Occurrence, Source Apportionment, and Risk Assessment of Antibiotics in the Zhuozhang River, China: A Specific Investigation in Water-Scarce and Human Activity-Intensive Regions.

Antibiotic contamination and its environmental impact in water-scarce and human activity-intensive regions have been poorly researched, particularly in the Zhuozhang River, China. Thus, this study investigated the occurrence, sources, and ecological risks of 27 different antibiotics in the Zhuozhang River, based on water samples collected from representative locations including major reservoirs, upstream of the river, the main river channel, and a wastewater treatment plant (WWTP). Results showed widespread contamination by quinolones, with concentrations ranged from 41.

Transient receptor potential melastatin 4 contributes to early-stage endothelial injury induced by arsenic trioxide.

Background/aims: To investigate the effect of Arsenic Trioxide (ATO) on endothelial cells injury and explore the role of transient receptor potential melastatin 4 channel (TRPM4) in ATO-induced endothelial injury.

Methods: qRT-PCR was used to examine the mRNA expression of TRPM4 in human umbilical vein endothelial cells (HUVECs). The protein levels were measured by Western blot and immunostaining.

The effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury.

The present study evaluated the effect of anagliptin on intimal hyperplasia following carotid artery injury in Sprague‑Dawley rats. Sprague‑Dawley rats weighing 280‑300 g were injured using a 2F Fogarty balloon embolectomy catheter. The rats were divided into injury‑(saline) and anagliptin‑(10 mg/kg/day) treated groups.

Transforming Growth Factor-β Receptor III is a Potential Regulator of Ischemia-Induced Cardiomyocyte Apoptosis.

Background: Myocardial infarction (MI) is often accompanied by cardiomyocyte apoptosis, which decreases heart function and leads to an increased risk of heart failure. The aim of this study was to examine the effects of transforming growth factor-β receptor III (TGFβR3) on cardiomyocyte apoptosis during MI.

Methods And Results: An MI mouse model was established by left anterior descending coronary artery ligation.