Recurrence formula-based automatic gradient eddy current compensation method for a 0.255 T MRI system.

Gradient coils play a critical role in magnetic resonance imaging (MRI) systems by enabling spatial encoding through generating rapidly switching magnetic fields. However, these time-varying fields induce eddy currents in surrounding conductive structures, leading to gradient field distortions and imaging artifacts. In this study, we propose an automatic eddy current compensation method implemented on a field-programmable gate array (FPGA) platform.

Automatic Magnetic Field Shimming by Spectrum Convergence Method: Evaluation at a 7-T Animal MRI System.

The ultrahigh field magnetic resonance imaging (MRI) superconducting magnets require a high homogeneous magnetic field within the diameter of spherical volume (DSV) to generate high-quality images. Spherical harmonic-based B shimming relies significantly on the fitting process, which can be computationally demanding, particularly when managing multiple shim coils. The study presents an automatic room-temperature shimming approach that iteratively adjusts shim coil currents to enhance magnetic field homogeneity, using the full width at half maximum (FWHM) of the spectrum as a metric.

The value and application of a poorly differentiated cluster-based Ezrin marginal score system in the prognostic assessment of colorectal cancer.

Aim: This study aimed to explore the distribution of Ezrin-positive cells in poorly differentiated cluster (PDC) of colorectal cancer (CRC), and its correlation with both traditional and auxiliary pathological indicators, including E-cadherin and tumor-stroma ratio (TSR), as well as patient prognosis.

Methods: We selected 59 patients with stage I-III who underwent radical surgery to observe the expression of CRC under hematoxylin and eosin (H&E) and immunohistochemistry (IHC) staining. This study establishes the poorly differentiated cluster-based Ezrin marginal score (PDC-EMS), which quantifies the tendency of Ezrin-positive cells to accumulate at the margins of PDC, to evaluate the validity and superiority of this assessment method.

promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.

Background: Clear cell renal cell carcinoma (ccRCC) represents the predominant form of kidney cancer. The Ras homology (Rho) GTPases family plays essential roles in several tumors. However, few studies have reported the function and clinical value of the Rho GTPases family in ccRCC.

The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi.

Preoperative downstaging of renal cell carcinoma with a tumor thrombus (RCC-TT) makes thrombectomy feasible. However, treatment resistance is common and may partly be attributed to the tumor-promoting role of the tumor microenvironment (TME). Herein, we sequenced, integrated, and comprehensively analyzed multi-center, multi-omics data from 164 RCC-TT patients and identified two clinically relevant RCC-TT subtypes.

Raman Spectroscopy Reveals the Multifunctional Role of Interfacial Water in CO-to-C Electroreduction on Cu() Surfaces.

Interfacial water serves as both a proton donor and a competitor for active sites at the copper-catalyst interface in the electrochemical CO reduction reaction (CORR). However, its precise impact on C product selectivity remains debatable. Here, through the utilization of Raman spectroscopy and theoretical calculations, we have discovered that the population of K cation hydrated water (K-HO) rises concurrently with the increase of C yield on atomically flat model Cu() single crystal surfaces.

Accelerating multi-directional diffusion MRI through patch-based joint reconstruction.

Diffusion magnetic resonance imaging (dMRI) is a valuable technique for studying tissue microstructure and connectivity in the brain. However, acquiring high-resolution dMRI data is time-consuming, limiting its clinical applicability. Traditional parallel imaging techniques can accelerate the acquisition of dMRI, but they are constrained by the geometry factor.

Gradient coil design for a 0.23 T NICU MRI system using an improved two-step Target-Field Method with enhanced linearity and compact design.

This study presents an optimized gradient coil design for a miniature 0.23 T MRI system, aimed at improving absolute and relative magnetic field linearity while accommodating various gradient thicknesses. The design uses a two-step optimization approach: the first step uses Tikhonov regularization to solve a linear problem, providing a stable solution, and the second step refines the solution through nonlinear constrained optimization to further enhance field linearity.

Revolutionizing the Female Reproductive System Research with Additive Manufacturing.

The female reproductive system is highly complex, making it essential for applied research and translational medicine to accurately model its intricate physiological functions or develop strategies for restoring them. However, significant structural and functional differences between human and animal models, along with the limitations of static 2D cell culture technologies, underscore the need for more dynamic and sophisticated platforms, as well as therapies. These advancements are critical for deepening our understanding of reproductive biology and supporting clinical applications.

Ultrahigh-field animal MRI system with advanced technological update.

Animal magnetic resonance imaging (MRI) systems typically deliver superior imaging performance over conventional human MRI systems, making them a prevailing instrument in preclinical research. It is challenging to achieve the high performance of these animal MRI systems, due to the multifaceted nature of the various system components and the complexity of integration debugging. This work described the design, fabrication, measurement and integration of a 7 T animal MRI system, which exhibits several performance highlights.

An L0-Norm-Based Method for Passive Shimming Design in MRI: A Simulation-Based Study.

In a magnetic resonance imaging (MRI) system, it is highly desirable to achieve superior homogeneity of the static magnetic field (B0) within the imaging region for high-performance imaging. Passive shimming (PS) is a widely used technique that employs ferromagnetic materials to reduce the B0 deviations. However, the PS installation process often involves multiple manual iterations due to system or human errors, causing efficiency and accuracy difficulties.

RBC balanced immuno-inflammatory signatures identify advanced breast cancer patients on CDK4/6 inhibitors at increased risk of progression and death.

The association of immuno-inflammatory parameters, especially RBC balanced signatures, with survival outcomes and adverse events still require investigation for advanced breast cancer (ABC) patients receiving cyclin-dependent kinase 4/6 inhibitor (CDKI). Herein, RBC balanced immuno-inflammatory (RBC-IMM) score was developed and capable of predicting progression-free survival (PFS) events ( < 0.001), death ( < 0.

