Case Report: A patient with an empty sella accompanied by rare thyrotoxicosis.

Empty sella (ES) involves herniation of the pituitary fossa, leading to pituitary flattening. While typically associated with central hypothyroidism, its co-occurrence with hyperthyroidism is rarely reported and often overlooked. We report a rare case of hyperthyroidism in a patient with ES.

Recurrence formula-based automatic gradient eddy current compensation method for a 0.255 T MRI system.

Gradient coils play a critical role in magnetic resonance imaging (MRI) systems by enabling spatial encoding through generating rapidly switching magnetic fields. However, these time-varying fields induce eddy currents in surrounding conductive structures, leading to gradient field distortions and imaging artifacts. In this study, we propose an automatic eddy current compensation method implemented on a field-programmable gate array (FPGA) platform.

Automatic Magnetic Field Shimming by Spectrum Convergence Method: Evaluation at a 7-T Animal MRI System.

The ultrahigh field magnetic resonance imaging (MRI) superconducting magnets require a high homogeneous magnetic field within the diameter of spherical volume (DSV) to generate high-quality images. Spherical harmonic-based B shimming relies significantly on the fitting process, which can be computationally demanding, particularly when managing multiple shim coils. The study presents an automatic room-temperature shimming approach that iteratively adjusts shim coil currents to enhance magnetic field homogeneity, using the full width at half maximum (FWHM) of the spectrum as a metric.

The Predictive Significance of Interleukin-2 Receptor in Patients with Hepatocellular Carcinoma.

Background: The tumor immune microenvironment (TME) plays a key role in the development of hepatocellular carcinoma (HCC). As the important components of TME, interleukin-2 (IL-2) mediates immune responses by specifically binding to the interleukin-2 receptor (IL-2R). This study aimed to explore the role of IL-2R in HCC development and provided possible clinical implications in HCC prognosis and treatment.

Electrical Connector Assembly Based on Compliant Tactile Finger with Fingernail.

Robotic assembly of electrical connectors enables the automation of high-efficiency production of electronic products. A rigid gripper is adopted as the end-effector by the majority of existing works with a force-torque sensor installed at the wrist, which suffers from very limited perception capability of the manipulated objects. Moreover, the grasping and movement actions, as well as the inconsistency between the robot base and the end-effector frame, tend to result in angular misalignment, usually leading to assembly failure.

Flexible ultrathin metasurface with open-ring spiral resonators for SNR enhancement in low-field 0.2 T MRI.

Low-field magnetic resonance imaging (MRI) systems (<0.5 T) have emerged as increasingly valuable tools for emergency and bedside imaging due to their cost-effectiveness and portability, but their adoption is limited by low signal-to-noise ratio (SNR). Conventional optimization methods offer limited improvements, while current metasurface technologies face challenges related to clinical integration, such as excessive dimensionality, and inadequate SNR enhancement at low magnetic field strengths.

Immunotherapy and radiotherapy: An effective combination in cancer treatment.

Immunotherapy has been widely used in cancer treatment in recent years and functions by stimulating the immune system to kill tumor cells. Radiation therapy (RT) uses radiation to induce DNA damage and kill tumor cells. However, this activates the body's immune system, promoting the release of tumor-related antigens from inactive dendritic cells, which stimulates the recurrence and metastasis of tumors in immune system tissues.

Fenbendazole induces pyroptosis in breast cancer cells through HK2/caspase-3/GSDME signaling pathway.

Introduction: Pyroptosis, a gasdermin (GSDM) - mediated programmed cell death associated with inflammation, has emerged as a promising strategy for cancer therapy. Metabolic reprogramming, a hallmark of cancer, presents potential targets for malignancy intervention. Fenbendazole (FBZ), a safe and inexpensive antiparasitic drug, has shown antitumor activities, but its underlying mechanisms remain unclear.

Detection of β-Hydroxybutyric Acid Based on a Fluorescent Probe of Lanthanide Complexes.

