Juvenile hormone signaling regulates apoptosis mediated chlorantraniliprole sensitivity in Spodoptera frugiperda (Lepidoptera: Noctuidae).

The fall armyworm (Spodoptera frugiperda, FAW) has developed varying degrees of resistance to chlorantraniliprole (CAP). Apoptosis serves as a critical defense mechanism against pesticide stress in insects. Here, we identified a juvenile hormone (JH)-mediated apoptotic pathway through RNA-seq, revealing nine JH-induced apoptosis-related genes (four positively correlated and five negatively correlated).

Organocatalytic Enantioselective Michael-Type Friedel-Crafts (Hetero)arylations of Aurone-Derived Azadienes with Indolizines.

Herein, we describe an enantioselective 1,4-addition of benzofuran-derived azadienes with indolizines under the catalysis of chiral phosphoric acid, which afforded new enantioenriched triarylmethane products in generally good yields (up to 90%) with high enantioselectivities (up to 98% ee). This method enabled the precise synthesis of enantioenriched triarylmethane products, which are notable for their intricate structures and the presence of two (hetero)aryls.

Synergistic Enhancement of Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination.

Coccidiosis is a major parasitic disease that suppresses poultry productivity and causes significant global economic losses. Currently, controlling parasites relies primarily on the use of anticoccidial drugs or live vaccines. However, these conventional control strategies face the dual constraints of escalating drug resistance and unsustainable economic expenditures.

The complex REDUCED COMPLEXITY locus contributes to leaf shape diversification in Brassica rapa.

Leaf shape is a vital economic and developmental trait of the leafy vegetable Chinese cabbage (Brassica rapa L. subsp. pekinensis).

Enrichment of short-chain fatty acid-producing bacteria by pH-responsive sodium alginate and chitosan-encapsulated quercetin.

Introduction: Conventional approaches to treat ulcerative colitis (UC) focus on suppressing excessive inflammation and immune responses. Nevertheless, these treatments fail to address gut dysbiosis or restore the intestinal mucosal barrier effectively. Regulating the intestinal microenvironment may be pivotal to more effective therapies for UC.

The toxin-producing diversity of Prorocentrum lima (Dinophyceae) populations of coastal China.

Prorocentrum lima (P. lima) is distributed in the four major seas of China. The diversity distribution of P.

Correction: Narcolepsy: a machine learning bibliometric analysis (1996-2024).

[This corrects the article DOI: 10.3389/fneur.2025.

A mitochondrial-derived peptide MOTS-c contributes to the protective effect against brain injury associated with LPS-induced sepsis by strengthening the blood-brain barrier's ultrastructure.

Background: Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis, increasing short-term and long-term mortality. It involves neuroinflammation, neuronal damage, and blood-brain barrier (BBB) disruption. MOTS-c, a mitochondrion-derived peptide, exerts neuroprotective effects by modulating inflammatory responses and cellular functions.

Attention-based multi-scale convolution and conformer for EEG-based depression detection.

Depression is a common mental health issue, and early detection is crucial for timely intervention. This study proposes an end-to-end EEG-based depression recognition model, AMCCBDep, which combines Attention-based Multi-scale Parallel Convolution (AMPC), Conformer, and Bidirectional Gated Recurrent Unit (BiGRU). The AMPC module captures temporal features through multiscale convolutions and extracts spatial features using depthwise separable convolutions, while applying the ECA attention mechanism to weigh key channels, enhancing the model's focus on crucial electrode channels.

Trajectories of Symptom Clusters and Their Predictive Factors in Patients With Colorectal Cancer 3 Months After Surgery: A Longitudinal Study.

Aims: To examine the changing trajectories of symptom clusters within 3 months following surgery in patients with colorectal cancer (CRC) and identify their predictive factors.

Design: A prospective longitudinal observational study.

Methods: Convenience sampling was used to recruit inpatients with CRC who were scheduled for surgical treatment at the Sichuan Provincial People's Hospital between October 2022 and September 2023.

Narcolepsy: a machine learning bibliometric analysis (1996-2024).

Background: Narcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.

Methods: Articles and reviews on narcolepsy were sourced from the Web of Science Core Collection.

Predicting the Oligomeric State of Proteins Using Multiple Templates Detected by Complementary Alignment Methods.

Recognizing the oligomeric state of proteins is crucial for understanding the structure and function of proteins. In the CASP16 experiment, a two-stage prediction is proposed to challenge structure predictors, in which the oligomeric state is unknown at the first stage. The correct prediction of the oligomeric state plays a vital role in the subsequent step of structure prediction.

Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer.

To investigate the ramifications of dose alterations and clinical outcomes linked to imperfect uterine tandem implantation within high dose rate brachytherapy (HDR-brachytherapy) for cervical cancer. A retrospective analysis was conducted on imperfect intrauterine insertion images from November 2020 to July 2021. The physicist reconfigured two-dimensions (2D) and three-dimensions (3D) plans based on prescription (6 Gy) for both the imperfection (IM) and perfect (PER) implantation.

A practical study of the discharge readiness for improving the quality of life of patients who underwent enterostomies.

Purpose: To investigate the discharge readiness index, to improve the quality of life of patients who undergo enterostomies, and to improve the quality of care.