Elevating Nitrate Reduction through the Mastery of Hierarchical Hydrogen-Bond Networks.

To effectively resolve environmental and industrial dilemmas, electrochemical reduction of nitrate (NO) to ammonia (NH) offers a brilliant strategy for tackling pollution and creating economic value, but the scarcity and reduced reactivity of available interfacial water and reactive adsorbates represent ongoing obstacles. Here, we reform the water-ion networks via electrolyte concentration manipulation and electrode construction on atomically flat Au single-crystal surfaces. With the combination of in situ Raman spectroscopy and multifidelity theoretical simulations, we pinpoint HO with dual hydrogen-bond donors as an observable indicator for nitrate electroreduction (NORR).

Functional polymorphism of CYCLE underlies the diapause variation in moths.

Diapause is a common seasonal adaptive strategy that regulates annual timing in insects. Very few causal loci underlying diapause variation have yet been identified. By leveraging cross-mapping and genome-wide association analysis, we identified the N terminus of the clock protein CYCLE as a major causal effector underlying embryonic diapause differences in the silk moth.

FBLIM1 drives bile duct ligation-induced liver fibrosis by regulating the TGF-β signaling pathway through WTAP-mediated m6A modification.

Background: Liver fibrosis is one of the main severe pathological consequences of obstructive jaundice, and an effective treatment strategy is urgently needed. Filamin-binding LIM protein 1 (FBLIM1) is associated with fibrosis, however, there is no evidence to show the effect of FBLIM1 on obstructive jaundice.

Methods: In our study, we investigated the function of FBLIM1 in bile duct ligation (BDL) rat models and human hepatic stellate cell (HSC) line LX-2.

Design and simulation of a 7.0 T conduction cooled superconducting magnet.

A Conduction cooled superconducting magnet (SM) for human magnetic resonance imaging, made of NbSn superconducting coils, has been designed. The magnet features a warm bore with a diameter of 850 mm and a central field strength of 7 T. The size and positioning of a bundle of seven epoxy-impregnated coils were determined using both linear and nonlinear optimization methods.

Family adenomatous polyposis come across dome type adenocarcinoma: a case report and literature review.

Dome-type carcinoma (DC), also referred as Gut-associated lymphoid tissue (GALT) carcinoma, is a rare variant of colorectal adenocarcinoma which has been seldomly reported up to now. We report a case of a DC lesion developed in a 33-year-old male diagnosed with family adenomatous polyposis (FAP). A 1.

Molecular basis of circadian rhythm divergence between diurnal and nocturnal lepidoperans.

Understanding the molecular basis of nocturnal and diurnal behaviors is crucial to uncovering adaptive specialization. Here, we employed the black cutworm (, BCW) to examine the rhythmic gene repertoire in nocturnal species. Daily eclosion patterns confirmed BCW's nocturnal behavior.

GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. Even though the targeted drugs for the treatment of ccRCC have a certain therapeutic effect, due to the problem of drug resistance, the search for new targets for targeted therapy of ccRCC remains urgent. GAMT is an enzyme involved in creatine metabolism.

Customizable bistable units for soft-rigid grippers enable handling of multi-feature objects data-driven design.

Soft-rigid grippers represent a novel paradigm for grasping complex objects, combining the high deformability of soft components with the high stiffness of rigid components. Recently, bistable structures, as architected materials for engineering soft components, have attracted significant attention for their ability to enable rapid-response grasping and shape self-locking. However, challenges persist in utilizing them for handling multi-feature objects, , irregular-shaped, fragile, and variable-weight objects.

Attenuation of cardiac ischemia/reperfusion injury via the decoy receptor DcR2 by targeting the PLAD domain of the death receptor DR5.

Myocardial cell death caused by ischemia and hypoxia is the main cause of myocardial injury. DcR2 is the decoy receptor of TRAIL, and the role of DcR2 in myocardial ischemia/reperfusion (I/R) injury is largely unknown. Recent studies have shown that DcR2 not only binds to TRAIL as a receptor but also acts as a ligand for DR5 to block TRAIL-induced apoptosis in vitro, but the preference of DcR2 for binding to TRAIL or DR5 in vivo remains unknown.

Diosmetin Inhibits NETs Formation in Neutrophils Through Regulating Nrf2 Signaling.

Background: Neutrophil extracellular traps (NETs) are important pieces of equipment for neutrophils. Excess NETs play promoting roles in cancer-associated thrombosis (CAT). Therefore, directing NETs formation is a promising therapeutic strategy in thrombosis and related diseases.

Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms.

Background: Recently, several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms (R-NENs). However, none of these methods can achieve 100% complete resection (CR), particularly in the vertical direction. Endoscopic full-thickness resection (EFTR) has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.

A multi-channel MRI console for ultra-high field up to 14 T.

Ultra-high field magnetic resonance imaging (MRI) offers significant advantages in terms of signal-to-noise ratio and spatial resolution. In this study, we detail the development of a multi-channel home-built MRI console operating at 14 T. We propose a hybrid analog-digital framework that shifts high-frequency radio frequency transmission and reception issues to lower frequencies, utilizing software-defined radio technology to process these low-frequency signals.

Design, Fabrication and Test of a Lightweight 3.0 T Cryogen-Free MRI System With GM Refrigerator for Imaging Small Animals and Materials.

Objective: To construct and evaluate a lightweight, high-performance and cost-effective 3.0 T MRI system with enhanced spatiotemporal magnetic field characteristics for advanced imaging applications.

Methods: A lightweight 3.