A novel shape-memory Bi-hook device for nasolacrimal duct stent implantation in canalicular laceration repair.

Purpose: To evaluate the clinical efficacy and safety of a novel shape-memory Bi-hook device in facilitating antegrade stent implantation for canalicular laceration repair.

Methods: In this retrospective comparative study, 76 patients (76 eyes) with canalicular laceration were enrolled: 39 patients (39 eyes) underwent Bi-hook-assisted stent implantation (Bi-hook group) and 37 patients received conventional Ritleng stent intubation (control group). The Bi-hook device was fabricated using a thermally shaped 0.

Genomic formation of lower Yellow River populations in the Han dynasty.

Background: As a key region in the lower Yellow River Basin, Shandong Province plays a central role in understanding the genetic history of East Asia. However, detailed ancient DNA data across its historical periods remains limited. This study aims to characterise the genomic profiles of Shandong populations during the Western Han Dynasty and trace their genetic connections with neighbouring regions.

Carbon emissions hotspots in the aquatic-terrestrial transition zone of boreal shallow lakes in arid semi-arid regions.

Lakes are important sources of greenhouse gases (GHGs), but the drivers of CO and CH emissions in the aquatic-terrestrial transition zone (ATTZ) of boreal lakes remain poorly understood. This study investigates CO and CH fluxes in the flooding (A), transition (B), and dry areas (C) of a boreal lake ATTZ. The results showed that CO fluxes peaked in the lake ATTZ during summer (85.

Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry.

While potentially toxic elements (PTE) in lake have been widely studied, their enrichment, fate and health risks associated with lacustrine groundwater discharge (LGD) remain poorly understood. Thus, self-organizing maps (SOM) and positive matrix factorization (PMF) were employed in present work to decipher source of selected PTE (Li, V, Mn, Cr, Co, Ni, Cu, Zn, Ba, Pb, U, Sr) in Ulansuhai Lake basin (Inner Mongolia, China). On this basis, multi-isotopic tracers (δD/δO, Sr/Sr, δS/δO, Rn) were used to indicate the geochemical processes related to PTE enrichment and fate.

Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer.

Background: Tumor-associated macrophages (TAMs) are among the most prevalent cells within the tumor microenvironment (TME) of cervical cancer (CC). Although TAMs frequently exhibit an immunosuppressive phenotype, their plasticity enables them as an intriguing reprogrammable target for immunotherapy of CC.

Methods: Consensus clustering was employed to delineate immune infiltration patterns in a cohort of 119 patients with CC.

Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study.

Background: While the specific effects of bedtime on androgen levels and lean muscle mass remain understudied, circadian misalignment and sleep disturbances have been well-established as risk factors for various metabolic disorders. The present study aimed to investigate the relationship between bedtime, androgen-associated traits, and dual-energy X-ray absorptiometry (DEXA)-based lean mass (LM) in polycystic ovary syndrome (PCOS).

Methods: This cross-sectional study recruited 899 reproductive-aged women with PCOS from the PCOS subspecialty clinic at Shanghai Tenth People's Hospital, and finally, 636 women were included in the study.

Impact of weight loss on epicardial adipose tissue after laparoscopic sleeve gastrectomy: a CT-based quantitative analysis using ITK-SNAP.

Background: Bariatric surgery is an effective method for weight reduction, and epicardial adipose tissue (EAT) is a recognized marker of cardiovascular disease risk. However, the impact of weight loss on EAT and the correlation between reduced body weight and changes in EAT remain unclear.

Objective: This study examines the impact of weight loss following laparoscopic sleeve gastrectomy (LSG) on EAT volume and its correlation with body mass index (BMI) reduction.

Spatio-seasonal variability of source contributions to water quality in a large irrigation drainage lake basin based on the entropy weighted quality index, positive matrix factorization, and isotopic tracers.

Understanding spatial-temporal variations in lake water quality sources is essential for addressing regional eco-environmental challenges. This study presents an integrated framework-combining stable isotope tracing, PMF modeling, and EWQI-to examine spatio-temporal variations in water quality across China's Ulansuhai Lake basin. Integrated analysis of temporal and spatial sample ratios from 198 samples collected in April, July, and October 2023 revealed that 95 % of groundwater, 53 % of river water, and 15 % of lake water exceeded the EWQI drinking-water threshold (EWQI ≥100).

