Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis.

Partial reprogramming (pulsed expression of reprogramming transcription factors) ameliorates multiple tissue functions in aged mice; however, its impact on peripheral nerve regeneration remains largely unexplored. In this study, the temporal dynamics of Schwann cells following sciatic nerve injury in young and aged rats are systematically examined using single-cell transcriptomics to identify a Runx2 cell population highly enriched with stress granules as transitional homeostatic cells during Schwann cell differentiation. It is found that pathological accumulation of this cluster during axonal regeneration constitutes a critical contributing factor to impaired neural repair in aging.

Surface plasmonic coupling-electrochemiluminescence biosensor based on Hf-nanoMOF/square-cavity Au nanostar@CuS nanocube array for the detection of miRNA-9 in glioma diagnosis.

The integration of luminescent materials with plasmonic nanomaterials holds the potential to give rise to innovative analytical and sensing applications. In this study, novel nano-scaled luminescent Hf-MOF (Hf-nanoMOF) was prepared by the modulator-induced defect approach. Acetate was used as a modulator to preferentially coordinate with metal centers, which inhibited the formation of coordination bond between the metal clusters and 2-aminobenzene-1,4-dicarboxylic acid and limited the Ostwald ripening effect.

Multi-omics characterization of autophagy-related molecular features in Intrahepatic cholestasis of pregnancy†.

Introduction: Despite the increasing body of evidence that autophagy implicate in Intrahepatic cholestasis of pregnancy (ICP), we are still far from a mechanistic understanding of the autophagy in ICP pathogenesis.

Methods: In this study, we performed untargeted lipidomics, scRNA-seq, and RNA-seq data to systematically demonstrate the lipid alterations, cells and gene expression closely related to autophagy in placenta. These results were also verified by tissue, cell, and animal experiments.

A GhBGH2-GhGLK1 Regulatory Module Mediates Salt Tolerance in Cotton.

Soil salinisation, exacerbated by climate change and human activities such as irrigation mismanagement, improper land use and excessive fertilisation, has become a major constraint on global crop production by disrupting fundamental metabolic processes like seed germination and photosynthesis. In our previous work, transcriptome sequencing of salt-tolerant and salt-sensitive cotton germplasms identified Gh_D04G136300, a negative regulatory gene downregulated in salt-tolerant and salt-sensitive materials. Phylogenetic analysis revealed its closest homologue to be AtBGH2, leading to its designation as GhBGH2.

A Multi-Modal Deep Learning Approach for Predicting Eligibility for Adaptive Radiation Therapy in Nasopharyngeal Carcinoma Patients.

Background: Adaptive radiation therapy (ART) can improve prognosis for nasopharyngeal carcinoma (NPC) patients. However, the inter-individual variability in anatomical changes, along with the resulting extension of treatment duration and increased workload for the radiologists, makes the selection of eligible patients a persistent challenge in clinical practice. The purpose of this study was to predict eligible ART candidates prior to radiation therapy (RT) for NPC patients using a classification neural network.

Sugammadex versus cholinesterase inhibitors to antagonize respiratory dysfunction after neuromuscular blockade in patients undergoing pulmonary surgery: a systematic review and meta-analysis.

Objective: The incidence of respiratory dysfunction associated with postoperative residual curarization (PORC) after thoracic surgery is high, even affecting the prognosis. There is no consensus on whether sugammadex is beneficial. This study aimed to elucidate the effect of sugammadex in the management of PORC-related respiratory dysfunction following thoracic surgery.

Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging.

Purpose: Accurate internal target volume (ITV) estimation is essential for effective and safe radiation therapy in liver cancer. This study evaluates the clinical value of an ultraquality 4-dimensional magnetic resonance imaging (UQ 4D-MRI) technique for ITV estimation.

Methods And Materials: The UQ 4D-MRI technique maps motion information from a low spatial resolution dynamic volumetric MRI onto a high-resolution 3-dimensional MRI used for radiation treatment planning.

Overexpressing CrSMT disrupts the growth and development of herbivorous insects by changing the composition of sterols in cotton.

Background: Herbivorous insects cause substantial losses in cotton production worldwide. To resolve insect resistance and environmental pollution challenges, an innovative and eco-friendly strategy for pest management is needed. Insects acquire sterols from dietary sources because they cannot endogenously synthesize them de novo.

