Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023-2024.

Background: Infants are vulnerable to acute respiratory infections (ARIs), which result in pediatric morbidity and even fatalities. A surge of ARIs among infants and young children was reported in China in 2023, garnering global attention. We aimed to investigate the frequency and types of respiratory pathogens associated with the risk of acute respiratory illnesses in infants and young children during this period.

Dosimetric and clinical outcomes study of occult uterine tandem imperfect implantation in HDR-brachytherapy for cervical cancer.

To investigate the ramifications of dose alterations and clinical outcomes linked to imperfect uterine tandem implantation within high dose rate brachytherapy (HDR-brachytherapy) for cervical cancer. A retrospective analysis was conducted on imperfect intrauterine insertion images from November 2020 to July 2021. The physicist reconfigured two-dimensions (2D) and three-dimensions (3D) plans based on prescription (6 Gy) for both the imperfection (IM) and perfect (PER) implantation.

Event-triggered consensus of multi-agent systems with uncertain control gain via distributed fuzzy logic observer.

An event-triggered adaptive backstepping control methodology is proposed to achieve leader-following consensus of uncertain nonlinear high-order multi-agent systems with unknown control gains. In light of the partial observability limitation, adaptive distributed observers are employed to estimate the unobservable states of the leader, whereas local state observers are utilized to reconstruct the states of the followers. By integrating fuzzy logic systems, the unknown nonlinear dynamics are modeled, guaranteeing reliable state prediction in complex and partially observable scenarios.

Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation.

Polycomb repressive complexes (PRCs) sustain regulatory T (Treg) cell identity through transcriptional silencing, yet their role in modulating Treg functional plasticity during immune adaptation remains unclear. Here, we identify KDM2B, a defining component of non-canonical PRC1.1, as a critical regulator for sustaining the proportion and immunosuppressive functions of active Treg (aTreg) cells without altering Treg abundance or identity.

Serine governs metabolic homeostasis and microbial crosstalk to promote the utilization of urea nitrogen in rumen fermentation in vitro.

Background: Urea is commonly used as a protein substitute in ruminant diets due to its nitrogen utilization efficiency and cost-effectiveness. Serine-derived downstream metabolism contributes to urea-enriched metabolic pathways in rumen fluid.

Results: This study examined the effects of 7.

Comparison of Myopic Maculopathy Progression in Patients with Myopic Traction Maculopathy undergoing Vitrectomy or Macular Buckling.

Purpose: To compare the progression of myopic maculopathy in patients with stage 3 myopic traction maculopathy (MTM) undergoing either pars plana vitrectomy (PPV) or macular buckling (MB).

Methods: A total of 61 eyes diagnosed with stage 3 MTM were retrospectively divided into two groups: PPV group (30 eyes) and MB group (31 eyes). Best-corrected visual acuity (BCVA), axial length (AL), myopic maculopathy progression, retinal and choroidal thickness were measured and compared.

Hepatic Eosinophilic Granuloma Mimicking Liver Metastases of Unknown Primary Focus on 18F-FDG and 68Ga-FAPI PET/CT.

A 53-year-old man presented with right upper abdominal pain for more than 3 weeks without an apparent cause. Multiple sequences of MR imaging detected multiple liver nodules with irregular peripheral enhancement. 18F-FDG and 68Ga-FAPI PET showed multiple elevated tracer uptake, which mimicked multiple liver metastases of unknown primary focus.

Fundus fluorescein angiography findings in eyes initially diagnosed with idiopathic epiretinal membrane.

Introduction: The aim of this study was to investigate the fundus fluorescein angiography (FFA) findings in eyes initially diagnosed with idiopathic epiretinal membrane (iERM) and assess their impact on best-corrected visual acuity (BCVA).

Methods: This retrospective comparative study included 136 patients (151 eyes) diagnosed with iERM and a control group of 121 healthy fellow eyes. All patients underwent FFA and optical coherence tomography (OCT).

Macular buckling combined with inverted internal limiting membrane flap technique and air tamponade in the treatment of macular hole retinal detachment in high myopia.

Purpose: The study aims to assess the efficacy of integrating macular buckling (MB) with pars plana vitrectomy (PPV), the inverted internal limiting membrane (ILM) flap technique, and air tamponade in treating macular hole retinal detachment (MHRD) in patients with high myopia.

Methods: This retrospective study included sixty-two eyes from sixty-two consecutive patients diagnosed with highly myopic MHRD. The participants were categorized into two groups: the PPV group (n=34) and the combination group (n=28).

Untargeted metabolomics revealed that quercetin improves rat renal metabolic disorders induced by chronic unpredictable mild stress.

Depression is a serious mental disease, and its accompanying abnormal changes in peripheral organs, including the kidney, are easy to be ignored. The metabolic abnormalities of the kidney and other organs will inevitably affect the progress of depression through the circulatory system. Quercetin has attracted much attention as a flavonoid with anti-inflammatory, antioxidant, neuroprotective, and antidepressant potential.

Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor.

Diabetic retinopathy (DR) is one of the major complications of diabetes, resulting in severe vision loss. Traction retinal detachment (TRD) is the main factor affecting the effect of proliferative diabetic retinopathy (PDR) surgery. Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) was adopted to analyze the proteomes of the vitreous in the TRD, vitreous hemorrhage (VH) and macular hole (MH) groups.

[A temporary trauma team established in primary hospital for disaster rescue].

Objective: To explore the feasibility of establishing a temporary trauma team led by trauma experts in primary hospitals for disaster medical rescue.

