Correction: Analysis of prognostic factors and nomogram construction for postoperative survival of triple-negative breast cancer.

[This corrects the article DOI: 10.3389/fimmu.2025.

Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation.

Ischemic heart disease lacks optimal therapies targeting post-infarction inflammation and remodeling. The role of TCA cycle metabolites in modulating macrophage-driven cardiac inflammation remains unclear. This study hypothesized that AKG supplementation attenuates cardiac dysfunction by regulating macrophage activation via TCA cycle replenishment and FTO-dependent epigenetic mechanisms.

Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome.

Polycystic ovary syndrome is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression. However, the underlying mechanism remains unclear.

Prenatal diagnosis and molecular cytogenetic characterization of 12 cases of chromosome 8 inverted duplication deletion syndrome.

Background: Inverted duplication of the short arm of chromosome 8 (inv dup del (8p)) and the deletion of its adjacent terminal represent a rare chromosomal rearrangement. To date, only a limited number of prenatal cases have been documented from a molecular cytogenetic perspective. This study investigates the molecular genetic characteristics and intrauterine ultrasound phenotypes of fetuses prenatally diagnosed with inv dup del (8p).

Transcriptomic analysis of the effect of dietary melatonin on liver immunity in rice field eel (Monopterus albus).

The aim of this study was to investigate the effects of the dietary effects of melatonin, particularly in relation to its ability to regulate the immune system. A total of 360 fish were fed with different concentrations of melatonin (0, 30, 60, 120, and 240 mg/kg) for 70 days. The activities of antioxidant and immune-related enzymes in the liver showed that at a concentration of 120 mg/kg, the activities of superoxide dismutase, catalase, glutathione peroxidase, lysozyme, and alkaline phosphatase were significantly increased, while the content of malondialdehyde and the activities of alanine aminotransferase and aspartate aminotransferase were decreased (p < 0.

Impact of airflow stimulation: mild cold airflow is more sensitive to influenza virus infection.

Background: With the popularity of heating, ventilation, and air conditioning (HVAC) and the growth of time that humans spend indoors, people have begun to think more about what kind of indoor air-conditioned environments are beneficial and sustainable for health, especially for preventing respiratory infectious diseases. This study aims to explore the role of airflow in mechanically ventilated environments in modulating airway immune and defense mechanisms.

Methods: Based on the self-developed mouse-applicable climate chamber system and the corresponding mouse model, this study investigated the health effects of exposure to thermal environments [(I) 20 ℃, 0 m/s; (II) 20 ℃, 1.

Comprehensive New Insights into Sweet Taste Transmission Mechanisms and Detection Methods.

Sweet taste plays a pivotal role in human dietary behavior and metabolic regulation. With the increasing incidence of metabolic disorders linked to excessive sugar intake, the development and accurate evaluation of new sweeteners have become critical topics in food science and public health. However, the structural diversity of sweeteners and their complex interactions with sweet taste receptors present major challenges for standardized sweetness detection.

Effects of Different Farming Models on Muscle Quality, Intestinal Microbiota Diversity, and Liver Metabolism of Rice Field Eel ().

As consumer demand for quality fish products continues to rise, quality has become a key factor in market competition. Ecological aquaculture research is exploring various farming methods to balance high-quality demand with environmental protection. This study compared three aquaculture models-cage culture (CG), recirculating aquaculture (RAG), and rice-fish co-culture (RG)-by analyzing muscle quality (AOAC, GC-MS), intestinal microbiota (16S rRNA), and liver metabolism (LC-MS) to assess their effects on .

Comparative biochemical, transcriptome and metabolome investigation on reproductive maturation of wild and captive female Monopterus albus.

The main purpose of this study is to systematically elucidate mechanisms underlying ovarian development in wild and captive female Monopterus albus at the biochemical, transcriptomic, and metabolomic levels. Wild and captive female M. albus in Shanghai were continually collected over 1 year, and their ovarian development was analyzed statistically.

CRISPR-Mediated Viral Gene Knock-In for Studying Viral-Host Interactions.

