Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins.

Cathepsin D (CTSD) is a lysosomal aspartic protease that plays vital roles in regulating the properties of solid tumors, including proliferation, apoptosis, migration, metastasis, and angiogenesis. However, the function of CTSD in haematological malignancies remains largely elusive. Here we show that CTSD is highly expressed in acute myeloid leukemia (AML) and that high CTSD expression is associated with unfavourable prognosis.

Hierarchically Engineered Flame-Retardant Triboelectric Yarn Exhibiting Robust Mechanical Performance and Humidity-Boosted Electrical Output for Firefighting Applications.

As urbanization progresses and building complexity grows, fire safety gains prominence, driving up demand for intelligent, high-performance fire-fighting gear. This study develops a super-intelligent fireproof yarn (SIFY) with a coaxial structure via hierarchical textile assembly. The middle waterproof and flame-retardant layer and the outer high-strength flame-retardant poly(p-phenylene benzobisoxazole) fibers endow SIFY with top-notch flame-retardant performance (limiting oxygen index of 50.

Decoding aortic dissection from potential drug targets to genetic risk factors: A Mendelian randomization study.

Aims: The aortic dissection (AD) is defined as the destruction of the tunica media and separation of the aortic wall, which can be fatal. To date, there is no clinical medication that has been developed to effectively prevent the progression of AD. Therefore, it is imperative to identify risk factors associated with AD and to discover potential therapeutic targets.

CO-selective molecular recognition in UiO-66 post-synthetic polyethylene glycol/amidoxime functionalization.

A diisocyanate-bridged polyethylene glycol modification and time-controlled amidoximation strategies are developed to engineer UiO-66 metal-organic frameworks (MOFs), achieving 115.3% and 130.0% CO/N adsorption selectivity enhancements escalated CO-MOF interactions.

Pan-genome and haplotype map of cassava cultivars and wild ancestors provide insights into its adaptive evolution and domestication.

Cassava is a highly resilient tropical crop that produces large, starchy storage roots and high biomass. However, how did cassava's remarkable environmental adaptability and key economic traits evolve from its wild species remain unclear. In this study, we obtained near complete telomere-to-telomere genome assemblies and their haplotype forms for the cultivar AM560, the wild ancestors FLA4047 and W14, constructed a graphic pan-genome of 30 representatives with a size of 1.

Rare presentation of multiple sinuses of Valsalva Aneurysms with rupture into the right atrium: An autopsy case.

In forensic practice, multiple sinuses of Valsalva Aneurysm resulting in death have rarely been reported. Here, we present the case of a 55-year-old man who was admitted to hospital with vomiting and recurrent abdominal pain. Ultrasonography showed that the aorta non-coronary sinus had an expansion to the right atrium with a range of about 19mm × 16mm and a rupture at the top of the aorta with a width of about 5mm.

Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases.

The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and disease-specific assemblies of chaperones and co-chaperones, exemplify this phenomenon. This review emphasizes the critical structural and functional distinctions between epichaperomes and canonical chaperones, highlighting their role in redefining therapeutic strategies.

Genome-Wide Identification and Expression Assessment for the Gene Family Within Sweet Potato Under Phosphorus Deficiency Stress.

Hainan's unique climate significantly contributes to soil acidification, causing phosphorus fixation into insoluble compounds, leading to phosphorus deficiency and reduced yield in sweet potatoes. The family, a group of trans-membrane phosphate transporters, is crucial for phosphate transport, distribution, and homeostasis regulation. Two genes, and , were first identified in sweet potato, and a phylogenetic analysis of 46 species showed high conservation of the gene family throughout plant evolution.

Identification of the cassava gene family and its response and regulation in photosynthesis.

NADP-malic enzyme (NADP-ME) is a crucial enzyme in C photosynthesis, responsible for the decarboxylation of malate in bundle sheath cells, enhancing the photosynthetic efficiency of C plants. Cultivated cassava exhibits high photosynthetic efficiency and biomass, and previous studies classify it as a C-C intermediate type. The biomass of cassava correlates positively with photosynthetic rate, and the promoter region of contains insertion selected in cultivars different from wild ancestors.

