Volatile organic compounds exposure with risk of thyroid function in U.S. general population: 2007-2012 NHANES.

Background: The link between exposure to environmental hazards and thyroid function has been relatively well established. However, evidence on environmental exposure to volatile organic compounds (VOCs) and thyroid function in the general population remains unclear.

Objectives: To assess the impact of individual and joint effects of VOCs exposure on thyroid function in a representative sample of U.

Traceable nanoparticles with mitochondria-targeting pyruvate-Cu induce cuproptosis for enhanced triple-negative breast cancer therapy in a mouse model.

We develop pyruvate with good biocompatibility and mitochondria-targeting ability as a copper ionophore (pyruvate-Cu). To further address its drawbacks, traceable nanoparticles are constructed to deliver pyruvate-Cu for triple negative breast cancer (TNBC) treatment. and results demonstrate that this work provides an efficient platform for enhanced TNBC therapy.

Mechanistic insights into Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonates (PFOS)-induced nitrification acceleration: Interkingdom collaboration of AOA-comammox in calcareous soils.

Emerging ecological risks of Per - and polyfluoroalkyl substances (PFASs) in terrestrial environments have received extensive attention. Yet, their impact on microbially-mediated nitrification processes in soils remains insufficiently investigated. Through a 42-day microcosm incubation experiment, we examined how two representative PFASs exposure, i.

Development and Validation of a Preoperative MRI Habitat Radiomics Model to Predict Variant Histology in Bladder Cancer.

Background: Bladder cancer (BCa) with variant histology (VH) is aggressive, leading to poor prognosis and resistance to neoadjuvant treatment (NAT). Preoperative identification of VH may be important for informing treatment options.

Purpose: To develop and validate a multiparametric MRI-based ensemble model to identify VH in BCa and explore its association with disease-free survival (DFS) and NAT response.

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies.

NMDA receptors (NMDARs) are widely distributed throughout the central nervous system (CNS) and play pivotal roles in normal physiological processes such as synaptic plasticity, learning, and memory. Substantial evidence indicates that NMDAR dysfunction, particularly excessive calcium influx, critically contributes to the pathogenesis of major neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). Dysregulated glutamatergic signaling synergizes with pathological protein aggregation (e.

How Childhood Maltreatment Influences Loneliness and Life Satisfaction Through Sleep Problems: A Serial Mediation Model and Network Analysis.

Childhood maltreatment is a known risk factor for physical and mental health, often reducing adult life satisfaction. Despite its importance, few studies have examined the relationship between childhood maltreatment and loneliness/life satisfaction from the perspective of sleep problems. A sample of 779 participants (40.

Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry.

While potentially toxic elements (PTE) in lake have been widely studied, their enrichment, fate and health risks associated with lacustrine groundwater discharge (LGD) remain poorly understood. Thus, self-organizing maps (SOM) and positive matrix factorization (PMF) were employed in present work to decipher source of selected PTE (Li, V, Mn, Cr, Co, Ni, Cu, Zn, Ba, Pb, U, Sr) in Ulansuhai Lake basin (Inner Mongolia, China). On this basis, multi-isotopic tracers (δD/δO, Sr/Sr, δS/δO, Rn) were used to indicate the geochemical processes related to PTE enrichment and fate.

Regulation, functions and therapeutic strategies of H2AK119ub1.

Histone H2A monoubiquitination at lysine 119 (H2AK119ub1) is a central epigenetic regulator that governs transcriptional control, chromatin architecture remodeling, and lineage commitment. The precise homeostatic balance of H2AK119ub1 is maintained through antagonistic coordination between polycomb repressive complex 1 and specialized deubiquitinases, forming a precise equilibrium that is critical for the regulation of gene expression. Dysregulation of H2AK119ub1 has been mechanistically linked to multiple human pathologies, indicating that its regulatory axis is a promising therapeutic target.

Multiparametric MRI for assessing residual tumors in patients with muscle-invasive bladder cancer after neoadjuvant treatment: a reliable tool for guiding bladder preservation.

Objective: To evaluate the clinical utility of multiparametric MRI in differentiating pathological stages (ypT0 vs ypT1-4) in patients with muscle-invasive bladder cancer (MIBCa) following neoadjuvant therapy (NAT).