Methods: In the coal mine flooding accident in Xiaoyi City, Shanxi Province on December 15, 2021, according to the local emergency plan and the characteristics of the accident, the trauma experts trained the medical staff from the local primary hospital on advanced trauma life support (ATLS) and damage control surgery (DCS) in the short time interval between the occurrence of the mine disaster and the admission of medical staff to the disaster scene. A temporary trauma team composed of trauma experts, ATLS team, and DCS team was formed to provide early diagnosis and treatment for survivors before and in the hospital.

CMTM3 regulates vascular endothelial cell dysfunction by influencing pulmonary vascular endothelial permeability and inflammation in ARDS.

Introduction: CMTM3 is a member of the human chemokine-like factor superfamily. The mechanistic role of CMTM3 in acute respiratory distress syndrome (ARDS) is not known. This study investigated the role of CMTM3 in the progression of ARDS and its impact on the function of vascular endothelial cells.

Integrating transcriptomics and network pharmacology to reveal the effect and mechanism of Bai-Jie-Jing-Xie ointment on improving skin inflammation of psoriasis.

Ethnopharmacological Relevance: Psoriasis is a global chronic, immune-mediated, inflammatory skin disease. Bai-Jie-Jing-Xie (BJJX) ointment has been widely used in the clinic practice for its notable efficacy and is an empirical prescription for psoriasis treatment in hospitals. Nevertheless, its precise mechanism of action on psoriasis remains unclear.

Association between dietary intake of flavonoids and perimenopausal depression, and the mediating role of high-density lipoprotein cholesterol: Evidence from NHANES 2005-2018.

Background: Perimenopausal depression seriously harms women's physical and mental health, and there is currently no safe and effective prevention and treatment method. Flavonoids not only have antidepressant effects, but can also promote the synthesis and utilization of high-density lipoprotein cholesterol (HDL-c), which are closely associated with depression. This study aimed to explore the association between flavonoid intake and the risk of perimenopausal depression and the mediating role of HDL-c.

Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa.

Saccharopolyspora spinosa is an industrial rare actinomycete capable of producing important environmental-friendly biopesticides, spinosyns. However, exploitation of S. spinosa has been limited due to its genetic inaccessibility and lack of effective genome engineering tools.

Association of clinical biomarker-based biological age and aging trajectory with cardiovascular disease and all-cause mortality in Chinese adults: a population-based cohort study.

Background: Evidence on the association of clinical biomarker-based biological age (BA) with cardiovascular disease (CVD) and mortality remains insufficient, particularly concerning aging trajectories' relationship with these two outcomes.

Methods: Seventy-five thousand five hundred thirty-seven Chinese adults from the Kailuan study who participated in the first checkup (2006-2007) were included. BA was predicted by 32 clinical indicators using deep neural networks models.

Spatiotemporal Dynamics of Bacterial Community Assembly and Co-Occurrence Patterns in Biological Soil Crusts of Desert Ecosystems.

Biological soil crusts (BSCs) play a fundamental role in desert ecosystems by stabilizing soil, cycling nutrients, and retaining moisture. However, the assembly processes governing bacterial communities within BSCs remain largely unknown. This study aimed to reveal the spatiotemporal variations in the bacterial community diversity, co-occurrence patterns, and ecological assembly processes of BSCs and their underlying soils across different desert and seasonal conditions.

Metabolomics revealed that quercetin improved spleen metabolism disorders and regulated the brain-spleen axis in perimenopausal depression model rats.

Perimenopausal depression is a subtype of depression that seriously harms women's health. The pathogenesis of perimenopausal depression remains unclear, which limits its prevention and therapy. Quercetin is a flavonoid with antidepressant and estrogen-like effects.

Exploring the association between composite dietary antioxidant index and ocular diseases: a cross-sectional study.

Objective: Globally, approximately 2.2 billion people suffer from visual impairments or blindness. Dietary patterns are closely associated with the prevalence of multiple ocular diseases.

Time in Target Range, All-Cause Mortality, and Cardiovascular Diseases.

Background: Time in target range (TTR) of systolic blood pressure (SBP) is a concept characterizing the extent of blood pressure (BP) control. We aimed to compare the risk of all-cause mortality and cardiovascular diseases (CVDs) in participants with >50% time of their SBP within different target ranges.

Methods: A total of 40,914 participants who had complete BP data and were free of CVDs or cancer were included.

Detecting Glaucoma in Highly Myopic Eyes From Fundus Photographs Using Deep Convolutional Neural Networks.

Background: High myopia (HM) is a major risk factor for glaucoma. However, glaucomatous optic neuropathy is often undiagnosed owing to atypical structural alterations with axial elongation. Moreover, an algorithm to detect glaucoma in highly myopic eyes has not yet been reported.

Untargeted metabolomics revealed that quercetin improved adrenal gland metabolism disorders and modulated the HPA axis in perimenopausal depression model rats.

Perimenopausal depression is a psychiatric disorder that occurs around the time of menopause and seriously affects women's health. The pathogenesis of perimenopausal depression is unclear which affects its prevention and treatment. Quercetin is a flavonoid compound with antidepressant and estrogen-like effects.

Perfusion Capacity as a Predictive Index for Assessing Visual Functional Recovery in Patients With Idiopathic Epiretinal Membrane.

Purpose: This study investigates the association between visual function and retinal vasculature metrics, particularly perfusion capacity (PC), in eyes with idiopathic epiretinal membrane (iERM), using optical coherence tomography angiography (OCTA).

Methods: This retrospective study includes 30 eyes from 30 iERM patients who had surgery, with a three-month follow-up period. In addition, 28 eyes from 28 healthy individuals served as a control group.

Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response.

: Tumor associated macrophages (TAMs) are critical components in regulating the immune statuses of the tumor microenvironments. Although TAM has been intensively studied, it is unclear how mitochondrial proteins such as AGK regulate the TAMs' function. : We investigated the AGK function in TAMs using macrophage-specific deficient mice with B16 and LLC syngeneic tumor models.