Modulating the electronic state of Ni active sites in medium-entropy borides for enhanced water oxidation performance.

Medium-entropy materials (MEMs) have attracted significant attention for electrocatalytic water oxidation due to their exceptional physicochemical properties. However, limited efforts have been made to elucidate the origins of their extraordinary activity and the intricacies of their atomic arrangements. Herein, we present a novel magnetic field-assisted interface co-assembly approach for synthesizing CoFeNiMnB nanochains (Mn-MEB), effectively overcoming the immiscibility challenges associated with combining multiple metal elements.

Immobilization and accelerated conversion of polysulfides using vanadium-regulated metal sulfide catalysts for Li-S batteries.

Lithium-sulfur batteries possess significant potential due to their high energy density and cost-effectiveness. However, sluggish redox kinetics, polysulfide shuttle effects, and the inadequate oxidation of LiS impede their practical application. To overcome these challenges, electrocatalysts with high intrinsic activity are essential for enhancing performance.

Multi-omics analyses the effect of Bifidobacterium longum subsp. longum BL21 supplementation on overweight and obese subjects: a randomized, double-blind, placebo-controlled study.

Background: Bifidobacterium longum subsp. longum BL21 has demonstrated promise in alleviating gut microbiota disturbances and metabolic regulation in high-fat diet-induced obesity and type 2 diabetes mellitus models. However, the effect of probiotic B.

Altered expression of TEF gene in childhood constipation leads to a decrease in CD56 NK cells.

Objectives: This study used a quantitative bioinformatic analysis of public RNA sequencing databases to study key molecules mediating the occurrence of childhood constipation (CHC) and explore associated immune cell abnormalities and the role of natural killer (NK) cells.

Methods: Gene expression profiling datasets, including CHC (GSE36701), were obtained. Immune genes were downloaded from the MSigDB database, and 3,907 immune-related genes were obtained.

Minimal logic gates for probiotic Nissle 1917 sensing and treatment of dual-bacteria intestinal infection.

Rapid development of synthetic biology has led to engineered probiotics to address the growing concern of infectious diseases and cancer. Dual or multiple bacterial infections are becoming more frequent, but there are few treatment options because complex approaches are needed to address different disease mechanisms. In this study, we designed a minimal logic gate to program Nissle 1917 to detect and treat the disease caused by and .

Highly efficient activation of periodate by anodic contact glow discharge electrolysis for 3-chlorophenol degradation in water.

Periodate (PI) activation by anodic contact glow discharge electrolysis (ACGDE) was used to degrade 3-chlorophenol (3-CP) in water. The effects of the PI concentration, current intensity (mA), anions (Cl and SO), organic compounds (humic acid and RhB), and initial solution pH on the 3-CP removal rate were studied. The results show that PI was efficiently activated by ACGDE, leading to the rapid degradation of 3-CP.

Central line-associated bloodstream infections in children: a systematic review and meta-analysis.

Background: Central line-associated bloodstream infection (CLABSI) in pediatric patients poses significant clinical challenges, with prevention strategies heavily reliant on identifying modifiable risk factors. Despite numerous studies investigating these risk factors, heterogeneity in study designs, populations, and regional settings necessitates a systematic synthesis of evidence to guide clinical practice. This meta-analysis aims to consolidate existing data and quantify key risk factors for pediatric CLABSI.

Effect of BC99 supplementation on body weight and gut microbiota in overweight and obese individual: a randomized, double-blind, placebo-controlled study.

Introduction: Probiotic supplementation is a safe and effective way to reduce overweight and obesity by regulating the gut microbiota. The strain BC99 is derived from humans and has various probiotic-related, acid resistance, bile salt resistance, and adhesion-related domains in the genome. This study aimed to assess the effects of BC99 on the gut microbiota, body weight and lipid profiles of overweight and obese individuals.

Epstein-Barr virus-positive small cell neuroendocrine carcinoma of the nasopharynx: A clinicopathologic study of 7 cases and literature review.

