Synergistic Mechanisms in Fenton-like Reactions: Coal Gasification Fine Slag-loaded Fe-Al LDH Catalysts for Phenolic Wastewater degradation.

Coal gasification fine slag (CGFS), a typical coal-based solid waste, poses significant environmental challenges with an annual output exceeding 50 million tons in China. The complex distribution of carbon and ash components necessitates the development of a material that can effectively harness both carbon and ash for comprehensive utilization. While layered double hydroxides (LDHs) exhibit catalytic potential, their performance is often limited by severe particle aggregation.

Impact of tertiary lymphoid structure scores and their stage of maturation on prognosis of colorectal cancer patients.

Tertiary lymphoid structures (TLSs) are essential for promoting immune responses against tumours. However, the impact of TLS score and its maturation stage on the prognosis of colorectal cancer (CRC) patients has not yet been clarified. The aim of this study was to investigate the relationship between TLS score and its maturation stage and CRC prognosis through a retrospective study.

Point Defect Detection and Classification in MoS Scanning Tunneling Microscopy Images: A Deep Learning Approach.

Point defects in two-dimensional materials such as MoS can critically impact their electronic and optoelectronic properties. Precise identification of these defects is essential for understanding defect physics and device performance. In this work, we acquire high-resolution scanning tunneling microscopy (STM) images of monolayer MoS and apply the Segment Anything Model (SAM) to automatically segment possible defect regions in the STM images.

Association of peripheral immune markers with brain age and dementia risk estimated using deep learning methods.

Background: The peripheral immune system is essential for maintaining central nervous system homeostasis. This study investigates the effects of peripheral immune markers on accelerated brain aging and dementia using brain-predicted age difference based on neuroimaging.

Methods: By leveraging data from the UK Biobank, Cox regression was used to explore the relationship between peripheral immune markers and dementia, and multivariate linear regression to assess associations between peripheral immune biomarkers and brain structure.

Collagen glycation-mediated mechanical stress aggravates ischemia-reperfusion injury.

Ischemia-reperfusion (IR) injury is a grave concern because of its substantial risk of organ failure in organ transplantation. Understanding its mechanism is essential for exploring potential management strategies to alleviate IR injury. In this study, we investigate the development of IR injury from a biomechanical perspective.

Associations of Estimated Glucose Disposal Rate With Stroke Risk and Poststroke Adverse Outcomes: A Prospective Cohort Study.

Aims: This study investigated the relationship between estimated glucose disposal rate (eGDR), a validated marker of insulin resistance, and stroke subtypes and poststroke outcomes. Despite eGDR's established role in predicting cardiovascular outcomes, its impact on stroke risk and prognosis has not been fully explored.

Methods: This study included 462,550 participants from the UK Biobank with eGDR assessments, and participants were stratified into three categories based on tertiles of eGDR.

Berberine hydrochloride-loaded liposomes-in-hydrogel microneedles achieve the efficient treatment for psoriasis.

Psoriasis is a common immune-mediated squamous skin disease, primarily characterized by the over proliferation of keratinocytes and a significant thickening of the stratum corneum. Traditional systemic drug delivery therapies often fall short due to low drug bioavailability and significant toxic side effects. Topical medications, while capable of achieving local or systemic treatment via transdermal routes, face limitations in psoriasis patients due to the abnormal thickening of the epidermis, which reduces skin permeability and hampers drug penetration efficiency.

Colloidal quantum dots: surface and interface engineering for light-driven hydrogen production.

Solar energy is the most abundant and clean energy resource for the production of hydrogen, which is inexpensive but requires robust semiconductors. Colloidal quantum dots (CQDs) are considered an ideal semiconductor for hydrogen production. Although light-driven hydrogen production systems have been explored for multifarious CQD-based materials and devices, a comprehensive summary on surface and interface engineering has been rarely reported.

Liposomes-in-Gel as the Docetaxel Delivery for the Effective Treatment of Psoriasis by Inhibiting the Proliferation of Blood Vessels.

Psoriasis is a chronic skin disease caused by the interaction of multiple factors that leads to the abnormal growth of stratum corneum cells and has been called an immortal cancer. Docetaxel has been trialed for the treatment of psoriasis due to its superior ability to induce apoptosis, but its insolubility and low bioavailability have hampered its development. Here, docetaxel (DTX)-loaded liposomes-in-gel (DTX-LP-G) as the transdermal delivery was investigated to the treatment of psoriasis via modulating the IL6-HIF-1α-VEGF axis.

Gut microbiota contributes to obstructive sleep apnea-induced hypertension by gut-heart axis in mice.

Background: The gut microbiome has been closely linked to obstructive sleep apnea (OSA)-associated hypertension (HTN). However, its precise role in the pathogenesis of OSA-induced HTN remains unclear.

Methods: To clarify the causal relationship between gut dysbiosis and OSA-related HTN, C57BL6J mice were randomly assigned to four groups.

Siblicide between fertilized and unfertilized ovaries within the maize ear.

