Plasma metabolites, metabolic risk score and colorectal cancer risk: a prospective cohort study.

The associations of colorectal cancer (CRC) risk with metabolites, lifestyle factors and their joint effects have not been fully elucidated. Therefore, we conducted a prospective cohort study to estimate the associations of CRC risk with metabolites, metabolic risk score (MRS) and its joint associations with lifestyle factors. This study included 82,514 participants with plasma metabolites data in the UK Biobank.

Investigation of Knowledge, Attitudes, and Practices Related to Pulmonary Rehabilitation Among AECOPD Patients During the Transitional Period After Discharge and Analysis of Influencing Factors.

Pulmonary rehabilitation is widely recognized as one of the most effective treatment strategies to improve dyspnea, health status, and exercise endurance in patients with chronic obstructive pulmonary disease (COPD). However, participation in pulmonary rehabilitation among patients experiencing acute exacerbation of COPD remains suboptimal. Current research primarily focuses on the knowledge, attitude, and practice (KAP) of pulmonary rehabilitation among COPD patients during hospitalization or at home, with limited studies investigating the transitional period following discharge.

Association between community environment and metabolic sydrome among Chinese middle-aged and older adults - Evidence from the national longitudinal surveys from 2011 to 2015.

Background: community environments that encourage active and socially engaged lifestyles may help reduce the risk of metabolic syndrome (MetS). This study aims to examine the relationship between community cultural and recreational environments and the incidence of MetS among middle-aged and older Chinese individuals. Methods: we used data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015, we included participants aged 45 years and older with complete relevant data.

Central line-associated bloodstream infections in children: a systematic review and meta-analysis.

Background: Central line-associated bloodstream infection (CLABSI) in pediatric patients poses significant clinical challenges, with prevention strategies heavily reliant on identifying modifiable risk factors. Despite numerous studies investigating these risk factors, heterogeneity in study designs, populations, and regional settings necessitates a systematic synthesis of evidence to guide clinical practice. This meta-analysis aims to consolidate existing data and quantify key risk factors for pediatric CLABSI.

Exercise Training Promotes Neural Remodeling and Vascular Regeneration in Cerebral Ischemic Rats Through the JNK/c-jun Signaling Pathway.

Exercise training can exert favorable effects on the remodeling of neural structures, functional reconstruction, and the recovery of neurovascular units after cerebral ischemia. It has also been documented to activate the JNK/c-jun pathway, which is involved in diverse cellular processes, including growth regulation, transformation, and programmed cell death. However, it remains obscure regarding the role of the JNK/c-jun pathway in the aforementioned exercise training-conferred neurological benefits.

Causal Association Between 12 Micronutrients and Common Chronic Respiratory Diseases: A Bidirectional Two-Sample Mendelian Randomization Study.

This study aims to investigate the causal relationships between 12 micronutrients and common chronic respiratory diseases, revealing whether these nutrients play a causative role in either preventing or exacerbating these conditions. We employed a bidirectional two-sample Mendelian randomization (MR) approach to explore the causal relationships between micronutrients and chronic respiratory diseases. Data were sourced from the IEU GWAS database, with micronutrients serving as exposure variables and chronic respiratory diseases as outcome variables for causal assessment.

Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial.

The optimal chemotherapy backbone and specific population of triple-negative breast cancer (TNBC) patients that benefit from neoadjuvant immunotherapy are not well established. This prospective, single-arm, phase II TREND trial assessed the efficacy and safety of tislelizumab plus nab-paclitaxel and epirubicin/cyclophosphamide-based chemotherapy as a neoadjuvant treatment for TNBC (ChiCTR2000035262). The primary endpoint was pathological complete response (pCR), with the secondary endpoints including safety assessment and objective response rate (ORR).

Honokiol in the treatment of triple-negative breast cancer: a network pharmacology approach and experimental validation.

Triple-negative breast cancer (TNBC) is a rare and highly metastatic form of cancer. Honokiol (HNK), a biphenolic compound, has been utilized in TNBC treatment, though its specific targets remain unclear. This study aimed to elucidate the effects of HNK on TNBC by combining network pharmacology predictions and experimental validation to uncover its mechanisms.

A novel SIV-infection animal model based on nude mice inoculated with MT-2 cells.

To establish a novel murine model conducive to simian immunodeficiency virus (SIV) replication in vivo, male BALB/c nude mice, aged three weeks, were administered a single intraperitoneal inoculation of SIV-infected MT-2 cells (derived from human T-cell leukemia). Subsequently, alterations in plasma viral load and the engraftment of MT-2 cells in vivo were examined, while immunological changes were assessed via ELISA and flow cytometry analysis. All of the mice in the experimental group exhibited detectable plasma viral loads in their peripheral circulation, largely due to the proliferation of SIV-infected MT-2 cells within the T-cell-deficient environment of nude mice, resulting in colonization of the abdominal cavity and lymph nodes and the subsequent release of free virions to perpetuate the infection.

A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma.

Liver hepatocellular carcinoma (LIHC) is a highly heterogeneous disease, necessitating the discovery of novel biomarkers to enhance individualized treatment approaches. Recent research has shown the significant involvement of ubiquitin-related genes (UbRGs) in the progression of LIHC. However, the prognostic value of UbRGs in LIHC has not been investigated.

Impact of aerobic exercise on brain metabolism: Insights from spatial metabolomic analysis.

Background: Exercise is acknowledged for its beneficial effects on brain health; however, the intricate underlying molecular mechanisms remain poorly understood.

Aims: This study aimed to explore aerobic exercise-induced metabolic alterations in the brain.

Methods: We conducted an eight-week treadmill running exercise program in two-month-old male C57/BL6J mice.

