An explainable radiomics-based machine learning model for preoperative differentiation of parathyroid carcinoma and atypical tumors on ultrasound: a retrospective diagnostic study.

Background: Parathyroid carcinoma (PC) and atypical parathyroid tumors (APT), constituting rare endocrine malignancies, demonstrate overlapping clinical-radiological presentations with benign adenomas. This study aimed to investigate the predictive performance of three radiomics-based machine learning models for the identification of PC/APT from solitary parathyroid lesions using ultrasound.

Methods: This retrospective diagnostic study analyzed 913 surgically-confirmed parathyroid neoplasms (mean age 54.

Research progress on mesenchymal stem cell‑derived exosomes in the treatment of osteoporosis induced by knee osteoarthritis (Review).

Knee osteoarthritis (KOA) and osteoporosis (OP) are closely related, age‑related, degenerative orthopedic conditions. Elderly patients with OP frequently develop concurrent KOA, with high co‑occurrence rates. Studies indicate that OP significantly increases KOA risk and that these conditions mutually exacerbate each other.

From misdiagnosis to precision therapy: A case of scedosporium apiospermum pneumonia in an immunocompetent host.

Scedosporium apiospermum, a rare but increasingly recognized fungal pathogen, poses significant diagnostic and therapeutic challenges. Traditionally associated with immunocompromised individuals. We present a case of S.

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection and is one of the leading causes of morbidity and mortality worldwide. Glycosylation is one of the key modes of protein modification, affecting protein folding, transportation, and localization. Glycosylation patterns are closely related to sepsis, but their specific impact still needs further investigation.

A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors.

Objective: Parathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare malignant parathyroid disorders with varying degrees of recurrence risk. The aim of this study was to determine an effective model for discriminating PC/APT among solitary parathyroid lesions.

Methods: A total of 439 patients with histologically confirmed primary hyperparathyroidism were retrospectively enrolled.

Corrigendum to "Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series" [Heliyon Volume 9, Issue 6, June 2023, Article e17132].

[This corrects the article DOI: 10.1016/j.heliyon.

CMTM3 regulates vascular endothelial cell dysfunction by influencing pulmonary vascular endothelial permeability and inflammation in ARDS.

Introduction: CMTM3 is a member of the human chemokine-like factor superfamily. The mechanistic role of CMTM3 in acute respiratory distress syndrome (ARDS) is not known. This study investigated the role of CMTM3 in the progression of ARDS and its impact on the function of vascular endothelial cells.

Image by co-reasoning: A collaborative reasoning-based implicit data augmentation method for dual-view CEUS classification.

Dual-view contrast-enhanced ultrasound (CEUS) data are often insufficient to train reliable machine learning models in typical clinical scenarios. A key issue is that limited clinical CEUS data fail to cover the underlying texture variations for specific diseases. Implicit data augmentation offers a flexible way to enrich sample diversity, however, inter-view semantic consistency has not been considered in previous studies.

Development of an early prediction model for vomiting during hemodialysis using LASSO regression and Boruta feature selection.

Hemodialysis patients (HD) frequently experience nausea and vomiting as side effects, which can make the procedure uncomfortable for them and cause it to end too soon. There are no known predictors of vomiting. We aim to create a nomogram that can anticipate vomiting in hemodialysis patients.

Exploring the impact of gut microbiota-mediated regulation of exosomal miRNAs from bone marrow mesenchymal stem cells on the regulation of bone metabolism.

Background: Osteoporosis, which is a prevalent metabolic bone disease, is closely associated with imbalances in the gut microbiota.

Methods: The ovaries of female 6-month-old Sprague-Dawley rats were surgically removed to induce osteoporosis. Subsequently, 16S rRNA sequencing was employed to characterize the gut microbiota in the osteoporotic rats.

CMTM3 regulates neutrophil activation and aggravates sepsis through TLR4 signaling.

Regulation of neutrophil activation plays a significant role in managing sepsis. CKLF-like MARVEL transmembrane domain containing (CMTM)3 is a membrane protein involved in immune response. Here, we find that CMTM3 expression is elevated in sepsis and plays a crucial role in mediating the imbalance of neutrophil migration.

Causal role of 731 immune cells in diabetic nephropathy: a bi-directional two-sample Mendelian randomization study.

Background: The primary cause of end-stage renal disease (ESRD) is diabetic nephropathy (DN), and a growing body of research indicates that immunology plays a part in how DN develops into ESRD. Our objective is to identify causal relationships between various immune invading cells and DN to identify possible targets for immunotherapy.

Methods: This study used a complete Mendelian randomization (MR) analysis with two samples to identify the underlying mechanism linking immune cell characteristics with DN.

DPP-IV Inhibitory Peptide against In Vitro Gastrointestinal Digestion Derived from Goat's Milk Protein and Its Activity Enhancement via Amino Acid Substitution.

