Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma.

There are no proven therapies for metastatic or unresectable Chromophobe Renal Cell Carcinoma (ChRCC). ChRCC is characterized by high glutathione levels and hypersensitivity to ferroptosis, an iron-dependent form of cell death characterized by peroxidation of polyunsaturated fatty acids. The underlying mechanisms leading to ferroptosis hypersensitivity are unknown.

Obesity hinders the efficacy of adipose-derived stem cells for knee osteoarthritis by reducing the proportion of DPP4+ stem cells.

Osteoarthritis (OA) is the most prevalent and disabling joint disease, while adipose-derived stem cells (ASCs) have emerged as a promising therapeutic option in pre-clinical studies. However, the therapeutic efficacy of ASCs may be influenced by the source of these cells, especially in obese patients. This study compared the effects of intra-articular injections of ASCs from wild-type (WT) and ob/ob (OB) mice.

Formation and Biological Characteristics Analysis of Artificial Gynogenetic WuLi Carp Induced by Inactivated Sperm of Megalobrama Amblycephala.

Artificial gynogenesis is an essential technique for aquaculture breeding. Fertile offspring of the WuLi carp ( var. Quanzhounensis, 2 = 100, WLC) were successfully produced via gynogenesis using ultraviolet-irradiated sperm from the blunt snout bream (, 2 = 48, BSB).

Modified Neutrophil Platelet Scores (MNPs): A Novel Prognostic Marker in Colorectal Cancer.

Background: Inflammation can influence how tumors develop and is linked to patient outcomes. We studied a new marker called the Modified Neutrophil Platelet Score (MNPs), which uses blood neutrophil and platelet counts. This research aimed to verify if MNPs and other clinical markers help doctors better predict disease severity after surgery for people with colorectal cancer.

Identification and exploration of novel biomarkers and potential therapeutic agents for the progression of sepsis to septic ARDS.

Patients with sepsis complicated by acute respiratory distress syndrome (ARDS) face a significantly increased risk of in-hospital death. This study aimed to identify sepsis-associated genes involved in ARDS pathogenesis and discover candidate biomarkers for its diagnosis. Gene expression profiling data from the Gene Expression Omnibus database were analyzed to identify key septic ARDS genes using differential expression analysis and weighted gene co-expression network analysis.

Insulin resistance, left atrial anatomical remodeling, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation.

Background: Insulin resistance (IR) is associated with both the anatomical remodeling of the left atrium and the pathogenesis of atrial fibrillation (AF). However, the exact extent of this correlation and its influence on AF recurrence in individuals undergoing radiofrequency catheter ablation (RFCA) remains unclear.

Methods: A total of 910 patients with AF who underwent RFCA were included in this analysis.

Proteomic profiling reveals distinct inflammatory and neurogenic endotypes in rosacea.

Background: Rosacea represents a chronic inflammatory dermatosis with potential systemic manifestations. While neuroimmune dysregulation and systemic inflammation are implicated in its pathogenesis, comprehensive proteomic profiling remains unexplored.

Objective: To characterize serum proteomic signatures and identify molecular endotypes in rosacea.

Development and validation of a pediatric pharmacological readiness assessment scale for recurrent respiratory infections.

To develop and validate a Pediatric Pharmacological Readiness Assessment Scale for recurrent respiratory infections, focusing on medication adherence, caregiver pharmacological knowledge, and pharmacist-led interventions. An initial scale was constructed through literature review, expert consultation, and a pilot survey, guided by the Pharmaceutical Care Practice Model. A convenience sample of 156 primary caregivers of children hospitalized for recurrent respiratory infections was surveyed between April 2023 and April 2024.

Comparative Effects of Maturity and Processing on Chemical Composition and Bioactivities in Leaves.