A patent review of IDH1 inhibitors (2018-present).

Introduction: isocitrate dehydrogenase 1 (IDH1), a key metabolic enzyme in the cytosol, catalyzes the oxidative decarboxylation of isocitrate to produce α-ketoglutarate (α-KG) and NADPH in the TCA cycle. Pan-cancer studies have demonstrated that IDH1 exhibits a higher mutation frequency and is implicated in a broader range of cancer types, indicating its potential as a promising anti-tumor target.

Areas Covered: We summarized patents from 2018 to the present that identify novel molecules, compounds, formulations, and methods for inhibiting mIDH1.

Study on the potential links between clinical features of oral lichenoid mucositis and systemic diseases.

Objective: This study aimed to analyze the clinical characteristics of oral lichenoid disease and investigate its potential association with systemic diseases.

Methods: This study was a retrospective cross-sectional analysis. The study comprised 116 patients who had been diagnosed with oral lichenoid disease, including 70 with oral lichen planus and 46 with lichenoid lesions.

An electrochemiluminescence sensor with wide stable potential detection window based on superhydrophilic amino acid polyionic liquid for the detection of miRNA-128 in colorectal cancer.

The stable potential detection window (PW) of electrodes in the commonly overlooked issue in electrochemiluminescence (ECL) research. In this study, an amino acid-based polyionic liquid (AAPIL) had been designed and synthesized to solve the problem of narrow potential detection window of the electrode. A biosensor was constructed based on the AAPIL to overcome the limitation and enhance ECL signals.

CYB5A promotes osteogenic differentiation of MC3T3-E1 cells through autophagy mediated by the AKT/mTOR/ULK1 signaling pathway.

Bone metabolism involves complex genetic and cellular processes. While many advances have been made in understanding the molecular mechanisms of osteogenic differentiation, many aspects remain to be fully elucidated. This study investigated the role of CYB5A in promoting osteogenic differentiation of MC3T3-E1 cells and explored the influence of autophagy via the AKT/mTOR/ULK1 signaling pathway.

Quasi-solid hydrogel electrolyte/nitrogen dot-based electrochemiluminescence sensor for enrofloxacin detection in milk.

In this study, a novel quasi-solid hydrogel-based electrochemiluminescence (ECL) sensor was developed to detect enrofloxacin (ENR) in milk. First, nitrogen-rich quantum dots ((5-AT-co-CA)-N-dots) with high luminescence efficiency were synthesized and served cathodic ECL luminophores. Second, the P(AM-co-AMPS)-PEDOT:PSS (PAMES) hydrogel was prepared as a quasi-solid electrolyte.

3D dual-network structure poly (vinyl alcohol)/cellulose nanofibers/MXene hydrogel evaporator with high-efficiency desalination for solar-driven water purification.

Interfacial solar steam generation (ISSG) provides a sustainable solution to global water scarcity, yet achieving high efficiency, salt resistance, and long-term stability remains challenging. Here, we report a 3D umbrella-shaped poly (vinyl alcohol)/cellulose nanofiber (CNF)/MXene (PCM) hydrogel evaporator with a rigid-flexible dual-network structure for efficient solar desalination. The dual-network architecture, combining rigid CNF and flexible PVA chains, reduces water evaporation enthalpy by 18 % (from 2223.

Plant genetic transformation: achievements, current status and future prospects.

Regeneration represents a fundamental biological process wherein an organism's tissues or organs repair and replace themselves following damage or environmental stress. In plant systems, injured tree branches can regenerate adventitious buds and develop new crowns through propagation techniques like cuttings and canopy pruning, while transgenic plants emerge via tissue culture in genetic engineering processes intimately connected to plant regeneration mechanisms. The advancement of plant regeneration technology is critical for addressing complex and dynamic climate challenges, ultimately ensuring global agricultural sustainability.

Self-Localized Plasmonic Nanocavity Strategy for the Glycosylation Detection of Glioblastoma Extracellular Vesicles.

