Unveiling the multifunctional roles of karrikin as a novel phytohormone in cadmium detoxification of bread wheat (Triticum aestivum L.).

Cadmium (Cd) contamination in bread wheat threatens global food security and crop sustainability. Karrikin (KAR), a newly identified phytohormone exhibiting established growth-promoting effects in crops, has not yet been mechanistically defined in Cd detoxification pathways. This study revealed that additional nanomolar KAR mitigated Cd toxicity through dual mechanisms: inhibiting Cd uptake and enhancing stress resilience.

Preparation and Characterization of D-Carvone-Doped Chitosan-Gelatin Bifunctional (Antioxidant and Antibacterial Properties) Film and Its Application in Xinjiang Ramen.

In this study, a composite film with dual antioxidant and antibacterial properties was prepared by combining 2% chitosan and 7% gelatin (2:1, w:w), with D-carvone (0-4%) as the primary active component. The effect of D-carvone content on the performance of the composite films was systematically investigated. The results showed that adding 1% D-carvone increased the water contact angle by 28%, increased the elongation at break by 35%, and decreased the WVTR by 18%.

Association of HLA-DRA expression with prognosis and tumor microenvironment in clear cell renal cell carcinoma.

Recombinant human leukocyte antigen class II histocompatibility antigen (HLA-DRA) has been implicated in the development of various cancers, but its specific role in clear cell renal cell carcinoma (ccRCC) remains unclear.Tissue samples and clinicopathological data from 78 ccRCC patients were collected. Immunohistochemical staining and H-Score analysis were performed to evaluate HLA-DRA expression and its association with clinicopathological features and prognosis.

Development and validation of an inflammatory-based nomogram for predicting arteriovenous fistula maturation failure in end-stage renal disease patients.

Background And Hypothesis: Arteriovenous fistula (AVF) is regarded as the most effective vascular access for hemodialysis in patients with end-stage renal disease (ESRD).However, research investigating the relationships between the systemic inflammation response index (SIRI), the triglyceride-glucose index combined with body mass index (TyG-BMI), and the high-sensitivity C-reactive protein to albumin ratio (HRR) with AVF maturation is still limited.

Methods: We included all ESRD patients undergoing first-time AVF creation between March and August 2024 at Haidian Hospital, Beijing (n = 249).

Developing a predictive nomogram for AMI in elderly patients with AHF: a retrospective analysis.

Background: This study focuses on the clinical issue of acute myocardial infarction (AMI) in the context of acute heart failure (AHF), particularly among the elderly population. Elderly patients with AHF experiencing AMI represent a severe cardiac condition with poor prognosis. Hence, this research aims to analyze potential risk factors and establish a clinical prediction model using logistic regression to facilitate early assessment and guide clinical decisions.

The internal and external reverse-reduction pathway involved in the degradation of free DNA bases during advanced oxidation processes.

The degradation kinetics and mechanism of four free bases were comparatively investigated during UV/HO and UV/PDS water treatment processes. The UV/PDS system demonstrated superior removal efficiency for all four bases compared to the UV/HO process. Pyrimidine bases (cytosine and thymine) exhibited notably faster degradation rates than purine bases (adenine and guanine) in both advanced oxidation systems.

Successful salvage therapy of ruxolitinib on interstitial pneumonia after long COVID or post-COVID-19 syndrome with follicular lymphoma: two case reports and literature review.

Background: Immunocompromised patients with B lymphocyte deficiency and hypogammaglobulinemia after anti-CD19 chimeric antigen receptor (CAR) T cell therapy for relapsed/refractory follicular lymphoma (FL) are at high risk of severe coronavirus disease 2019 (COVID-19) infection.

Case Description: In our study, two patients with refractory FL had persistent COVID-19 infection after their anti-CD19 CAR T cell therapy. The patients were diagnosed with post-COVID-19 syndrome or COVID-19 with interstitial inflammation and persistent hypoxemia.

3D printed osteochondral lineage-specific biphasic scaffolds for functional repair of full-thickness articular cartilage defects in weight-bearing area.