Materials And Methods: In this double-center cohort study, post-NAT multiparametric MRI in all consecutive patients who underwent surgery after NAT was analyzed. Two experienced radiologists independently evaluated the MRI features obtained after NAT.

Therapeutic Lipid Nanoparticles Delivery of Small Interfering RNA for the Synergistic Treatment of Hepatic Inflammation.

Small interfering RNA (siRNA) against tumor necrosis factor-alpha (TNF-α) is a valuable therapeutic agent for hepatic inflammation. However, lipid nanoparticles (LNPs), the most clinically advanced vectors for delivering siRNA to the liver, have no therapeutic effect on diseases themselves. Here, therapeutic L-LNPs are developed by replacing the helper lipid in Onpattro with 1,2-dilauryl-sn-glycero-3-phosphocholine (DLPC).

Spatio-seasonal variability of source contributions to water quality in a large irrigation drainage lake basin based on the entropy weighted quality index, positive matrix factorization, and isotopic tracers.

Understanding spatial-temporal variations in lake water quality sources is essential for addressing regional eco-environmental challenges. This study presents an integrated framework-combining stable isotope tracing, PMF modeling, and EWQI-to examine spatio-temporal variations in water quality across China's Ulansuhai Lake basin. Integrated analysis of temporal and spatial sample ratios from 198 samples collected in April, July, and October 2023 revealed that 95 % of groundwater, 53 % of river water, and 15 % of lake water exceeded the EWQI drinking-water threshold (EWQI ≥100).

Engineering 3D-BMSC exosome-based hydrogels that collaboratively regulate bone microenvironment and promote osteogenesis for enhanced cell-free bone regeneration.

Large bone defects are a significant clinical challenge due to their frequent failure to heal spontaneously. Recently, BMSC-derived exosomes (Exo) based cell-free bone regeneration offer several distinct advantages over BMSCs themselves in the repair of damaged tissue, including enhanced repair ability and superior biocompatibility, which can be further augmented under 3D-cultured conditions. However, their therapeutic efficacy for bone regeneration is significantly constrained by hypoxic bone microenvironment and short retention time in bone defect region.

Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation.

Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased lineage commitment remains elusive. Here we show that MG53, also named as TRIM72, prompts ISCs to secretory lineages via upregulating peroxisome proliferator-activated receptor α (PPARα), thus maintaining intestinal epithelium integrity against noxious insults.

Association of Vitiligo With Autoimmune Disorders: A Bidirectional Two-Sample and Summary-Based Mendelian Randomization Study.

Background: The existence of a definite direct causal relationship between vitiligo and diverse autoimmune disorders remains unknown due to the influence of confounding factors and potential reverse causality.

Methods: Mendelian randomization (MR) is a technique employed to explore causal connections between two phenotypes. In our research, bidirectional two-sample MR analyses were utilized to evaluate the causal connections between vitiligo and multiple autoimmune diseases (systemic lupus erythematosus, Graves' disease, inflammatory bowel disease, alopecia areata [AA], type 1 diabetes mellitus [T1MD], and rheumatoid arthritis [RA]).

Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway.

: Vascular smooth muscle cells (VSMCs) senescence exacerbates vascular diseases like atherosclerosis and hypertension. Angiotensin II (Ang II) is a strong inducer of VSMCs senescence, causing vascular damage, though its exact mechanism is unclear. Nicotinamide mononucleotide (NMN), a NAD precursor, has gained attention for its anti-senescence potential, yet its role in inhibiting VSMCs senescence is not fully understood.

Spatial variability of lacustrine groundwater discharge and pollutant fluxes in the sandy-land lake group basins: Influence from land use types.

Deciphering lacustrine groundwater discharge (LGD) processes and pollutant fluxes in sandy-land lake basins remain difficult due to the complex hydrogeological conditions and land use types. In this study, the spatial variability of LGD in a sandy-land lake group (Bahannao Lake Group Basin) was quantitatively estimated using the radon (Rn) mass balance model. The 5 lakes in the study area, with their various land use and hydrogeological conditions, were categorized into 3 ranges based on LGD rates: <20.

Association Between Collateral Status, Blood Pressure During Thrombectomy, and Clinical Outcomes in Patients With Basilar Artery Occlusion.

