The Specificity of Metacognition Questionnaire-30 Subdimensions: Findings From Connectome-Based Predictive Modeling.

The maladaptive metacognition measured by the Metacognition Questionnaire-30 (MCQ-30) is often linked to a wide range of affective disorders. However, few studies have elucidated the neural underpinnings of different metacognition subdimensions. Additionally, the relationship between these functional neural bases and longitudinal changes in individual emotional distresses remains unclear.

GRK2 Orchestrates VSMC Phenotypic Modulation via DNMT1-Mediated DNA Methylation Reprogramming.

Background: Vascular smooth muscle cell (VSMC) phenotypic modulation is responsible for the pathogenesis of hyper-muscularized arterial diseases. Recent studies have highlighted the critical role of epigenetic regulation in VSMC fate. However, the mechanisms underlying the precise regulation of the epigenetic machinery in VSMC remain unclear.

Integrating bioinformatics and machine learning to elucidate the role of protein glycosylation-related genes in the pathogenesis of diabetic kidney disease.

Background: Diabetic kidney disease (DKD) is a severe global complication of diabetes, yet its molecular mechanisms remain incompletely understood. This study aimed to investigate the role of protein glycosylation in DKD pathogenesis and its association with gene expression changes, with the goal of identifying diagnostic biomarkers and personalized therapeutic targets.

Methods: Integrated bioinformatics and machine learning approaches were applied to analyze multiple gene expression datasets.

Comprehensive soil greenhouse gas flux dataset from a temperate old-growth forest: Effects of decade-long nitrogen addition and biological factor manipulation.

This dataset presents greenhouse gas (CO₂, CH₄, N₂O) flux measurements and associated environmental variables from a temperate old-growth forest (approximately 300 years old) under different nitrogen addition regimes (control, short-term 1-year, and long-term 10-year treatments) combined with biological factor manipulations (root exclusion, fungal suppression, and litter removal). Data were collected throughout the 2018 growing season (May to September) at 10-day intervals. The dataset includes measurements of three greenhouse gas fluxes, δ¹³C isotopic composition, soil temperature and moisture, pH, ammonium and nitrate nitrogen, dissolved organic carbon, microbial biomass carbon and nitrogen, and total soil carbon and nitrogen.

Enhancing the cycling stability of Co-free high-Ni layered cathodes through MgO surface engineering.

A magnesium oxide (MgO) coating strategy is proposed for improving the cobalt-free high-nickel LiNiMnO cathode. It is revealed that a MgO coating can stabilize reversible Ni/Ni redox and suppress structural degradation. The MgO coated LiNiMnO exhibits a promising capacity retention of 66.

From Simple to Polychromatic: An Empirical Study on Optimal Color Schemes for Optical See-through Head-Mounted Displays.

Optical see-through head-mounted displays (OHMDs) blend digital content with the physical world, presenting unique color management challenges. Previous literature suggests using green as the main color, but this severely limits creative freedom. To address this, we conducted an empirical study with 30 participants, evaluating 216 colors under various OHMD usage conditions.

Quinoxaline-based double responsive fluorescent probe: An effective tool for detection of aniline and p-nitroaniline in the environment.

Aniline and p-nitroaniline, as crucial intermediates in organic synthesis, find extensive applications in the fields of medicine, pesticides, and beyond. However, due to their significant toxicity and carcinogenic potential, these compounds pose severe risks to both ecological environments and human health. In this work, a novel fluorescent probe PAMD for the detection of aniline and p-nitroaniline was constructed and synthesized from camphorquinone.

Remnant cholesterol, high-sensitivity C-reactive protein, and risk of incident coronary heart disease among patients with chronic kidney disease based on UK biobank.

Background: Patients with chronic kidney disease (CKD) exhibit elevated remnant cholesterol (RC) and high-sensitivity C-reactive protein (hs-CRP), and both of them contribute to the residual cardiovascular risk. However, the independent effects of RC and its joint effects with hs-CRP remain unknown. This study aimed to explore the associations of RC and its joint categories with hs-CRP with coronary heart disease (CHD), myocardial infarction (MI), and angina among patients with CKD.