CRISPR-mediated gene knock-in is a powerful tool for studying virus-host interactions. In this protocol, we describe the methodology for the knock-in of a red fluorescent protein, mCherry, fused to the viral protein VP26, a component of the herpesvirus capsid. By integrating the mCherry gene into the HSV-1 genome, we enable detailed studies of viral protein dynamics, viral replication, and virus-host interactions in living cells.

Improved management of hospital-acquired infections with DRG-based payment system: an interrupted time‑series analysis.

Background: While diagnosis-related group (DRG) payment system has been shown to improve healthcare quality and reduce costs in high-income countries, its effectiveness in developing countries, particularly in terms of hospital-acquired infection (HAI) management, remains unclear.

Methods: HAI surveillance data were collected from nine public hospitals in Zhejiang province, China, that implemented the DRG system in 2020. Changes in HAI incidence rates following DRG adoption were assessed using interrupted time-series analysis with a generalized additive model, covering the period from January 2016 to September 2023.

Tire wear particle leachate induces lipid metabolism disorders in Procambarus clarkii, leading to liver inflammation and mitochondrial dysfunction in hepatocytes.

Tire wear particle (TWP) leachate, an emerging pollutant that has gained widespread attention in recent years, poses a serious threat to aquatic ecosystems and particularly to economically important freshwater species. The toxicity of TWP leachate to aquatic organisms underscores its detrimental impact on these ecosystems. In this study, the crayfish Procambarus clarkii was exposed to TWPs at concentrations of 0 %, 0.

Impact of Rearing Duration on Nutritional Composition, Flavor Characteristics, and Physical Properties of Asian Swamp Eel ().

The Asian eel, a medicinal and edible species, lacks systematic research on age-related nutritional and flavor dynamics. To optimize breeding strategies and product differentiation, this study systematically investigated the nutritional composition, flavor profiles, and physical properties of Asian eel muscles across five distinct growth stages (1, 3, 7, 11, and 22 years). Results showed that unsaturated fatty acids increased with age, while ω-3/ω-6 ratios peaked in 1-year-old eels.

A review on recent advancement in algal-bacterial aerobic granular sludge: From inoculation approaches to operation strategies.

In recent years, the environmental unsustainability of traditional wastewater treatment processes, alongside the growing emphasis on carbon neutrality and self-sufficiency in wastewater treatment plants (WWTPs), has drawn attention to algal-bacterial aerobic granular sludge (AGS) systems. This review synthesizes recent advances in algal-bacterial AGS, focusing on the latest research on its granulation mechanisms under both hydrostatic and hydrodynamic conditions and providing a comprehensive overview of cultivation strategies based on various sludges. We discuss the latest reports on the impacts of process operation strategies for algal-bacterial AGS and emphasize the operation performance and design of different bioreactor configurations.

Cardiac magnetic resonance feature tracking evaluates left atrial strain in patients with systemic lupus erythematosus and mitral regurgitation.

PurposeTo explore left atrial (LA) function in patients with systemic lupus erythematosus (SLE) and mitral regurgitation assessed by cardiac magnetic resonance imaging feature tracking (MRI-FT).MethodIn this study, 64 SLE patients (35.0 ± 12.

Romantic Relationships with Virtual Agents and People's Marriage Intention in Real Life: An Exploration of the Mediation Mechanisms.

Virtual agents (VA) are animated characters with human-like appearances or behaviors, which are designed based on artificial intelligence-powered software programs to interact with people in various circumstances (e.g., nonplayer characters in video games, and virtual assistants like Siri).

Analysis of prognostic factors and nomogram construction for postoperative survival of triple-negative breast cancer.

Introduction: Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype associated with poor prognosis and limited treatment options. This study utilized the SEER database to investigate clinicopathologic characteristics and prognostic factors in TNBC patients.

Methods: Machine learning algorithms specifically Gradient Boosting Machines (XGBoost) and Random Forest classifiers were applied to develop survival prediction models and identify key prognostic markers.

Degradation of Organic Matter in Sauce-Flavored Liquor Wastewater by Catalytic Oxidation Performance of MnCuO/AlO Catalysts in Treatment and Mechanism Research.