In this paper, a lanthanide complex-based fluorescent sensor Tb(4-MBA) was developed for the selective recognition of diabetic ketoacidosis (DKA) and the diabetes biomarker β-hydroxybutyric (β-Hb). β-Hb significantly enhanced the fluorescence emission of the Tb(4-MBA) complex at 539  nm. Based on the analysis of the surface electrostatic potential distribution and time-resolved spectra, we speculate that in the reaction system of β-Hb with Tb(4-MBA), β-Hb and Tb(4-MBA) may form a complex through hydrogen bonding interactions, which brings β-Hb closer to Tb and thus reduces the non-radiative energy loss of the solvent molecules to Tb and significantly enhances the Tb(4-MBA) fluorescence intensity.

Dual RNA-seq analysis reveals the interaction between multidrug-resistant Klebsiella pneumoniae and host in a mouse model of pneumonia.

Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a significant global health threat, associated with high morbidity and mortality rates among hospitalized patients. The interaction between MDR-KP and its host is highly complex, and few studies have investigated these interactions from both the pathogen and host perspectives. Here, we explored these interactions in a mouse model of pneumonia using dual RNA-seq analysis.

A fluorescent probe based on the interaction of ofloxacin with gold nanoparticles for the sensitive detection of melamine.

Melamine (MEL) is frequently adulterated in dairy products to manipulate protein content test results due to its high nitrogen content. In this study, a fluorescent probe based on ofloxacin (OFL) and gold nanoparticles (AuNPs) was proposed for the specific and sensitive detection of MEL. In the pH range of 4.

PP2C-Mediated ABA Signaling Pathway Underlies Exogenous Abscisic Acid-Induced Enhancement of Saline-Alkaline Tolerance in Potato ( L.).

Saline-alkali stress severely inhibited potato growth, yield, and quality, and exogenous abscisic acid (ABA) played an important role in plant stress resistance. In this study, potato tissue culture seedlings were used as experimental materials, the control group was cultured in the MS medium without adding any substances, and the treatment group was cultured in MS medium supplemented with 50 mmol/L NaHCO or 50 mmol/L NaHCO + 38 µM ABA, respectively. To explore the effect of exogenous ABA on the biological characteristics of potato plants under saline-alkali stress, a genetic improvement strategy was designed based on PP2C (PGSC0003DMT400046381), a key gene of the ABA signaling pathway.

Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice.

Background: Enterovirus 71 (EV71) is the primary cause of severe neurological infections associated with Hand, Foot and Mouth Disease (HFMD) in children, and no specific therapeutic agent is available. Breviscapine injection (BRE Injection) is widely used in China for its neuroprotective properties in ischemic stroke.

Objective: To investigate the therapeutic impact and mechanisms of BRE Injection and its main component scutellarin in preventing fatal infection of EV71 in newborn mice.

Ultrahigh-field animal MRI system with advanced technological update.

Animal magnetic resonance imaging (MRI) systems typically deliver superior imaging performance over conventional human MRI systems, making them a prevailing instrument in preclinical research. It is challenging to achieve the high performance of these animal MRI systems, due to the multifaceted nature of the various system components and the complexity of integration debugging. This work described the design, fabrication, measurement and integration of a 7 T animal MRI system, which exhibits several performance highlights.

Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment.

There is increasing evidence that the intake of specific dietary supplements may reduce the risk of breast cancer. Pterostilbene (PTE), a naturally occurring stilbene compound that is widely found in berries, induced pyroptosis in EMT6 and 4T1 cells in a dose-dependent manner. Additionally, si Gasdermin E (GSDME) and Z-DEVD-FMK (a caspase-3 enzymatic activity inhibitor) significantly inhibited PTE-induced pyroptosis in these cells.

Dual-barrier traversing liposomes with ROS-responsive rigidity tuning for oral ischemic stroke therapy.

For sustained ischemic stroke intervention, oral delivery remains optimal. However, conventional nanocarriers like liposomes fail to overcome both the intestinal epithelial (IEB) and blood-brain barriers (BBB). We engineered dual-functional, butylphthalide (NBP)-loaded liposomes (C-NBP Lip) via amphiphilic cytidine-lipoic acid conjugate (LA-C) functionalization, establishing the first unified nanoplatform for nucleoside transporter-mediated targeting and reactive oxygen species (ROS)-responsive membrane modulation.

