A 2-nm mode-hop-free tunable 1018-nm DBR single-frequency low-noise fiber laser.

This paper presents a comprehensive optimization of tuning capability and noise characteristics in 1018-nm distributed Bragg reflector (DBR) single-frequency fiber lasers. By implementing an advanced doped fiber design and a dual-stage precision thermal control system, for the first time, we demonstrate a fusion-spliced DBR fiber laser incorporating an 8-mm Yb-doped fiber that achieves >2 nm mode-hop-free continuous tuning across an extended temperature range of -20 °C to 175 °C. The integration of a piezoelectric transducer (PZT) tuning mechanism enables rapid frequency adjustment with a 10-GHz tuning bandwidth.

Assessment of facial pressure sensitivity of head-mounted displays based on practical application scenarios.

With the development of Virtual Reality and Augmented Reality technologies, improving the comfort of head-mounted displays (HMDs) is crucial for optimizing user experience. Although pressure threshold measurements have been widely applied in the design of wearable devices, no studies have yet investigated pressure sensitivity specific to HMDs. This study developed a novel handheld electronic force gauge to measure subjective discomfort sensitivity at nine key contact points between the HMD and the face under varying applied forces.

Analysis of laser spot centroiding errors for laser acquisition system in gravitational wave detection missions.

In space-based gravitational wave detection, establishing ultra-long-distance and ultra-high-precision laser links between satellites is achieved through the laser acquisition and tracking system. The laser spot centroid positioning method, which offers low computational complexity and strong adaptability to beam shape, is currently the core measurement method during the laser acquisition phase. However, due to various interference factors encountered in practical tests, this algorithm often falls short of meeting the extremely high requirements.

Evaluating the impact of weight and center of mass on comfort in head-mounted displays.

This study investigates the impact of the weight and centre of mass (COM) position of Head-Mounted Displays (HMDs) on the subjective evaluation of users during prolonged wearing tasks. This study involved 88 participants completing 1860 sets of experiments under three conditions: sitting still, turning the head, and moving, providing subjective evaluations of wearing HMDs. A static torque testing device was used to simulate neck torque under flexion states.

Optimizing sports performance in China: Investigating the influence of training, recovery, motivation, and environmental support within a moderation-mediation framework.

The expansion of sports in China is astounding. Given the country's focus on athletic achievement, it is crucial to comprehend the different facets of sports. This research examines China's athletic success in training, recuperation, motivation, and environment.

Experimental demonstration of constant amplitude modulation heterodyne interferometry.

In the space gravitational wave detection, numerous laser interferometer strategies have been proposed to reduce the complexity of traditional heterodyne interferometers. Previously, we proposed a novel interferometric strategy and simulated its effectiveness, called CAM (constant amplitude modulation) heterodyne interferometry. Compared with other methods, the CAM can introduce the OPT (optical pilot tone) for the common-mode noise rejection.

Multi-frequency signal acquisition and phase measurement in space gravitational wave detection.

To enhance the accuracy of phase measurement and to prevent tracking errors, it is crucial to effectively read the multi-frequency signal in space gravitational wave detection. In this paper, a novel signal acquisition method called the multi-frequency acquisition algorithm is proposed and implemented. Different from the traditional single-frequency acquisition, the signal characteristics of amplitude and frequency are both considered to better distinguish different frequency components.

Verification of Laser Heterodyne Interferometric Bench for Chinese Spaceborne Gravitational Wave Detection Missions.

Construction of laser heterodyne interferometric bench to measure tiny translation and tilt with picometer- and nanoradian-level sensitivity in the millihertz band is critical for the success of spaceborne gravitational wave detection, including the LISA, Taiji, and Tianqin missions. In this paper, we report on the construction and testing of a laser heterodyne interferometric bench that contains two optical path designs, the dual-beam heterodyne interferometry and the polarization-multiplexing heterodyne interferometry. The measurement sensitivity of translation and tilt reaches below 3 pm/Hz and 12 nrad/Hz for frequencies above 10 mHz, respectively.

Effect of Virtual Reality Upper Limb Rehabilitation Training on Older Adults.