Methodology: One hundred and fifty patients who underwent enterostomies were randomly divided into two groups (75 patients per group), with the control group receiving usual care and the intervention group completing the discharge readiness planning program.

Results: The patients in the intervention group had significantly higher discharge readiness scores than did those in the control group (116.

An intracranial dissection of human escape circuits.

Predators attack across diverse spatiotemporal scales, prompting prey to respond through simple motor reactions (e.g., fleeing) or more complex cognitive processes (e.

Causal relationships between leukocyte telomere length and female reproductive system diseases: a bidirectional Mendelian randomization study.

Objective: Although numerous observational studies have revealed a correlation between leukocyte telomere length (LTL) and female reproductive system diseases (RSDs), the findings of these studies have tended to be consistent. In this study, we accordingly sought to clarify the causal relationships between LTL and RSDs.

Methods: We performed a bidirectional two-sample Mendelian randomization (MR) analysis using pooled statistics from genome-wide association studies of LTL and nine female RSDs.

Ternary composite material based on copper-metal organic frameworks, Mxene and carbon nanotubes as a sensitive electrochemical platform for determination of dopamine in aquatic environments.

Dopamine (DA) is a crucial neurotransmitter, however, its excessive use can lead to its accumulation as a micropollutant in aquatic ecosystems, thereby presenting various health risks to humans. Consequently, the accurate determination of dopamine levels is of paramount importance and has attracted considerable attention within scientific and regulatory communities. In this work, a ternary composite material (Cu-MOF/MXene/CNTs, MMC) based on copper-metal organic framework (Cu-MOF), the MXene and carbon nanotubes (CNTs) was developed using the hydrothermal method for sensitive electrochemical detection of DA.

The full‑length genome sequence of a novel polymycovirus infecting the phytopathogenic fungus Botryosphaeria dothidea.

Here, a novel dsRNA virus belonging to the family Polymycoviridae was identified in the phytopathogenic fungal strain B. dothidea ZM200473 and tentatively named "Botryosphaeria dothidea polymycovirus 2" (BdPmV2). The genome of BdPmV2 consists of five genomic dsRNA segments, ranging in size from 1224 to 2407 bp, each containing an open reading frame (ORF).

The nursing service needs of old adults in long term care facilities: current status and associated factors.

Background: Long term care facilities, as an integral part of the current social nursing service system, bear the important function of providing nursing services for the older adults. This study conducts an in-depth analysis of the nursing service needs of the older adults, to offer a scientific basis for the improvement of nursing services in long term care facilities.

Methodsd: A questionnaire survey was conducted among the older adults of 24 long term care facilities in Hangzhou, China from March 1 to June 30, 2024.

Molecular characterization of a novel non-segmented double stranded RNA mycovirus infecting the phytopathogenic fungus Botryosphaeria dothidea.

Botryosphaeria dothidea is a prevalent pathogen of woody plants with a global distribution. In this study, we identified a novel mycovirus from the B. dothidea strain ZM200473, which we have tentatively designated "Botryosphaeria dothidea non-segmented dsRNA virus" (BdNSRV1).

Prevalence of Toxocara infection and associated risk factors: a cross-sectional study in Zhejiang, China.

Background: Human toxocariasis, caused by the zoonotic parasites Toxocara canis (dog roundworm) and T. cati (cat roundworm), affects approximately 19% of the global population, ranking it among the most prevalent neglected infection of poverty. However, public awareness about this zoonotic disease has not yet been achieved in China.

Multi-omics analysis reveals metabolic disruptions in cardiac tissues of aging nonhuman primates with spontaneous type 2 diabetes.

Background: The complex interplay between type 2 diabetes (TM) and obesity, particularly in aging populations, is increasingly recognized for its significant contribution to cardiac dysfunction. However, the metabolic changes within cardiac tissues that underlie this relationship remain poorly understood.

Methods: We employed a multi-omics approach to investigate the metabolic alterations in cardiac tissues of aging nonhuman primates with spontaneous TM and obesity.

Research on the value assessment methods for natural resource damage on typical uninhabited islands: A case study of an uninhabited island subject to tourism development.

Approximately 28 % uninhabited islands in China have been developed to varying degrees. Roughly 73 % of them are distributed on vegetated bedrock islands, causing damage of various extents to local natural resources. Ecological restoration of uninhabited islands is an important part of ecological protection that China plans to implement, with one of its preconditions being quantitative assessment of the extent of natural resource damage.

Modified jute for adsorption and in situ reduction to prepare metal nanozymes for nitrite detection.

Nitrite, a common food additive and environmental pollutant, poses potential health risks, making its accurate detection essential for food safety. This study reports a nanozyme platform based on modified jute loaded with platinum nanoparticles (Pt/MJT) for the colorimetric detection of nitrite. The Pt/MJT nanozyme exhibits exceptional catalytic activity and selectivity.

Paralytic Shellfish Toxins in Coastal Waters of Changdao Island (China): Toxin Profiles, Potential Producers, and Environmental Conditions.

In recent decades, there have been frequent occurrences of paralytic shellfish toxin (PST) contamination in the Yellow and Bohai Seas, China. The waters around Changdao Island, situated at the convergence of these two seas, have suffered harmful algal blooms of spp., indicating a potential risk of PST contamination in shellfish.