("Heiyouchun") is a traditional Chinese woody vegetable, the leaves of which can also be processed into tea, known for its distinctive flavor and diverse bioactivities. However, the effects of leaf maturity and processing methods on its phytochemical composition and functional properties remain unclear. In this study, metabolomic analysis revealed 35 significantly different metabolites between tender and mature leaves, with higher concentrations of flavonoids, flavonoid glycosides, limonoids, and amino acids in tender leaves.

Multi-channel enhanced high-precision 3D structured light measurement.

This paper investigates a structured illumination microscopy method based on multi-channel information fusion (multi-channel information fusion structured illumination microscopy [MF-SIM]) to enhance the accuracy and stability of micro-nano 3D morphological measurements. The method utilizes multi-channel images captured by a color CCD and leverages the characteristics of different wavelengths corresponding to distinct focal planes to extract abundant modulation information from a single frame. By fusing multi-channel data, it effectively overcomes the vulnerability to noise interference caused by small gradients at the modulation peak in traditional single-channel systems.

Correction: Systematic analysis of the interaction mechanism between platelets and coronary heart disease: From molecular pathways to new strategies for plant based antiplatelet therapy.

[This corrects the article DOI: 10.3389/fphar.2025.

Physiological pH Responsive Integrated Antifouling and Antimicrobial Interface with Long-Term Activity via Amino-Carboxylate Coordination Chemistry.

Microbial colonization and infection of biomedical devices remain a persistent clinical challenge. Interfacial coatings with antifouling and antimicrobial functions simultaneously under physiological conditions are highly desired to mitigate the infection risks. Herein, we constructed a durable serine-derived zwitterionic antifouling and antimicrobial interfacial structure amino-carboxylate coordination with Cu(II) ions in alkaline aqueous solutions.

Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia.

Androgenetic alopecia (AGA), a pervasive hair loss disorder, lacks effective therapies due to incomplete pathogenic understanding. Growing evidence suggests a connection between AGA and metabolic disorders. Leveraging unbiased serum metabolomics, a strikingly differentiated metabolic signature in AGA patients compared to healthy controls is identified, with arginine deficiency exhibiting the most pronounced reduction among all amino acids.

Skin burns after high-intensity focused ultrasound ablation: a retrospective control study.

High-intensity focused ultrasound (HIFU) ablation is a minimally invasive treatment for benign gynecological diseases, though skin burns remain a potential complication. Understanding risk factors is critical for improving safety. In this study, we aimed to investigate the risk factors for skin burns in patients who underwent HIFU ablation.

Local stress-geometry equation of 2D frictionless granular systems.

For a static granular system, the constitutive equation of its stress tensor is of great significance for understanding its mechanical behaviors. Under isostatic state, it can have the form of stress-geometry equation. To investigate the force moment tensor and the stress-geometry equation of a two-dimensional (2D) granular system in theory, we propose some algebraic theories such as the decomposition formula of a second-order tensor and the cross-product of two symmetric tensors for the dyadic space .

Clinical efficacy of combined detection of serum procalcitonin and C-reactive protein in early differential diagnosis of bacterial and viral pneumonia and analysis of related inflammatory response mechanisms.

Background: Early distinction of bacterial etiology from viral causes represents a cornerstone for rational antimicrobial therapy. Through evaluation of dual-biomarker strategies, this investigation examined the diagnostic utility of simultaneous PCT and CRP measurement while elucidating underlying inflammatory pathways.

Methods: A retrospective analysis encompassed 284 patients diagnosed with pneumonia (bacterial:  = 162, viral:  = 122) hospitalized during January 2023 through December 2024.

Clinical adverse events to voclosporin: a real-world drug safety study based on FDA Adverse Event Reporting System.

Objectives: Voclosporin, a novel calcineurin inhibitor, is emerging as a promising treatment for lupus nephritis (LN). It inhibits T and B cell activation with unique pharmacokinetic profile and superior safety. To optimise clinical management, a comprehensive assessment of real-world safety is urgently needed.

Breaking Tumor Chemoresistance via METTL3 Regulation Enhanced by Sequential Delivery of Dexamethasone.

