C/N-Driven Synergies: Earthworms optimize CO/NO mitigation and soil quality in floral waste recycling.

The expansion of floriculture has increased the need for sustainable floral waste management to support agricultural carbon neutrality. This study assessed the impact of carnation, lily, and rose straw amendments (with varying C/N ratios, lignin, and cellulose) on GHG emissions and soil quality with earthworm (Eisenia fetida). Controlled microcosm experiments were conducted to examine the effects of straw types and earthworms on CO and NO fluxes, as well as soil properties, enzyme activities, and microbial functions.

A Novel Theoretical Hypothesis on Comorbidity in the Elderly-The Disease of Sympathetic Overdrive (DSO).

The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration. The disease of sympathetic overdrive (DSO) is a new hypothesis, a disease full of characteristics of organics and emotion, multiple systems, and lifestyle illness. The hypothesis of DSO might be able to explain and improve the theory about the coexistence of multimorbidity and geriatric syndromes and even more!.

4'-Hydroxychalcone Induces Ferroptosis in Glioblastoma Through the xCT/GSH/GPX4 Axis Under the Regulation of the AKT/mTORC1/4EBP1 Pathway.

Glioblastoma multiforme (GBM) is a common and malignant tumor in the field of neurosurgery. Natural chemotherapeutic agents are an appealing option due to their diverse activities and low cost. Ferroptosis, a form of programmed cell death, holds great potential for treating resistant cancers.

Pointing jitter correction in hollow-core fiber nonlinear systems based on LSTM.

Hollow-core fiber has been widely used for laser spectrum broadening and pulse duration compression, and its performance is highly sensitive to pointing instability caused by environmental interference and system nonlinearity. Here, we propose a feedback control system based on a three-layer long short-term memory network for real-time pointing jitter correction, which reduces the beam pointing jitter from 4.04 and 4.

Plumbagin activates NLRP3/caspase-1/GSDMD-mediated pyroptosis by decreasing DUSP4 expression to exhibit anticancer property in cholangiocarcinoma.

Background: Plumbagin is effective in treating cholangiocarcinoma (CCA), however, the potential mechanism of plumbagin therapy is still unclear. This study aims to uncover the anti-tumor nature of plumbagin and the specific mechanism by which plumbagin alleviates NLRP3/caspase-1/GSDMD-induced pyroptosis.

Methods: Human CCA cells lines HuCCT1 and RBE and the CCA mouse model injected with HuCCT1 cells were used for the mechanism exploration.

Prediction and immune infiltration analysis of lipid metabolism-related immune genes in the treatment of non-small cell lung cancer.

This study investigates the role of lipid metabolism-related immune genes in the treatment of non-small cell lung cancer (NSCLC), with a particular focus on the differences between Lung adenocarcinoma (LUAD) and Lung squamous cell carcinoma (LUSC). Utilizing data from The Cancer Genome Atlas (TCGA), the research analyzed tumor samples from both LUSC and LUAD, identifying differentially expressed genes (DEGs) associated with lipid metabolism and immunity. The results revealed significant differences in gene expression between LUSC and LUAD, suggesting that lipid metabolism-related genes could play a crucial role in prognostic prediction and response to immunotherapy.

Vitamin K2 inhibits PGE2-mediated osteoblast ferroptosis by upregulation of CBR1 via the Nrf2/Keap1 pathway.

Osteoporosis is increasingly attracting attention. Studies have indicated a correlation between vitamin K2 levels and bone mass, but the specific mechanisms remain unclear. Therefore, this study aims to further elucidate the specific molecular mechanisms and related target proteins.

The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review.

Purpose: The purpose of this review is to discuss the role of fat-soluble vitamins in bone metabolism and explore whether there is a relationship between each fat-soluble vitamins in the occurrence and development of osteoporosis.

Methods: We selected several databases, including PubMed, PubMed Central (PMC), Embase, and Web of Science, as the primary sources for the search. Keywords closely related to the subject of this study, such as 'osteoporosis', 'vitamin A', 'vitamin D', 'vitamin E', 'Vitamin K', 'ferroptosis', 'osteoblast' and 'osteoclast', were used in the search.