Background And Objectives: We investigated the relationship between intraprocedural blood pressure (BP) and clinical outcomes in patients with basilar artery occlusion (BAO) undergoing endovascular treatment (EVT), exploring whether it is modifiable by collateral status.

Methods: Patient data from the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) randomized trial were analyzed for those with BAO who received EVT. Intraprocedural BP data were extracted, with collateral status assessed using the Basilar Artery on CT Angiography (BATMAN) score (BATMAN score ≥7 favorable collateral status, <7 unfavorable).

Impacts of Topical Treatments and Phototherapy on Stratum Corneum Hydration, Sebum and Elasticity in Vitiligo Skin.

Introduction: Vitiligo is a prevalent depigmentation disorder. Due to the depigmentation and treatments, skin function of patients with vitiligo may be affected, manifested by changes in the stratum corneum (SC) hydration, sebum and elasticity. However, few researchers have paid attention to the skin condition of vitiligo after treatment.

Computed Tomography Perfusion Parameters: A Potential Tool for Treatment Selection in Basilar Artery Occlusion.

Objective: This study aimed to evaluate the association between computed tomography perfusion (CTP) parameters and outcomes in basilar artery occlusion (BAO), and to select patients with BAO who may benefit from thrombectomy.

Methods: We performed a post-hoc analysis of patients from the ATTENTION trial with available admission CTP data. CTP parameters evaluated included time to maximum (T) >6 s/8 s/10 s, relative cerebral blood flow (rCBF) <20%/30%/34%/38%/50%, Critical Area Perfusion Score (CAPS), and CTP-posterior circulation acute stroke prognosis early computed tomography score (CTP-pc-ASPECTS), pons-midbrain-thalamus (PMT) hypoperfusion.

3D Self-Driven Underwater Aerofluidic Systems Woven with Femtosecond Laser-Structured Superhydrophobic Wires.

To overcome the inherent limitations of 2D aerofluidic systems, we propose a novel strategy that combines traditional Chinese weaving technology with superhydrophobic metal wires to construct 3D underwater aerofluidic systems. In water, air is trapped between the femtosecond laser-structured superhydrophobic stainless steel wires and the surrounding water, creating a microscale channel for gas transport within the designed aerofluidic system. The Laplace pressure difference of bubbles across different circular regions woven with superhydrophobic wires can drive spontaneous gas transport along microscale connecting lines in 3D space.

Adverse event of ruxolitinib cream: a real-world analysis based on FDA Adverse Event Reporting System from 2021 to 2024.

Background: Ruxolitinib cream, a topical Janus kinase (JAK) inhibitor, is a widely used treatment for various dermatological diseases. This study employs the FDA Adverse Event Reporting System (FAERS) database to examine adverse events (AEs) associated with ruxolitinib cream.

Methods: This study employed disproportionate analysis methods, including reported odds ratio and proportional reporting ratio, to collate AEs reported from the fourth quarter of 2021 to the first quarter of 2024.

Roughing Nitrogen-Doped Carbon Nanosheets for Loading of Monatomic Fe and Electroreduction of CO to CO.

The catalyst is the pivotal component in CO electroreduction systems for converting CO into valuable products. Carbon-based single-atom materials (CSAMs) have emerged as promising catalyst candidates due to their low cost and high atomic utilization efficiency. The rational design of the morphology and microstructure of such materials is desirable but poses a challenge.

The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study.

Purpose: Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.

Knowledge Structure and Trends of Vitiligo From 2002 to 2023: A Bibliometric Analysis.

Introduction: Vitiligo is a common acquired depigmenting dermatosis resulting from a loss of epidermal melanocytes. The academic attention to vitiligo has gradually increased over the past two decades.

Objective: We aimed to explore the current research structure and trends of vitiligo.

Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013-2014.

Background: A relatively well-established link was observed between metal mixtures exposure and neurodegenerative diseases. However, the relationship between metal mixtures exposure and serum neurofilament light chain (sNfL) concentrations, a valuable non-invasive biomarker of neurodegenerative diseases, in general adult populations remains understudied and unclear.

Objective: This study seeks to elucidate the potential impact of metal mixtures exposure on sNfL concentrations in a representative sample of U.