An equivalent circulating density prediction model for extended-reach horizontal wells considering drill strings sinusoidal buckling.

Sinusoidal buckling of drill strings will be easily caused during drilling process of extended-reach horizontal wells due to the factors such as excessive well length and larger friction torque, which will cause measurement errors of well depth and vertical depth and furthermore influence the accurate calculation of ECD. We have corrected the traditional ECD calculation model, considered the measurement errors of well depth and vertical depth caused by the sinusoidal buckling of drill strings, and established a set of equivalent circulating density (ECD) calculation model suitable for extended-reach horizontal wells to meet the requirements for fine ECD control during the drilling operation. We have combined the data from an extended-reach horizontal well in the East China Sea and compared the ECD data obtained from the recorded stand pipe pressure with the prediction results from Landmark commercial software、the model in this work and the conventional model.

Natural active ingredients targeted inflammatory cytokines and major blinding eye diseases: a two-sample Mendelian randomization and molecular docking analysis.

Objectives: Previous studies have reported that a few inflammatory cytokines have associations with ocular diseases. The objective of this study is to explore the causal relationship between 41 inflammatory cytokines and five ocular diseases using Mendelian randomization (MR) method and study the interaction between five natural active ingredients and inflammatory cytokines through molecular docking.

Methods: The two-sample MR study employed genetic variances related to age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), myopia, and cataract.

Regulation, functions and therapeutic strategies of H2AK119ub1.

Histone H2A monoubiquitination at lysine 119 (H2AK119ub1) is a central epigenetic regulator that governs transcriptional control, chromatin architecture remodeling, and lineage commitment. The precise homeostatic balance of H2AK119ub1 is maintained through antagonistic coordination between polycomb repressive complex 1 and specialized deubiquitinases, forming a precise equilibrium that is critical for the regulation of gene expression. Dysregulation of H2AK119ub1 has been mechanistically linked to multiple human pathologies, indicating that its regulatory axis is a promising therapeutic target.

Circadian clocks and their role in kidney and eye diseases across organ systems.

Circadian rhythms, the body's intrinsic 24-h cycles, regulate essential physiological processes across multiple organ systems. Disruptions in these rhythms are increasingly recognized as significant contributors to chronic kidney disease and ocular diseases such as glaucoma, dry eye disease, and diabetic retinopathy. This review examines the interconnections between circadian rhythms in kidney and eye health, focusing on shared pathological pathways including oxidative stress, inflammation, and fibrosis.

The GRK2/AP-1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress.

Disturbed blood flow and the resulting oscillatory low shear stress (OSS) are key contributors to vascular endothelial dysfunction and the initiation of atherosclerosis. However, the molecular mediators that translate abnormal hemodynamic signals into pathological vascular endothelial responses remain unclear. G protein-coupled receptors (GPCRs) are classical mechanosensors in the vascular endothelium.

Impact of autoinducer-2 activity on quality characteristics and bacterial community of fermented sausage.

The quality of fermented sausages is significantly influenced by microbial metabolism, with quorum sensing serving a crucial regulatory role. This study investigated the impact of exogenous autoinducer-2 (AI-2) activity on the functional properties of Limosilactobacillus fermentum 332 and the quality of fermented sausages. The results showed that adding AI-2 at concentrations up to 100 μmol/L enhanced the hydroxyl radical scavenging and anti-lipid peroxidation abilities of L.

Comparative Transcriptomics and Intestinal Microbiome Analysis Provide Insights into the Semi-Terrestrial Adaptation of .

, a Grapsidae family member, can adapt to terrestrial and semi-terrestrial environments. This study used transcriptomic and microbiome analyses to explore its adaptation mechanisms. Transcriptome analysis showed gene changes related to cytoskeleton-motor, water-osmotic pressure, and energy metabolism.

[Ga]Ga-NOTA-T4 ImmunoPET imaging for evaluating TROP2 expression in patients with solid tumors.