Electrically Driven Chimeric Extracellular Vesicles Crossing the Fundus Barrier for Retinoblastoma Treatment.

The internal limiting membrane (ILM), which separates the vitreous from the retina, hinders the delivery of extracellular vesicles (EVs) to the fundus via intravitreal injection for retinoblastoma treatment. In addition, EVs need to traverse biological barriers and selectively target retinoblastoma cells. To address these challenges, we designed an electroactive microneedle (e-MN) device to actively propel macrophage- and retinoblastoma-derived chimeric EVs across the ILM and precisely localize them to tumor cells.

The association between short-term postoperative complications and bowel function after surgery for Hirschsprung disease.

Objective: This study aims to investigate the relationship between postoperative short-term complications and bowel function in patients with Hirschsprung disease (HSCR), and to explore the risk factors affecting bowel function.

Methods: The medical records of 367 eligible patients diagnosed with HSCR were reviewed. According to the bowel function score (BFS), patients were divided into a normal bowel function group (200 cases, BFS > 17) and an abnormal bowel function group (167 cases, BFS ≤ 17), and the possible risk factors for poor bowel function were evaluated through univariate and multivariate analysis.

[Toric-ICL shows better predictability and efficacy than FS-LASIK for myopia correction in patients with moderate to high myopia and astigmatism].

Objectives: To compare the efficacy of toric implantable collamer lens (Toric-ICL) and femtosecond laser-assisted keratomileusis (FS-LASIK) for myopia correction in patients with moderate to high myopia complicated with astigmatism.

Methods: We retrospectively collected data from 64 patients (aged 18-42 years) with moderate to high myopia complicated with astigmatism (128 eyes) undergoing either Toric-ICL (28 patients/56 eyes) or FS-LASIK (36 patients/72 eyes) at our department between January, 2019 and December, 2020. The changes of uncorrected distance visual acuity (UCVA), spherical equivalent (SE), mean astigmatism correction index (CI), corneal endothelial cell density (ECD) and intraocular pressure (IOP) following the procedures were compared between the two groups.

An Integrated Approach for Simultaneous Calibration and 3D Coronary Artery Centerline Reconstruction from Two Non-Simultaneous Angiographic Images.

The three-dimensional (3D) reconstruction of the coronary artery from angiographic images is crucial for diagnosing and treating coronary artery disease. However, accurate reconstruction is challenging due to the non-simultaneous acquisition of angiographic images and the complex motion patterns of coronary arteries. State-of-the-art methods typically involve a two-stage process: manual selection of corresponding point pairs for spatial geometric calibration, followed by centerline reconstruction.

Cadmium stress drives remodeling of earthworm mucus metabolism: Hormetic antioxidant response and synergistic amino acid defence mechanisms.

Sensitive biomarkers are urgently required for the ecological risk assessment of heavy metal-contaminated soils. However, the synergistic defense mechanism involving oxidative stress and mucus metabolism in earthworms under cadmium (Cd) stress remains poorly understood, limiting insights into soil animal adaptation strategies. This study employed the earthworm 'Eisenia fetida' as a model organism.

Preparation of non-spherical nano-FeO and its effect on thermal decomposition of AP and combustion performance of composite fuels.

Based on the aqueous sol-gel method, three types of nano-FeO particles with different microstructures were synthesized with FeSO solution as the precursor. The structural characteristics of these FeO particles and their effects on the high-temperature thermal decomposition of ammonium perchlorate (AP) and the combustion performance of AP/aluminum (Al) composite fuels were analyzed with scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), surface area analysis, differential scanning calorimetry (DSC), and high-speed imaging. The results indicate that at a pH of 8, the synthesized nanoparticles comprise bulk and fibrous particles with an average particle size of approximately 70 nm, exhibiting some degrees of agglomeration.

Thermally Crosslinked Triphenylamine-Fluorene Conjugated Polymers: A Strategy for Stable and Efficient Electrochromic Materials.

