Comprehensive genomic characterization of the soybean G3PDH gene family and its role in virus resistance.

Background: Glycerol 3-phosphate dehydrogenase (G3PDH) mediated the reduction of dihydroxyacetone phosphate to generate Glycerol 3-phosphate (G3P). G3P plays a significant role in plant anti-viral systemic acquired resistance (SAR). Therefore, it is crucial to systematically characterize the G3PDH gene family, especially its role in virus infection in soybean, to facilitate the cultivation of disease-resistant soybean seeds.

Association between complete blood count-derived inflammatory biomarkers and renal failure: a cross-sectional study from NHANES 2007-2020.

Objective: Renal failure is a serious public health concern, and its prevalence has been steadily increasing in recent years. This study aims to use data from a nationally representative sample of adults in the USA to investigate the association between inflammatory markers derived from complete blood counts and the prevalence of renal failure.

Design: This study is a cross-sectional study.

Tire wear particles (TWPs) induced toxicity in wheat (Triticum aestivum L.) by affecting osmotic regulation, redox homeostasis, photosynthesis, and microbial density.

Tire wear particles (TWPs) are commonly found in soil environments; however, their impacts on soil ecosystems, particularly on wheat (Triticum aestivum L.) physiology, remain largely unexplored. This study aimed to investigate the effects of TWPs at concentrations of T0 (control), T1 (0.

Characteristic Analysis of and Screening Validation of Interacting Proteins with 1.

The innate immune response is an important defense against invading pathogens. Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. However, some viruses have evolved the ability to inhibit the function of STING and evade the host antiviral defenses.

The role of LKB1 in prostate cancer: implications for tumor progression and therapy.

Liver kinase B1 (LKB1/STK11) is a key tumor suppressor that regulates cellular metabolism, epigenetic states, and multiple signaling pathways in prostate cancer (PCa). Recent studies reveal that both genetic and non-genetic LKB1 loss drives metabolic reprogramming, lineage plasticity, and treatment resistance, mainly through dysregulation of the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), and Hedgehog (Hh) pathways. This review summarizes current evidence on LKB1-centered networks in PCa, highlighting the potential link between LKB1 inactivation, epigenetic remodeling, and aggressive tumor phenotypes.

Effects of landscape fragmentation on floodplain fishes as revealed by species-habitat networks.

How species interact with habitat patches is influenced primarily by habitat configuration (e.g., connectivity) and species' functional traits.

Alkaline stress suppresses soybean waterlogging tolerance by exacerbating energy expenditure and ROS accumulation.

To clarify the synergistic inhibition mechanisms of saline-alkali and waterlogging combined stress on soybean physiology, this study systematically analyzed phenotypic traits, photosynthetic characteristics, reactive oxygen species (ROS) metabolism, and energy metabolism under saline-alkali (A + NW), waterlogging (NA + W), and combined stress (A + W). Results demonstrated that saline-alkali stress significantly impaired waterlogging-induced morphological adaptations, with A + W reducing dry weight and adventitious root number compared to W alone. Synergistic photosynthetic damage was observed: net photosynthetic rate (Pn) under A + W decreased markedly versus controls, while chlorophyll b content increased, suggesting PSII light-harvesting complex reorganization to mitigate photoinhibition.

Modulating the electronic state of Ni active sites in medium-entropy borides for enhanced water oxidation performance.

Medium-entropy materials (MEMs) have attracted significant attention for electrocatalytic water oxidation due to their exceptional physicochemical properties. However, limited efforts have been made to elucidate the origins of their extraordinary activity and the intricacies of their atomic arrangements. Herein, we present a novel magnetic field-assisted interface co-assembly approach for synthesizing CoFeNiMnB nanochains (Mn-MEB), effectively overcoming the immiscibility challenges associated with combining multiple metal elements.

Progress in the Application of Fluorescent Probes for Surgical Navigation in Breast Cancer Models.

Breast cancer surgery presents significant challenges, including difficulties in accurately localizing tumors, detecting small lesions, and identifying lymph node metastases, all of which compromise therapeutic outcomes and increase the risk of postoperative recurrence. Near-infrared fluorescence (NIRF) imaging technology has emerged as a promising tool for surgical navigation in breast cancer surgery due to its high resolution, real-time imaging capability, excellent biocompatibility, and minimal background interference. This review provides a comprehensive overview of recent advances in fluorescent probes for breast cancer surgical navigation with an emphasis on preclinical studies conducted in small animal models.