Evaluation of antibody titer and associated risk factors of goat pox vaccine against lumpy skin disease in crossbred buffaloes.

Lumpy skin disease (LSD) is an infectious disease affecting large ruminants, caused by the lumpy skin disease virus (LSDV). It is characterized by symptoms such as hyperthermia, emaciation, lymphadenopathy, and skin nodules. Pregnant animals affected by LSD often experience abortions and may develop infertility syndrome, while affected males can become sterile.

Renewable Phenolic Resins Based on Nitrogen-Coordinated Cyclic Boronic Ester Bonds.

Phenolic resins (PRs) are known for their exceptional performance due to their 3D cross-linked structure formed during curing. However, this crosslinking makes them non-reprocessable and difficult to recycle, leading to significant environmental pollution and resource waste. In this study, the reactivity of the phenolic hydroxyl group in thermoplastic PR (abbreviated as NR) is utilized to introduce a highly stable nitrogen-coordinated cyclic boronic ester (NCB) group into traditional carbon-chain polymers with the aid of aliphatic isocyanates.

Creating Bridged-H* Bond Structure for Boosting Electrocatalytic Hydrogen Evolution via Phosphorus-Doped Iridium Nanosheets.

Iridium (Ir) is recognized to have extremely high catalytic activity in the hydrogen evolution reaction (HER). However, there are still technical challenges in maximizing the utilization of Ir atoms in the catalytic reaction process through dimensional regulation strategies. Herein, an innovative strategy is utilized to fabricate porous phosphorus-doped iridium (P-Ir) with a 2D structure, specifically the reduction of 1T phase-IrO (1T-IrO) nanosheets using phosphine gas.

SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.

In recent years, targeting mitochondrial apoptosis has emerged as a promising therapeutic strategy for Acute Myeloid Leukemia (AML). The SLC25 family of mitochondrial carriers plays a critical role in maintaining mitochondrial function and regulating apoptosis. However, the role of SLC25A21, an oxodicarboxylate carrier, in AML progression and its potential as a prognostic biomarker remain underexplored.

[Bedside ultrasound monitoring of optic nerve sheath diameter is a predictive factor for 28-day coma, delirium and death in etiologically diverse critically ill patients].

Objective: To explore whether the optic nerve sheath diameter (ONSD) within 24 hours of intensive care unit (ICU) admission is the predictor of 28-day delirium or coma and death in etiologically diverse critically ill patients.

Methods: A prospective, observational study was conducted. The critically ill patients admitted to the emergency ICU of Cangzhou Central Hospital from January 2021 to October 2022 were enrolled.

Interface Engineering for Improved Large-Current Oxygen Evolution via Partial Phosphorization of Ce-MOF/NiCo-MOF Heterostructure.

Interface engineering for electrocatalysts has proven to be an effective method for modulating electrocatalytic properties, yet a more efficient and straightforward strategy to construct a valid heterointerface for further enhancing interface effects is urgently needed for boosting oxygen evolution reactions (OER) at large current. Herein, a closely compacted heterostructure combining NiCo-metal-organic framework (MOF) and Ce-MOF is in situ formed through a one-step hydrothermal treatment, and partial phosphorization is employed to further enhance the interface effect between the newly formed urchin-shaped NiCoP shells and hexagonal rod-like Ce-MOF cores on nickel foam (NiCoP/Ce-MOF@NF). Experimental and theoretical results indicate that the heterogeneous NiCoP/Ce-MOF@NF, characterized by a more intensive interface rather than a simple physical mixture, generates an OER-beneficial electronic structure, significantly facilitates charge transfer and reaction kinetics, and creates a synergistically stable structure.

Waist-to-hip ratio and nonalcoholic fatty liver disease: a clinical observational and Mendelian randomization analysis.