Functional repair of full-thickness defects in the weight-bearing articular cartilage has been one of the major challenges in orthopeadics. Whereas the advanced 3D printing technique allows the construction of bionic bioscaffolds that supporttissue regeneration. Herein, we developed a sort of lineage-specific biphasic scaffolds for osteochondral regeneration, fabricated via consecutive 3D-printing and lyophilization.

Error-Constrained Entropy-Minimizing Strategies for Multi-UAV Deception Against Networked Radars.

In complex electromagnetic environments, spatial coupling uncertainties-position errors and timing jitter-increase false target information entropy, reducing strategy effectiveness and posing challenges for robust UAV swarm track deception. This paper proposes an error-constrained entropy-minimizing compensation framework to model radar/UAV errors and their spatial coupling. The framework establishes closed-form gate association conditions based on the principle of entropy minimization, ensuring mutual consistency of false target measurements across multiple radars.

Inhibition by dissolved organic matter of the degradation of purine compounds by the sulfate radical.

Dissolved organic matter (DOM) has been known to inhibit the degradation of compounds in advanced oxidation processes but quantitative understanding is lacking. Given the variable concentrations and properties of DOM in real aquatic systems, the concentration-dependent kinetics of compounds degradation were systematically investigated in the presence of 8 DOM isolates separately during UV/peroxydisulfate (UV/PDS) process. Due to the ubiquitous presence of purine compounds in aquatic environments, guanine was selected as a model purine compound.

Co-embedding of curcumin and gold nanoparticles with ZIF-8 nanoparticles for the treatment of liver cancer and its impact on metabolomics.

The mortality rate of primary liver malignant tumors is very high. Curcumin (Cur) is one of the most commonly used drugs for the treatment of liver cancer. However, due to its low bioavailability, nano-drug delivery systems are rapidly developing.

Separation and Identification of a Novel Antioxidant and Calcium-Binding Peptide Derived from Phosvitin Hydrolysates: and Prediction.

This study aimed to identify a novel peptide from phosvitin hydrolysates with enhanced antioxidant and calcium absorption-promoting properties. Simultaneous enzymatic hydrolysates (trypsin + alkaline protease) exhibited better bifunctional activity than sequential enzymatic hydrolysates. Three components of phosvitin hydrolysates (PPP0, PPP1, and PPP2) were isolated by anion-exchange chromatography, and PPP2 displayed the highest activity.

WH021 Alleviates Lipopolysaccharide-Induced Neuroinflammation via Regulating the Intestinal Microenvironment and Protecting the Barrier Integrity.

Neuroinflammation is one of the major pathological factors leading to neurodegenerative diseases (NDs). Currently, drug treatment is the main strategy for controlling NDs, but long-term drug use has many side effects. Studies have shown that probiotics can regulate neuroinflammation via the microbiota-gut-brain axis, thereby preventing and alleviating NDs.

Insights into Chemoreceptor MCP2201-Sensing D-Malate.

Bacterial chemoreceptors sense extracellular stimuli and drive bacteria toward a beneficial environment or away from harm. Their ligand-binding domains (LBDs) are highly diverse in terms of sequence and structure, and their ligands cover various chemical molecules that could serve as nitrogen, carbon, and energy sources. The mechanism of how this diverse range of LBDs senses different ligands is essential to signal transduction.

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1-Cx3cr1 Axis.

This study aimed to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) on cognitive recovery in Alzheimer's disease (AD) by exploring the role of GABAergic neuron activation and modulation of the Cx3cl1-Cx3cr1 signalling axis. The 5xFAD mouse model was utilised for scRNA-seq analysis to examine changes in gene expression post-rTMS. Microglial phagocytic activity, amyloid plaque burden, cell-cell communication, microglial morphology and neuroinflammation markers were assessed.

Mechanistic insight into anaphase bridge signaling to the abscission checkpoint.

During cytokinesis in human cells, a failure to resolve persistent DNA bridges that span the cell-division plane maintains the Aurora B-dependent abscission checkpoint in an active state. However, the molecular mechanism by which unresolved sister-chromatid bridging signals to this checkpoint is poorly defined. Here, we define an essential role for the Bloom's syndrome helicase, BLM, in signaling to the abscission-checkpoint machinery in response to replication stress through the conversion of dsDNA bridges into RPA-coated ssDNA.

