Efficacy and safety of electroacupuncture-based comprehensive treatment for post-stroke depression: a systematic review and meta-analysis of randomized controlled trials.

Objective: This research aims to assess the therapeutic effects and safety of treatments for PSD by conducting a thorough systematic review and meta-analysis.

Methods: Randomized controlled trials (RCTs) were retrieved from PubMed, Embase, Web of Science, The Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wan Fang, covering all available records up to September 30, 2024. RCTs evaluating on the efficacy and safety of electroacupuncture in individuals with PSD were included.

Electroacupuncture with different current intensities can improve gastrointestinal motility in diabetic gastroparesis vagal and sympathetic pathways.

Background: Diabetic gastroparesis (DGP) disrupts gastric motility. Electroacupuncture (EA) at Zusanli (ST36) may alleviate DGP symptoms neural pathways.

Aim: To investigate how EA current intensities at ST36 regulate neural pathways and improve gastric motility in DGP models.

Mid-Term Management of Operating Room Equipment: Improving Surgical Quality.

This study focuses on the mid-term management theory of equipment lifecycle and systematically examines the impact of operating room instrument management on operational efficiency optimization. The review mainly covers four key aspects: operator training, information technology application, cost control, and quality assurance. The results indicate that mid-term management plays a crucial role in the full lifecycle management of operating room equipment and plays a key role in improving the quality of operating room operations.

Dietary omega-3 polyunsaturated fatty acids as a protective factor of myopia: the Hong Kong Children Eye Study.

Purpose: To evaluate the associations between omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and other dietary factors with myopia.

Methods: A total of 1005 Chinese children, aged from 6 to 8 years, from a population-based Hong Kong Children Eye Study, were included in the analysis. Diet was assessed using a validated food-frequency questionnaire.

Personality traits: an important factor affecting fear of movement in dialysis patients.

Background: This study investigated predictive factors and personality determinants of kinesiophobia (fear of movement) in dialysis patients. Methods: Using the Chinese versions of the Ten-Item Personality Inventory (TIPI-C) and Tampa Scale for Kinesiophobia Heart (TSK-SV heart), we assessed 329 patients from December 2022 to February 2023. The influencing factors of fear of movement were identified by univariate analysis and multiple linear regression.

Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers.

Cadherin 17 (CDH17) is found to be abnormally expressed in colorectal cancer (CRC) and linked to a prognosis. Its consistent presence in both primary and metastatic CRC positions it as a promising biomarker. This study aims to develop CDH17-targeted immuno-positron emission tomography (immunoPET) probes and evaluate their potential for diagnosing CRC.

A dynamic reconstruction and motion estimation framework for cardiorespiratory motion-resolved real-time volumetric MR imaging (DREME-MR).

Based on a 3D pre-treatment magnetic resonance (MR) scan, we developed DREME-MR to jointly reconstruct the reference patient anatomy and solve a data-driven, patient-specific cardiorespiratory motion model. Via a motion encoder simultaneously learned during the reconstruction, DREME-MR further enables real-time volumetric MR imaging and cardiorespiratory motion tracking with minimal intra-treatment k-space data. Approach: DREME-MR integrates dynamic MRI reconstruction and real-time MR imaging into a unified, dual-task learning framework.

Chromosome-level genome assembly of the autotetraploid yellow pitaya provides novel insights into evolution of trait patterning in pitaya species with different ploidy.

Background: Yellow pitaya (Selenicereus megalanthus, 2n = 4x = 44) breeding remains severely hindered due to the lack of a reference genome.

Results: Here, we present a high-quality chromosome-level genome assembly of yellow pitaya using PacBio HiFi sequencing and Hi-C scaffolding technologies. We identify yellow pitaya as an autotetraploid with a genome size of 1.

SAM2-Aug: Prior knowledge-based Augmentation for Target Volume Auto-Segmentation in Adaptive Radiation Therapy Using Segment Anything Model 2.

Purpose: Accurate tumor segmentation is vital for adaptive radiation therapy (ART) but remains time-consuming and user-dependent. Segment Anything Model 2 (SAM2) shows promise for prompt-based segmentation but struggles with tumor accuracy. We propose prior knowledge-based augmentation strategies to enhance SAM2 for ART.

Time-resolved dynamic CBCT reconstruction using prior-model-free spatiotemporal Gaussian representation (PMF-STGR).