Background: Obesity often coincides with non-alcoholic fatty liver disease (NAFLD), yet a significant portion of NAFLD patients exhibit normal body mass index (BMI) but have abdominal obesity. Recognizing this discrepancy, we aimed to delve deeper into this phenomenon through observational studies coupled with two-sample Mendelian randomization (MR) analysis, with waist-to-hip ratio (WHR) serving as the indicator for abdominal obesity. Our objective was to ascertain whether WHR correlates with an increased risk of NAFLD development.

Zinc oxide nanoparticle-reinforced sodium alginate/hydroxyapatite scaffolds for osteoporosis treatment in fragility fracture patients: Development and characterization using artificial neural networks (ANNs) modeling.

Objectives: Osteoporosis is a significant public health concern due to its association with fragility fractures. Despite experiencing such fractures, many patients remain at high risk of future fractures due to inadequate management and treatment of their underlying osteoporosis. This research presents a comprehensive intervention to enhance osteoporosis management in patients with fragility fractures.

Analytical modelling and analysis of the meander-line coil EMATs.

The meander-line coil electromagnetic acoustic transducer (EMAT) is widely used in the field of ultrasonic nondestructive testing due to its convenience to generate specific mode of guided waves. Some design methods of the meander-coil EMATs are developed in the frequency-wavenumber domain while others in the time-space domain. In this paper, a unified theoretical framework is developed by proposing an analytical model from the system perspective.

Multiple Transformation Matrix-Based Adaptive Projective Vortex Formation Tracking for Multiagent Systems With a Leader of Completely Unknown Input.

This article systematically studies projective vortex formation tracking (PVFT) of linear multiagent systems (MASs) on directed graphs through multiple transformation matrices, in which the input of leader and its upper bound information are not available to any follower. First, an innovative class of distributed adaptive observer is designed using the projection matrices to capture multiple desired virtual signals of the leader. Next, a novel kind of distributed PVFT protocol based on distributed observer, local observer and coordinates coupling matrices are proposed.

Proteomics of severe SARS-COV-2 infection and paraquat poisoning in human lung tissue samples: comparison of microbial infected and toxic pulmonary fibrosis.

Introduction: Pulmonary fibrosis (PF) encompasses a spectrum of lung conditions characterized by the abnormal accumulation of scar tissue in the lungs, leading to impaired respiratory function. Various conditions can result in severe PF, among which viral infections have emerged as significant triggers. In addition to viral infections, exposure to toxic substances such as paraquat represents another significant risk factor for PF.

Effect of dietary Chinese herbal preparation on dry matter intake, milk yield and milk composition, serum biochemistry, hematological profile, and reproductive efficiency of Holstein dairy cows in early postpartum period.

The present study investigated the effects of various inclusion levels of dietary Chinese herbal medicine (CHM) preparation on feed consumption, milk yield and milk composition, serum biochemistry, hematological profile, and reproductive efficiency of Holstein dairy cows. A total of 117 lactating Holstein cows were randomly divided into four groups as control ( = 27; without CHM supplementation) and treatment groups CHM-0.5 ( = 31), CHM-0.

In situ interfacial evaluation of aramid/epoxy composites by interfacial stress transfer characteristics.

Interfacial bonding between aramid fibers and epoxy resin is crucial for the mechanical properties of fiber-reinforced epoxy composites. Interfacial stress transfer between resin and fibers bridges microscopic and macroscopic properties. Using micro-Raman spectroscopy for in situ stress measurement offers insights into interface bonding through assessment of interfacial stress transfer characteristics.

Intrapuparial stage aging and PMI estimation based on the developmental transcriptomes of forensically important (Diptera: Calliphoridae) gene expression.

Background: The expression profiles of differentially expressed genes (DEGs) during pupal development have been demonstrated to be vital in age estimation of forensic entomological study. Here, using forensically important (Diptera: Calliphoridae), we aimed to explore the potential of intrapuparial stage aging and postmortem interval (PMI) estimation based on characterization of successive developmental transcriptomes and gene expression patterns.

Methods: We collected pupae at 11 successive intrapuparial stages at 20 °C and used the RNA-seq technique to build the transcriptome profiles of their intrapuparial stages.