Virtual reality has gained more attention in the physical training field, but few studies focus on the effects of VR on older adults. Based on existing study we suggest that VR-based upper limb training might be more effective for older adults and used functional near inferred spectrum and movement analysis to evaluate the effects of VR-based training on older adults. 20 older and 20 youth adults were recruited to perform VR training by extending their upper limb to reaching the objects, and non-VR training as a contrast.

Study on the Effect of Micro-Force Perturbations and Temperature Fluctuation on Interferometer for the Taiji Program.

To increase the interferometric measurement resolution in the Taiji program, we present a noise suppression method in this paper. Taking the specific micro-force perturbation and temperature fluctuation in the Taiji-1 interferometer as an example, we set up and experimentally verified the corresponding transfer function to quantify the effect of both noise sources on the interferometric results. Consistent results were obtained between the numerical and experimental results for the transfer function.

Design and Construction of the Optical Bench Interferometer for the Taiji Program.

A kind of full-function two-sided optical bench interferometer (OBI) is designed to meet the practical requirements of the Taiji Program for space gravitational wave detection. The main optical paths are arranged on the A-side for transmission and interference, and other optical paths and electronic devices are placed on the B-side. According to the design scheme, we successfully constructed two OBIs by using hydrogen-oxygen catalytic stress-free bonding technology.

Using DWS Optical Readout to Improve the Sensitivity of Torsion Pendulum.

In space gravitational wave detection missions, a drag-free system is used to keep the test mass (TM) free-falling in an ultralow-noise environment. Ground verification experiments should be carried out to clarify the shielding and compensating capabilities of the system for multiple stray force noises. A hybrid apparatus was designed and analyzed based on the traditional torsion pendulum, and a technique for enhancing the sensitivity of the torsion pendulum system by employing the differential wavefront sensing (DWS) optical readout was proposed.

Measurement of pressure discomfort threshold in auricular concha for in-ear wearables design.

In an effort to mitigate the homogenization of in-ear wearables, designers have been focusing on finding new solutions to enhance user comfort. While the concept of pressure discomfort thresholds (PDT) in humans has been applied to product design, research on the auricular concha remains scarce. In this study, we conducted an experiment to measure the PDT at six points in the auricular concha of 80 participants.

Olanzapine With or Without Fosaprepitant for Preventing Chemotherapy Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy: A Phase III Randomized, Double-Blind, Placebo-Controlled Trial (ALLIANCE A221602).

Purpose: A protocol was developed to evaluate the value of an NK-1 receptor antagonist for preventing nausea and vomiting resulting from highly emetogenic chemotherapy when an olanzapine-based antiemetogenic regimen was used.

Materials And Methods: A221602, a prospective double-blind, placebo-controlled clinical trial, was developed to compare 2 -olanzapine-containing antiemetic regimens, one with an NK-1 receptor antagonist (aprepitant or fosaprepitant) and one without. Trial patients had a malignant disease for which they received intravenous highly emetogenic chemotherapy (single day cisplatin ≥ 70 mg/m2 or doxorubicin plus cyclophosphamide on 1 day).

Constant amplitude modulation heterodyne interferometry.

Laser interferometer with picometer precision is a key technology in the space gravitational wave detection. Many interferometry strategies have been put forward for the multiple purposes in the past 10 yr. We propose a new interferometry method, called constant amplitude modulation (CAM) heterodyne interferometry.

A functional near-infrared spectroscopy study of the effects of video game-based bilateral upper limb training on brain cortical activation and functional connectivity.

Video game-based therapies are widely used in rehabilitation. Compared with conventional bilateral upper limb training (CBULT), the effects of video game-based bilateral upper limb training (VGBULT) on brain cortical activation and functional connectivity, still not fully clear. We have developed a VGBULT system, and measured the brain activity of 20 elderly subjects (10 male, mean age = 62.

Age-related changes in brain functional networks under multisensory-guided hand movements assessed by the functional near - Infrared spectroscopy.

Objectives: This study aims to explore the age-related effects of hand rehabilitation training under multisensory stimulation interaction on brain functional networks.

Methods: A multisensory stimulation training glove (MSTG) was designed to realize 3 sensory guidance modes, namely audio-visual guidance (AVG), visual guidance (VG) and no guidance (NG). This study recruited 20 older subjects as the experimental group and 22 young people as the control group.