The protein glycosylation of extracellular vesicles (EVs) is involved in cellular recognition and emerges as a promising biomarker for cancer diagnosis. However, the lack of efficient labeling and high-resolution detection strategies limits their clinical application. Herein, we developed a self-localized plasmonic nanocavity strategy to analyze the glycosylation characteristics of glioblastoma EVs.

CuS@Ag Heterostructure-based Surface Plasmonic Coupling Electrochemiluminescence Sensor for Glioma miRNA-124-3p Detection.

As an emerging class of extended crystalline organic materials, covalent organic framework (COF)-based aggregation-induced emission luminogen (AIE-gen) exhibited encouraging emissive properties. In this work, 4',4'',4‴,4‴'-(1,1,2,2-Ethenetetrayl)tetra(4-biphenylcarbaldehyde) (ETBC) as AIEgen was used to prepare AIE-COF (ET-COF-COOH) luminescent nanoprobe. ETBC and 1,3,5-Tris(4-aminophenyl)benzene (TAPB) had an extended π electronic system that allowed electron delocalization and overlapping transport.

TiCT/Au NPs/PPy ternary heterostructure-based intra-capacitive self-powered sensor for DEHP detection.

Phthalate esters, particularly di(2-ethylhexyl) phthalate (DEHP), are widely used plasticizers found in various consumer products, posing significant environmental and health risks due to their endocrine-disrupting effects. In this study, a novel enzyme-free intra-capacitive biofuel cell self-powered sensor (ICBFC-SPS) was developed. The ICBFC-SPS integrated a ternary heterostructure-based capacitive anode and a cathode with a sensing interface into a single-chamber electrolytic cell.

Global Potential Geographic Distribution of Anthonomus eugenii Under Climate Change: A Comprehensive Analysis Based on an Ensemble Modeling Approach.

Climate warming is affecting the ranges and population dynamics of invasive species, including insects, which have become a global problem, causing biodiversity declines and agricultural economic losses. Anthonomus eugenii as an important invasive pest on pepper is now mainly located in the USA and Mexico. However, the global potential geographic distribution (PGD) of A.

Holocellulose nanofibrils biomimetic entrapment of liquid metal enable ultrastrong, tough, and lower-voltage-driven paper device.

Integrating liquid metal (LM) with wood fibers for flexible paper electronics is intriguing yet extremely challenging due to poor mechanical performance. Here, we disclose a hemicellulose trapping strategy to achieve exceptional ultrastrong and tough LM-based paper electronics. Holocellulose nanofibrils (HCNFs) with hemicellulose retention of approximately 20 % are found to effectively entrap nanoscale LM within the fibril network, analogous to spider silk capturing small water droplets.

Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review.

Hericium erinaceus (Bull.) Pers. is a respected medicinal and edible fungus known for its outstanding nutritional profile.

A novel protein corona-induced aggregation-ECL strategy based on poly-l-cys/Cu NCs for detecting microplastics in water.

To address the health risks posed by microplastics (MPs), this work developed a poly-l-cysteine (poly-L-cys)-based electrochemiluminescence (ECL) sensor for detecting MPs in water environments. The porous structure of poly-L-cys film can regulate the generation of copper nanoclusters (Cu NCs) in the pores, effectively limiting the migration and aggregation of nanopaticles. In addition, poly-L-cys film also acted as co-reactant promoters, promoting electron transfer and effectively enhancing ECL signal of Cu NCs.

Gold metallene-based ECL biosensor to detect miRNA-126 for coronary artery calcification diagnosis.

Coronary artery calcification (CAC) is a pathological change and independent risk factor in cardiovascular diseases. In this work, a gold-based metallene structure was prepared as sensing interface based on mPEG-SH modified Au nanoparticles for the CAC detection. Firstly, a novel nanovesicle was self-assembled with excellent conductivity.

SnS QDs@MXene Ohmic Junction-Based Surface Plasmon Coupling ECL Sensor to Detect Saliva Exosome for the Diagnosis of Childhood Asthma.

This study represents a novel surface plasmon coupling electrochemiluminescence (SPC-ECL) method for detecting salivary exosomes and the diagnosis of childhood asthma. First, SnS QDs@MXene Ohmic junctions was developed as efficient ECL emitters. The Ohmic junction provided a low resistance to reduce the contact resistance and improve charge injection efficiency, which enhanced the ECL signal by 2.