Exploring the network structure of virtual water trade among China's cities.

A virtual water trade system based on a multiregional input-output (MRIO) model has been regarded as a network with regions as nodes and virtual water flows between regions as the directional, weighted links. Therefore, exploring the network structure can provide additional insights for understanding how the virtual water trade system works. This study employs the integration of the MRIO model and the complex network theory to investigate the network structure of the virtual water system for trade among China's cities, which has not been well understood.

Getting Up in the Morning and Chronotype in Relation to Polycystic Ovarian Syndrome: A Mendelian Randomization and Cross-Sectional Study.

Background: Although a connection between circadian rhythm and polycystic ovarian syndrome (PCOS) has been shown in previous studies, the exact cause of this association is not well understood.

Purpose: This study aimed to use Mendelian randomization (MR) method to analyze the potential association between getting up in the morning and chronotype with PCOS, and a cross-sectional study was conducted to further validate these results.

Methods: Using summary information from large-scale genome-wide association studies (GWASs) in people of European ancestry, we conducted univariable MR (UVMR) and multivariable MR (MVMR) analyses to examine the causal effect of genetically determined getting up in the morning and chronotype on PCOS.

Development and validation of machine learning models for predicting low muscle mass in patients with obesity and diabetes.

Background And Aims: Low muscle mass (LMM) is a critical complication in patients with obesity and diabetes, exacerbating metabolic and cardiovascular risks. Novel obesity indices, such as the body roundness index (BRI), conicity index, and relative fat mass, have shown promise for assessing body composition. This study aimed to investigate the associations of these indices with LMM and to develop machine learning models for accurate and accessible LMM prediction.

Impact of preoperative intraocular pressure on corneal endothelial cell loss after phacoemulsification in acute primary angle-closure glaucoma with cataracts.

Purpose: This study aimed to assess corneal endothelial cell loss (ECL) following phacoemulsification and intraocular lens implantation (Phaco+IOL) in eyes with acute primary angle-closure glaucoma (APACG) and cataracts under different preoperative intraocular pressure (IOP) levels.

Methods: This non-randomized controlled trial included 75 eyes from 75 patients with APACG and cataracts who underwent Phaco+IOL. All patients received pharmacotherapy and anterior chamber paracentesis before surgery and were grouped according to their preoperative IOP: the high-IOP group (IOP ≥ 25 mmHg) and the IOP-controlled group (IOP < 25 mmHg).

Unveiling sources and fate of sulfate in lake-groundwater system combined Bayesian isotope mixing model with radon mass balance model.

The role of various natural and anthropogenic factors in controlling sulfate behavior in lake-groundwater system is not fully understood. In this study, a hybrid isotopic approach incorporating multi-isotopes (D/O/S/O/Rn) and quantitative models was used to reveal and quantify the sources and fate of sulfate in two lake-groundwater systems (Daihai and Ulansuhai Lake basins) in Inner Mongolia, China. In the Daihai Lake basin, dissolved sulfate was mainly derived from evaporite dissolution (> 50 %) and sulfide oxidation (10 % ∼ 30 %; including mineralization and pyrite oxidation).

Spatial variability of lacustrine groundwater discharge and pollutant fluxes in the sandy-land lake group basins: Influence from land use types.

Deciphering lacustrine groundwater discharge (LGD) processes and pollutant fluxes in sandy-land lake basins remain difficult due to the complex hydrogeological conditions and land use types. In this study, the spatial variability of LGD in a sandy-land lake group (Bahannao Lake Group Basin) was quantitatively estimated using the radon (Rn) mass balance model. The 5 lakes in the study area, with their various land use and hydrogeological conditions, were categorized into 3 ranges based on LGD rates: <20.

EFEMP1-Mediated Regulation of Choroidal Vascular Dysfunction in Myopia: Insights Into the FOXO3/VEGFA Pathway as a Therapeutic Target.

Purpose: This study investigates the role of EFEMP1 in choroidal vascular dysfunction and its implications for myopia progression, specifically focusing on the FOXO3/VEGFA signaling pathway as a potential therapeutic target.

