Investigate the Potential Mechanism of Against Alcoholic Liver Injury.

As one of the medicinal and edible resources, (GE) is considered to hold potential in alleviating alcoholic liver injury, yet its mechanism needs further elucidation. To explore the molecular mechanisms of GE against alcoholic liver injury, network pharmacology, molecular docking, molecular dynamics simulations, and cell experiments were employed. Thirty-two active components of GE may exert efficacy against alcohol-induced liver injury via regulating 207 targets.