Molecular mechanism of the combined exposure to AFB1 and DON in promoting the functional and phenotypic remodeling of porcine alveolar macrophages.

Aflatoxin B1 (AFB1) and deoxynivalenol (DON) often coexist and exhibit immunotoxicity. Recent studies have reported that AFB1 and DON exposure alone not only promoted immunosuppression, but also induced inflammation, demonstrating as bidirectional immunotoxicity. Nevertheless, whether the combination of AFB1 and DON exhibit bidirectional immunotoxicity and their mechanism remain unclear.

A Chemically Tailorable Multifunctional Protein Platform for Glutamatergic Neuron Targeting in Mouse Brain.

Targeting glutamatergic neurons is critical for understanding brain functions and treating neurological disorders linked to glutamate dysregulation. However, existing methods face challenges including low specificity, slow kinetics, poor blood-brain barrier (BBB) penetration, and reliance on transgenic pathways. Here, we report the cyanobacterial ferredoxin-dependent glutamate synthase (Fd-GOGAT) as a non-transgenic, multifunctional platform for rapid and selective targeting of glutamatergic neurons in vivo.

Nitrogen-Modulated Reaction Pathways for Densified Carbon Architectures with Enhanced Volumetric Capacity.

Volumetric performance is critical due to space constraints in practical applications. However, although conventional high-surface-area porous carbons show high gravimetric capacity, their low density limits volumetric energy density. Herein, a compact carbon material was constructed through nitrogen chemical engineering, achieving a high area-specific capacity (1.

A case report of adenoid cystic carcinoma combined with giant renal metastasis treated with robotic surgery.

Adenoid cystic carcinoma (ACC) is a rare head and neck tumor with low incidence, characterized by local recurrence and early metastasis following surgical treatment. The common sites of metastasis for this cancer are typically the lungs, liver, brain, and bone, while metastasis to the kidneys is rare. This article reports a case of renal metastasis in a patient with adenoid cystic carcinoma of the maxillary sinus, occurring 16 years after surgery.

NRDR Inhibits the Migration of Endometrial Cancer Cells and Affects Their Gene Expression.

Studying the pathogenesis of endometrial cancer is important to treatment of endometrial cancer. NADP(H)-dependent retinol dehydrogenase/reductase (NRDR) is associated with the development of cancer. Our previous research has found that NRDR can inhibit the synthesis of estradiol (E2) in granulosa cells.

Periodontal disease and chronic kidney disease: mechanistic insights and novel therapeutic perspectives.

Periodontal disease (PD) is one of the most common chronic diseases of the oral cavity, and it usually refers to chronic inflammatory diseases caused by the infection of pathogenic microorganisms in the oral cavity. PD mainly affects the tissues around the teeth, causing inflammation of the gums and periodontium, destroying the alveolar bone, and even leading to tooth loosening. Many studies have shown that PD is not only limited to oral health but is also associated with diseases of multiple systems throughout the body.

Optimizing machine learning methods for groundwater quality prediction: Case study in District Bagh, Azad Kashmir, Pakistan.

Groundwater quality monitoring is crucial for protecting the environment and human health. Machine learning (ML) offers substantial potential for enhancing groundwater quality prediction, classification, and identification of pollution indicators. This study evaluates various base ML algorithms and stacking ensemble classifiers (meta-classifiers) using data from 90 groundwater samples collected in District Bagh, Azad Kashmir, Pakistan.

Integrated assessment of groundwater hydrogeochemistry and quality using multivariate statistical analysis, self-organizing maps, and water quality indices in District Bagh, AJK, Pakistan.

Groundwater is a critical resource in the District Bagh, Azad Jammu & Kashmir, Pakistan, but its quality is deteriorating due to anthropogenic and natural impacts. This study evaluates the hydrochemistry and quality of groundwater using an integrated approach that includes Multivariate Statistical Analysis, Self-Organizing Maps, Weighted Arithmetic Water Quality Index, Multiple Linear Regression and Irrigation Water Quality Indices. The study revealed significant differences in physicochemical characteristics, such as cations and anions in the groundwater samples, suggesting both natural and anthropogenic impacts.