Epstein-Barr virus (EBV)-positive small cell neuroendocrine carcinoma (NEC) of the nasopharynx is a rare entity with poorly characterized clinicopathological and prognostic features. In this study, seven cases of EBV-positive nasopharyngeal small cell NEC will be compared to 6 EBV-negative cases of nasopharyngeal small cell NEC. The overall EBV-positive rate, defined by EBV-encoded small RNAs (EBERs) in situ hybridization of nasopharyngeal small cell NEC, was 53.

Functional study of Bergeyella cardium KP-43 subfamily peptidases as putative T9SS cargo.

Bergeyella cardium causes infections in human organs. However, the mechanism of the virulence of B. cardium is unclear.

Phase-engineered metal boride nanobeads for highly efficient oxygen evolution.

Non-precious metals with tailored phase structures show promise as oxygen evolution reaction (OER) catalysts due to their high inherent catalytic activity and extensive exposed active surface area. However, the mechanisms by which phase structures enhance catalytic performance remain unclear. Herein, we synthesized an amorphous cobalt boride (CoB) catalyst via a magnetic field-assisted method, yielding uniform nanoparticles that self-assemble into a nanobead structure.

A novel predefined-time projective synchronization strategy for multi-modal memristive neural networks.

Due to its complexity, the problem of predefined-time synchronization in multimodal memristive neural networks has rarely been explored in the literature. This paper is the first to systematically study this issue, filling a research gap in the field and further enriching the related theoretical framework. First, a novel predefined-time stability theorem is proposed, which features more lenient judgment conditions compared to existing methods.

FTO-mediated regulation of Kupffer cell polarization and interleukin-6 secretion promotes biliary epithelial cell proliferation in intrahepatic bile duct stones.

Objective: Intrahepatic cholangiolithiasis (Intrahepatic bile duct stones, IBDSs) is a common hepatobiliary disease characterized by bile duct obstruction and inflammation, often leading to severe complications such as cholangitis, cirrhosis, and cholangiocarcinoma. This study investigates the role of fat mass and obesity-associated (FTO) protein, an RNA demethylase, in regulating Kupffer cell (KC) polarization, interleukin (IL)-6 secretion, and subsequent human intrahepatic biliary epithelial cell (HiBEC) proliferation in IBDS.

Material And Methods: Liver tissues from patients with IBDS were analyzed for FTO expression, KC M2 polarization, and IL-6 levels.

Inhibition of glutaminase 1 reduces M1 macrophage polarization to protect against monocrotaline-induced pulmonary arterial hypertension.

(1) BACKGROUND: Metabolic abnormalities and immune inflammation are key elements within pathogenesis of pulmonary arterial hypertension (PAH). And in PAH patients, aberrant glutamine metabolism has been observed; however, the function of glutaminase 1 (GLS1) in macrophage is still unknown. So we aims to investigate GLS1's impact upon macrophages in PAH.

Microbiome and metabolome analysis in smoking and non-smoking pancreatic ductal adenocarcinoma patients.

Background: Smoking is a significant risk factor for pancreatic ductal adenocarcinoma (PDAC). This study aimed to investigate the effects of smoking on the pancreatic microbiome and metabolome in resectable and unresectable male PDAC patients.

Methods: The pancreatic tissue samples were collected from resectable PDACs via surgery and unresectable PDACs via endoscopic ultrasound fine needle aspiration (EUS-FNA).

Controlled Heterovalent Vanadium Ion Coordinated Flower-Shaped Supramolecules Cathode for Zinc-Ion Storage.

Vanadium-based materials, which offer multiple oxidation states and rich redox reactions in zinc-ion batteries (ZIBs), have gained substantial attention. However, achieving green and efficient preparation of vanadium oxides-based materials featured with a controlled content of different heterovalent vanadium remains a significant challenge. Herein, a vanadium-supramolecular flower-shaped material (VSF) with heterovalent vanadium was prepared using NHVO as vanadium metal center and hexamethylenetetramine as organic ligand in aqueous solution.

Twelve Shugan Lidan Granules from traditional Chinese medicine can improve liver function in patients with postoperative hepatolithiasis by inhibiting the Hippo signaling pathway.

Introduction: Hepatolithiasis (HL) is a complex liver and biliary disorder characterized by high rates of recurrence. This study aimed to evaluate the efficacy of Twelve Shugan Lidan Granules (TSLG), a compound herbal traditional Chinese formulation, in the treatment of HL, as well as to investigate its underlying mechanism.