Evolutionarily, plants overproduce ovaries but selectively eliminate those inferiors to ensure competitive offspring to set. This sibling rivalry, reducing grain number, is detrimental agronomically. However, the interaction between early-fertilized and unfertilized ovaries in sequentially-pollinated panicles is unclear.

Low-threshold colloidal quantum dot polariton lasing a strong coupling microcavity at room temperature.

Colloidal quantum dots (CQDs) are excellent optical gain media that can be synthesized through low-cost and easily controlled techniques, holding significant promise for applications in semiconductor laser devices. In this study, we demonstrated polariton coherent lasing based on a CdSe-based CQD microcavity device at room-temperature (RT) for the first time. The dispersion behaviors of CQD polaritons with different excitation powers were comprehensively analyzed using angle-resolved spectroscopy techniques.

Association of nutritional and inflammatory status with all-cause and cardiovascular mortality in adults with sarcopenia: Insights from NHANES.

Objective: Associations between scores on the advanced lung cancer inflammation index (ALI) and mortality among sarcopenic adults remains unknown. This study investigates the relationship between ALI and both all-cause and cardiovascular mortality among adults with sarcopenia.

Methods: The study involved sarcopenic adults from the National Health and Nutrition Examination Survey (NHANES), conducted between 1999 and 2006 and 2011-2018.

Enhanced Ultra-narrowband Fast Response Ultraviolet Photodetector based on GaN Homojunction with a Carbon-Doped Semi-insulating Intermediate Layer.

A narrowband detection photodetector (PD) serves as a rapid identifier of specific wavebands, holding immense significance in secure communication and spectral recognition. Herein, after carbon is doped into GaN, an acceptor energy level emerges in its band structure, which will compensate with donor states in GaN to reduce carrier concentration and make GaN semi-insulating, and it affected the dark current and electric field distribution of the GaN p-i-n PD. Operating at a bias of 0 V, the C-doped GaN p-i-n PD demonstrates an ultralow dark current density and a high light-to-dark current ratio compared to the undoped intrinsic i-layer GaN p-i-n PD.

The efficiency of endocardial suture occlusion of the left atrial appendage at a single institution: MICs vs. sternotomy.

Background: Most thrombi originate from the left atrial appendage (LAA), preventing thromboembolic stroke is an important aspect of stroke prevention. Previous studies have found that LAA closure is beneficial for preventing thrombosis. Currently, surgical procedures can achieve LAA closure by closing the endocardium or epicardium.

HIV-1 Vpu and SARS-CoV-2 ORF3a proteins disrupt STING-mediated activation of antiviral NF-κB signaling.

Activation of the stimulator of interferon genes (STING) pathway by cytosolic DNA leads to the activation of the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NF-κB). Although many viruses produce proteins that inhibit IRF3-dependent antiviral responses, some viruses produce proteins that inhibit STING-induced NF-κB activation without blocking IRF3 activation. Here, we found that STING-activated, NF-κB-dependent, and IRF3-independent innate immunity inhibited the replication of the DNA virus herpes simplex virus type 1 (HSV-1), the RNA virus coxsackievirus A16 (CV-A16), and the retrovirus HIV-1.

Association between depression and liver function biomarkers among US cancer survivors in NHANES 2005-2020.

Depression frequently comorbidities with cancer, adversely affecting survivors' quality of life. Liver dysfunction is also prevalent among cancer survivors. However, the association between these two conditions remains unclear.

Incomplete filling in the basal region of maize endosperm: timing of development of starch synthesis and cell vitality.

Starch synthesis in maize endosperm adheres to the basipetal sequence from the apex downwards. However, the mechanism underlying nonuniformity among regions of the endosperm in starch accumulation and its significance is poorly understood. Here, we examined the spatiotemporal transcriptomes and starch accumulation dynamics in apical (AE), middle (ME), and basal (BE) regions of endosperm throughout the filling stage.

Curcumin-Loaded Liposomes in Gel Protect the Skin of Mice against Oxidative Stress from Photodamage Induced by UV Irradiation.

Prolonged exposure to ultraviolet (UV) irradiation can cause oxidative stress in the skin, accompanied by rapid immunosuppressive effects, resulting in a peroxidation reaction throughout the body. Curcumin (Cur), as the bioactive compound of turmeric, is a natural polyphenol with potent antioxidant properties but is often overlooked due to its poor solubility and low bioavailability. In this study, curcumin-loaded liposomes in a sodium alginate gel complex preparation were designed to improve the bioavailability of curcumin and to study its preventive effect on photodamage.

P4HA3 promotes head and neck squamous cell carcinoma progression via the WNT/β-catenin signaling pathway.

Here, we explored the role of Prolyl 4-Hydroxylase Subunit Alpha 3 (P4HA3), the most recently identified member of the prolyl-4-hydroxylase (P4H) family, in head and neck squamous cell carcinoma (HNSCC) progression. P4HA3 is upregulated during cancer progression; however, its specific role in HNSCC progression remains elusive. Thus, this study aimed to elucidate the regulatory function of P4HA3 in HNSCC development and progression and to describe the underlying mechanisms.