A Unified Microstructure-Based Constitutive Model for a Ni-Based Superalloy and Its Application in the Forging Processes of Disk.

This study proposes a novel unified constitutive model that systematically integrates the microstructure evolution and macroscopic stress-strain response during the hot deformation of a Ni-based superalloy. The proposed model incorporates a suite of microstructural variables, including damage fraction, recrystallization fraction, δ phase content, average grain size, and dislocation density. Furthermore, the model explicitly considers critical macroscopic stress state parameters, specifically the magnitude and orientation of maximum principal stress, hydrostatic stress component, and Mises equivalent stress.

Mechanical bowel preparation versus no bowel preparation for oesophageal cancer surgery: a multicentre, randomized, parallel, open-labelled trial.

Objectives: To compare post-operation influence between mechanical bowel preparation (MBP) and no MBP (NBP) before surgery for patients with oesophageal cancer.

Methods: In this multicentre, parallel, open-labelled trial, eligible patients who were prepared to undergo oesophagectomy in 3 hospitals in China were randomly assigned (1:1) to an MBP or NBP group. Patients allocated to the MBP group prepared their bowel by drinking 3-4 l of polyethylene glycol dissolved in water the day before surgery.

Percutaneous nephrolithotomy for renal stones combined with laser endoscopy for ipsilateral renal cysts: a case report and literature review.

Renal cysts and renal stones are common diseases in urology, but it is less common for both to coexist in a patient's kidney. In some unsophisticated urology clinics, separate elective treatments for renal cysts and renal stones are usually chosen, reducing the surgery risk but increasing the financial burden for patients. In this paper, we report a case of percutaneous nephrolithotomy for managing renal stones and endoscopy of renal cysts.

An intelligent system for precise management of coagulants in sludge conditioning: Inspired by the exploratory behavior in primates using senses.

Coagulation conditioning is a key step for sludge dewatering, while the control of optimal coagulant dosing is still a challenge. This study proposes an intelligent system for the precise management of coagulants (IIS) in sludge conditioning. This system was assembled using an electrical impedance spectroscopy (EIS)-based sensor and a decision-making model to conduct the self-perception, decision-making, execution, and dosage optimization in sludge conditioning through a feedback-driven exploratory trial process, conceptually inspired by structured exploration behavior observed in primates.

A Chemistry-Informed Generative Deep Learning Approach for Enhancing Voltammetric Neurochemical Sensing in Living Mouse Brain.

Exploring the time-resolved dynamics of neurochemicals is essential for deciphering neuronal functions, intercellular communication, and neurophysiological or pathological mechanisms. However, the complex interplay among neurochemicals between neurocytes, coupled with extensive chemical signal crosstalk, puts simultaneous sensing of multiple neurochemicals into a longstanding challenge. Herein, we report a chemistry-informed generative neural network (CIGNN) model to separate the Faradaic and the non-Faradaic components from voltammetric currents, minimizing their mutual interference and enhancing quantitative accuracy.

Ex Vivo Pharmacokinetic/Pharmacodynamic Integration Model of Cefquinome Against in Foals.

Cefquinome is used to treat septicemia caused by () and respiratory infections caused by subsp. in foals. However, studies reporting the use of cefquinome to target as pathogens of sepsis are lacking.

Influence of Preheating on the Microstructure of a Hot Extruded Nickel-Based Superalloy.

Some studies have reported the microstructure evolution of nickel-based superalloys during isothermal forging (IF). However, most of them have not taken into account the microstructure evolution during the preheating stage in manufacturing processes. Investigating the microstructure evolution mechanisms during preheating of nickel-based superalloy can provide a more accurate characterization of the initial microstructures prior to IF.

Improving the washability of conductive textiles by constructing a dually crosslinked polyvinyl alcohol network with silver nanowires.

Conductive textiles, as an important platform for developing wearable electronic devices, often face challenges related to washing to remove dirt while retaining conductivity. It is still a great challenge to manufacture textiles with high conductivity, washability and uniformity in an efficient and economical way. Polyvinyl alcohol (PVA) containing numerous hydroxyl groups allowing easy modification and crosslinking is a promising candidate for conductive textile construction.