Diet and Health-related Quality of Life Among Men on Active Surveillance for Early-stage Prostate Cancer: The Men's Eating and Living Study (Cancer and Leukemia Group 70807 [Alliance]).

Background: Health-related quality of life (HRQoL) among patients with localized prostate cancer (PC) on active surveillance (AS) and whether it may be improved through lifestyle-focused interventions remain underdefined.

Objective: To assess longitudinal changes in HRQoL in patients who received and those who did not receive a behavioral intervention that increased vegetable intake.

Design, Setting, And Participants: A secondary analysis of participants in the Men's Eating and Living (MEAL) study (Cancer and Leukemia Group 70807 [Alliance]), a randomized trial of vegetable consumption in patients on AS, was conducted.

Randomized Phase II Study of Two Doses of Pixantrone in Patients with Metastatic Breast Cancer (NCCTG N1031, Alliance).

Background: Anthracycline use in metastatic breast cancer (MBC) is hindered by cumulative exposure limits and risk of cardiotoxicity. Pixantrone, a novel aza-anthracenedione with structural similarities to mitoxantrone and anthracyclines, is theorized to exhibit less cardiotoxicity, mainly due to lack of iron binding. We conducted a randomized phase II study to evaluate the efficacy and safety of 2 dosing schedules of pixantrone in patients with refractory HER2-negative MBC.

Inter-spacecraft offset frequency setting strategy in the Taiji program.

For controlling the beat frequency of heterodyne interferometry so that the Taiji program can detect gravitational waves in space, an offset frequency setting strategy based on a linear programming algorithm is proposed. Considering factors such as Doppler frequency shift, phase-locking scheme, laser relative intensity noise, and phase detector bandwidth, inter-spacecraft offset frequency setting results suitable for the Taiji program are obtained. During the six years of running the detection process, the use of frequency bounds in the range of [5 MHz, 25 MHz] showed that offset frequencies will remain unchanged for a maximum of 1931 days.

Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial.

Importance: Nearly 96% of patients with high-grade glioma (HGG) report moderate-to-severe fatigue. Armodafinil is a psychostimulant that might help cancer-related fatigue in patients with HGG.

Objective: To determine whether armodafinil reduces fatigue in patients with HGG and moderate-to-severe fatigue.

A low-noise analog frontend design for the Taiji phasemeter prototype.

The Taiji program plans to utilize the laser interferometer to measure the movement at the picometer level between free-floating test masses. As the phase readout equipment, the phasemeter needs to obtain the beat note with an accuracy of μrad/Hz. The main source of noise in the phasemeter is the analog frontend of the analog to digital converter.

Prognostic and Predictive Impact of Primary Tumor Sidedness for Previously Untreated Advanced Colorectal Cancer.

Background: Unplanned subgroup analyses from several studies have suggested primary tumor sidedness (PTS) as a potential prognostic and predictive parameter in metastatic colorectal cancer (mCRC). We aimed to investigate the impact of PTS on outcomes of mCRC patients.

Methods: PTS data of 9277 mCRC patients from 12 first-line randomized trials in the ARCAD database were pooled.

The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial.

Current therapies for breast cancer prevention only prevent estrogen receptor positive (ER+) disease and toxicity limits use of these agents. Vitamin D is a potential prevention therapy for both ER+ and ER- disease and is safe with few side effects. This study evaluates the effect of 1-year of vitamin D supplementation on mammographic density (MD), a biomarker of breast cancer risk in a multicenter randomized controlled trial.

BRAF V600E Mutation in First-Line Metastatic Colorectal Cancer: An Analysis of Individual Patient Data From the ARCAD Database.

Background: First-line therapeutic strategies for patients with BRAFV600E-mutated (BRAFmt) metastatic colorectal cancer (mCRC) mainly rely on subgroup analyses from randomized controlled trials (RCTs). We aimed to assess the prognostic and predictive impact of BRAFmt on the efficacy of targeted therapies with first-line chemotherapy.

Methods: Individual patient data from first-line RCTs with BRAF and KRAS status data in the ARCAD database were pooled.