Goat milk protein can release a variety of bioactive peptides after digestion, while most of them are digested into free amino acids or dipeptides via the GI tract. We investigated the peptide profiles of goat milk protein following in vitro gastrointestinal digestion using LC-MS/MS and identified 683 bioactive peptides, including 105 DPP-IV inhibitory peptides. Among these peptides, ILDKVGINY (IL), derived from β-lactoglobulin, was found to be high in content and resistance to digestion.

Incidence and risk factors for acute kidney injury after traumatic hemorrhagic shock: A 10-year retrospective cohort study.

Background: Acute kidney injury (AKI) is a common complication of traumatic hemorrhagic shock. The risk factors for AKI after traumatic hemorrhagic shock remain unclear. The aim of this study was to investigate the risk factors for AKI after traumatic hemorrhagic shock.

[Clinical characteristics and labial gland pathological features in children with systemic lupus erythematosus complicated by Sjögren's syndrome].

Objectives: To study the clinical manifestations, laboratory features, and labial gland pathological features in children with systemic lupus erythematosus (SLE) complicated by Sjögren's syndrome (SS).

Methods: A retrospective analysis was conducted on 102 children with SLE who underwent labial gland biopsies at Renji Hospital, Shanghai Jiao Tong University School of Medicine from January 2013 to December 2022. The children were divided into two groups based on the presence of SS: the SLE with SS group (SLE-SS; 60 children) and the SLE-only group (42 children).

Pharmacotherapy and cardiovascular challenges: a case report of olverembatinib-induced myocardial infarction with non-obstructive coronary arteries.

The anticancer drug of tyrosine kinase-inhibitors (TKIs) has significantly improved the prognosis of patients with specific leukemia but has also increased the risk of organ adverse reactions. Herein, we present a case of a patient diagnosed with myeloproliferative neoplasms who experienced recurrent chest pain after receiving treatment with Olverembatinib. Electrocardiography and coronary angiography confirmed the diagnosis of myocardial infarction with non-obstructive coronary arteries.

Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study.

Background: Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chronic kidney disease (CKD) and mortality.

Methods: From January 2018 to December 2021, 158 patients undergoing CRS-HIPEC were retrospectively reviewed.

A comprehensive analysis of immune features and construction of an immune gene diagnostic model for sepsis.

Sepsis is a life-threatening syndrome resulting from immune system dysfunction that is caused by infection. It is of great importance to analyze the immune characteristics of sepsis, identify the key immune system related genes, and construct diagnostic models for sepsis. In this study, the sepsis transcriptome and expression profiling data were merged into an integrated dataset containing 277 sepsis samples and 117 non-sepsis control samples.

Alveoli-Mimetic Synergistic Liquid and Solid Thermal Conductive Interface as a Novel Strategy for Designing High-Performance Thermal Interface Materials.

Thermal interface materials (TIMs) are in desperate desire with the development of the modern electronic industry. An excellent TIM needs desired comprehensive properties including but not limited to high thermal conductivity, low Yong's modulus, lightweight, as well as low price. However, as is typically the case, those properties are naturally contradictory.

Exploring Lipoic Acid-Mediated Dynamic Bottlebrush Elastomers as a New Platform for the Design of High-Performance Thermally Conductive Materials.

The development of high-performance thermally conductive interface materials is the key to unlocking the serious bottleneck of modern microelectronic technology through enhanced heat dispersion. Existing methods that utilize silicone composites rely either on loading large doses of randomly distributed thermal conductive fillers or on filling prealigned thermal conductive scaffolds with liquid silicone precursors. Both approaches suffer from several limitations in terms of physical traits and processability.

Experience in the diagnosis and treatment of pneumonia caused by infection with : A case series.

(TW) is the root cause of Whipple's disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen's surreptitious nature. However and significantly, with the advent of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF), it offers clinicians a potent tool at their disposal to detect TW infections.

Association between calf circumference and cardiac metabolic risk factors in middle-aged and elderly women.

Aims: To assess the correlation between calf circumference and cardiac metabolic risk factors such as hypertension, abnormal blood glucose and dyslipidaemia among middle-aged and elderly women.

Methods: The cross-sectional study population consisted of 476 female participants aged 40-80 years, including 304 perimenopausal and 172 postmenopausal women. Calf circumference, body mass index (BMI), blood pressure, blood glucose and blood lipids were measured.

Dynamic Perfusion Representation and Aggregation Network for Nodule Segmentation Using Contrast-Enhanced US.

Dynamic contrast-enhanced ultrasound (CEUS) imaging has been widely applied in lesion detection and characterization, due to its offered real-time observation of microvascular perfusion. Accurate lesion segmentation is of great importance to the quantitative and qualitative perfusion analysis. In this paper, we propose a novel dynamic perfusion representation and aggregation network (DpRAN) for the automatic segmentation of lesions using dynamic CEUS imaging.

Resveratrol suppresses lipopolysaccharide-mediated activation of osteoclast precursor RAW 264.7 cells by increasing miR-181a-5p expression.

Resveratrol (Res) has anti-inflammation and antiosteoporosis functions. We evaluated the effect of Res on osteoclast differentiation by releasing inflammatory cytokines from osteoclast precursor RAW 264.7 cells stimulated by lipopolysaccharide (LPS).