Methods: A retrospective analysis was conducted involving 157 patients diagnosed with HL, who were divided into two groups: the control group and the research group.

Polysaccharides from Lycium barbarum, yam, and sunflower ameliorate colitis in a structure and intrinsic flora-dependent manner.

Polysaccharides have been suggested to ameliorate metabolic diseases. However, their differential colitis-mitigating effects in mouse models with different colony structures remain poorly understood. Therefore, this study investigated the effects of polysaccharides from Lycium barbarum (LBP), sunflower (SP), and yam (YP) on colitis in C57BL/6 J (B6) mice born via vaginal delivery (VD) and in both caesarean section (CS)- and VD-born Institute of Cancer Research (ICR) mice.

Succession of the multi-site microbiome along pancreatic ductal adenocarcinoma tumorigenesis.

Background: To investigate microbial characteristics across multibody sites from chronic pancreatitis (CP), through pancreatic benign tumors, to pancreatic ductal adenocarcinoma (PDAC) at different stages.

Methods: 16S ribosomal RNA (rRNA) amplicon sequencing was conducted on saliva, duodenal fluid, and pancreatic tissue obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of patients with CP, pancreatic benign tumors, PDAC in stage I/II, III, and IV. The neutral community model (NCM) assessed the microbial assembly contribution and MaAslin2 identified the differential microbes.

Probiotics and their metabolite spermidine enhance IFN-γCD4 T cell immunity to inhibit hepatitis B virus.

The therapeutic potential of commensal microbes and their metabolites is promising in the functional cure of chronic hepatitis B virus (HBV) infection, which is defined as hepatitis B surface antigen (HBsAg) loss. Here, using both specific-pathogen-free and germ-free mice, we report that probiotics significantly promote the decline of HBsAg and inhibit HBV replication by enhancing intestinal homeostasis and provoking intrahepatic interferon (IFN)-γCD4 T cell immune response. Depletion of CD4 T cells or blockage of IFN-γ abolishes probiotics-mediated HBV inhibition.

Effect of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during eradication: a randomized, double-blind, placebo-controlled trial.

Background: () eradication has been reported to affect gut microbiota distribution. This study aimed to evaluate the effect of probiotic supplementation on the gastrointestinal microbiota during eradication and the efficacy of bismuth-containing quadruple therapy.

Methods: One hundred treatment-naïve -positive patients were randomly assigned 1:1 to receive 14-day bismuth-containing quadruple therapy (esomeprazole, bismuth, amoxicillin, and clarithromycin) combined with the probiotic ( subsp.

Comparison on clinical efficacy and adverse reactions between TPICC and ultrasound-guided PICC for advanced tumors: A retrospective study.

Comparing the differences in efficacy and adverse reactions on the application between tunnel peripherally inserted central catheter (TPICC) and ultrasound-guided peripherally inserted central catheter (PICC) in patients with advanced tumors. A retrospective investigation was conducted to collect treatment data. We randomly selected 200 patients with advanced tumors who were admitted to our hospital from January 2020 to January 2022 as the research subjects.

Sensing of Liver-Derived Nicotinamide by Intestinal Group 2 Innate Lymphoid Cells Links Liver Cirrhosis and Ulcerative Colitis Susceptibility.

The correlation between liver disease and the progression of ulcerative colitis (UC) has remained elusive. In this study, it demonstrates that liver injury is intricately linked to the heightened severity of UC in patients, and causes more profound intestinal damage during DSS-induced colitis in mice. Metabolomics analysis of plasma from liver cirrhosis patients shows liver injury compromising nicotinamide supply for NAD biosynthesis in the intestine.

β-catenin mediates monocrotaline-induced pulmonary hypertension via glycolysis in rats.

Background: Metabolic abnormalities and immune inflammation are deeply involved in pulmonary vascular remodelling and the development of pulmonary hypertension (PH). However, the regulatory mechanisms of glycolysis in macrophages are still elusive. Cumulative evidence indicates that β-catenin plays a crucial role in metabolic reprogramming.