The frequent occurrence of chemoresistance in breast tumors remains a challenge to achieving satisfactory therapeutic efficacy, and a smart drug delivery system with flexible properties is urgently needed to achieve an all-in-one combination anticancer therapy. In this study, an efficiency delivery system with a pH-triggered detachable PEG layer (sPEG) and a folic acid (FA)-modified cationic liposome core (FLip) is constructed for codelivering doxorubicin (DOX) and METTL3 siRNA (siMETTL3). The obtained codelivery nanoparticles (NPs), sPEG-FLip@DOX/siMETTL3, can maintain circulatory stability with minimized systemic toxicity, which is attributed to the negatively charged sPEG layer, and expose the positively charged FLip core in the weakly acidic extracellular environment to facilitate the internalization by MCF-7/ADR cells.

Adaptive wavelength calibration for robust multi-plane phase retrieval.

Multi-plane phase retrieval reconstructs complex wavefronts from axially scanned diffraction patterns. However, laser instability or calibration errors can cause the experimental wavelength to deviate from the nominal value, resulting in cumulative phase errors and resolution loss. Here, we propose an adaptive wavelength calibration (AWC) algorithm to compensate for wavelength deviations by adjusting axial propagation distances during iteration.

An improved lightweight tongue segmentation model with self-attention parallel network and progressive upsampling.

Tongue diagnosis is a crucial component of the Four Diagnostic Methods in Traditional Chinese Medicine (TCM), which include observing, listening and smelling, inquiring, and palpation. Tongue image segmentation holds great significance in advancing the intelligentization of tongue diagnosis research. This paper introduces an improved model called Parallel Attention and Progressive Upsampling for Tongue Segmentation (PAPU_TonSeg), based on the Segformer architecture, to address the issues of inaccurate and blurred tongue edge segmentation in tongue semantic segmentation.

Dynamic Changes in Sensory Quality and Chemical Components of Bingdao Ancient Tree Tea During Multiple Brewing.

Bingdao ancient tree tea (BATT), a type of raw Pu-erh tea, is renowned for its brewing durability, characterized by a unique aroma and flavor. To explore the dynamic changes in infusion quality and the impact of multiple steeping process, BATT was brewed 14 times, and its sensory attributes, infusion color, and chemical composition were assessed across different brewing intervals. The color of the tea infusion remained relatively stable throughout the brewing process.

Reliability of ultrasound-based measurements for tongue-palate distance and tongue thickness assessment in healthy individuals.

Objective: The morphology of the tongue and its relationship with the hard palate play an important role in the rehabilitation of patents with temporomandibular joint disorders (TMD). This study aimed to evaluate the intra-and inter-evaluator reliability of ultrasound measurements of tongue-palate distance and tongue thickness in healthy individuals.

Methods: Thirty healthy volunteers were assessed using a Mindray ultrasound device with a C5-1s probe.

Endoplasmic reticulum-targeted strategies for programmed cell death in cancer therapy: Approaches and prospects.

The endoplasmic reticulum (ER) plays a dual role in cancer biology, functioning both to preserve cellular homeostasis and to facilitate pathological progression. Rapidly proliferating cancer cells, which exhibit heightened metabolic activity, frequently experience ER stress that activates the unfolded protein response (UPR), a mechanism that promotes cellular adaptation and survival. However, when ER stress is prolonged or excessive, it can shift the balance toward programmed cell death (PCD), including apoptosis, autophagy, ferroptosis, pyroptosis, and necroptosis.

Comparative analysis of fruit microbiota and metabolites in two bayberry cultivars: implications for fruit quality and postharvest disease control.

The fruit microbiome is crucial for fruit quality and postharvest characteristic. This study characterized the microbiome and metabolome of two bayberry cultivars ( cv. DongKui and Dingao) across three orchardsusing high-throughput sequencing and GC-MS metabolomics.