A series of thermally crosslinkable triphenylamine-fluorene conjugated polymers (MeVb1, MeVb2, and MeVb3) with varying crosslinking densities are synthesized and systematically studied. Upon thermal crosslinking, these polymers exhibit enhanced solvent resistance and uniform film morphology. All films demonstrate stable electrochromic behavior, with tunable color transitions from transmissive yellow to deeper color.

Distribution characteristics of earthworms in different climatic zones of Yunnan Province, Southwest China.

Earthworms, as large soil animals, play a crucial role in soil ecological functions. We investigated the spatial distribution characteristics of earthworms by collecting 1984 earthworm individuals from six climatic zones in Yunnan Province. The results showed that and were the dominant earthworm species in Yunnan Province.

Incidence of ocular ischemic syndrome in patients with asymptomatic severe internal carotid artery stenosis.

Objectives: To evaluate the incidence of ocular ischemic syndrome (OIS) in patients with asymptomatic Severe Internal Carotid Artery Stenosis or occluded (ipICA-SO).

Design And Methods: 260 patients with ipICA stenosis ≥ 70%, 120 patients with ipsilateral OIS, and 140 with normal ocular condition. The logistic regression analysis was conducted to establish risk prediction models of OIS/Neovascular-OIS/Chronic-OIS for patients with ipICA-SO.

Inflammation Targeting and Responsive Multifunctional Drug-Delivery Nanoplatforms for Combined Therapy of Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation, joint swelling, pain, and progressive joint destruction. Methotrexate (MTX) is the standard first-line treatment for RA, but its clinical application is hindered by poor water solubility and non-specific delivery. In this work, a multifunctional drug-delivery nanoplatform that targets both macrophages and tumor necrosis factor α (TNFα) is developed to enhance the therapeutic efficacy of MTX in RA.

Molecular Anchoring Strategies for Enhanced Thermal Stability in Organic Field-Effect Transistors.

Thermally stable organic transistors are crucial for ensuring reliable performance in diverse applications, including high-temperature environments and thermally demanding electronic systems. However, developing thermally stable organic semiconductors with excellent charge transport capability remains a great challenge. Here, a thermally stable and high-performance organic semiconductor, [1]benzothieno[3,2-][1]benzothiophene (BTBT) derivative BTBT-PO8OP, is designed by incorporating a phenyl-anchored unit in the side chain.

Solute carrier family 15 member 4, an emerging therapeutic target for systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by excessive production of type I interferons (IFNs) and autoantibodies with limited effective clinical treatments. Solute carrier family 15 member 4 (SLC15A4), a proton-coupled oligopeptide transporter, facilitates the transmembrane transport of L-histidine and some di- and tripeptides from the lysosome to the cytosol. A growing body of evidence has elucidated the critical role of SLC15A4 in pathogenesis and disease progression of SLE.

Enhancing Electrochromic Stability of Triphenylamine-Based Polymers via Monomer Ratio Optimization.

In the pursuit of high-performance organic electrochromic (OEC) materials that transition from transparent to deep colors, we design and synthesize a series of copolymers─termed MeTPhF─composed of TPA and fluorene with triethylene glycol and ester groups incorporated. This is achieved through gradient tuning of monomer ratios via Suzuki copolymerization. Five of these polymers exhibit excellent film-forming properties, and their electrochromic devices demonstrate remarkable pale blue-to-reddish brown switching behavior.

Genome-Wide Identification and Expression Assessment for the Gene Family Within Sweet Potato Under Phosphorus Deficiency Stress.

Hainan's unique climate significantly contributes to soil acidification, causing phosphorus fixation into insoluble compounds, leading to phosphorus deficiency and reduced yield in sweet potatoes. The family, a group of trans-membrane phosphate transporters, is crucial for phosphate transport, distribution, and homeostasis regulation. Two genes, and , were first identified in sweet potato, and a phylogenetic analysis of 46 species showed high conservation of the gene family throughout plant evolution.

Implication of Immunobiological Function of Melanocytes in Dermatology.

Melanocytes are essential for regulating pigmentation and providing photoprotection in human skin. Originating from neural crest cells, these cells migrate to the basal layer of the epidermis and hair follicles during embryogenesis. Melanosomes, the specialized, membrane-bound organelles are essential for melanin synthesis.