Comparative Efficacy of Different Targeted Therapies in Patients With Moderate-to-Severe Ulcerative Colitis: Systematic Review/Network Meta-Analysis and Mechanistic Overview.

Ongoing evaluations of targeted therapies for moderate-to-severe ulcerative colitis (UC) continue to unfold, with the emergence of novel drugs. However, head-to-head trials comparing these therapies are still lacking. The aim of this study is to investigate the therapeutic effects of targeted therapies in moderate-to-severe UC.

Multi-omics analysis reveals metabolic disruptions in cardiac tissues of aging nonhuman primates with spontaneous type 2 diabetes.

Background: The complex interplay between type 2 diabetes (TM) and obesity, particularly in aging populations, is increasingly recognized for its significant contribution to cardiac dysfunction. However, the metabolic changes within cardiac tissues that underlie this relationship remain poorly understood.

Methods: We employed a multi-omics approach to investigate the metabolic alterations in cardiac tissues of aging nonhuman primates with spontaneous TM and obesity.

Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.

Radiotherapy remains the cornerstone of treatment for glioblastoma (GBM). However, the frequent occurrence of radiation resistance presents a significant therapeutic challenge. A comprehensive understanding of the mechanisms underlying this resistance is essential for improving GBM treatment strategies.

The Relationships Among Family Involvement, Diabetes Self-Management and Glycaemic Control in Patients With Type 2 Diabetes: A Cross-Sectional Study.

Aims: To investigate diabetes family involvement, including supportive and nonsupportive family behaviours in China, and explore the relationships among opposite forms of family involvement, diabetes self-management and glycaemic control.

Design: A cross-sectional study.

Methods: Type 2 diabetes patients were recruited from hospitals in Nanjing, Shanghai and Jinan, and communities across China, between April 2023 and August 2023.

Psychological intervention in individuals with subthreshold depression: individual participant data meta-analysis of treatment effects and moderators.

Background: It remains unclear which individuals with subthreshold depression benefit most from psychological intervention, and what long-term effects this has on symptom deterioration, response and remission.

Aims: To synthesise psychological intervention benefits in adults with subthreshold depression up to 2 years, and explore participant-level effect-modifiers.

Method: Randomised trials comparing psychological intervention with inactive control were identified via systematic search.

Nitrogen and sulfur co-doped carbon dots for the fluorescence detection of lactose in milk.

For lactose-intolerant patients, controlling lactose intake is crucial. To address this need, we developed carbon dot-based sensors for lactose detection in milk. Using citric acid and sulfamic acid as precursors, we synthesized nitrogen and sulfur co-doped carbon dots (N,S-CDs) via hydrothermal method.

Ability of SPP1 to Alleviate Post-Intracerebral Hemorrhage Ferroptosis via Nrf2/HO1 Pathway.

Purpose: This study aimed to investigate the role of secretory phosphoprotein 1 (SPP1/OPN) in modulating iron-induced cell death (ferroptosis) following intracerebral hemorrhage (ICH). By integrating transcriptomic analysis and experimental validation, we sought to identify key molecular pathways and therapeutic targets associated with ferroptosis in ICH.

Method: The Gene Expression Omnibus Series GSE24265 dataset was analyzed using the limma package (R platform) to identify differentially expressed genes.

CitACOS5 is crucial for male fertility in citrus by influencing pollen exine formation.

Male sterility (MS) holds great potential and value for breeding seedless cultivars of fruit trees. However, functional characterization of MS-related genes has been difficult in perennial fruit crops, because of extended juvenile period and difficulties in genetic transformation. In this study, we compared anther development of 'Qianyang Seedless' (QS), a natural seedless bud sport (somatic mutation) of Ponkan mandarin (Citrus reticulata Blanco) with a stable MS phenotype, with that of the seedy wild-type 'Egan NO.

Evaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.

Objective: We undertook this study to assess the efficacy of probiotics in managing adverse reactions during chemoradiotherapy in patients with colorectal cancer.

Method: A comprehensive literature search was conducted on PubMed, ClinicalTrials.gov, Embase, Cochrane library,Web of Science, and Chinese databases until July 27, 2024.