Synergistic combination of cinnamaldehyde with citral for improving bread preservation: inhibition of and .

Unlabelled: In order to improve the antifungal activity of natural fungicides to control the fungal contamination on bread products, the synergistic combination of cinnamaldehyde with citral (S) against main bread spoilage fungi ( and ) was screened. Compared to the single MICs of cinnamaldehyde and citral, the MICs of them against both fungi were significantly reduced by 74-87% when presented in S. In vitro tests demonstrated that S completely inhibited the spore germination and mycelial growth of both fungi at its MIC.

De novo AML spontaneously achieved PR after COVID-19 infection, and CR after reduced dose of azacytidine combined with venetoclax: A case report and literature review.

Rationale: Coronavirus disease (COVID-19) infection increases the mortality of patients with hematological malignancies. The optimal treatment for de novo acute myeloid leukemia (AML) patients with severe pneumonia caused by COVID-19 is not clear.

Patient Concerns: A 59-year-old woman was admitted to our department with fever, cough dyspnea, and thrombocytopenia for 1 week.

Outcomes of ultrasound-guided percutaneous ablation of >5 ≤ 5 colorectal liver metastases: a propensity score matching study.

Objectives: To investigate the effectiveness and safety of microwave ablation (MWA) in patients with 1-5 colorectal liver metastases (CRLM) those with 6-9 CRLM.

Methods: Data from patients with 1-9 CRLM, who underwent ultrasound (US)-guided percutaneous MWA between January 2018 and May 2023, were retrospectively analyzed. Propensity score matching (PSM) at a ratio of 1:2 was used to balance potential bias between the groups.

LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress.

Background: Clear cell renal cell carcinoma (ccRCC) accounts for 70% of renal cell carcinoma (RCC) cases. Although surgery remains the mainstay treatment, renal injury and high metastasis rates after nephrectomy dramatically reduce patient quality of life. Drugs that stimulate the immune system by targeting checkpoint pathways improve overall survival in patients with RCC.

Regulation of alkyl hydroperoxidase D by AhpdR in the antioxidant enzyme system of Pseudomonas aeruginosa.

An overabundance of reactive oxygen species (ROS) can disrupt the initial redox equilibrium within cells, resulting in metabolic issues, cellular harm, and potentially death. Pseudomonas aeruginosa is a widespread gram-negative environmental pathogen that causes serious infectious diseases in humans. P.

Association of preablation tumor biopsy and long-term outcomes of colorectal liver oligometastases.

Objective: To explore the association of preablation liver biopsy and long-term oncological outcomes in colorectal liver oligometastases (CLOM) (lesions, ≤5; diameter, <5cm).

Materials And Methods: This retrospective study included 149 patients who underwent percutaneous liver biopsy before microwave ablation and 259 patients who did not receive preablation biopsy between September 2009 and June 2023 from two tertiary hospitals. Primary outcome, intrahepatic recurrence-free survival (IRFS), and secondary outcomes, disease-free survival (DFS) and overall survival (OS) were analyzed using Cox regression and Kaplan-Meier methods.

Adaptive Dual-Task Deep Learning for Automated Thyroid Cancer Triaging at Screening US.

Purpose To develop an adaptive dual-task deep learning model (ThyNet-S) for detection and classification of thyroid lesions at US screening. Materials and Methods This retrospective study used a multicenter dataset comprising 35 008 thyroid US images of 23 294 individual examinations (mean age, 40.4 years ± 13.

Global trends in staphylococcus aureus-related lower respiratory infections from 1990 to 2021: findings from the 2021 global burden of disease report.

Background: Lower respiratory infections (LRIs) represent a significant global health issue, especially affecting low- and middle-income countries. In this study, we explored the mortality and disability-adjusted life years (DALYs) associated with Staphylococcus aureus-related LRIs from 1990 to 2021, highlighting trends by age, sex, and Socio-Demographic Index (SDI).

Methods: Data were derived from the 2021 Global Burden of Disease (GBD) database.