Rap1a regulates CUMS-induced neuroinflammation and cognitive dysfunction and emotional abnormalities in mice.

Rap1a is a member of the Ras family of proteins and first came into view as an immune modulator of cells, playing roles in both innate and adaptive immunity. It is widely distributed in various tissue cells and is closely related to multiple biological functions of cells, including immunity, proliferation, differentiation, adhesion, and angiogenesis. Homocysteine (HCY) is a sulfur-containing non-essential amino acid that does not participate in protein synthesis.

Fungal Communities in Various Environments.

Fungi are fundamental components of ecosystems that play indispensable roles in biomass decomposition and nutrient cycling [...

Effects of multiple freeze-thaw cycles on the foaming and structural properties of egg whites subjected to different thawing methods.

This study systematically investigated the effects of multiple freeze-thaw(F-T)cycles using four thawing methods on the foaming characteristics of egg white proteins and their regulatory mechanisms. The results indicated that the foaming capacity of air and water bath thawed samples increased with the number of F-T cycles. In contrast, vacuum thawing significantly reduced the foaming capacity, while ultrasonic thawing exhibited the optimal foaming capacity.

Taxonomic Characterization and Genome Analysis of Polaribacter gochangensis sp. nov., Isolated From a Tidal Clam Farm.

Strain MF5-112 is a Gram-negative, aerobic, non-motile, ovoid, and non-flagellated bacterium with yellow pigmentation that exhibits oxidase-positive and catalase-negative characteristics. It was isolated from tidal mudflat sediment at a clam farm in Gochang, Republic of Korea. Phylogenetic analysis based on 16S rRNA gene sequence comparisons revealed that strain MF5-112 belongs to the family Flavobacteriaceae.

A T-cell intrinsic Role for Risk Alleles in Allograft Rejection.

African Americans have an increased risk of kidney disease due to exonic variants in Apolipoprotein-L1 (G1 and G2). These prevalent variants have also been linked with kidney rejection, but outside of association with African ancestry, underpinning causal mechanisms are unknown. We investigated T-cell function using transgenic mice with physiologic expression of wild type (G0-), G1-, or G2-APOL1.

Characterization of Sulfitobacter sediminivivens sp. nov., A Novel Halotolerant, Nitrogen-Assimilating Bacterium from Tidal Flat Sediment.

A novel halotolerant bacterial strain, designated MF3-043, was isolated from marine sediment collected at the Gunsan tidal flat, South Korea. The strain was characterized as a Gram-negative, aerobic, non-motile, oval-shaped rod bacterium that exhibited catalase and oxidase-positive activities. Colonies were circular, convex, and cream-white in color.

gen. nov., sp. nov., a novel member of the isolated from tidal flat sediment.

A strictly aerobic, Gram-stain-negative, ovoid-shaped and non-motile bacterium, designated as strain MJ-SS7, was isolated from tidal mudflat sediment collected at a macro-tidal clam farm in Gochang, Republic of Korea. Strain MJ-SS7 exhibited oxidase- and catalase-positive activities. Growth occurred at 20-37 °C (optimum: 30 °C), pH 6-8 (optimum: pH 7) and in the presence of 0-9% (w/v) NaCl (optimum: 3%).

High-resolution monochromatic backlit imaging of the Cu Kα characteristic line using a toroidal crystal system for plasma diagnostics.

Laser-driven plasma diagnostics commonly rely on high-resolution monochromatic x-ray imaging using α-quartz (211) spherical crystals at an 88.7° Bragg angle for the Cu Kα characteristic line. However, the performance of this imaging approach is constrained by astigmatism-induced resolution limits (<10 μm) and background noise interference.

Eutrophication influences diversity and community-level change points of mycoplankton in subtropical estuaries.

Mycoplankton are essential for biogeochemical cycles in natural water bodies. However, the distribution of the mycoplanktonic community and its community-level change points in subtropical estuaries remain unclear. In this study, we employed 18S rRNA high-throughput sequencing to explore the mycoplanktonic community structure and environmental thresholds in the Dafengjiang River Estuary.

Dissolved oxygen and nitrates gradient influence marine microbial complexity and stability in Beibu Gulf.

Environmental gradients are important for bacteria community in marine ecosystems. However, the tipping points of environmental heterogeneity and ecological responses to disturbances in marine ecosystems are still unclear. In this study, we sampled seawater from different layers of Beibu Gulf to investigate bacterial composition, diversity, network complexity and stability, and environmental thresholds.

Occurrence, Source Apportionment, and Risk Assessment of Antibiotics in the Zhuozhang River, China: A Specific Investigation in Water-Scarce and Human Activity-Intensive Regions.

Antibiotic contamination and its environmental impact in water-scarce and human activity-intensive regions have been poorly researched, particularly in the Zhuozhang River, China. Thus, this study investigated the occurrence, sources, and ecological risks of 27 different antibiotics in the Zhuozhang River, based on water samples collected from representative locations including major reservoirs, upstream of the river, the main river channel, and a wastewater treatment plant (WWTP). Results showed widespread contamination by quinolones, with concentrations ranged from 41.

PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer.

Introduction: Breast cancer (BRCA) is a phenotypically and functionally heterogeneous disease. New biomarkers or therapeutic targets must be discovered to improve treatment effects. The polymeric immunoglobulin receptor (PIGR) plays an anti-cancer role in various human malignancies.

OTUD3 inhibits breast cancer cell metastasis by regulating TGF-β pathway through deubiquitinating SMAD7.

Background: Breast cancer (BRCA) is the most common malignant tumor in women, and distant metastasis is an important cause of death. Epithelial mesenchymal transition (EMT) is an important factor in tumor cell metastasis, in which TGF-β signaling pathway plays an important role. SMAD7 can inhibit TGF-β pathway.