With the rapid growth of the sauce-flavored liquor industry, the treatment of wastewater has become an increasingly critical challenge. This study seeks to assess the catalytic oxidation efficacy of MnCuO/AlO catalysts in the degradation of organic pollutants present in sauce-flavored liquor wastewater, while also elucidating the mechanisms underpinning their performance. MnCuO/AlO catalysts were synthesized, and their physicochemical properties were thoroughly characterized using advanced techniques such as Brunauer-Emmett-Teller (BET) analysis, N sorption isotherm analysis, scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS).

Long-term rice-eel co-culture system effectively alleviated the accumulation of antibiotic resistance genes in soil.

Alleviating the accumulation of antibiotic resistance genes (ARGs) in farmlands is crucial for restricting the transfer of ARGs to crops and controlling the soil-borne microbiological health risk. Rice and eel co-culture (REC) systems have recently been used as an emerging integrated farming model that can stabilize grain yields and improve fertilizer availability. However, the influence of long-term REC system concerning the aggregation and health risk of ARGs in rice fields is still unclear.

Impacts of hydraulic retention time on organic removal in treating liquor wastewater via algal-bacterial granular sludge.

This study optimized hydraulic retention time (HRT) to improve p-cresol and chemical oxygen demand (COD) removal and promote algal-bacterial granular sludge (ABGS) formation in Chinese fermented liquor wastewater treatment. At an HRT of 4 h, no granules formed in the sequential batch reactor, and after 30 days, the removal efficiencies were low for both COD (58.5 %) and p-cresol (21.

Impact of sleep chronotype on blood pressure and metabolic markers.

Objective: The aim of this study was to investigate the correlation between sleep chronotype and metabolic markers to further reveal the influence of sleep chronotype on human health.

Methods: The Morningness-Eveningness Questionnaire was administered to 442 volunteers aged 23-70 years old. The sleep chronotype was divided into morning type (167 cases), neither type (224 cases), and evening type (51 cases).

Synthesis of Non-Symmetric Biaryldiols via Organo-Electro Catalyzed Aryl-Aryl Dehydrogenative Cross-Coupling.

Despite a few successful examples, controlling the enantioselectivity in the asymmetric synthesis of non--symmetric biaryldiols has long been challenging. To address the issues of enantioselectivity and regioselectivity, we introduced a novel organoelectrocatalytic strategy enabling asymmetric aryl-aryl dehydrogenative cross-coupling reactions. Using this approach, valuable non--symmetric biaryldiols were obtained in up to 95% yields and 97% enantiomeric excesses (s), and these compounds could be further applied as versatile ligands in asymmetric reactions.

Research Trends in Isothermal Near-Net-Shape Forming Process of High-Performance Titanium Alloys.

Titanium alloys find extensive applications in aviation, maritime, and chemical engineering applications. Nonetheless, these alloys encounter significant challenges during the conventional forging process, which include high deformation resistance, limited processing temperature ranges, and inhomogeneous microstructure. Isothermal forging, as a near-net-shape forming technique, can alleviate the microstructural inhomogeneity caused by deformation dead zones in conventional forging, thus enabling the direct production of complex shapes.

Strengths Knowledge Defend Against Depression: The Contribution of University Students' Family Functioning During COVID-19.

Strengths knowledge refers to individuals' perceptions and recognition of their strengths, and is recognized for its protective role in mental health. Family functioning provides certain environmental conditions for the healthy development of family members in physical, psychological, and social aspects, particularly during stressful periods such as the COVID-19 pandemic. It also plays an important role in youth's ability to cope with stressful situations.

The GlnE protein of Azorhizobium caulinodans ORS571 plays a crucial role in the nodulation process of the legume host Sesbania rostrata.

The GlnE enzyme, functioning as an adenylyltransferase/adenylyl-removing enzyme, plays a crucial role in reversible adenylylation of glutamine synthetase (GS), which in turn regulates bacterial nitrogen assimilation. Genomic analysis of Azorhizobium caulinodans ORS571 revealed an open reading frame encoding a GlnE protein, whose function in the free-living and symbiotic states remains to be elucidated. A glnE deletion mutant retained high GS activity even under nitrogen-rich conditions.