Methods: We utilized adeno-associated virus (AAV) to overexpress and knock down EFEMP1 in the choroid of guinea pigs. Subsequent proteomic analyses were conducted on the choroidal tissue.

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer.

New treatment strategies are urgently needed for patients with advanced cervical cancer (CC). Here, a synergistic anti-CC effect of a novel combinatorial immunotherapy with adoptively transferred autologous Vγ9Vδ2 T cells and αβ T cells is shown. The pivotal role of both circulating and tumor-infiltrating Vγ9Vδ2 T cells in anti-CC immunity is uncovered.

Hydrochemical insights into spatiotemporal characteristics of groundwater salinization and health risk assessment of fluoride in the south bank of Yellow River irrigation area, Northwest China.

The groundwater salinization problem in the south bank of the Yellow River irrigation area is severe, restricting the sustainability of groundwater resources. However, the groundwater salinization formation mechanism is unclear. Accordingly, this study analyzed the chemical characteristics and salinization mechanism of groundwater based on hydrochemical analyses (self-organizing maps, SOM), isotope analyses (δO and δD), and quantitative models (Rayleigh distillation model), as well as evaluating the potential health risks of fluoride.

Emission factors and driving forces of provincial-level CO from electricity production and consumption in China from 2013 to 2020.

China's power sector has significant CO emissions, posing a substantial reduction challenge. Current emission reduction measures lack a systematic perspective, failing to adequately consider the primary drivers of emission growth associated with electricity consumption. Most existing driving force analyses overlook the role of electricity consumption and the complexities of the power transmission networks.

A deep learning-based psi CT network effectively predicts early recurrence after hepatectomy in HCC patients.

Background: Hepatocellular carcinoma (HCC) exhibits a high recurrence rate, and early recurrence significantly jeopardizes patient prognosis, necessitating reliable methods for early recurrence prediction.

Methods: Utilizing multi-institutional data and integrating deep learning (DL) techniques, we established a neural network based on DenseNet capable of concurrently processing patients' triphasic enhanced CT scans. By incorporating an attention mechanism, the model automatically focuses on regions that significantly impact patient survival.

Symptom clusters, fear of disease progression, and quality of life in postoperative gastric cancer patients: a cross-sectional study.

Background: Gastric cancer is a common tumor globally. Surgery is the preferred treatment for gastric cancer. Yet, little is known about its symptom clusters, fear of disease progression, and quality of life (QoL).

Developmental validation of the AGCU EX-38 typing system: a comprehensive forensic tool for enhanced genetic identification.

The necessity for developing the AGCU EX-38 typing system arises from the ever-increasing demand for more accurate and comprehensive forensic tools. Traditional kits with fewer STRs often fall short in complex cases requiring higher resolution. The AGCU EX-38 typing system incorporates 35 autosomal STRs, including extended CODIS loci as well as additional non-CODIS loci (D6S1043, D19S3045, D3S3045, D7S3048, D11S2368, D4S2366, D8S1132, D15S659, Penta D, Penta E, D6S447, D3S1744, D14S608, D18S535).

Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study.

Background: Vitamin D is crucial for regulating calcium and phosphorus metabolism. More studies have revealed its role in chronic diseases. Our study aimed to examine the relationship between thyroid function and Type 2 Diabetes Mellitus (T2DM).

Association Between TyG-BMI Index and Hyperuricemia in Adult Women.

Purpose: This study aimed to explore the relationship between hyperuricemia (HUA), the triglyceride-glucose index (TyG) and its derivatives in adult women.

Methods: A cross-sectional analysis was conducted on 1105 female patients from Shanghai Tenth People's Hospital. Participants were divided into HUA (n = 331) and non-HUA (n = 774) groups.

Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study.

Background: Alanine aminotransferase (ALT) is an enzyme crucial for energy and protein metabolism in muscle cells. Despite this, its association with sarcopenia remains inadequately explored. This study aims to investigate the correlation between serum levels of ALT-related indicators (ALT activity, ALT1, ALT2, and ALT1/ALT2 ratio) and sarcopenia measures, as well as to develop a diagnostic model for sarcopenia in older individuals.