Dietary habit and risk of rheumatoid arthritis: a mendelian randomization study identifying protective and risk factors.

Purpose: Dietary habit significantly contributes to the initiation and progression of rheumatoid arthritis (RA). Dietary choices intersect with a range of clinical and societal factors. The utilization of cross-sectional methodologies in numerous studies poses a challenge in establishing definitive causality for the noted associations.

Perceived effectiveness of the person-environment-occupation innovative teaching model in rehabilitation therapy students.

Background: Given the characteristics of the rehabilitation therapy specialty and the drawback of the traditional didactic teaching approach, we developed the innovative teaching approach from the students' perspective using the person-environment-occupation (PEO) model. The new model was developed from the original PEO model to be applied in pedagogical contexts and tailored to the characteristics of an application-oriented specialty, such as rehabilitation therapy. The present study aimed to examine the perceived effectiveness of the PEO innovative teaching model applied to rehabilitation therapy students.

The Incidence and Risk Factors of Frailty in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis.

Objective: COPD patients have a high incidence of frailty and numerous complications, which seriously affect their quality of life. This study systematically evaluated and analyzed the current state of frailty incidence and risk factors in COPD patients to reduce the prevalence of frailty and enhance their quality of life.

Method: The Cochrane Library, PubMed, Embase, Web of Science, CBM, CNKI, VIP, and Wanfang databases were searched for relevant studies from the inception of each database until November 2022.

Development of an obesity-related multi-gene prognostic model incorporating clinical characteristics in luminal breast cancer.

Despite adjuvant chemotherapy and endocrine therapy in luminal breast cancer (LBC), relapses are common. Addressing this, we aim to develop a prognostic model to refine adjuvant therapy strategies, particularly for patients at high recurrence risk. Notably, obesity profoundly affects the tumor microenvironment (TME) of LBC.

Protection effects of mice liver and lung injury induced by coronavirus infection of Qingfei Paidu decoction involve inhibition of the NLRP3 signaling pathway.

Ethnopharmacological Relevance: Coronavirus Disease 2019 (COVID-19) is a grave and pervasive global infectious malady brought about by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), posing a significant menace to human well-being. Qingfei Paidu decoction (QFPD) represents a pioneering formulation derived from four classical Chinese medicine prescriptions. Substantiated evidence attests to its efficacy in alleviating clinical manifestations, mitigating the incidence of severe and critical conditions, and reducing mortality rates among COVID-19 patients.

Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?

Background: It's still controversial whether Helicobacter pylori (H. pylori) eradication can reverse atrophic gastritis (AG) and intestinal metaplasia (IM). Therefore, we performed a meta-analysis to estimate the effect of H.

Major depressive disorder and chronic gastritis: A bidirectional two-sample Mendelian randomization study.

Objective: Observational studies have posited a strong correlation between chronic gastritis (CG) and major depressive disorder (MDD), but the nature of this association remains uncertain, owing to the challenges of establishing the temporal sequence. The present study sought to elucidate the elusive relationship between CG and MDD by employing a bidirectional two-sample Mendelian randomization (MR) approach.

Methods: We extracted instrumental variants for MDD and CG from published genome-wide association study data, focusing on individuals of primarily European descent.

Variations of the double superior mesenteric vein are not rare: An observational study using computed tomography, three-dimensional image reconstruction, and surgery.

Introduction: Few studies have evaluated variations of the main trunk of the superior mesenteric vessels. Particularly, the double superior mesenteric vein (DSMV) has not been described in detail. This study aimed to establish the definition, anatomical characteristics, and underlying clinical significance of the DSMV.

Electroacupuncture-modulated extracellular ATP levels in prefrontal cortex ameliorated depressive-like behavior of maternal separation rats.

Maternal separation (MS) is a type of early-life stress that has been linked to neuropsychiatric disorders, especially depression. Increasing evidence indicates that the adenosine triphosphate (ATP) level in the prefrontal cortex (PFC) is involved in the pathophysiology of depression. To investigate the potential relationship between ATP in PFC and antidepressant effects of electroacupuncture (EA) treatment, we assessed genes involved in ATP biosynthesis as well as the extracellular ATP levels in a rat model exposed to neonatal MS.

Predation preference for extracellular polysaccharides by paramecia and rotifers may have accelerated the decline of membrane biofilm hydraulic resistance.

The hydraulic resistance of biofilm layer on membranes impacts the filtration resistance significantly. The effect of predation by two model microfauna (i.e.

Analysis of Erosion Characteristics and Erosion Mechanism of Polypropylene Fiber Tailings Recycled Concrete in Salt Spray Environment.

Economic development and infrastructure improvement will inevitably lead to the accumulation of construction waste and tailings, which has not only a huge impact on the environment but is also a waste of resources. Recycling these resources and making green concrete is an effective way to solve these problems. In this study, the salt spray erosion characteristics and erosion mechanism of tailings recycled concrete (TRC) with polypropylene fibers were studied through macro and micro methods.

Gastroprotective mechanism of modified lvdou gancao decoction on ethanol-induced gastric lesions in mice: Involvement of Nrf-2/HO-1/NF-κB signaling pathway.

Modified Lvdou Gancao decoction (MLG), a traditional Chinese medicine formula, has been put into clinical use to treat the diseases of the digestive system for a long run, showing great faculty in gastric protection and anti-inflammatory, whereas its protective mechanisms have not been determined. The current study puts the focus on the protective effect and its possible mechanisms of MLG on ethanol-induced gastric lesions in mice. In addition to various gastric lesion parameters and histopathology analysis, the activities of a list of relevant indicators in gastric mucosa were explored including ALDH, ADH, MDA, T-SOD, GSH-Px, and MPO, and the mechanisms were clarified using RT-qPCR, ELISA Western Blot and immunofluorescence staining.