Skin Care Supports Overall Well-Being.

Skin is more than a physical barrier; it plays a crucial role in overall health, emotional well-being, and social interactions. Beyond its primary function in protection and sensation, the skin actively influences extracutaneous systems through immune regulation, endocrine signaling, and microbiome interactions. Dermatological conditions such as psoriasis, eczema, and rosacea are linked to systemic inflammation, cardiovascular risks, and metabolic disorders, demonstrating the skin's far-reaching impact on overall health.

PB/CeO Nanoparticles Regulating Reactive Oxygen Species for the Control of Enterococcus faecalis Infection in Root Canals.

To investigate the antibacterial effect, mechanism, and cytotoxicity of Prussian blue/Cerium dioxide (PB/CeO) nanoparticles against Enterococcus faecalis (E. faecalis) and biofilm. PB/CeO nanoparticles were synthesized and characterized.

Multi-omics and physiological traits analysis revealed the regulatory mechanism of selenium reducing cadmium toxicity in Desmodesmus abundans.

Cadmium (Cd) is a toxic non-essential heavy metal. Cd pollution has emerged as a serious environmental issue. Selenium (Se) is an essential trace element for human health.

Mussel-Inspired Adhesive and Tough Hydrogel Based on Silk-Triggered Dopamine Polymerization for Wound Healing.

Tissue engineering is a great alternative to repair and regenerate damaged tissues and organs. Hydrogels are promising materials for tissue repair, but optimizing their various functions-such as adhesion, mechanical properties, and vascularization-to suit the complexity of different organs and tissues remains a significant challenge. In this study, we explore a tough and adhesive polydopamine (PDA)-silk-polyacrylamide (PAM) hydrogel inspired by the mussel-inspired adhesion of PDA and the vascularization potential of silk.

Subtraction fractional flow reserve with computed tomography and pericoronary fat attenuation index enhances the identification of revascularization needs in patients.

Background: Fractional flow reserve with computed tomography (FFR-CT) is influenced by calcified plaque artifacts, which can reduce its accuracy in predicting myocardial ischemia. Subtraction techniques can mitigate these artifacts, thereby enhancing diagnostic precision. However, the potential of subtraction FFR-CT and the pericoronary fat attenuation index (FAI) to improve the prediction of revascularization in patients with coronary artery disease (CAD) remains unclear.

Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China.

Objective: This study aimed to clarify the demographics, evaluate risk factors associated with malignant progression, and assess pregnancy outcomes among patients with hydatidiform mole (HM) using a large, retrospective cohort study in Shanghai.

Methods: This retrospective cohort study included patients with pathologically confirmed HM from 2019 to 2023. Descriptive analyses were performed to describe the demographic characteristics, progression to postmolar gestational trophoblastic neoplasia (pGTN), and reproductive outcomes of patients.

Transport of cholesterol to ovary via the Srb selective uptake pathway supports Star-mediated steroidogenesis in swimming crab (Portunus trituberculatus).

Cholesterol, essential for steroidogenesis, is crucial in ovarian development. In crustaceans, scavenger receptor class B member (Srb) and steroidogenic acute regulatory protein (Star) may be key proteins in cholesterol transport and steroidogenesis, respectively. This study aimed to explore cholesterol's role in steroidogenesis and ovarian development in female swimming crabs through in vivo and in vitro experiments.

Ammoxidation of Methylarenes Mediated by a Photo-/Iron Relay.

A photothermal coupling system comprising NHOH·HCl, NHCl, and Fe(SO) has been developed for the direct ammoxidation of methylarenes under O and long-wavelength ultraviolet (UV) light (UVA) irradiation. This light-driven system is applicable to a broad spectrum of methylarenes, facilitating access to diverse aryl nitriles, which are ubiquitous in the field of fine chemicals. Mechanistic investigations suggest that the reaction is an integration of two steps: chlorine-radical-mediated photooxidation and subsequent Fe-promoted thermal cyanation via a five-membered cyclic Fe-dioxime complex.