Purpose: Gallium-68 (Ga)-labeled [Ga]Ga-NOTA-T4 immuno-positron emission tomography (immunoPET) holds great promise as a non-invasive technique for visualizing the expression of trophoblast cell-surface antigen 2 (TROP2). This approach may potentially assist in making clinical decisions regarding TROP2-targeted therapies. The present study aims to evaluate the utility of [Ga]Ga-NOTA-T4 PET/CT in detecting TROP2 expression levels, diagnosing primary tumors and metastatic lesions.

Head-to-head comparison of peptide-based and nanobody-based radiotracers in detecting PD-L1 expression in non-small cell lung cancer.

Background: Immunotherapy based on programmed cell death protein receptor 1 and its ligand (PD-1/PD-L1) has become an important method for treating non-small cell lung cancer (NSCLC). Peptide-based and nanobody-based PET tracers offer potential advantages in PD-L1 detection, yet their comparative tumor uptake and biodistribution remain unclear. This study aimed to evaluate and compare [Ga]Ga-DOTA-WL12 (a peptide-based tracer) and [Ga]Ga-NOTA-RW102 (a nanobody-based tracer) in assessing PD-L1 expression in primary and metastatic NSCLC, providing insights for future radiotracer design and theranostic applications.

Surprising pressure-induced magnetic transformations from helimagnetic order to antiferromagnetic state in NiI.

Interlayer magnetic interactions play a pivotal role in determining the magnetic arrangement within van der Waals (vdW) magnets, and the remarkable tunability of these interactions through applied pressure further enhances their significance. Here, we investigate NiI flakes, a representative vdW magnet, under hydrostatic pressures up to 11 GPa. We reveal a notable increase in magnetic transition temperatures for both helimagnetic and antiferromagnetic states, and find that a reversible transition between helimagnetic and antiferromagnetic (AFM) phases at approximately 7 GPa challenges established theoretical and experimental expectations.

Predictive factors associated with the onset of Kummell's disease.

Background Context: Kummell's disease (KD) is a long-term complication of vertebral compression fractures, resulting in vertebral collapse and kyphosis. Despite its clinical significance, the underlying mechanisms remain poorly understood.

Purpose: To identify the predictive factors for the onset of KD and provide clinical insights for early screening and intervention in KD patients.

Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury.

Mitochondrial dysfunction-induced oxidative stress is a key pathogenic factor in acute kidney injury (AKI). Despite this, current mitochondrial-targeted antioxidant therapies have shown limited efficacy in clinical settings. In this study, we introduce a novel renal-clearable and mitochondria-targeted antioxidant nanozyme (TPP@RuCDzyme) designed to precisely modulate mitochondrial oxidative stress and mitigate AKI progression.

Lack of Association Between Intraoperative Hypotension and Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A Retrospective Cohort Study.

Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients undergoing pancreaticoduodenectomy.

The J-shaped relationship between body roundness index and adult asthma: insights from NHANES 2001-2018.

Background: Many studies have used Body Mass Index (BMI) to define obesity and examine its potential link to adult asthma. However, BMI overlooks body fat distribution, which may significantly impact health. Unlike BMI, the Body Roundness Index (BRI) can more accurately reflect body fat distribution.

Associations of polycyclic aromatic hydrocarbons exposure with perinatal anxiety symptoms.

Background: Polycyclic aromatic hydrocarbons (PAHs) have recently garnered attention for their possible neurotoxic effects. This study was meticulously crafted to assess the influence of PAHs exposure on the emergence of perinatal anxiety symptoms.

Methods: From April 28, 2020, to July 20, 2021, a case-control study recruiting eligible pregnant women was conducted in two primary hospitals in Hefei City, China.

Effects of storage on the physicochemical characteristics of rice with different starch lysophospholipids contents.

Whether paddy rice varieties with different starch lysophospholipids (LPLs) exhibit similar changes in the physicochemical characteristics during storage remain largely unknown. This study investigated the dynamic changes in the physicochemical properties of a japonica rice and its low- and high-LPLs mutants during storage at 24 and 37 °C for one year. During storage, resistant starch (RS), peak viscosity, breakdown viscosity, pasting temperature and enthalpy of gelatinization gradually increased, with higher values observed at 37 °C compared to 24 °C after one year of storage.