Time-resolved CBCT imaging, which reconstructs a dynamic sequence of CBCTs reflecting intra-scan motion (one CBCT per x-ray projection without phase sorting/binning), is highly desired for regular/irregular motion characterization, patient setup, and motion-adapted radiotherapy. Representing patient anatomy and associated motion fields as 3D Gaussians, we developed a Gaussian representation-based framework (PMF-STGR) for fast and accurate dynamic CBCT reconstruction.PMF-STGR comprises three major components: a dense set of 3D Gaussians to reconstruct a reference-frame CBCT for the dynamic sequence; another 3D Gaussian set to capture three-level, coarse-to-fine motion-basis-components (MBCs) to model the intra-scan motion; and a CNN-based motion encoder to solve projection-specific temporal coefficients for the MBCs.

Self-Assembled Nanobody-Albumin Platform with Dye Encapsulation for NIR-II Imaging-Guided Photodynamic Therapy.

Nanobodies have emerged as a promising alternative to full-length immunoglobulin G (IgG) in a wide range of biomedical applications. However, the low molecular weight of nanobodies causes a limited drug-loading capacity and rapid renal clearance in vivo, leading to diminished delivery efficiency. Here, we describe a tumor-targeted nanobody platform that employs albumin binding and dye encapsulation for NIR-II imaging-guided photodynamic therapy.

AI-Powered Assessment of Motor Development: Using Platforms Like KineticAI to Analyze Fundamental Movement Skills in Children.

The aim of this study is to examine the precision, dependability, and relevance of AI-based evaluations in contrast to conventional human evaluations. In all, 200 7-8-year-old students from urban and suburban schools participated in the study. Based on movement speed, accuracy, and smoothness, KineticAI's assessment of their motor skills divided them into three categories: proficiency, developing, and emerging.

Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis the nucleus tractus solitarius-vagal axis.

Background: Diabetic gastroparesis (DGP), characterized by delayed gastric emptying and impaired motility, poses significant therapeutic challenges due to its complex neural and molecular pathophysiology. Emerging evidence suggests that electroacupuncture (EA) at ST36 modulates gastrointestinal function; however, the precise neuromolecular pathways underlying its efficacy in DGP remain incompletely defined.

Aim: To elucidate the neural mechanisms underlying EA at ST36 improving DGP gastric motility through the nucleus tractus solitarius (NTS)-vagal axis.

Attenuation of IFITM proteins' antiviral activity through sequestration into intraluminal vesicles of late endosomes.

Interferon-induced transmembrane proteins (IFITMs) inhibit the entry of diverse enveloped viruses. The spectrum of antiviral activity of IFITMs is largely determined by their subcellular localization. IFITM1 localizes to and primarily blocks viral fusion at the plasma membrane, while IFITM3 prevents viral fusion in late endosomes by accumulating in these compartments.

Up-conversion luminescence and temperature sensing based on BaY(BO):Er,Yb phosphors.

Noncontact fluorescence temperature detection systems have become a significant research focus. In this study, a new BaY(BO) phosphor co-doped with Er/Yb was successfully synthesized using a high-temperature solid phase method. The introduction of Yb as a sensitizer enhanced the luminescence properties of the BaY(BO) phosphor.

Development and Validation of a Neonatal Hypothermia Prediction Model for In-Hospital Transport Using Machine Learning Algorithms: A Single-Center Retrospective Study.

Objective: This study aims to predict hypothermia during neonatal in-hospital transport using machine learning techniques, identify risk factors, rank their importance, and visualize the results, allowing healthcare providers to rapidly assess the probability of hypothermia risk during transport.

Methods: Clinical data of 9,060 neonates transported within a tertiary maternity hospital in Shanghai between January 2023 and June 2024 were collected, including maternal and neonatal data. Variables were selected using LASSO regression.

A conditional point cloud diffusion model for deformable liver motion tracking via a single arbitrarily-angled x-ray projection.

Deformable liver motion tracking using a single x-ray projection enables real-time motion monitoring and treatment intervention. We introduce a conditional point cloud diffusion (PCD) model-based framework for accurate and robust liver motion tracking from arbitrarily angled single x-ray projections.We propose a conditional PCD model for liver motion tracking (PCD-Liver), which estimates volumetric liver motion by solving deformable vector fields (DVFs) of a prior liver surface point cloud, based on a single x-ray image.

Inflammatory Burden Index Associated with Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation.