Chiral P,N,N-Ligands for the Manganese-Catalyzed Asymmetric Formal Hydroamination of Allylic Alcohols.

Application of chiral P,N,N-ligands in the manganese-catalyzed formal asymmetric hydroamination of allylic alcohols through a borrowing-hydrogen strategy was demonstrated. A series of racemic allylic alcohols could react with various secondary amines, affording chiral γ-amino alcohols in up to 93% yield with 96% ee.

The role of multimorbidity in suspected dementia among elderly in Shanghai, China: a community-based cross-sectional study.

Introduction: Many studies have shown some chronic diseases are one of the key risk factors for accelerating cognitive decline. and multimorbidity are common in the elderly population. The evidence of the impact of multimorbidity on dementia among elderly people in China is scarce in detail.

A study of motor imagery EEG classification based on feature fusion and attentional mechanisms.

Introduction: Motor imagery EEG-based action recognition is an emerging field arising from the intersection of brain science and information science, which has promising applications in the fields of neurorehabilitation and human-computer collaboration. However, existing methods face challenges including the low signal-to-noise ratio of EEG signals, inter-subject variability, and model overfitting.

Methods: We propose HA-FuseNet, an end-to-end motor imagery action classification network.

The impact of sarcopenia on prognosis and fruquintinib efficacy in advanced colorectal cancer: a retrospective and mendelian randomization study.

Background: Reportedly, sarcopenia is associated with prognosis in advanced colorectal cancer (CRC) patients and can lead to reduced efficacy of targeted therapy. However, studies on the relationship between sarcopenia and the prognosis (or efficacy) of advanced CRC patients receiving fruquintinib targeted therapy remains scarce. Therefore, we conducted a comprehensive assessment of the relationship between nutritional status, inflammation, immune function, and cancer-related sarcopenia.

Explainable machine learning for predicting ICU mortality in myocardial infarction patients using pseudo-dynamic data.

Myocardial infarction (MI) remains one of the greatest contributors to mortality, and patients admitted to the intensive care unit (ICU) with myocardial infarction are at higher risk of death. In this study, we use two retrospective cohorts extracted from two US-based ICU databases, eICU and MIMIC-IV, to develop an explainable pseudo-dynamic machine learning framework for mortality prediction in the ICU. The method provides accurate prediction for ICU patients up to 24 hours before the event and provides time-resolved interpretability.

Dose-dependent immunomodulation by dietary conjugated linoleic acid (CLA) in black seabream (Acanthopagrus schlegelii) via Keap1/Nrf2 and NF-κB pathways.

Conjugated linoleic acid (CLA) is a natural bioactive compound with antioxidant, anti-inflammatory, and antibacterial properties. This study investigated the dose-dependent effects of dietary CLA on oxidative stress (OS), inflammatory response and apoptosis in black seabream (Acanthopagrus schlegelii). Four isonitrogen and isolipid diets were formulated with graded levels of CLA: 0 % (CLA0), 0.

Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.

Sepsis-associated acute kidney injury (SA-AKI) portends severe health burden due to significant morbidity and mortality, while early diagnosis remains challenging. In this study, proximity-dependent barcoding assay (PBA) is established to profile the surface proteome of single urinary extracellular vesicle (uEV). Principle uEV clusters with unique function and origination are profiled in SA-AKI in a screening cohort.

YOLO-RGDD: A Novel Method for the Online Detection of Tomato Surface Defects.

With the advancement of automation in modern agriculture, the demand for intelligence in the post-picking sorting of fruits and vegetables is increasing. As a significant global agricultural product, the defect detection and sorting of tomato is essential to ensure quality and improve economic value. However, the traditional detection method (manual screening) is inefficient and involves high labor intensity.

Evaluation of factors influencing xanthelasma palpebrarum in Chinese patients: A case-control study.