Comparative efficacy of rTMS on different targets in Alzheimer's disease: a systematic review and meta-analysis.

Background: Repetitive transcranial magnetic stimulation (rTMS) is emerging as a promising non-invasive intervention for Alzheimer's disease (AD), yet therapeutic outcomes remain inconsistent across studies. This meta-analysis aimed to evaluate the cognitive benefits of rTMS in AD patients, with a specific focus on stimulation targets and protocols variations.

Methods: A systematic literature search was conducted in PubMed, Web of Science, Embase, and Cochrane Library for relevant English-language studies published up to 31 May 2024.

CRISPR mutant rapid identification in : RNA-Seq functional profiling and breeding technology application.

Introduction: Traditional rapeseed breeding is inefficient and imprecise. CRISPR genome editing offers a precise alternative for trait improvement. Here, we edited the gene in elite rapeseed cultivar ZS11 to study its role in floral organ abcission and enable rapid trait transfer to elite lines.

MXene and its composites combined with photocatalytic degradation of Perfluorooctanoic acid: efficiency and active species study.

Perfluorooctanoic acid (PFOA), a persistent pollutant with severe environmental and health risks, demands advanced degradation strategies. This study introduces MXene-based composites combined with TiO for efficient photocatalytic PFOA degradation. MXene was synthesized via HCl/LiF etching, achieving a 97.

Fungal Community Complexity and Stability in Clay Loam and Sandy Soils in Mangrove Ecosystems.

Soil fungi in mangroves are diverse and crucial for organic matter decomposition and element cycling. However, the drivers influencing network complexity and the stability of fungal communities across different mangrove soil habitats remain unclear. This study investigated the main factors driving the composition, diversity, complexity, and stability of fungal communities in clay loam and sandy soils in mangrove ecosystems.

Cerebral CIC-NUTM1 rearrangement sarcoma- case report and review of the literature.

Background: Ewing sarcoma and Ewing-like sarcoma are both highly aggressive small round cell sarcomas, while CIC rearranged sarcoma (CRS), the most common specific type of Ewing-like sarcoma, exhibits a more aggressive course than Ewing sarcoma and represents a distinct family of sarcomas. NUT midline carcinoma family member 1 (NUTM1) is a characteristic fusion gene of NUT midline carcinoma. In this paper, the intracranial tumor CIC is mainly fused with NUTM1, which is considered to be a molecular variant of CIC sarcoma.

Event-related dynamic phase-amplitude coupling analysis reveals facial emotional processing deficits in patients with major depressive disorder: a cross-sectional study.

Background: Phase-amplitude coupling (PAC) measures the interaction between neural oscillations in different frequency bands and reflects brain functional network coordination in psychiatric patients. The event-related dynamic changes in PAC characteristics and their association with the neural physiological mechanisms under emotional stimulation in major depressive disorder (MDD) remain poorly understood.

Methods: We proposed a cross-sectional study that investigated three PAC methods using simulated data and selected the Gaussian-Copula Event-Related PAC (GC-ERPAC) method for dynamic analysis of 128-channel electroencephalogram data from 53 participants, including 24 patients with MDD and 29 healthy controls (HCs).

sp. nov., isolated from commercial soil.

A novel bacterial strain, designated DS6, was isolated from the commercial soil for biofertilization and characterized as a novel species within the phylum. The morphological and biochemical analysis revealed that strain DS6 is a Gram-positive, rod-shaped bacterium with pili, forming ivory colonies on R2A agar after 3 days of incubation at 25 °C. The strain shows a broad growth pH range of 4-9, with an optimum pH of 8, and can tolerate temperatures between 20 and 45 °C, optimally growing at 37 °C.

PRDX6 knockdown sensitizes multiple myeloma cells to ferroptosis through inactivation of the PI3K/AKT pathway.

Background: This study probes into the impact and mechanisms of PRDX6 on ferroptosis multiple myeloma (MM).

Research Design And Methods: PRDX6 expression in MM cells were determined using Western blotting and qRT-PCR. MM cells were treated with pLKO-shPRDX6 vectors expressing PRDX6 shRNA alone or in combination with Erastin/ferrostatin-1 (ferroptosis activator/inhibitor) or 740Y-P (PI3K/AKT pathway activator).

Causal Contributions and Interhemispheric Interactions of the Left and Right Supramarginal Gyri in Vocal Feedback Control: Insights From Dual-Site Transcranial Magnetic Stimulation.

The bilateral supramarginal gyri (SMGs) have been implicated in sensorimotor control of speech production, yet their precise roles and interhemispheric interactions are poorly understood. This event-related potential study employed dual-site continuous theta burst stimulation (c-TBS) over the bilateral SMGs simultaneously to investigate their functional dynamics in vocal motor control. Following unilateral and bilateral c-TBS over the SMG as well as sham stimulation, participants vocalized the vowel sounds while exposed to unexpected pitch perturbations in auditory feedback.

Divergent spatiotemporal signatures characterize impaired facial emotional recognition in major depressive disorder: An event-related microstate study.

Background: Major depressive disorder (MDD) is a chronic affective mental disorder with intricate neuropathological characteristics. Microstate analysis has proved its ability to reveal the relatively stable features in a specific brain process. However, the relationship between event-related microstate networks and affective dysfunctions in patients with MDD is not well known.

Customizable bistable units for soft-rigid grippers enable handling of multi-feature objects data-driven design.

Soft-rigid grippers represent a novel paradigm for grasping complex objects, combining the high deformability of soft components with the high stiffness of rigid components. Recently, bistable structures, as architected materials for engineering soft components, have attracted significant attention for their ability to enable rapid-response grasping and shape self-locking. However, challenges persist in utilizing them for handling multi-feature objects, , irregular-shaped, fragile, and variable-weight objects.