Background: Recurrence rates of atrial fibrillation (AF) remain high after radiofrequency catheter ablation (RFCA), and inflammation plays an important role in the process. Inflammatory burden index (IBI) as a new inflammatory marker has been found to be associated with worse prognosis in cardiovascular disease. But there are no studies on its role in predicting AF recurrence.

Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging.

Purpose: Accurate internal target volume (ITV) estimation is essential for effective and safe radiation therapy in liver cancer. This study evaluates the clinical value of an ultraquality 4-dimensional magnetic resonance imaging (UQ 4D-MRI) technique for ITV estimation.

Methods And Materials: The UQ 4D-MRI technique maps motion information from a low spatial resolution dynamic volumetric MRI onto a high-resolution 3-dimensional MRI used for radiation treatment planning.

'One Stop' Therapy has a Satisfying Performance on AF Patients with Interatrial Communication: Evidence from Pooled Clinical Experience.

Background: Left atrial appendage closure (LAAC) has been reported to be a viable alternative to prevent thromboembolic events for atrial fibrillation (AF) patients. Interatrial communication closure, such as atrial septal defect (ASD) and patent foramen ovale (PFO) closure could significantly decrease the occurrence of stroke. For AF patients with interatrial communication, the success rate as well as the long-term outcomes of 'One stop' closure remain elusive.

[Ga]Ga-NOTA-T4 ImmunoPET imaging for evaluating TROP2 expression in patients with solid tumors.

Purpose: Gallium-68 (Ga)-labeled [Ga]Ga-NOTA-T4 immuno-positron emission tomography (immunoPET) holds great promise as a non-invasive technique for visualizing the expression of trophoblast cell-surface antigen 2 (TROP2). This approach may potentially assist in making clinical decisions regarding TROP2-targeted therapies. The present study aims to evaluate the utility of [Ga]Ga-NOTA-T4 PET/CT in detecting TROP2 expression levels, diagnosing primary tumors and metastatic lesions.

Head-to-head comparison of peptide-based and nanobody-based radiotracers in detecting PD-L1 expression in non-small cell lung cancer.

Background: Immunotherapy based on programmed cell death protein receptor 1 and its ligand (PD-1/PD-L1) has become an important method for treating non-small cell lung cancer (NSCLC). Peptide-based and nanobody-based PET tracers offer potential advantages in PD-L1 detection, yet their comparative tumor uptake and biodistribution remain unclear. This study aimed to evaluate and compare [Ga]Ga-DOTA-WL12 (a peptide-based tracer) and [Ga]Ga-NOTA-RW102 (a nanobody-based tracer) in assessing PD-L1 expression in primary and metastatic NSCLC, providing insights for future radiotracer design and theranostic applications.

Universal mapping and patient-specific prior implicit neural representation for enhanced high-resolution MRI in MRI-guided radiotherapy.

Background: Magnetic resonance imaging (MRI), known for its superior soft tissue contrast, plays a crucial role in radiation therapy (RT). The introduction of MR-LINAC systems enables the use of on-board MRI for adaptive radiotherapy (ART) on the day of treatment to maximize treatment accuracy.

Purpose: Due to patient comfort considerations and the time constraints associated with adaptive radiation therapy (ART), reducing the resolution of on-board MRI to accelerate image acquisition can improve efficiency, especially when acquiring multiple MRIs with different contrast weightings.

CD70-Targeted [F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study.

CD70 has emerged as a promising biomarker for nasopharyngeal carcinoma (NPC). This study investigated CD70 expression patterns in NPC specimens and evaluated the diagnostic potential of CD70-targeted [F]RCCB6 immuno-PET/CT in patients with NPC. CD70 expression was analyzed in 80 archived NPC specimens and correlated with clinical and pathologic features.

Luteolin alleviates estrogen deficiency-induced muscle atrophy via targeting SLC7A11-mediated ferroptosis.

Background: Skeletal muscle atrophy, which is a debilitating condition exacerbated by estrogen deficiency, lacks effective therapeutic interventions. Although ferroptosis (an iron-dependent form of cell death driven by lipid peroxidation) has emerged as a contributor to muscle degeneration, its regulatory mechanisms remain poorly defined. In this study, we identified luteolin, which is a natural flavonoid, as a potent inhibitor of ferroptosis that mitigates estrogen deficiency-induced muscle atrophy by targeting SLC7A11.