Xanthelasma palpebrarum (XP) is a yellow plaque lesion near the eyelid, which was previously found to be associated with dyslipidemia, metabolic syndrome, and cardiovascular disease. This study aimed to explore the clinical characteristics and potential mechanisms underlying its development by analyzing body mass index (BMI), lipid levels, blood glucose, and blood type in affected individuals. A case-control study was conducted involving 44 patients with XP between 2019 and 2023 and 44 age- and sex-matched healthy controls.

Explainability in the age of large language models for healthcare.

Large language models show remarkable potential in healthcare but face critical explainability challenges that must be addressed before widespread clinical deployment. Here, we examine technical and regulatory solutions needed to develop trustworthy, transparent large language models for responsible healthcare integration.

Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights.

Oxytocin, often called the "love hormone," is well-known for its roles in childbirth and lactation. Beyond these traditional functions, it plays a vital role in emotional and social behaviors, mood regulation, stress responses, and various physiological processes. Blood oxytocin levels are typically low under basal conditions but increase significantly during labor, breastfeeding, sexual activity, and positive social interactions.

Exploring the complex relationship between systemic lupus erythematosus and coronavirus disease 2019: genetic insights and potential protective mechanisms.

Background: Severe coronavirus disease 2019 (COVID-19) and systemic lupus erythematosus (SLE) have been reported to share common gene loci, but the causal relationship between them remains controversial.

Methods: We conducted a linkage disequilibrium score regression analysis to assess the genetic correlations between SLE and the two traits (infection and severity) of COVID-19 in European populations. Mendelian randomisation analysis was then performed to explore the causal effect of SLE on susceptibility to these traits in both European and East Asian data sets.

Targeting Programmed Cell Death as an Innovative Strategy Against Atherosclerosis: Potential of Natural Compound Supplements.

Atherosclerosis (AS) is the primary pathological basis of various cardiovascular diseases. Its pathogenesis involves multiple processes, including inflammatory responses, lipid metabolism disorders, and cell death. Recently, programmed cell death (PCD), comprising apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis, has attracted considerable attention as a potential therapeutic target in AS progression.

Activation of Sirt1 protects from single-walled carbon nanotubes-induced pulmonary fibrosis by inhibiting alveolar macrophage senescence.

Purpose: Expanding industrial applications of carbon nanotube (CNT) have led to the concern for the increased risk of pulmonary fibrosis. The current study investigated the role of alveolar macrophages (AMs) senescence during single-walled CNT (SWCNT)-provoked pulmonary fibrosis and the underlying mechanism.

Methods: Mice were intratracheally instilled with 40 μg SWCNT, then sacrificed on days 1, 7 and 28 post administration.

Successful salvage therapy of ruxolitinib on interstitial pneumonia after long COVID or post-COVID-19 syndrome with follicular lymphoma: two case reports and literature review.

Background: Immunocompromised patients with B lymphocyte deficiency and hypogammaglobulinemia after anti-CD19 chimeric antigen receptor (CAR) T cell therapy for relapsed/refractory follicular lymphoma (FL) are at high risk of severe coronavirus disease 2019 (COVID-19) infection.

Case Description: In our study, two patients with refractory FL had persistent COVID-19 infection after their anti-CD19 CAR T cell therapy. The patients were diagnosed with post-COVID-19 syndrome or COVID-19 with interstitial inflammation and persistent hypoxemia.

Investigation of Knowledge, Attitudes, and Practices Related to Pulmonary Rehabilitation Among AECOPD Patients During the Transitional Period After Discharge and Analysis of Influencing Factors.

Pulmonary rehabilitation is widely recognized as one of the most effective treatment strategies to improve dyspnea, health status, and exercise endurance in patients with chronic obstructive pulmonary disease (COPD). However, participation in pulmonary rehabilitation among patients experiencing acute exacerbation of COPD remains suboptimal. Current research primarily focuses on the knowledge, attitude, and practice (KAP) of pulmonary rehabilitation among COPD patients during hospitalization or at home, with limited studies investigating the transitional period following discharge.